EKS-DRM-00043

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00043

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	379.9	1.5E-113	2430	2706	277

Status

Reviewed

Ensembl Protein

FBpp0110174

UniProt Accession

Q5EAK6; Q0KI71; Q6TKQ1; Q8MZG4; Q9VFB1;

Protein Name

Serine/threonine-protein kinase ATM

Protein Synonyms/Alias

Telomere fusion protein;

Gene Name

tefu

Gene Synonyms/Alias

tefu; atm; CG6535;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0045035	FBpp0110174	FBtr0110874

Organism

Drosophila melanogaster

Functional Description

Serine/threonine-protein kinase which recognizes thesubstrate consensus sequence [ST]-Q. Required to suppress spontaneous apoptosis of proliferating cells during development, and for their proper differentiation. Required for female fertility. Protects telomeres from fusion, maybe by recruiting or maintaining chromatin-modifying complexes such as Su(var)205/HP1. May activate checkpoint signaling in response to DNA double- stranded breaks induced by low-dose ionizing radiation. May phosphorylate histone H2AV.

Protein Length

2767

Protein Sequence
(FASTA)

MSALLNEIQR ILGDLQSGKA ASRNKGIQQL DEKLSSCRED LDKLFLSKTS DISWTTIFEA 60

SKEALFKQAG NLEDVNEKVF KTLAGKNYLY DNVLEKITQF NLEAGSQTSG NGHFLAKTSI 120

FSAFEDGIKM RVVVKYFGDR ILSLLEKGIY SSVSYVRDLK INEYSRILSY LFELNVDMDE 180

VLRTRILKCI TRTVSLAKDR VQLHVDLVEY LPELSSFALS AFGARKTEIV RVYLIFASEL 240

AVNYNHQLNV HMQEILPKLC EYHDEDAFRD DTRNLFFQCV SKSLHSMYLK MDMCDFNTLG 300

VPVHEKWPQT LLRLKTIVNV EIRKNSWARC KNALLSNNKF SDPFIKMSAL AMYIVLWHLE 360

TKKADENGEG DAPKKIPKPA DKMETIFSLI DKKENTFNDV WLAIFTEILQ LSSVILNVAN 420

YQMALTTVAE IMQMYGNAKN LRNLRLCLAH LLTKEQELLH SKSIREDFLG ELWSQMANQL 480

ISETTTNSEE IKEKQLVLQM LIRHNKLNQK LSSTLLNNII SNEMLKRNEC LATIREIFIH 540

ADKCGQDKAS ADLEPIIAWA YGSADRFIAA QMIHNIDSID AQLQADTFAI SIINFLDVQQ 600

LRQISQSEHI VPSTERNLLA YKYNEQLICF DKDYATPFES ITHIQSETKN CLIQSNYDCL 660

MRGLNFEIAK ENKPAAIIKN LNSLLKLICT MERLLHYKVF DADTYTGCPL IKRIGLYLSH 720

IEFQLKANGA EILDKSDLPE ILRLEIYVLD VFRTNLVLLD YLERQPIEML VEFVGAALKL 780

HSMQRERSVD ADHGTITRLC LNILAGLCAY NSHRDEAFEH IVKVTMRWHP QDVLIVTKML 840

CSCQTISEAS SSWLVSKLKT LFQQHHQDAE LMDKVVQHMP TIFYFVRHKE NHLDDMLMAL 900

NSLLRIAIKK SYTSNLTAKI VRCVGLIAQR CPDIYLLENF AVICKSTAKF ITMPTLEVRF 960

ATLFTFTILL ESNCVTSDAI GHSRTHWDFC QELYESIEFK KLTYNNEDAI QNSNALIVQM 1020

LIAIFLRSSF HQEIALKELL HHCALRRLTE REFISLQSMS SCHRQTVRDL IRPFAAILLH 1080

HWSSKRWPIS KFPYFLCYST KSEFRKTHAS EIMAYTFLYG KTEDIERCSK SISEELALPI 1140

LASFLLIKNS SCSESEGQNF KEHLQLLSEN LSYSQLNATD VDLDLDILCY VISMLHDPQE 1200

MMRLFGSLAI CNRTASWYSL SGESLFKCLN FHIDPEMRPS MDSRIQSMTT LQTKHSRVLV 1260

DIFGRLKTNC YSASFSSQAL HDFFLYCEVA DAVYDAARKN ETIVTQCSFF VRDIWFFVVR 1320

LLIHTKFIRV QMAALTFLEL LLNKHNFRLD DYQNHFGDIA KLLSNFQLCC EAKEVREKTM 1380

SIVMYILESK KGHINLNSFL EETTDCEFLK PLREDCKSSQ PNIDRADVAN YLRSFLLSPT 1440

PERLRDLRTY IAEHKDKVQE HEKLLFGVIN KLIQMTRDAH NKTTSIDSLK CLAQIGPLKI 1500

STVSYYFQTD FEAFEKSNGE PMEAFLGVVC HSLDTSLFQF DPKTHEGLVS VAIQVVNSKP 1560

GSNIMERYKN LRIFADKSTA STFLHSNKQI RRIDWLSILK ATKSLSYEPW MCAFVSKVFQ 1620

MCGWLGFDKL AATSFAFAKT CLLPFIKLLL ENSLEHVESL SQMLDYFFEG FTSSTAPNSQ 1680

EIFRNKRAIK KFLHICEYIR IFNNWTIPIN LSNVVMASNH CQAYFLSIMY LELWACSESP 1740

KSKADFLDNE CFQDGAKKAY ESIGCLDAIP GFVNPMRSRL DFLGHGSNLS TILLESDHLD 1800

RASGQLCIDI MKGNGLWSFA KLQQHQNIEP DYEIFWRLGQ WDSLTDPKHQ QNQTVVRTSL 1860

DLEQEFKRHH FVALRSIGQR EEENSLSAIE QAYSCVRDIL MEISVECLQS VYKYLTWLCS 1920

LQQAEDFCQI QFGTQLDPAS TTKIFRKWQT ELELKYGNFS CKEYVIAHQI ALLKLAGTRA 1980

SRRMSEFYQK DPISTYLMKG IEECKSAGKL NLAAKYTATL RELPNIRESI KISVLLEDAE 2040

INLKMGNQQI AKAILDYVTN NNEFVYCVQR VPALRMQGEF LLDCNAETLS WVQSHKFNNS 2100

LKLIDDFVQH RQTLSEKYRD IFDWHQLDAY ASKQRTAAYA TIAKYADREY QQLHDYRHSQ 2160

EYQTLKDIIE QNRQTAEKVT QRENQDRRVI SVQMKRYASL DEQQLNQIEE KLTEYLRLAL 2220

TNYMAYCRLD SGFSSAAIYR IISLWFTNAT SKQCQECIKD EILTVPSYKF ICAANQLTAR 2280

LNSKNTSLLK GLTDLLVQCG KDHPYHTFYQ LYPLVFAHLD GENSNTERSG IARKIIAMIC 2340

EKNGTAGECS KQLESLLPAL ITFANEGKTN DNRPVSDSVR NKQFDKVRRW RNLNAVHCPT 2400

LELPVMPSKE YSIISVVKWT NETTQCGGLN APVKIMCVCS DGKIRAQLVK GKDDLRQDAV 2460

MQQVFGIVNE LLNQDSEFIE RKLKLRTYKV TPLSMRSGIL EWCTNSVPVG HYLVVEGKGG 2520

AHARYRPNDW NNNKCRKLSS DHLKSPKETR YAIYKKICEN IKPVFHYFLL EKFPIPGVWF 2580

ERRLAYTNSV ATTSMVGYVL GLGDRHTQNI LVDQQTAEVI HIDFGIAFEQ GKIQTTPETV 2640

PFRLTRDFVA PMGICGTKGV FAKSCEATMH ILRRYKSVFT TILEVLLYDP LFIWGVLKKK 2700

QSPQQSGEES VNLVAQRALL LVQNKLDGRE AGTMGDSNVE AQVERLINEA TLPSNLCMLF 2760

PGWDPHL 2767

Nucleotide Sequence
(FASTA)

ATGAGTGCAC TTCTAAACGA AATCCAGCGG ATACTCGGGG ACCTTCAGTC GGGGAAGGCA 60

GCCAGCCGAA ACAAGGGCAT CCAACAGCTG GATGAAAAGC TCTCAAGTTG CCGAGAGGAT 120

CTGGATAAGT TGTTTCTTAG CAAAACTTCG GATATATCCT GGACCACAAT CTTTGAAGCG 180

TCGAAGGAGG CTCTCTTTAA GCAAGCTGGA AATCTGGAGG ATGTCAACGA GAAAGTATTC 240

AAAACGCTGG CGGGAAAAAA CTACTTGTAC GATAATGTCC TCGAGAAGAT CACACAATTC 300

AACTTGGAAG CGGGGTCGCA GACCTCCGGA AATGGGCATT TCCTGGCCAA AACAAGCATA 360

TTTAGTGCAT TCGAGGATGG CATCAAGATG CGAGTGGTAG TCAAGTATTT TGGCGACCGC 420

ATTCTGAGCC TGCTGGAAAA GGGCATTTAC TCATCGGTCA GCTATGTGCG CGACCTTAAA 480

ATTAACGAAT ACAGTAGGAT TCTCTCCTAT CTTTTTGAAC TGAATGTCGA TATGGACGAG 540

GTCTTGCGAA CCAGAATACT GAAATGCATC ACAAGAACCG TCAGTTTGGC CAAGGACCGG 600

GTTCAGCTGC ACGTGGATCT AGTGGAATAT CTGCCGGAGC TCAGCAGCTT TGCGCTCTCC 660

GCTTTTGGAG CCAGAAAAAC TGAGATTGTT CGCGTCTACT TAATATTTGC ATCAGAGCTT 720

GCTGTCAACT ACAATCACCA ATTGAACGTG CACATGCAGG AGATTCTACC TAAACTATGC 780

GAGTATCATG ACGAGGATGC GTTCCGGGAC GACACCAGAA ATCTGTTCTT TCAGTGCGTT 840

TCAAAGTCGC TCCATTCAAT GTATCTCAAA ATGGATATGT GTGACTTTAA TACACTCGGT 900

GTGCCTGTTC ATGAAAAGTG GCCGCAAACT TTACTGCGGC TGAAAACTAT TGTCAATGTG 960

GAGATCCGAA AGAATTCCTG GGCTCGCTGC AAGAACGCAC TACTGAGCAA TAATAAATTT 1020

TCTGACCCCT TCATCAAGAT GTCTGCCCTG GCTATGTATA TAGTGCTTTG GCACTTGGAG 1080

ACGAAAAAGG CTGATGAAAA TGGGGAAGGC GATGCGCCGA AAAAGATCCC GAAGCCTGCA 1140

GATAAAATGG AAACTATATT TAGTCTGATC GACAAAAAGG AAAACACCTT TAACGACGTC 1200

TGGCTTGCGA TATTCACTGA GATACTTCAG CTGAGTAGCG TGATCCTAAA TGTGGCCAAC 1260

TACCAAATGG CGCTAACCAC CGTGGCGGAA ATAATGCAAA TGTACGGCAA TGCGAAAAAT 1320

CTCCGGAACC TTCGGTTATG CCTGGCTCAT CTTTTGACTA AAGAACAGGA GCTTTTGCAC 1380

TCTAAATCTA TTCGGGAGGA TTTTCTGGGT GAGCTTTGGA GTCAAATGGC AAACCAGCTC 1440

ATATCAGAGA CAACAACAAA CAGTGAGGAG ATCAAGGAGA AGCAATTGGT GCTGCAGATG 1500

CTGATCAGAC ACAATAAACT AAATCAAAAG TTGTCCAGCA CGCTGCTTAA CAATATTATC 1560

TCGAATGAAA TGCTAAAGCG CAACGAATGC TTAGCGACGA TTCGAGAGAT CTTCATCCAT 1620

GCTGATAAAT GTGGTCAAGA TAAGGCGTCC GCTGACTTAG AACCCATCAT AGCTTGGGCA 1680

TACGGAAGTG CGGATAGATT CATCGCCGCT CAGATGATAC ACAATATAGA CAGTATTGAT 1740

GCCCAGTTGC AGGCGGATAC TTTTGCAATC AGCATTATAA ATTTTTTGGA TGTCCAGCAA 1800

TTGCGACAGA TCTCTCAATC AGAACACATT GTTCCTTCCA CCGAACGCAA TCTTTTGGCC 1860

TACAAGTACA ACGAACAGCT TATTTGCTTT GACAAGGACT ACGCCACTCC TTTTGAGTCA 1920

ATCACTCACA TTCAGAGCGA AACAAAGAAT TGTTTGATTC AATCCAATTA TGATTGCCTA 1980

ATGCGAGGCC TTAACTTTGA GATCGCGAAG GAGAACAAAC CGGCGGCAAT AATAAAAAAC 2040

CTGAATAGTC TATTAAAGTT GATCTGCACA ATGGAAAGGC TTTTGCATTA CAAGGTTTTC 2100

GATGCAGATA CCTATACTGG CTGTCCACTT ATAAAAAGAA TTGGACTATA TCTCAGCCAC 2160

ATTGAGTTCC AGCTCAAGGC GAACGGAGCT GAGATTTTAG ATAAGAGCGA TTTACCAGAG 2220

ATTTTACGTC TGGAAATCTA TGTACTTGAT GTATTCAGGA CGAATTTAGT CTTACTCGAT 2280

TATTTGGAAA GGCAACCCAT TGAAATGTTG GTGGAATTTG TTGGCGCTGC TCTCAAGTTG 2340

CATTCCATGC AGAGGGAGCG ATCTGTAGAT GCAGATCATG GAACAATAAC GCGTCTGTGC 2400

CTTAATATTT TGGCTGGTCT TTGTGCGTAC AATTCGCACC GGGATGAAGC ATTCGAGCAC 2460

ATAGTAAAGG TAACGATGCG TTGGCATCCA CAGGATGTGC TTATTGTGAC CAAGATGTTA 2520

TGCAGCTGCC AAACGATTTC TGAAGCATCC AGCTCTTGGT TAGTGAGCAA ATTGAAGACG 2580

CTTTTCCAGC AGCATCATCA GGATGCGGAA TTGATGGACA AAGTGGTTCA ACATATGCCC 2640

ACCATTTTTT ACTTCGTAAG GCACAAAGAA AATCATTTGG ACGACATGCT TATGGCCCTT 2700

AATTCCCTTT TAAGGATTGC CATTAAGAAG TCGTACACAT CGAATTTAAC AGCGAAAATT 2760

GTACGCTGCG TGGGATTGAT TGCTCAGCGT TGTCCGGACA TTTACCTTCT AGAGAACTTT 2820

GCTGTGATAT GCAAGTCCAC TGCGAAATTC ATCACCATGC CCACGTTAGA AGTGCGCTTT 2880

GCCACACTCT TCACATTCAC CATCCTGCTG GAATCGAATT GCGTCACTAG CGATGCCATT 2940

GGTCATTCTC GGACGCACTG GGACTTCTGC CAGGAGCTGT ACGAGAGCAT TGAGTTTAAG 3000

AAACTGACGT ACAACAACGA GGATGCCATT CAAAACAGCA ATGCGTTAAT CGTACAAATG 3060

TTAATTGCAA TATTCTTGCG CAGCTCATTC CACCAAGAGA TAGCACTGAA GGAGCTGCTG 3120

CATCATTGTG CCTTGCGAAG GCTAACTGAA AGGGAGTTTA TTTCCCTGCA GAGTATGTCA 3180

TCCTGCCATC GGCAAACAGT GCGTGATCTT ATCAGACCAT TTGCGGCCAT TCTTCTTCAT 3240

CATTGGAGCT CCAAGCGCTG GCCCATTTCC AAGTTTCCCT ATTTTCTGTG CTATTCAACG 3300

AAGAGTGAAT TCCGCAAAAC ACACGCCAGT GAAATTATGG CATATACCTT TCTATATGGC 3360

AAAACAGAGG ATATAGAACG GTGCAGTAAA TCCATCAGCG AGGAGCTGGC CCTTCCGATA 3420

CTGGCTTCAT TTCTACTGAT CAAAAACAGC TCGTGCAGCG AAAGCGAAGG TCAGAACTTT 3480

AAAGAACACC TCCAGCTATT GTCGGAGAAT CTCAGTTACT CTCAGCTGAA TGCCACAGAT 3540

GTTGATCTTG ATTTGGATAT TCTTTGCTAT GTGATAAGCA TGCTGCACGA TCCGCAGGAA 3600

ATGATGAGAT TGTTTGGTTC CCTTGCGATC TGCAACAGAA CAGCCAGTTG GTATAGTCTG 3660

AGTGGAGAAT CGCTTTTTAA GTGTCTGAAC TTTCACATTG ACCCTGAAAT GAGGCCATCG 3720

ATGGACAGTC GGATCCAGTC CATGACCACG CTTCAAACCA AACATTCCCG TGTGCTGGTC 3780

GATATTTTTG GACGCTTAAA GACCAACTGT TATTCGGCCT CTTTTTCTAG TCAGGCCTTG 3840

CATGACTTTT TCCTCTACTG TGAAGTTGCA GATGCTGTCT ATGATGCAGC CAGAAAAAAT 3900

GAAACCATAG TTACCCAGTG CTCCTTCTTT GTTCGTGATA TTTGGTTTTT TGTGGTGCGA 3960

CTTCTAATCC ATACAAAGTT CATCCGCGTC CAAATGGCTG CTCTGACATT TTTGGAACTT 4020

TTGCTTAACA AACACAACTT CCGATTGGAT GATTACCAAA ATCACTTCGG AGACATAGCT 4080

AAGCTATTGA GCAATTTTCA ACTATGCTGC GAAGCGAAAG AAGTTAGAGA GAAGACCATG 4140

TCGATAGTAA TGTACATTTT GGAATCAAAA AAGGGCCACA TTAACCTGAA TTCCTTTTTG 4200

GAAGAGACAA CGGACTGCGA GTTTCTTAAA CCTCTGCGAG AGGATTGCAA GTCCAGTCAA 4260

CCCAATATTG ATAGGGCGGA TGTCGCCAAT TATTTGCGCT CATTTCTGTT AAGTCCGACG 4320

CCAGAAAGAT TACGCGATCT GAGGACATAT ATTGCCGAGC ACAAGGACAA AGTGCAAGAA 4380

CATGAAAAAC TTTTGTTTGG GGTTATTAAC AAGCTCATTC AGATGACACG GGATGCGCAT 4440

AATAAGACAA CTAGCATTGA TTCCCTTAAG TGCTTGGCTC AAATTGGACC GCTAAAAATA 4500

TCCACAGTTT CGTACTATTT TCAGACTGAT TTTGAAGCAT TTGAAAAGTC TAATGGGGAG 4560

CCGATGGAAG CTTTCTTAGG TGTTGTCTGT CACAGTTTGG ATACATCCTT ATTCCAATTC 4620

GATCCCAAAA CTCACGAGGG TCTTGTGTCC GTAGCAATTC AGGTGGTTAA TAGTAAGCCT 4680

GGATCAAATA TTATGGAACG CTATAAAAAT CTAAGAATCT TTGCTGACAA GTCAACCGCA 4740

TCGACTTTTC TGCATTCTAA TAAACAAATT CGTCGCATCG ACTGGCTGTC AATACTTAAA 4800

GCAACGAAAA GCCTTAGCTA CGAGCCTTGG ATGTGCGCCT TTGTCTCGAA AGTGTTTCAA 4860

ATGTGTGGCT GGTTGGGATT CGATAAACTG GCCGCCACTT CTTTTGCCTT TGCCAAGACC 4920

TGCCTGCTGC CTTTTATTAA ATTACTATTG GAAAATAGTC TAGAGCACGT GGAGAGTCTG 4980

TCTCAGATGT TGGATTACTT TTTCGAAGGT TTTACTAGCT CGACGGCACC GAACTCCCAG 5040

GAGATATTCC GCAATAAAAG AGCCATCAAG AAGTTTCTGC ATATCTGCGA ATACATACGA 5100

ATCTTTAATA ATTGGACCAT CCCCATTAAT CTGAGCAATG TGGTTATGGC TAGCAATCAC 5160

TGTCAAGCCT ATTTCCTGAG TATAATGTAT CTAGAGCTAT GGGCCTGCTC AGAGAGTCCC 5220

AAGAGCAAAG CCGATTTCTT GGACAACGAA TGCTTTCAAG ATGGCGCAAA AAAGGCATAC 5280

GAATCAATTG GCTGCTTAGA TGCCATTCCA GGCTTTGTAA ATCCCATGCG CTCACGTTTG 5340

GATTTCCTTG GCCACGGCAG CAATCTATCC ACCATTCTGT TGGAGTCCGA CCACTTGGAC 5400

AGGGCCAGTG GTCAACTCTG CATAGACATA ATGAAAGGAA ATGGTTTGTG GTCTTTTGCC 5460

AAACTCCAGC AGCACCAGAA CATTGAGCCC GACTATGAAA TATTTTGGCG CCTTGGACAG 5520

TGGGATTCGC TAACAGACCC AAAGCATCAG CAAAATCAGA CGGTGGTTAG AACATCGCTT 5580

GATCTGGAGC AGGAGTTCAA GCGGCACCAC TTCGTTGCCC TCAGAAGTAT TGGCCAGCGG 5640

GAGGAGGAGA ACAGCTTATC GGCCATCGAA CAGGCGTATA GCTGTGTGCG CGACATTCTG 5700

ATGGAGATCA GCGTGGAGTG CCTGCAAAGT GTGTACAAAT ACCTGACATG GCTGTGTTCC 5760

CTTCAACAAG CAGAGGATTT TTGCCAGATC CAATTTGGCA CTCAACTGGA TCCTGCTTCA 5820

ACGACCAAGA TTTTTAGAAA GTGGCAAACA GAATTGGAGC TTAAGTACGG AAATTTTTCT 5880

TGTAAGGAAT ACGTGATTGC ACATCAGATT GCTTTGCTGA AGTTAGCGGG TACAAGGGCT 5940

AGTCGCAGAA TGAGTGAGTT CTATCAAAAG GATCCGATTA GCACGTACCT AATGAAGGGA 6000

ATTGAGGAGT GCAAAAGCGC TGGCAAGTTA AATCTGGCAG CCAAGTACAC AGCTACTTTA 6060

CGGGAGCTCC CTAATATTAG GGAGTCAATC AAGATTAGCG TTCTGCTGGA AGATGCCGAA 6120

ATCAATCTGA AGATGGGCAA CCAACAAATT GCCAAGGCCA TTTTGGACTA TGTGACCAAC 6180

AATAATGAGT TTGTCTACTG CGTCCAAAGA GTTCCTGCAC TTCGGATGCA GGGCGAGTTC 6240

CTCTTAGACT GCAATGCTGA GACTTTAAGT TGGGTTCAGT CTCACAAATT CAATAATTCG 6300

CTTAAGCTGA TTGATGATTT TGTGCAGCAC CGCCAGACGC TGAGCGAAAA GTATCGGGAC 6360

ATCTTCGATT GGCATCAGCT TGATGCCTAC GCCAGTAAAC AAAGAACGGC TGCCTATGCA 6420

ACGATTGCAA AGTATGCTGA TCGGGAGTAT CAGCAACTAC ACGACTACAG GCACTCGCAG 6480

GAGTATCAAA CGCTCAAGGA TATCATCGAG CAGAACCGCC AGACGGCGGA GAAGGTGACC 6540

CAGCGCGAGA ACCAGGACCG GCGCGTCATA TCCGTGCAGA TGAAACGTTA CGCTAGTTTG 6600

GATGAGCAGC AGCTAAATCA GATTGAGGAG AAGCTGACAG AGTATCTGCG CCTGGCATTG 6660

ACCAATTATA TGGCATACTG TCGACTGGAC AGTGGCTTTT CCAGTGCGGC CATATATCGC 6720

ATCATTTCGC TGTGGTTCAC CAATGCCACC AGTAAACAGT GCCAGGAGTG TATCAAGGAT 6780

GAGATCCTTA CAGTGCCCAG TTACAAATTC ATCTGTGCCG CCAACCAATT GACCGCCCGC 6840

CTTAACTCCA AAAACACGAG TCTGCTCAAG GGGCTGACGG ACCTTCTGGT GCAATGTGGC 6900

AAAGATCATC CATATCATAC ATTCTACCAG CTGTATCCCC TGGTGTTTGC ACACCTGGAT 6960

GGCGAGAACA GCAATACAGA GCGATCAGGA ATCGCACGTA AGATTATTGC TATGATCTGC 7020

GAAAAGAATG GCACAGCGGG GGAATGCAGC AAGCAGCTGG AATCGCTGCT ACCAGCCCTC 7080

ATCACATTTG CAAACGAGGG GAAGACGAAC GATAACAGGC CGGTGTCCGA TTCCGTGCGT 7140

AATAAGCAAT TTGACAAGGT GAGGCGCTGG CGGAATCTCA ACGCTGTACA TTGCCCGACC 7200

CTTGAGTTGC CCGTTATGCC CAGCAAGGAG TACAGTATAA TAAGTGTCGT CAAGTGGACC 7260

AACGAGACTA CACAGTGTGG GGGATTAAAT GCGCCTGTTA AAATAATGTG CGTATGCTCT 7320

GATGGTAAAA TTCGAGCGCA ACTGGTCAAG GGAAAGGATG ATCTTCGACA GGATGCCGTG 7380

ATGCAGCAGG TTTTTGGAAT TGTCAACGAG TTGCTCAATC AGGATTCCGA ATTCATCGAG 7440

CGTAAGCTGA AGTTGCGCAC CTATAAGGTC ACCCCGCTGT CCATGCGTAG TGGCATCCTG 7500

GAGTGGTGCA CCAATTCGGT TCCTGTGGGT CACTATTTGG TTGTTGAGGG CAAGGGAGGA 7560

GCGCATGCGC GATACCGACC AAACGACTGG AATAACAACA AGTGCCGCAA GTTGTCATCT 7620

GATCACCTAA AGTCTCCCAA GGAGACACGA TATGCCATTT ACAAGAAAAT ATGCGAGAAT 7680

ATTAAACCCG TTTTCCATTA TTTCCTGCTG GAGAAGTTCC CGATTCCGGG CGTCTGGTTT 7740

GAAAGGCGAC TGGCGTACAC CAACAGCGTA GCCACTACCT CAATGGTTGG CTACGTTCTT 7800

GGACTGGGTG ATCGGCACAC ACAAAATATC CTAGTAGACC AGCAGACAGC GGAGGTCATT 7860

CATATCGATT TTGGTATTGC CTTTGAGCAG GGCAAAATTC AGACGACACC AGAGACCGTT 7920

CCCTTTCGTT TAACACGCGA CTTTGTGGCA CCAATGGGAA TTTGTGGTAC AAAAGGAGTC 7980

TTTGCCAAAT CCTGTGAAGC TACCATGCAC ATTCTGCGCC GATATAAGTC AGTTTTTACC 8040

ACAATTCTCG AGGTTTTGCT GTACGATCCA CTTTTCATTT GGGGTGTACT TAAAAAGAAG 8100

CAATCACCAC AGCAATCCGG TGAAGAATCA GTGAATTTGG TAGCCCAGCG AGCTTTGCTT 8160

CTTGTGCAAA ACAAATTGGA TGGCAGAGAG GCCGGCACCA TGGGTGACTC GAATGTCGAG 8220

GCACAAGTGG AGCGATTGAT CAATGAAGCC ACTCTACCAA GCAATCTCTG CATGCTTTTT 8280

CCGGGCTGGG ACCCACACCT TTAA 8304

Domain Profile

S: 15    qkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrrkLkirtyk  74

         ++p k++   sdgk++++Lvkgk+Dlrqd++++q+f++vN+lL++d+e+ +rkLk+rtyk

Q: 2430  NAPVKIMCVCSDGKIRAQLVKGKDDLRQDAVMQQVFGIVNELLNQDSEFIERKLKLRTYK  2489

         6799********************************************************

S: 75    VvplstrsgliewventvsLkellkklvekkavlldqpisyrykdlstvqarkpklkhlk  134

         V+pls+rsg++ew++n+v+++++l   ve k+++++   +yr++d++++++rk +++hlk

Q: 2490  VTPLSMRSGILEWCTNSVPVGHYLV--VEGKGGAHA---RYRPNDWNNNKCRKLSSDHLK  2544

         ************************5..********9...*********************

S: 135   ls....levfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislvgyiLgL  190

         +     ++++k+++en++p  +++++llekfp p +wfe+r ayt+s+A++s+vgy+LgL

Q: 2545  SPketrYAIYKKICENIKP--VFHYFLLEKFPIPGVWFERRLAYTNSVATTSMVGYVLGL  2602

         9999***************..9**************************************

S: 191   gdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvtgveGvf  250

         gdrh++n+l+dq+t+ev+hidfg+afe++k+ +++pe+vPFRLTr++v+ +g++g++Gvf

Q: 2603  GDRHTQNILVDQQTAEVIHIDFGIAFEQGKI-QTTPETVPFRLTRDFVAPMGICGTKGVF  2661

         *******************************.****************************

S: 251   rasceavlrvlreskeklltiLevflydplvdwkk.kkktskete  294

         ++scea++++lr++k+ ++tiLev+lydpl+ w + kkk+s++++

Q: 2662  AKSCEATMHILRRYKSVFTTILEVLLYDPLFIWGVlKKKQSPQQS  2706

         **********************************95333333332

Domain Sequence
(FASTA)

NAPVKIMCVC SDGKIRAQLV KGKDDLRQDA VMQQVFGIVN ELLNQDSEFI ERKLKLRTYK 60

VTPLSMRSGI LEWCTNSVPV GHYLVVEGKG GAHARYRPND WNNNKCRKLS SDHLKSPKET 120

RYAIYKKICE NIKPVFHYFL LEKFPIPGVW FERRLAYTNS VATTSMVGYV LGLGDRHTQN 180

ILVDQQTAEV IHIDFGIAFE QGKIQTTPET VPFRLTRDFV APMGICGTKG VFAKSCEATM 240

HILRRYKSVF TTILEVLLYD PLFIWGVLKK KQSPQQS 277

Keyword

ATP-binding; Cell cycle; Chromatin regulator; Chromosome; Complete proteome; Developmental protein; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Telomere; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006348	; P:chromatin silencing at telomere
GO:0016572	; P:histone phosphorylation
GO:0030717	; P:karyosome formation
GO:0000706	; P:meiotic DNA double-strand break processing
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0007275	; P:multicellular organismal development
GO:0045494	; P:photoreceptor cell maintenance
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0016233	; P:telomere capping

KEGG

dme:Dmel_CG6535

;

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR014009	; PIK_FAT.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013