EKS-DRM-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/Haspin	297.3	1.2E-88	250	523	274

Status

Reviewed

Ensembl Protein

FBpp0112507

UniProt Accession

P83103; Q7PLN2;

Protein Name

Putative serine/threonine-protein kinase haspin homolog

Protein Synonyms/Alias

Gene Name

Haspin

Gene Synonyms/Alias

Haspin; CG40080;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0046706	FBpp0112507	FBtr0113784

Organism

Drosophila melanogaster

Functional Description

Protein Length

566

Protein Sequence
(FASTA)

MLSISKTKMD FLEEGRWKDP FDELLDSRTK LSKMNIVKQN VRVTYNIDSS VENSSYIEIK 60

EPNHKNEPLT LEDCSIKVYC PSDSISTPCD KRLGGTTGLF ETDLSPITRL KLEGVEDSRD 120

KCADTNEADL YVNVEILFQN INSSPKKCSN FGKKRLSNLN KMVTAVHPSI SLNPGKWRKS 180

LNNFIRSKIT ETNFTKKVER RSSICQDRKS LVLKGEHKFE NKYEEDVLKY CHQCTPLPFN 240

TAYEQHKLLN TKKIGEGAYG EVFRCSRNQE VLKDHISDIV LKIIPLEGST VINGEKQKTF 300

SQILPEIIIT KKMCSLRTSK TNSTNGFVSI QKVSLVKGRY PPHFIKLWEK YDNEKGSEND 360

HPELFGDNQL FAVLELKFAG SDMANFKFLN SEQSYYALQQ IILALAVGEE EYQFEHRDLH 420

LGNILIEYTN KKHIVCTFKS SNLTLLSKGV NVTIIDYTLS RVTINDCCYF NDLSRDEELF 480

QATGDYQYDV YRMMRNELKN NWSSFSPKTN IIWLSYVIVK VLDSVKYKSI NTKVHRMYID 540

KIKELKNIIM TFESASHCAN YLFNLN 566

Nucleotide Sequence
(FASTA)

ATGCTCAGCA TTAGCAAAAC AAAAATGGAT TTTTTAGAGG AAGGTAGATG GAAGGATCCG 60

TTTGATGAAC TTTTGGACTC CAGAACGAAA CTAAGTAAAA TGAACATAGT AAAACAAAAT 120

GTACGAGTAA CCTATAACAT TGACTCTAGT GTTGAAAATA GCAGCTATAT AGAAATAAAA 180

GAACCAAATC ACAAAAACGA ACCTTTAACT CTTGAAGATT GCTCTATAAA AGTGTATTGC 240

CCCAGTGATT CTATATCAAC TCCTTGCGAT AAACGATTAG GAGGCACAAC AGGATTATTT 300

GAAACCGACC TCTCTCCAAT TACTCGCTTA AAACTTGAAG GTGTGGAAGA CAGTAGAGAC 360

AAATGCGCTG ATACTAATGA GGCAGATTTA TATGTAAATG TTGAAATTCT TTTTCAAAAC 420

ATAAATTCCA GCCCTAAAAA ATGTTCTAAT TTTGGGAAAA AACGATTGAG TAATTTAAAT 480

AAGATGGTTA CTGCTGTACA CCCTTCGATT TCATTAAATC CGGGAAAATG GAGAAAATCG 540

CTAAACAATT TTATCAGATC AAAAATAACC GAAACAAATT TCACGAAAAA GGTAGAACGT 600

CGAAGCTCAA TATGCCAGGA TCGAAAATCA TTAGTTTTGA AAGGCGAACA TAAATTTGAG 660

AATAAATATG AAGAAGATGT TCTTAAATAT TGCCATCAGT GTACACCACT TCCGTTTAAT 720

ACTGCATACG AACAACATAA ATTATTGAAT ACTAAGAAGA TTGGCGAAGG GGCTTATGGA 780

GAAGTATTTC GTTGTTCGAG AAATCAAGAA GTACTGAAAG ACCACATCTC TGATATTGTA 840

TTAAAGATTA TACCTTTGGA GGGTTCCACT GTAATTAATG GAGAAAAGCA AAAAACATTC 900

AGTCAAATTT TACCAGAAAT AATTATAACT AAAAAAATGT GCAGCCTTCG AACAAGTAAA 960

ACTAATTCTA CGAATGGATT TGTGAGCATA CAAAAGGTAT CACTAGTTAA AGGAAGGTAT 1020

CCACCACATT TTATAAAGCT TTGGGAAAAG TATGACAACG AAAAGGGATC TGAAAATGAC 1080

CATCCGGAAC TTTTTGGAGA CAATCAACTT TTTGCAGTCC TAGAACTGAA GTTTGCCGGA 1140

AGTGACATGG CAAATTTTAA ATTTTTAAAT TCCGAACAAT CATATTACGC TTTACAACAG 1200

ATTATTCTAG CGCTTGCTGT TGGTGAAGAA GAGTATCAAT TTGAGCACAG GGACCTTCAT 1260

TTGGGAAACA TATTAATTGA ATACACCAAT AAGAAGCACA TAGTTTGTAC ATTCAAAAGC 1320

AGTAATTTAA CTTTGCTTTC AAAAGGAGTG AACGTTACTA TTATTGACTA CACACTTTCA 1380

AGAGTTACAA TTAATGACTG CTGCTATTTT AATGATCTCT CAAGAGATGA GGAACTTTTC 1440

CAGGCAACAG GAGATTATCA ATACGATGTC TATCGAATGA TGCGGAATGA GTTAAAGAAC 1500

AACTGGTCAT CGTTTTCACC CAAAACAAAT ATCATATGGC TATCATATGT TATCGTTAAG 1560

GTACTGGATA GCGTGAAATA CAAAAGCATC AATACGAAAG TTCACAGGAT GTACATTGAT 1620

AAAATAAAGG AATTGAAAAA CATTATAATG ACATTTGAAA GTGCTTCTCA TTGCGCAAAT 1680

TATCTGTTTA ATTTAAATTA A 1701

Domain Profile

S: 3     kvkklGeGayGevfsvtwkg.......kevvlKiiplegsdv........keealkElii  47

         ++kk+GeGayGevf++++++       +++vlKiiplegs+v        ++++l+E+ii

Q: 250   NTKKIGEGAYGEVFRCSRNQevlkdhiSDIVLKIIPLEGSTVingekqktFSQILPEIII  309

         79**********************************************************

S: 48    lkklsklske..nstpnFlellgakvvkgdvpkellkawdkydkekes..........dq  95

         +kk+++l+++  nst++F++++++++vkg++p++++k w+kyd+ek+s          +q

Q: 310   TKKMCSLRTSktNSTNGFVSIQKVSLVKGRYPPHFIKLWEKYDNEKGSendhpelfgdNQ  369

         **********9*************************************************

S: 96    lylvllleeggtsldniklksesqllsilqqlvlslaiaekelkfeHrDlhlgNvLikkt  155

         l+ vl+l+++g++++n+k+++ +q+++ lqq++l+la++e+e++feHrDlhlgN+Li++t

Q: 370   LFAVLELKFAGSDMANFKFLNSEQSYYALQQIILALAVGEEEYQFEHRDLHLGNILIEYT  429

         ************************************************************

S: 156   kkkeleYtldgkkiklkskgvlvtiIDftksrlvkkdkevvyedlevdeelfegkgdkqf  215

         +kk++ +t+++++++l skgv+vtiID+t+sr v+ +++++++dl++deelf+++gd+q+

Q: 430   NKKHIVCTFKSSNLTLLSKGVNVTIIDYTLSR-VTINDCCYFNDLSRDEELFQATGDYQY  488

         ********************************.***************************

S: 216   dvyrlmranvknewkefepktnllwltylsskllk  250

         dvyr+mr+++kn+w++f+pktn++wl+y+  k+l+

Q: 489   DVYRMMRNELKNNWSSFSPKTNIIWLSYVIVKVLD  523

         *****************************999986

Domain Sequence
(FASTA)

NTKKIGEGAY GEVFRCSRNQ EVLKDHISDI VLKIIPLEGS TVINGEKQKT FSQILPEIII 60

TKKMCSLRTS KTNSTNGFVS IQKVSLVKGR YPPHFIKLWE KYDNEKGSEN DHPELFGDNQ 120

LFAVLELKFA GSDMANFKFL NSEQSYYALQ QIILALAVGE EEYQFEHRDL HLGNILIEYT 180

NKKHIVCTFK SSNLTLLSKG VNVTIIDYTL SRVTINDCCY FNDLSRDEEL FQATGDYQYD 240

VYRMMRNELK NNWSSFSPKT NIIWLSYVIV KVLD 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade
GO:0006468	; P:protein phosphorylation

KEGG

dme:Dmel_CG40080

;

InterPros

IPR024604	; DUF3635.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF12330

; DUF3635; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.

Prints

Created Date

20-Feb-2013