EKS-DRM-00101
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00101
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/LISK459.73.5E-138187472286
StatusReviewed
Ensembl ProteinFBpp0291045
UniProt AccessionQ8IR79; Q8IR78; Q9GV18; Q9GV19; Q9VYL6;
Protein NameLIM domain kinase 1
Protein Synonyms/Alias LIMK-1; dLIMK;
Gene NameLIMK1
Gene Synonyms/Alias LIMK1; LIMK; CG1848;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0041203FBpp0291044FBtr0301830
FBgn0041203FBpp0291045FBtr0301831
FBgn0041203FBpp0073494FBtr0073661
FBgn0041203FBpp0073493FBtr0073660
FBgn0041203FBpp0073492FBtr0073659
OrganismDrosophila melanogaster
Functional DescriptionProtein kinase which regulates actin filament dynamics.Phosphorylates and inactivates the actin binding/depolymerizing factor tsr/cofilin, thereby stabilizing the actin cytoskeleton. Modulation of actin cytoskeleton dynamics may be essential for imaginal disk morphogenesis and axon guidance.
Protein Length1043
Protein Sequence
(FASTA)
MAEQCCGAPY RIDVNLTNLH IGDRILEVNG TPVSDSSVEQ IDKLIRSNEK MLQLTVEHDP 60
VQVCRSCSQA DIQRAMSAST LILPLSTSAS SVEVGRERLY KTPGEQGTKA RKLRQATNAS 120
TTIPPAAGAT AMTQLKEKER CSSLSKLLDE QHQAQQHSAH PQLYDLSRTQ SCRVVQKPQR 180
IFRATDLVIG EKLGEGFFGK VFKVTHRQSG EVMVLKELHR ADEEAQRNFI KEVAVLRLLD 240
HRHVLKFIGV LYKDKKLHMV TEYVAGGCLK ELIHDPAQVL PWPQRVRLAR DIACGMSYLH 300
SMNIIHRDLN SMNCLVREDR SVIVADFGLA RSVDAPRLPS GNMTPGGYGS GANSDAPMSP 360
SGTLRRSKSR QRRQRYTVVG NPYWMAPEMM KGLKYDEKVD VFSFGIMLCE IIGRVEADPD 420
FMPRNSDFSL NQQEFREKFC AQCPEPFVKV AFVCCDLNPD MRPCFETLHV WLQRLADDLA 480
ADRVPPERLL HEIETFQEWY ASSEDALSPT SQRSLNNLDE LVKSAVDSEI SPVEKEKENM 540
VIKPQDIPKS PHLGKDFSPS GERLRDSMRA RRRQRFLGAQ EERRNLTPDT ESKERALKKA 600
LKKCRPFGER GYLVDLRAGA ELQLEDVRDL NTYSDVDSSC DTSLNYHDVN NLPAAQEDEN 660
TVKPGKEELL EESTNKPSNQ ESQHHRLAID DMRTRLNQCR SKFEHLEEAS RRNFNQSQHS 720
MKNFFKTPPV ALKMFQRLEH EAAALNGGNN CPPPPPRTQR INQTPIFGRK NPPVAIVGQK 780
LQHAESLEDL ASSGVAKQLA TPAPKRSKAT ATTKGGQSSN PPLFLPPSLN ISVALNSNGN 840
VTTTTNTNSS CPPSASDWLP KKHKLTLPLP SAQQQRTSSN HRLPMCNNKG KTLKPLPSRT 900
GSQGIPASNC VSPTRSSRPG SPTKHLAQRH TAATAQRLTN AAATHQQQHQ QQSSKTTRLN 960
ILSPEKVHRL GARLTDQKQK MREEAAATAS SVGGAGCAAG TAAGSLNGHR TIGSSGTPNS 1020
AVGERRRRAA PSPPVRTHFN TRC 1043
Nucleotide Sequence
(FASTA)
ATGGCGGAAC AGTGCTGTGG GGCGCCTTAT AGAATTGATG TGAATCTTAC AAATCTGCAT 60
ATTGGAGATA GGATATTGGA GGTGAACGGC ACACCAGTTA GTGATTCGTC CGTGGAACAG 120
ATCGACAAAT TGATACGGAG TAATGAGAAG ATGCTTCAGC TGACCGTGGA GCATGATCCG 180
GTGCAAGTGT GCCGCTCCTG CAGCCAAGCG GACATCCAGC GGGCCATGTC AGCGTCCACG 240
TTAATCCTGC CGCTCAGCAC ATCGGCCTCC AGTGTCGAGG TGGGCAGGGA GCGTCTGTAC 300
AAGACACCCG GCGAACAGGG CACGAAGGCC AGGAAACTGC GACAAGCCAC CAATGCCTCT 360
ACGACAATAC CACCGGCAGC TGGAGCCACC GCAATGACGC AACTAAAGGA GAAGGAGCGT 420
TGTTCCAGTC TGTCCAAGTT GCTGGATGAA CAGCATCAGG CACAACAGCA TTCGGCGCAT 480
CCTCAGCTCT ATGATCTGTC CAGGACGCAA TCCTGCCGTG TCGTCCAAAA GCCACAACGA 540
ATCTTTCGTG CAACTGATCT GGTTATAGGA GAGAAGCTAG GCGAGGGCTT CTTTGGCAAG 600
GTTTTCAAGG TGACCCACCG TCAGAGCGGC GAGGTGATGG TCCTCAAAGA ACTGCATCGT 660
GCGGATGAGG AAGCGCAAAG GAATTTCATC AAGGAAGTGG CCGTTCTCCG TTTGCTGGAC 720
CATCGGCATG TGCTCAAATT CATTGGTGTT CTGTACAAGG ATAAGAAACT GCACATGGTC 780
ACGGAGTACG TGGCCGGTGG TTGTCTCAAG GAGCTGATCC ACGATCCAGC CCAAGTACTC 840
CCTTGGCCCC AGCGCGTCCG CTTGGCCAGG GATATTGCGT GCGGCATGAG CTATCTGCAC 900
TCGATGAACA TCATCCATCG CGATTTGAAC TCAATGAATT GCCTGGTCCG TGAAGATCGC 960
TCGGTCATAG TGGCGGATTT TGGACTAGCT CGCAGTGTGG ATGCGCCGCG GCTGCCAAGT 1020
GGCAATATGA CGCCAGGCGG CTATGGATCA GGCGCTAACA GCGATGCGCC CATGTCACCG 1080
AGTGGAACAC TAAGGCGCAG CAAGAGCAGG CAGCGAAGGC AACGTTACAC GGTGGTCGGG 1140
AATCCCTACT GGATGGCACC CGAGATGATG AAAGGTCTCA AATACGACGA AAAGGTGGAT 1200
GTCTTCTCCT TTGGCATTAT GTTGTGTGAG ATCATTGGAC GCGTGGAAGC CGATCCGGAT 1260
TTTATGCCTC GCAATTCGGA CTTCAGTCTC AATCAGCAGG AGTTTCGCGA GAAGTTCTGC 1320
GCTCAGTGTC CAGAGCCTTT CGTTAAAGTG GCCTTCGTGT GCTGTGATCT TAATCCCGAT 1380
ATGCGTCCGT GTTTCGAAAC TCTGCACGTT TGGCTGCAGC GTCTCGCCGA TGATCTGGCC 1440
GCCGATCGTG TGCCGCCAGA GCGTCTGCTG CACGAGATTG AGACCTTTCA GGAATGGTAC 1500
GCCAGCTCTG AGGACGCCTT GTCACCCACC TCCCAGCGCA GCTTAAATAA TCTCGATGAG 1560
TTGGTCAAGA GTGCGGTGGA TTCGGAAATT TCGCCGGTAG AAAAAGAGAA GGAGAATATG 1620
GTGATTAAGC CCCAGGATAT ACCGAAATCT CCGCATCTCG GCAAGGATTT CTCGCCCAGC 1680
GGCGAGAGAC TGCGTGACAG TATGCGGGCC AGGCGTCGCC AACGTTTCTT GGGCGCCCAG 1740
GAGGAGCGTC GTAATCTCAC GCCCGACACG GAGTCCAAGG AAAGGGCTTT GAAGAAGGCG 1800
CTGAAGAAAT GTCGTCCGTT TGGCGAAAGA GGTTACCTGG TGGATCTGCG TGCCGGTGCC 1860
GAATTGCAGC TAGAGGATGT CAGGGATTTG AACACCTATT CCGATGTGGA CTCCAGTTGC 1920
GATACTAGCC TAAATTACCA TGATGTAAAT AATCTGCCAG CAGCGCAAGA GGATGAGAAT 1980
ACAGTGAAAC CGGGCAAGGA AGAACTGTTG GAGGAGAGCA CAAATAAACC CAGCAACCAG 2040
GAGTCACAAC ACCATCGTCT GGCCATCGAT GATATGCGCA CCCGCCTGAA TCAGTGCCGC 2100
AGCAAATTCG AGCATTTGGA GGAGGCTAGT CGGCGGAACT TCAACCAGTC GCAGCACTCC 2160
ATGAAGAACT TTTTCAAAAC CCCACCGGTG GCCCTTAAGA TGTTTCAGCG CCTGGAGCAC 2220
GAGGCTGCAG CCCTGAATGG TGGCAACAAT TGCCCACCGC CACCACCACG TACGCAGCGC 2280
ATCAATCAGA CGCCCATTTT CGGTCGAAAG AATCCGCCAG TGGCAATCGT CGGGCAAAAA 2340
CTACAGCATG CTGAGTCCCT AGAGGACCTG GCCTCCAGCG GAGTTGCCAA ACAGCTGGCC 2400
ACACCAGCAC CCAAACGCAG CAAAGCCACA GCAACGACCA AAGGCGGCCA GAGCAGCAAT 2460
CCGCCACTTT TCCTGCCGCC TAGCCTTAAC ATAAGTGTCG CATTAAATAG CAATGGAAAT 2520
GTGACCACAA CGACCAATAC CAATAGTAGT TGTCCACCAT CCGCATCAGA CTGGCTGCCG 2580
AAGAAGCACA AGCTAACTTT GCCACTTCCG TCGGCCCAAC AGCAGCGAAC GAGCAGCAAT 2640
CATCGCCTGC CAATGTGCAA TAACAAAGGG AAGACACTGA AGCCACTGCC AAGTCGCACG 2700
GGCAGTCAAG GCATTCCCGC AAGCAATTGC GTCTCGCCGA CGAGGAGCAG CAGGCCCGGA 2760
TCACCCACCA AGCATCTGGC CCAGAGGCAC ACAGCCGCCA CGGCGCAGCG ACTGACAAAT 2820
GCGGCCGCCA CTCACCAGCA GCAGCATCAG CAACAATCCT CGAAGACGAC GCGCCTGAAT 2880
ATCCTGAGTC CGGAAAAGGT GCATCGCCTG GGCGCTCGAC TCACCGATCA GAAGCAGAAA 2940
ATGCGCGAGG AGGCCGCAGC GACGGCCTCG TCCGTCGGAG GAGCCGGTTG TGCGGCAGGA 3000
ACAGCGGCTG GAAGCTTAAA TGGTCATCGG ACCATCGGAT CCTCCGGCAC ACCGAATTCG 3060
GCGGTCGGTG AACGGAGGAG GCGAGCAGCT CCATCGCCGC CAGTTCGCAC GCATTTCAAT 3120
ACGCGCTGCT AG 3132
Domain Profile
S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60
         l++geklG+Gff++vfkvthr+sGevmvlkel+radee+++n++kev++lr l+h++vlk
Q: 187   LVIGEKLGEGFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLK  246
         6799********************************************************
S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119
         fiGvl+kdkklh++tey++gG+lkel++++++ lpw+qrvrla+dia+G+sylhs++iih
Q: 247   FIGVLYKDKKLHMVTEYVAGGCLKELIHDPAQvLPWPQRVRLARDIACGMSYLHSMNIIH  306
         ******************************999***************************
S: 120   rdlnsknclvredksvvvadfGlarlvveerkks.....................eklrs  158
         rdlns+nclvred+sv+vadfGlar+v+++r +s                      +lr+
Q: 307   RDLNSMNCLVREDRSVIVADFGLARSVDAPRLPSgnmtpggygsgansdapmspsGTLRR  366
         *******************************************************9****
S: 159   lkkkdrkkrltvvGsPywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrte  218
         +k+++r++r+tvvG+PywmaPe++kg +ydekvdvfsfGi+lceii+rveadPd++Pr++
Q: 367   SKSRQRRQRYTVVGNPYWMAPEMMKGLKYDEKVDVFSFGIMLCEIIGRVEADPDFMPRNS  426
         ************************************************************
S: 219   dfgldvkafreklvaedcPeaflklavvccdldpesrpsfeelekkl  265
         df+l++++frek++a +cPe+f+k+a+vccdl+p++rp+fe+l+ +l
Q: 427   DFSLNQQEFREKFCA-QCPEPFVKVAFVCCDLNPDMRPCFETLHVWL  472
         ***************.***************************9987
Domain Sequence
(FASTA)
LVIGEKLGEG FFGKVFKVTH RQSGEVMVLK ELHRADEEAQ RNFIKEVAVL RLLDHRHVLK 60
FIGVLYKDKK LHMVTEYVAG GCLKELIHDP AQVLPWPQRV RLARDIACGM SYLHSMNIIH 120
RDLNSMNCLV REDRSVIVAD FGLARSVDAP RLPSGNMTPG GYGSGANSDA PMSPSGTLRR 180
SKSRQRRQRY TVVGNPYWMA PEMMKGLKYD EKVDVFSFGI MLCEIIGRVE ADPDFMPRNS 240
DFSLNQQEFR EKFCAQCPEP FVKVAFVCCD LNPDMRPCFE TLHVWL 286
KeywordAlternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; LIM domain; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00180
EKS-ANC-00185
EKS-BOT-00191
EKS-CAJ-00198
EKS-CAF-00197
EKS-CAP-00216
EKS-CHH-00035
EKS-CII-00124
EKS-CIS-00229
EKS-DAR-00493
EKS-DIO-00098
EKS-ECT-00068
EKS-EQC-00186
EKS-FEC-00179
EKS-GAM-00108
EKS-GAG-00164
EKS-GAA-00234
EKS-GOG-00189
EKS-HOS-00197
EKS-ICT-00183
EKS-LAC-00202
EKS-LOA-00188
EKS-MAM-00192
EKS-MAE-00074
EKS-MEG-00151
EKS-MIM-00089
EKS-MOD-00190
EKS-MUM-00194
EKS-MUP-00193
EKS-MYL-00196
EKS-NOL-00180
EKS-OCP-00125
EKS-ORN-00242
EKS-ORA-00169
EKS-ORC-00174
EKS-ORL-00227
EKS-OTG-00197
EKS-PAT-00182
EKS-PES-00167
EKS-PRC-00065
EKS-PTV-00169
EKS-RAN-00185
EKS-SAH-00184
EKS-SUS-00165
EKS-TAG-00217
EKS-TAR-00248
EKS-TEN-00244
EKS-TUT-00179
EKS-XET-00223
EKS-XIM-00238
Gene Ontology
GO:0005826; C:actomyosin contractile ring
GO:0032154; C:cleavage furrow
GO:0030496; C:midbody
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0008270; F:zinc ion binding
GO:0030036; P:actin cytoskeleton organization
GO:0048749; P:compound eye development
GO:0001737; P:establishment of imaginal disc-derived wing hair orientation
GO:0050770; P:regulation of axonogenesis
GO:0051124; P:synaptic growth at neuromuscular junction
KEGG
dme:Dmel_CG1848;
InterPros
IPR011009; Kinase-like_dom.
IPR001478; PDZ.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001781; Znf_LIM.
Pfam
PF00412; LIM; 2.
PF00595; PDZ; 1.
PF00069; Pkinase; 1.
SMARTs
SM00132; LIM; 2.
SM00228; PDZ; 1.
Prosites
PS00478; LIM_DOMAIN_1; 2.
PS50023; LIM_DOMAIN_2; 2.
PS50106; PDZ; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013