EKS-DRM-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/DAPK	388.4	1.9E-116	43	295	253

Status

Reviewed

Ensembl Protein

FBpp0290242

UniProt Accession

Q0KHT7; Q86P19;

Protein Name

Probable serine/threonine-protein kinase CG32666

Protein Synonyms/Alias

Gene Name

Drak

Gene Synonyms/Alias

CG32666;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0052666	FBpp0073356	FBtr0073507
FBgn0052666	FBpp0073357	FBtr0073508
FBgn0052666	FBpp0290242	FBtr0301020
FBgn0052666	FBpp0290243	FBtr0301021

Organism

Drosophila melanogaster

Functional Description

Protein Length

674

Protein Sequence
(FASTA)

MFTEKGIFPI GDGLLDVDAD RLKGLLVSCP DINEIYEVEQ TPFARGKFAA VRRAIHKNTG 60

SHFAAKFLKR RRRAQSSDKE IKHEIAVLML CEGEDNIVNL NAVHETRSDT ALLLELATGG 120

ELQTILDNEE CLTEAQARHC MREVLKALKF LHDRSIAHLD LKPQNILLAG ERIEDGLKLC 180

DFGISRVVCE GINVREMAGT PDYVAPEVLQ YEPLSLLTDI WSVGVLTYVL LSGFSPFGGD 240

TKQETFLNIS QCALTFPDNL FGGVSPVAID FIRRALRIKP NDRMNATGCL DHIWLKDDCS 300

LDRQIYLQPQ SDAEEEEEED VDDDVEDEEE EEQVEEEEEE TQNVEEPTTE APQQQQQPVQ 360

QHQLAKSGQI HSKPTHNGHH RANSGGSISK IPIATSKLQS TPSSETTTAI HTLTSNSNGH 420

VHKPTQIVTP TRRASDSDKE NTYTATFVKK PVATIQLGSS NGIEDATVVA TLTLFPDAPT 480

TPKVIRKTPT GESNGSATSV KALVKKFQLE DSSGSAVARR SGGAVTSSSG LHSPTTTSVR 540

LNSIRRASEP LTTVYKKQTS QNGCSSTSNP SSSPGSSPTT SGSTATLLIH SQRLGNSTAP 600

ASHCVAVPAT ATATSSASSS NSSSGKSTSA AHHLHHHHMH HHHHHHHHHV VIAAKNAAAV 660

AATNNLSLDQ GIIC 674

Nucleotide Sequence
(FASTA)

ATGTTCACCG AAAAGGGAAT TTTTCCCATT GGCGACGGAC TTTTGGATGT GGACGCCGAT 60

CGGCTGAAGG GACTCCTCGT CTCATGTCCC GACATCAACG AGATCTACGA AGTGGAACAG 120

ACGCCGTTTG CCAGGGGCAA ATTCGCCGCC GTTCGACGCG CCATTCACAA GAACACGGGC 180

TCGCACTTTG CGGCAAAGTT CCTGAAGCGG AGGCGCCGGG CGCAGAGTAG CGACAAGGAG 240

ATCAAGCACG AGATCGCGGT GCTGATGCTC TGCGAGGGCG AGGACAACAT CGTCAACCTC 300

AATGCCGTTC ACGAGACGCG CTCGGACACA GCACTCCTCC TCGAGCTAGC CACTGGTGGC 360

GAGCTGCAGA CGATCCTGGA CAACGAGGAG TGCCTGACGG AGGCGCAGGC CCGCCACTGC 420

ATGCGCGAGG TGCTCAAGGC GCTGAAGTTC CTGCACGATC GCTCCATTGC CCATTTGGAC 480

CTCAAGCCGC AGAACATCCT GCTCGCCGGC GAGCGCATAG AAGATGGATT GAAGCTGTGC 540

GACTTTGGGA TCTCGCGGGT GGTGTGCGAG GGCATCAATG TGCGGGAAAT GGCCGGAACA 600

CCAGACTACG TGGCCCCCGA GGTGCTGCAA TACGAGCCGC TGTCCCTGCT GACGGACATC 660

TGGTCGGTGG GCGTGCTCAC CTACGTGCTG CTATCCGGAT TCTCGCCCTT TGGCGGCGAC 720

ACCAAACAGG AGACCTTCCT CAACATCTCG CAGTGCGCCC TCACCTTTCC GGACAACCTC 780

TTCGGCGGCG TCTCGCCGGT GGCCATCGAC TTCATCCGTC GCGCATTGCG AATTAAGCCA 840

AACGATCGCA TGAATGCCAC TGGCTGCTTG GATCACATTT GGTTGAAGGA CGACTGCTCG 900

CTGGACAGAC AGATTTATCT GCAGCCCCAG AGCGATGCCG AAGAGGAGGA AGAGGAGGAT 960

GTCGACGACG ATGTGGAGGA CGAGGAAGAG GAGGAGCAGG TGGAGGAGGA GGAGGAGGAG 1020

ACACAGAACG TGGAGGAGCC AACGACAGAA GCGCCACAAC AACAGCAACA ACCTGTCCAG 1080

CAGCATCAGC TAGCCAAATC CGGCCAAATT CACAGCAAAC CGACGCACAA TGGCCACCAT 1140

CGGGCAAACA GTGGCGGCAG CATCTCCAAG ATACCCATTG CGACAAGCAA ACTGCAGAGC 1200

ACTCCCAGCT CCGAGACCAC CACGGCCATC CACACGCTGA CCAGCAACAG CAATGGACAC 1260

GTCCACAAGC CCACTCAGAT TGTGACGCCA ACGCGAAGAG CCTCGGATTC GGACAAGGAG 1320

AACACGTATA CGGCCACGTT TGTAAAGAAG CCAGTCGCCA CCATCCAGCT GGGCAGCTCC 1380

AATGGCATCG AGGATGCCAC GGTTGTGGCC ACACTCACTC TGTTTCCCGA CGCACCCACC 1440

ACACCAAAGG TGATTCGCAA GACGCCGACG GGTGAGTCGA ATGGCTCGGC AACGTCTGTC 1500

AAGGCTCTGG TGAAGAAATT TCAACTGGAG GACTCGAGCG GTTCGGCGGT GGCACGACGC 1560

AGTGGAGGAG CGGTGACCAG CAGCAGTGGA CTGCATTCGC CAACGACGAC ATCGGTCAGG 1620

TTGAATAGCA TTCGTCGCGC CTCGGAGCCG CTGACCACGG TCTACAAGAA GCAGACGTCA 1680

CAGAATGGAT GCAGCAGCAC TTCGAATCCG AGCTCAAGTC CCGGCAGCAG TCCCACCACA 1740

TCCGGCAGCA CCGCCACTCT GCTGATCCAC AGTCAGCGTT TGGGCAACAG CACAGCGCCG 1800

GCGAGCCACT GCGTCGCCGT TCCAGCAACA GCCACAGCCA CCTCCTCCGC CAGCAGCAGC 1860

AACAGCAGCT CAGGGAAGTC AACAAGTGCC GCCCACCATT TGCACCATCA TCATATGCAC 1920

CACCATCATC ATCACCACCA CCATCATGTG GTGATTGCGG CAAAGAATGC CGCTGCCGTG 1980

GCCGCCACCA ACAACTTGAG CCTGGATCAG GGTATCATCT GTTAG 2025

Domain Profile

S: 7     lgsGkfavvrkcrekstGkeyaakflkkrrlkssrrgvsreeierevavlkeirsepnvi  66

         + +Gkfa+vr++++k+tG+++aakflk+rr    r+++s++ei++e+avl+++++e+n++

Q: 43    FARGKFAAVRRAIHKNTGSHFAAKFLKRRR----RAQSSDKEIKHEIAVLMLCEGEDNIV  98

         579***************************....**************************

S: 67    nlhevyenksdvililelvaGGelfdllaekeslseeeatellkqilegvkylhskkivh  126

         nl++v+e++sd++l+lel++GGel+++l+++e+l+e++a+++++++l+++k+lh+++i+h

Q: 99    NLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAH  158

         ************************************************************

S: 127   ldlkPenillldkkvpkgdiklidfGlsrkieegaelkeilGtPefvaPeivnyeplsle  186

         ldlkP+nill+ +++++g +kl+dfG+sr ++eg++++e++GtP++vaPe+++yeplsl

Q: 159   LDLKPQNILLAGERIEDG-LKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLL  217

         ****************99.*****************************************

S: 187   tdmwsiGvityillsgasPflGdtkqetllnisavnldfseelfssvselakdfirrllv  246

         td+ws+Gv+ty+llsg+sPf Gdtkqet+lnis+++l+f ++lf  vs +a+dfirr+l+

Q: 218   TDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALR  277

         ************************************************************

S: 247   kdpekrltieeclehswl  264

          +p++r++++ cl+h+wl

Q: 278   IKPNDRMNATGCLDHIWL  295

         *****************7

Domain Sequence
(FASTA)

FARGKFAAVR RAIHKNTGSH FAAKFLKRRR RAQSSDKEIK HEIAVLMLCE GEDNIVNLNA 60

VHETRSDTAL LLELATGGEL QTILDNEECL TEAQARHCMR EVLKALKFLH DRSIAHLDLK 120

PQNILLAGER IEDGLKLCDF GISRVVCEGI NVREMAGTPD YVAPEVLQYE PLSLLTDIWS 180

VGVLTYVLLS GFSPFGGDTK QETFLNISQC ALTFPDNLFG GVSPVAIDFI RRALRIKPND 240

RMNATGCLDH IWL 253

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007155	; P:cell adhesion
GO:0007480	; P:imaginal disc-derived leg morphogenesis
GO:0007476	; P:imaginal disc-derived wing morphogenesis
GO:0002009	; P:morphogenesis of an epithelium
GO:0008360	; P:regulation of cell shape

KEGG

dme:Dmel_CG32666

;

InterPros

IPR011009	; Kinase-like_dom.
IPR020675	; Myosin_light_ch_kinase-rel.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR020677	; Ser/Thr_kinase_Y2666_prd.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013