EKS-DRM-00042

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00042

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	381.4	5.3E-114	3425	3751	327

Status

Reviewed

Ensembl Protein

FBpp0292385

UniProt Accession

Q8I8U7; Q8T3L7; Q9V9E9;

Protein Name

Transcription-associated protein 1

Protein Synonyms/Alias

dTRA1;

Gene Name

Nipped-A

Gene Synonyms/Alias

Nipped-A; Tra1; CG2905;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0053554	FBpp0292385	FBtr0303293
FBgn0053554	FBpp0085431	FBtr0091528

Organism

Drosophila melanogaster

Functional Description

Part of the Tip60 chromatin-remodeling complex which isinvolved in DNA repair. Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV.

Protein Length

3790

Protein Sequence
(FASTA)

MSVIENVPVN TFRNYLNILN DSSSKDELKL KATQELSEHF EMIMQSPAYP SFLDNSLKIF 60

MRILQDGEPQ FIQENTMQHI RKLILEMIHR LPITESLRQH VKTIITMMLK ILKTDNEENV 120

LVCLRIIIEL HKHFRPSFNS EIQLFLGFVK EIYTNLPNHL TSIFETSNDV WVTDLKDLNL 180

EVLLSESYSV RTIHVEKALD SNSQQQIYNL LPRGILSLKV LQELPIIVVL MYQIYKNAVH 240

QEVSEFIPLI LTTINLQPTV TRRNSPQKEI YVEFMGAQIK TLSFLAYIVR IFQEVVIASS 300

LSVTSGMLNL MKNCPKEAAH LRKELLIAAR HIFATDLRQK FIPSIEQLFD EDLLIGKGVT 360

LDSIRPLAYS TLADLAHHVR QSLNIDVLIK AVNLFSKNVH DESLAVGIQT MSCKLLLNLV 420

DCLRHHSETE PQRSKALLSK LLKVFVKKFE TIAKIQLPLI IQKCKGHAFS GALVNSSGNA 480

SLSHINAPDL KDDISNIQVS ASGSQWIYSV NVAEFRSLVK TLVGGVKTIT WGFFNSKFQL 540

TDTKLANHEK IFGPEIVCSY IDLVYYAMEA LDIYTINVNP NQQRTSGLIS RSKEEKEVLE 600

HFSGIFLMMH SQNFQEIFST TINFLVERIY KNQSLQVIAN SFLANPTTSP LFATVLVEYL 660

LNKMEEMGSN LERSNLYLRL FKLVFGSVSL FPVENEQMLR PHLHKIVNRS MELALISEEP 720

YNYFLLLRAL FRSIGGGSHD LLYQEFLPLL PNLLEGLNRL QSGFHKQHMR DLFVELCLTV 780

PVRLSSLLPY LPMLMDPLVS ALNGSPTLIS QGLRTLELCV DNLQPDFLYD HIQPVRAALM 840

QALWKTLRNQ DNAALVAFRV LGKFGGGNRK MMVEPQALSY IINDKPTISI VTYFQEYETP 900

IDFPVDEAIK SAFRALGSNS TDQFYRRQSW EVIRCFLAAF ISLDDEKHML LKLFTHVDFV 960

ENKIMNWSTF QHKAGNETVR ETHQTALIGM LVASATKDLR DSVCPVMAAV VRHYTMVAIA 1020

QQAGPFPQKG YQATHGIDPM ILIDALASCM GHEEKELCKP GIACMGIILD TATNIMGNKD 1080

RACKLPIIQY LAEKMVSLCY DRPWYSKVGG CQAIQFLCKH MSLRALFQNL FNFLKAFMFV 1140

LMDLEGDVSN GAIEITKSYM KSMLEICLTP INECYKNIDL KDLQAKATYE VIHELVRHIT 1200

SPNTIVREES MVLLKHIGTI QSKTVSEVMD PHKDVLADII PPKKHLLRHQ PANAQIGLMD 1260

GNTFCTTLEP RLFTIDLTNT YHKLFFHELL TLSEAEDATL AKLDCYKNVP NLIPLRTSAL 1320

RALAACHYIS DIGYKEKIIN IIFKVMESDK SELQTTAFHC MKHFITGVTL EKEKVQSAMR 1380

PLLLKLGDHR NLSIPAIKRL SYFTQIFPQM FNEKLSEQIL QHCSKIMEIF VSEYKSTSPN 1440

VNFFASSKGG EYEQKIVILI EMFFYISASV KYIEKLCQLV LKTEKNLMIE ASSPYREALI 1500

KFLQRFPTET VDLFLTESLM IDPQWNRLFI YLLKHETGVS FRAVIKSSRY NNLIHYLNTH 1560

TEFPEALKYE IQHQAVLIIF TLMESDDQWI PTRQDIVDAL KNCWQNYLST LSSEDVLCDL 1620

WHLIGKILLH YFSNNTNDIE LLFQLLRALC FRFIPDVYFL RDFLQHTVAQ SFTVNWKRNA 1680

FFYFVENFNN SFLSEELKAK IITAVIIPCF AVSFDKGEGN KLIGAPPTPY QEDEKNIVSV 1740

FINKVFDPDK QYDDAVRIAL LQLACLLVER ASQHIHDGDA NNKRQGNKLR RLMTFAWPCL 1800

LSKSSVDPTA RYHGHLLLSH IIARLAIHKK IVLQVFHSLL KGHALEARSI VKQALDVLTP 1860

AMPLRMEDGN TMLTHWTKKI IVEEGHAMQQ LFHILQLIIR HYKVYFPVRH QLVQHLINYM 1920

QRLGFPPTAS IEHKKLAVDL AEVIIKWELH RIKDDRETKT DGTEEELIQE SSVKRSGIDL 1980

VETRKKSFDI IRETTVQGVG SHTKPDDILR SIDKSYCDTV LNFLIRLACQ VNDPQAPILS 2040

PGESLSRRCV MLLKMAMRPE IWPQPFDIKL NWLDKVLATV ETPHHNLNNI CTGIDFLTFL 2100

TTILSPDQLV SIIRPVQRGL SLCIIHQNTR IVRLMHMFLT RIMAIFPPDT QHKHEDLDLL 2160

YTAVSKMIAE NLTSYEKSPQ PNASSLFGTL MILKACTTNN ASYIDRILVQ FIRVLNHLTR 2220

DHINTIGGNT VISQSPDSNA LPLELLVLSL ELIKNRIFVM SVEIRKLFIG TILVSLIEKS 2280

TEVKIIKCII KMLDEWIKTK EPNVMTQVPS IREKSALLVK LMQNVEKKFT DEIELNIQFL 2340

EIINFIYRDE ILKQTELTNK LEGAFLNGLR FQNPNVRSKF FEILDSSMRR RLHDRLLYII 2400

CSQAWDTIGS HYWIKQCIEL LILTANTMMQ IQCSNEQFKI PSITSVIPVN SSETQENSFV 2460

SFLSSHSESF DIIQTVDDKD DVYDIDLNAD RKEDCQQILP NRRVTLVELV YKQAEFLEAN 2520

RNIRTDQMLV ATSQLCHIDT QLAQSVWLSM FPRIWSIFTE DQRCNITKEL IPFLSSGTNV 2580

NQKDCHPSTL NTFVESLTKC APPIYIPPNL LAYLGKSHNL WHRAILVLED MAVNQSMQSK 2640

DIDGGENQFS DLDVQQSNNI FDSLSKMYSS MHEEDLWAGL WLKFAHYPET NIAVSYEQMG 2700

FFEEAQGAYD LAMTKFKQDL SNGVVNTYVN SELLLWENHW MRCAKELNQW DILLDYAQTN 2760

KDKNMFLILE SSWRVPDWNL MKIALAKTEQ CYLKHYGFKI NLYKGYLSIL HQEERQTGNI 2820

ERYVEIASSL CIREWRRLPN IVSHIHLPYL QASQQIMELH EASQIHQGLA QSRNNSLHDM 2880

KAIVKTWRNR LPIISDDLSH WSDIFTWRQH HYQIITQHLE QQSDQGSTML GVHASAQAII 2940

SFGKIARKHN LTGVCQETLS RIYTIPSVPI VDCFQKIRQQ VKCYLQMPST SGKNEINEAL 3000

EVIESTNLKY FTGEMNAEFY ALKGLLLAQI GRSEEAGKSF SVAAQLHDGL TKAWAMWGDY 3060

MEQIFLKERK ITLAVDALIC YLQASRNQIE SKTRKYIAKV LWFLSYDNNT KILISTLEKH 3120

VAGIPPSYWL PWIPQLLCCL EQFEGDVILN LLSQIGRLYP QAVYFPIRTL YLTLKIEQRE 3180

KHKTAEQAVK SSCSNIDGTT LSFGRGASHG NIPSINPIKA TPPMWRCSKV MQLQREVHPT 3240

ILSSLEGIVD QMVWFRESWT EEVLRQLRQG LIKCYAIAFE KRDTVQHSTI TPHTLHFVKK 3300

LGSTFGIGIE NVPGSVTSSI SNSAASESLA RRAQVTFQDP VFQKMKEQFT NDFDFSKPGA 3360

MKLHNLISKL KTWIKVLETK VKKLPTSFLI EDKCRFLSNF SQKTAEVELP GELLIPLSSH 3420

YYVRIARFMP RVEIVQKNNT AARRLYIRGT NGKIYPYLVV LDSGLGDARR EERVLQLKRM 3480

LNYYLEKQKE TSRRFLNITV PRVVPISPQM RLAEDNPNSI SLLKIFKKCC QSMQVDYDMP 3540

IVKYYDRLSE VQARGTPTTH TLLREIFSEI QWTMVPKTLL KHWALKTFLA ATDFWHFRKM 3600

LTLQLALAFL CEHALNLTRL NADMMYLHQD SGLMNISYFK FDVNDDKCQL NQHRPVPFRL 3660

TPNVGEFITH FGITGPLSAA IVATARCFIQ PNYKLSSILQ TILRDEIIAL QKKGFRECKL 3720

IEGSEDRYSD GNCMEHSVNI VNSAVDIIMT RFNKISYFDS IENKKISVLV QSATNIDNLC 3780

RMDPAWHPWL 3790

Nucleotide Sequence
(FASTA)

ATGTCGGTTA TTGAAAATGT ACCGGTGAAT ACATTTCGGA ATTATTTAAA TATTTTAAAT 60

GATTCCTCTT CTAAAGACGA ACTTAAGCTG AAAGCTACTC AAGAGCTAAG TGAACACTTT 120

GAAATGATAA TGCAAAGTCC GGCATATCCG TCGTTCTTAG ATAATTCTTT AAAAATATTT 180

ATGCGGATAC TTCAGGATGG CGAACCTCAG TTCATTCAAG AAAATACAAT GCAACACATA 240

CGTAAACTGA TTTTAGAGAT GATTCATCGA TTGCCTATAA CAGAAAGCTT AAGGCAACAT 300

GTAAAGACAA TAATAACAAT GATGCTTAAA ATACTTAAAA CTGACAACGA AGAAAATGTT 360

CTTGTATGTC TTCGCATTAT AATTGAACTG CATAAGCATT TTCGTCCATC ATTTAATTCT 420

GAAATTCAAC TATTTTTGGG ATTTGTTAAG GAAATCTATA CAAATCTTCC TAACCATCTT 480

ACATCTATAT TTGAAACATC GAATGATGTT TGGGTTACCG ATTTAAAGGA CTTAAATTTG 540

GAAGTACTTT TATCCGAATC ATATTCTGTT AGAACTATCC ATGTCGAAAA GGCACTTGAT 600

TCAAATTCTC AACAACAAAT TTATAATCTC CTTCCTCGTG GAATATTATC TTTGAAAGTT 660

TTACAAGAGC TCCCAATAAT AGTAGTACTA ATGTACCAAA TATATAAAAA CGCAGTACAT 720

CAAGAAGTTT CTGAATTCAT TCCTCTTATA TTGACTACTA TTAATTTGCA ACCAACAGTA 780

ACACGAAGAA ATTCTCCTCA GAAAGAAATA TATGTCGAAT TCATGGGTGC ACAAATTAAA 840

ACTCTGTCAT TTTTGGCGTA CATTGTCCGA ATATTTCAGG AAGTGGTAAT AGCTAGTTCA 900

TTATCTGTAA CCAGCGGAAT GCTCAACCTT ATGAAAAATT GTCCCAAGGA AGCCGCTCAT 960

CTCAGAAAAG AACTTTTAAT TGCTGCCCGT CATATATTTG CTACAGATTT ACGTCAAAAA 1020

TTTATTCCAT CAATCGAACA ATTGTTTGAT GAGGATTTGC TTATTGGAAA AGGAGTTACA 1080

TTGGATTCTA TTCGGCCATT GGCGTATTCA ACTTTAGCTG ACCTAGCTCA CCACGTTCGC 1140

CAAAGCCTAA ATATAGACGT TTTAATAAAG GCAGTGAATC TCTTTTCAAA AAATGTTCAT 1200

GATGAATCAC TTGCTGTGGG AATACAAACT ATGTCATGCA AGCTTTTGTT AAATCTAGTT 1260

GATTGTTTAC GTCATCACAG TGAAACAGAA CCACAAAGAT CAAAAGCTCT ACTCTCAAAA 1320

CTGTTAAAAG TGTTTGTAAA AAAATTTGAA ACTATAGCTA AAATTCAGCT TCCATTAATA 1380

ATTCAAAAGT GCAAAGGGCA CGCATTTTCT GGAGCATTGG TAAATTCATC TGGCAACGCT 1440

TCCTTATCAC ACATTAACGC GCCAGATCTA AAAGACGACA TATCCAACAT CCAAGTATCT 1500

GCATCTGGAT CACAATGGAT ATATTCCGTC AATGTCGCTG AATTTCGAAG CTTAGTAAAA 1560

ACCCTTGTTG GTGGAGTAAA AACAATAACT TGGGGTTTTT TTAACTCAAA GTTTCAGCTA 1620

ACTGATACCA AACTGGCCAA CCATGAAAAA ATTTTTGGAC CTGAAATCGT ATGTTCTTAC 1680

ATCGACTTGG TTTACTATGC GATGGAGGCT CTAGATATAT ACACTATAAA CGTTAATCCA 1740

AATCAACAGA GAACGTCTGG GTTGATTTCC AGAAGTAAAG AAGAAAAAGA AGTCTTGGAG 1800

CATTTTAGTG GCATATTTTT AATGATGCAC TCCCAAAACT TTCAAGAAAT ATTTTCTACT 1860

ACGATTAATT TTTTGGTGGA AAGGATCTAC AAAAATCAGT CCTTACAAGT GATAGCGAAC 1920

TCCTTTTTAG CAAATCCTAC TACTTCACCT CTGTTTGCCA CTGTTCTAGT GGAATATCTT 1980

TTGAACAAAA TGGAAGAAAT GGGATCAAAC TTGGAACGCT CCAACTTGTA TCTACGATTA 2040

TTCAAGTTGG TATTCGGCAG CGTAAGTCTT TTTCCAGTCG AAAATGAACA GATGTTGCGT 2100

CCACATCTTC ATAAAATAGT CAATAGATCC ATGGAATTGG CTTTGATATC GGAGGAGCCG 2160

TATAACTATT TTTTACTTCT GAGGGCATTG TTTAGATCGA TTGGAGGAGG AAGCCATGAC 2220

CTATTATACC AAGAGTTTCT GCCACTTTTA CCAAACTTAT TAGAAGGATT AAATCGCCTA 2280

CAGAGTGGAT TTCATAAGCA GCACATGCGA GATCTTTTCG TGGAACTTTG CCTTACAGTT 2340

CCGGTCCGCT TGTCATCTTT ACTGCCCTAT TTACCAATGT TGATGGACCC ATTAGTTTCT 2400

GCGTTAAACG GATCTCCAAC ATTAATAAGT CAGGGCCTGC GAACCTTAGA GCTTTGCGTT 2460

GACAATTTGC AGCCAGACTT TTTATATGAT CATATACAAC CAGTAAGAGC TGCTTTAATG 2520

CAAGCATTGT GGAAAACTTT AAGAAATCAG GATAACGCCG CTTTGGTTGC CTTTCGCGTT 2580

CTAGGAAAAT TTGGTGGCGG CAATCGAAAA ATGATGGTGG AGCCACAAGC TTTGTCGTAT 2640

ATTATAAACG ACAAGCCCAC CATTTCCATT GTAACTTATT TTCAGGAATA CGAAACACCA 2700

ATAGATTTTC CTGTTGATGA AGCGATTAAG TCCGCCTTTA GAGCATTGGG ATCAAATTCT 2760

ACTGACCAGT TTTATAGGAG GCAAAGCTGG GAAGTAATCA GGTGCTTCTT AGCTGCTTTT 2820

ATTAGTTTGG ATGATGAAAA ACATATGCTG CTGAAACTTT TTACACATGT AGATTTTGTT 2880

GAAAATAAAA TTATGAATTG GTCTACGTTT CAACATAAAG CCGGGAACGA AACTGTACGA 2940

GAAACTCATC AGACAGCCCT CATAGGTATG TTGGTTGCAT CAGCAACAAA GGACTTGCGT 3000

GATTCAGTGT GCCCAGTAAT GGCCGCTGTT GTGAGGCATT ATACTATGGT AGCTATTGCA 3060

CAGCAGGCCG GACCTTTTCC ACAAAAAGGC TACCAAGCCA CTCATGGAAT TGACCCCATG 3120

ATATTAATAG ATGCTTTAGC CTCTTGCATG GGTCATGAAG AAAAGGAGTT ATGCAAACCC 3180

GGAATAGCTT GTATGGGTAT TATACTTGAC ACTGCAACAA ATATTATGGG TAATAAAGAC 3240

AGAGCGTGTA AATTGCCCAT AATACAGTAT CTAGCAGAAA AAATGGTATC CTTATGCTAT 3300

GATCGGCCAT GGTACTCAAA AGTAGGCGGT TGCCAAGCAA TTCAATTTTT ATGCAAACAT 3360

ATGTCTTTGC GAGCCCTTTT TCAAAATCTC TTTAATTTTT TAAAAGCTTT CATGTTTGTA 3420

TTAATGGACC TAGAGGGAGA CGTTTCTAAT GGGGCTATTG AAATAACAAA AAGTTATATG 3480

AAAAGCATGT TGGAAATTTG TTTAACGCCA ATAAATGAAT GTTATAAGAA TATAGATCTA 3540

AAGGACTTAC AAGCCAAAGC CACTTATGAA GTTATTCACG AATTAGTGCG GCACATCACA 3600

AGCCCTAATA CCATTGTTAG AGAAGAATCT ATGGTACTAC TTAAACATAT TGGTACAATA 3660

CAATCCAAAA CCGTTTCTGA AGTTATGGAT CCTCATAAAG ACGTTCTCGC TGACATTATA 3720

CCGCCAAAGA AGCATTTATT GAGACATCAA CCCGCAAATG CGCAAATCGG ACTTATGGAT 3780

GGCAATACAT TCTGCACAAC TTTGGAGCCA AGACTTTTTA CAATTGATTT GACGAATACC 3840

TACCACAAAT TATTTTTTCA CGAGTTACTT ACACTAAGTG AAGCCGAAGA TGCCACTTTA 3900

GCAAAGTTGG ACTGTTACAA AAACGTTCCG AATCTTATAC CACTTAGGAC TAGTGCGTTG 3960

CGAGCTTTAG CAGCATGCCA CTATATAAGT GATATCGGAT ACAAAGAAAA AATAATAAAT 4020

ATAATTTTTA AAGTAATGGA AAGTGATAAA TCAGAACTTC AGACAACTGC GTTTCATTGC 4080

ATGAAGCATT TTATAACTGG AGTTACTCTG GAAAAAGAAA AGGTACAATC TGCAATGCGC 4140

CCACTGCTAT TAAAATTGGG CGACCACAGA AATTTATCGA TACCAGCAAT AAAACGCTTA 4200

TCTTACTTTA CTCAGATCTT TCCTCAAATG TTCAATGAGA AGTTAAGTGA GCAAATTTTG 4260

CAACATTGCT CTAAAATTAT GGAAATATTT GTTAGTGAAT ACAAATCCAC AAGTCCAAAC 4320

GTTAATTTTT TTGCATCATC GAAAGGTGGA GAATATGAAC AGAAAATTGT CATACTAATC 4380

GAAATGTTTT TCTATATATC AGCATCAGTA AAATACATTG AAAAGCTGTG CCAACTTGTT 4440

TTAAAAACGG AAAAAAACTT AATGATTGAG GCATCGAGTC CATATCGAGA AGCCCTAATT 4500

AAGTTTCTTC AACGATTTCC AACAGAAACT GTGGATTTAT TTTTAACGGA ATCTCTTATG 4560

ATAGATCCGC AATGGAATCG TCTTTTTATA TACTTGTTGA AACACGAAAC GGGAGTATCA 4620

TTTCGAGCAG TTATTAAAAG TAGTCGGTAT AATAATTTAA TACATTATTT AAATACACAC 4680

ACAGAATTTC CAGAAGCACT CAAATATGAA ATTCAGCACC AAGCCGTTTT AATAATTTTT 4740

ACATTAATGG AATCAGACGA TCAATGGATA CCAACACGAC AAGATATTGT TGACGCCCTT 4800

AAAAATTGTT GGCAGAATTA TTTAAGTACA TTAAGCTCTG AAGACGTTCT GTGTGACTTA 4860

TGGCATTTGA TTGGAAAAAT ACTTTTGCAT TATTTTTCTA ACAATACAAA TGACATTGAA 4920

CTGCTGTTTC AATTATTACG TGCTTTATGC TTCCGATTTA TACCGGATGT CTATTTCCTG 4980

CGGGACTTCT TGCAACACAC AGTAGCACAA AGTTTTACGG TTAACTGGAA ACGAAACGCA 5040

TTCTTTTACT TTGTTGAAAA CTTTAATAAC AGCTTTCTTT CAGAAGAGCT AAAGGCAAAA 5100

ATAATAACAG CAGTCATAAT ACCCTGTTTT GCTGTAAGTT TCGATAAAGG TGAAGGAAAT 5160

AAACTAATTG GGGCTCCTCC GACCCCGTAT CAAGAAGATG AAAAAAATAT TGTGTCCGTT 5220

TTTATTAATA AAGTGTTTGA CCCAGATAAA CAGTATGATG ATGCAGTAAG AATTGCTCTA 5280

TTACAACTAG CATGCTTATT GGTAGAACGT GCATCTCAGC ACATACATGA CGGAGATGCT 5340

AATAATAAGC GCCAAGGCAA TAAGCTTAGA CGACTCATGA CCTTTGCCTG GCCCTGTTTG 5400

CTGAGTAAAA GTTCAGTGGA TCCTACTGCA CGATACCACG GTCACTTATT ACTTTCGCAT 5460

ATAATCGCAA GATTGGCCAT TCACAAGAAA ATAGTTTTAC AAGTATTTCA TTCCTTGTTG 5520

AAAGGACACG CATTAGAGGC CAGATCTATT GTTAAACAGG CACTTGATGT TCTAACGCCA 5580

GCTATGCCGT TGCGAATGGA GGATGGAAAT ACTATGCTAA CACACTGGAC AAAAAAAATT 5640

ATAGTTGAAG AAGGTCACGC TATGCAGCAG TTATTTCATA TTTTGCAGCT CATTATTCGT 5700

CATTATAAAG TGTATTTTCC GGTTCGACAT CAACTAGTGC AACACTTGAT TAACTATATG 5760

CAGCGCCTTG GGTTTCCTCC TACTGCATCT ATTGAACATA AAAAACTTGC TGTGGACTTA 5820

GCAGAAGTTA TTATAAAATG GGAACTTCAT CGTATTAAGG ATGATCGTGA AACTAAAACA 5880

GATGGAACCG AAGAGGAGTT AATACAGGAA AGCTCAGTAA AACGATCAGG GATCGATTTA 5940

GTAGAAACTC GAAAAAAGTC ATTCGATATT ATAAGAGAAA CAACAGTCCA AGGAGTGGGA 6000

TCACATACCA AGCCTGATGA CATACTGCGA TCAATAGATA AATCCTATTG TGATACGGTT 6060

TTAAATTTCT TGATACGTTT AGCATGTCAG GTTAATGACC CGCAAGCCCC AATACTTTCG 6120

CCAGGAGAAA GTTTGTCTCG AAGGTGCGTT ATGCTATTAA AAATGGCGAT GCGTCCCGAG 6180

ATCTGGCCTC AACCATTTGA TATTAAGCTT AATTGGCTTG ATAAAGTTCT TGCTACAGTG 6240

GAAACCCCTC ATCACAACTT AAACAACATA TGTACTGGAA TAGATTTTTT AACATTTTTA 6300

ACTACTATAC TAAGTCCAGA TCAGTTGGTG TCAATTATAC GACCGGTTCA ACGAGGCCTG 6360

TCCTTGTGTA TAATTCATCA AAATACACGA ATTGTGCGGT TAATGCATAT GTTTTTGACG 6420

CGAATAATGG CAATTTTTCC ACCTGACACC CAACACAAGC ATGAAGATCT TGATTTGTTA 6480

TATACCGCTG TTAGTAAAAT GATCGCTGAA AACCTAACAA GTTACGAAAA GAGTCCACAA 6540

CCGAATGCTT CTTCGCTTTT TGGTACCTTA ATGATTTTGA AAGCGTGCAC TACTAATAAT 6600

GCAAGTTATA TTGATCGAAT TTTAGTCCAG TTTATAAGGG TTCTGAATCA TCTTACAAGG 6660

GATCATATTA ACACCATTGG TGGTAACACT GTTATTAGCC AATCTCCTGA TTCAAATGCT 6720

TTACCTTTAG AACTCTTAGT TCTCTCTTTG GAATTAATCA AGAATAGGAT CTTTGTAATG 6780

AGTGTGGAAA TCAGAAAACT TTTCATAGGC ACCATTTTGG TTAGTCTTAT AGAAAAGAGC 6840

ACGGAGGTAA AAATTATAAA ATGTATAATT AAAATGCTGG ATGAATGGAT TAAAACGAAA 6900

GAGCCAAATG TTATGACACA AGTTCCTTCT ATTCGCGAAA AGTCGGCCTT GCTGGTAAAG 6960

TTAATGCAAA ACGTTGAAAA GAAATTTACT GATGAAATAG AGCTTAATAT ACAATTCTTG 7020

GAAATCATAA ATTTTATATA TAGAGATGAA ATTCTTAAAC AAACTGAGTT AACAAACAAA 7080

CTAGAGGGAG CTTTTTTAAA CGGATTACGT TTTCAAAATC CAAACGTACG CTCGAAATTT 7140

TTTGAGATTT TAGACTCATC AATGCGGCGT AGACTTCACG ATCGATTGTT ATATATAATT 7200

TGTTCCCAAG CTTGGGACAC AATTGGTTCC CATTATTGGA TAAAACAATG CATTGAATTG 7260

CTTATTTTAA CAGCCAATAC AATGATGCAA ATTCAATGTT CAAATGAACA ATTTAAAATA 7320

CCCAGCATTA CTTCAGTCAT TCCAGTGAAT TCATCAGAAA CACAGGAAAA TTCCTTTGTA 7380

TCCTTCTTAT CCTCTCATTC CGAATCTTTT GACATTATAC AAACTGTTGA TGATAAAGAC 7440

GACGTGTATG ATATCGATTT AAATGCTGAT CGCAAAGAAG ATTGTCAACA AATACTACCA 7500

AATCGACGTG TTACTCTTGT TGAACTAGTT TACAAGCAAG CTGAATTTTT AGAAGCAAAC 7560

CGAAATATTA GGACCGACCA GATGCTTGTC GCCACATCTC AGCTATGTCA TATTGATACA 7620

CAGTTAGCTC AAAGCGTATG GTTATCTATG TTTCCACGTA TTTGGAGTAT ATTCACTGAA 7680

GATCAAAGGT GTAATATCAC AAAAGAACTG ATTCCCTTTT TATCGTCTGG AACTAACGTT 7740

AATCAAAAAG ACTGCCATCC AAGTACATTA AATACTTTTG TAGAGAGTTT AACTAAATGT 7800

GCGCCACCCA TATATATTCC ACCTAATTTA TTAGCATACC TAGGCAAATC TCATAACCTA 7860

TGGCATAGAG CTATACTTGT TTTAGAAGAT ATGGCCGTTA ATCAATCAAT GCAATCCAAG 7920

GATATTGATG GCGGTGAAAA TCAATTCTCT GACTTGGATG TACAACAATC AAATAATATA 7980

TTTGATTCAC TTTCAAAAAT GTATTCTTCG ATGCATGAGG AAGATCTTTG GGCTGGCCTA 8040

TGGCTTAAAT TTGCACACTA CCCGGAAACA AATATAGCTG TTTCGTATGA GCAAATGGGA 8100

TTTTTCGAAG AAGCCCAAGG TGCCTATGAT CTAGCAATGA CCAAATTTAA ACAAGATCTA 8160

AGTAATGGTG TAGTTAATAC ATATGTTAAT AGTGAATTAT TATTGTGGGA AAATCACTGG 8220

ATGCGATGTG CTAAAGAATT GAACCAATGG GACATTTTAC TGGACTATGC CCAAACTAAT 8280

AAGGACAAAA ATATGTTTTT GATTCTGGAA AGTTCGTGGC GCGTACCTGA TTGGAATTTG 8340

ATGAAAATCG CACTGGCTAA AACAGAACAA TGCTATTTAA AACACTACGG CTTTAAAATC 8400

AACCTTTACA AAGGGTATTT GAGTATTCTC CACCAAGAAG AAAGGCAAAC AGGCAATATC 8460

GAACGATATG TTGAAATTGC ATCCAGCTTA TGCATTCGTG AATGGCGTCG ATTGCCGAAC 8520

ATAGTTTCAC ATATTCATTT GCCATATCTT CAAGCATCAC AACAAATTAT GGAGCTTCAT 8580

GAAGCAAGTC AAATCCATCA GGGACTTGCT CAATCGCGCA ACAATTCACT TCACGATATG 8640

AAAGCTATCG TGAAAACTTG GCGTAATCGT TTACCTATTA TTTCTGATGA CTTATCGCAT 8700

TGGAGTGACA TATTTACATG GAGACAACAT CACTACCAAA TAATAACACA ACACCTAGAA 8760

CAACAATCGG ATCAAGGAAG TACAATGCTA GGAGTTCACG CATCAGCACA AGCTATAATT 8820

TCTTTTGGAA AAATAGCTCG GAAACACAAT TTGACTGGTG TTTGTCAGGA GACGTTGTCC 8880

AGGATATATA CAATTCCGTC TGTTCCTATC GTGGATTGTT TTCAGAAAAT TCGGCAGCAA 8940

GTAAAATGCT ACCTGCAAAT GCCCTCAACA TCTGGAAAAA ATGAAATTAA TGAAGCCTTG 9000

GAAGTAATTG AGTCCACGAA TTTAAAATAC TTCACTGGTG AAATGAATGC TGAATTTTAC 9060

GCTCTAAAGG GGCTATTATT AGCACAAATT GGAAGATCAG AAGAGGCTGG AAAATCATTT 9120

AGTGTTGCTG CTCAGCTTCA TGATGGTCTT ACCAAAGCCT GGGCAATGTG GGGTGACTAT 9180

ATGGAACAAA TATTTTTAAA AGAAAGGAAA ATCACATTAG CCGTCGATGC TTTAATTTGT 9240

TATTTACAAG CAAGCAGAAA TCAAATTGAA AGCAAAACCC GAAAATATAT TGCAAAAGTT 9300

TTGTGGTTTC TGTCTTATGA TAATAATACT AAAATCCTCA TAAGCACTTT AGAAAAGCAT 9360

GTGGCAGGCA TTCCACCCTC TTATTGGCTA CCATGGATTC CTCAGTTGCT CTGTTGCTTA 9420

GAACAGTTCG AAGGGGATGT TATATTAAAT CTCTTAAGCC AAATTGGACG CCTTTATCCT 9480

CAAGCGGTAT ATTTCCCGAT TCGGACTTTA TATTTGACTT TAAAAATCGA ACAACGCGAA 9540

AAACATAAAA CTGCTGAACA GGCTGTAAAA AGTTCATGCT CGAACATCGA TGGAACTACT 9600

TTAAGCTTTG GAAGGGGAGC AAGTCACGGA AACATTCCAT CAATAAATCC CATTAAAGCA 9660

ACTCCGCCCA TGTGGCGCTG CTCTAAGGTG ATGCAATTAC AGAGAGAAGT ACATCCAACA 9720

ATATTAAGTT CATTGGAAGG AATTGTAGAC CAAATGGTTT GGTTTAGAGA AAGCTGGACA 9780

GAGGAAGTTC TTCGACAACT ACGCCAAGGC CTAATTAAAT GCTATGCCAT AGCCTTTGAA 9840

AAAAGGGATA CTGTTCAACA TTCTACCATA ACACCTCACA CGTTGCATTT TGTCAAAAAG 9900

CTGGGTTCTA CGTTTGGCAT TGGAATAGAA AATGTTCCGG GATCAGTAAC CTCCTCAATT 9960

TCTAATTCAG CAGCCTCGGA GTCTCTTGCT CGACGCGCCC AAGTTACTTT TCAAGATCCA 10020

GTATTTCAAA AAATGAAGGA GCAATTCACT AATGACTTCG ATTTTTCAAA ACCTGGTGCC 10080

ATGAAATTGC ACAACTTGAT ATCAAAATTA AAAACATGGA TAAAAGTCCT GGAGACTAAA 10140

GTTAAAAAAT TACCCACGTC CTTTTTGATA GAAGACAAGT GTAGGTTTTT ATCAAACTTT 10200

AGTCAGAAGA CAGCTGAGGT TGAACTTCCT GGAGAATTGT TAATTCCCTT ATCATCTCAT 10260

TATTATGTAA GAATCGCAAG ATTCATGCCG CGTGTGGAAA TTGTACAAAA AAATAACACA 10320

GCAGCGCGTA GGTTATATAT AAGAGGTACT AACGGGAAAA TCTATCCGTA CCTTGTAGTT 10380

CTTGATTCAG GTTTGGGAGA TGCTCGCCGA GAGGAAAGAG TTTTGCAGTT AAAACGCATG 10440

TTGAATTACT ATTTAGAAAA ACAAAAAGAG ACAAGTCGAA GATTTCTTAA CATAACGGTA 10500

CCAAGGGTTG TCCCGATATC GCCCCAAATG AGATTGGCAG AAGATAACCC AAACAGTATT 10560

TCATTGTTAA AAATATTTAA AAAATGCTGT CAAAGTATGC AGGTTGACTA CGACATGCCA 10620

ATAGTTAAGT ATTATGACCG TCTTTCTGAA GTACAGGCAA GAGGCACTCC AACTACACAT 10680

ACCCTATTGA GAGAAATATT CTCTGAAATT CAATGGACTA TGGTCCCAAA AACATTACTA 10740

AAGCATTGGG CTTTGAAAAC ATTCTTGGCG GCTACTGACT TTTGGCATTT CCGAAAAATG 10800

CTTACCCTGC AGTTGGCTTT GGCATTTTTA TGCGAACACG CTTTGAATCT TACTCGACTG 10860

AATGCGGATA TGATGTACCT TCATCAAGAC TCAGGACTTA TGAACATATC TTATTTTAAG 10920

TTTGATGTAA ATGATGATAA GTGCCAGCTT AATCAACACC GACCTGTACC ATTTCGCCTG 10980

ACTCCGAATG TTGGTGAATT CATAACACAT TTTGGAATAA CTGGACCTTT ATCTGCAGCA 11040

ATTGTGGCAA CGGCTCGGTG TTTTATTCAA CCAAATTACA AATTAAGCTC AATATTACAA 11100

ACCATTTTAA GAGATGAAAT AATAGCCCTG CAAAAAAAAG GATTCAGAGA ATGTAAACTA 11160

ATCGAAGGCT CTGAAGACCG TTATTCCGAT GGAAATTGTA TGGAGCACTC AGTAAACATT 11220

GTGAATTCAG CGGTGGATAT CATAATGACG CGTTTTAATA AAATATCTTA TTTTGATAGC 11280

ATTGAAAATA AGAAGATTTC CGTGCTCGTT CAATCGGCAA CTAACATTGA TAATCTTTGT 11340

CGTATGGATC CTGCTTGGCA TCCCTGGCTA TAA 11373

Domain Profile

S: 1     iagfderveilask.qkpkklllrGsdgkeypyLv...kgkeDlrqdervlqlfslvNtl  56

         ia+f++rvei+++  +++++l++rG +gk+ypyLv   +g++D+r++ervlql++++N++

Q: 3425  IARFMPRVEIVQKNnTAARRLYIRGTNGKIYPYLVvldSGLGDARREERVLQLKRMLNYY  3484

         89**********9989********************************************

S: 57    LakdketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyr  116

         L+k+ketsrr L+i++++Vvp+s++++l+e+++n++sL +++kk++++++v++d+pi+++

Q: 3485  LEKQKETSRRFLNITVPRVVPISPQMRLAEDNPNSISLLKIFKKCCQSMQVDYDMPIVKY  3544

         ************************************************************

S: 117   ykdlstvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytr  176

         y++ls+vqar++ ++h+ l+ e+f+e+++++vpk+llk+++l++f+++++++++rk++t

Q: 3545  YDRLSEVQARGTPTTHTLLR-EIFSEIQWTMVPKTLLKHWALKTFLAATDFWHFRKMLTL  3603

         ********************.***************************************

S: 177   slAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrn  236

         +lA+++l++++L+L+++++++++++q++g +++++f+++++++k+ql+++++vPFRLT+n

Q: 3604  QLALAFLCEHALNLTRLNADMMYLHQDSGLMNISYFKFDVNDDKCQLNQHRPVPFRLTPN  3663

         ************************************************************

S: 237   ivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeee  296

         + ++++++g++G+++a+++a++r+++++++kl++iL+++l+d++++++k k+ ++ + +e

Q: 3664  VGEFITHFGITGPLSAAIVATARCFIQPNYKLSSILQTILRDEIIALQK-KGFRECKLIE  3722

         ************************************************8.4444444444

S: 297   laekakaealki.kkllskvekaenavatr  325

          + ++++++ ++ ++ ++ v+ a+  ++tr

Q: 3723  GS-EDRYSDGNCmEHSVNIVNSAVDIIMTR  3751

         44.455555544155666677777766665

Domain Sequence
(FASTA)

IARFMPRVEI VQKNNTAARR LYIRGTNGKI YPYLVVLDSG LGDARREERV LQLKRMLNYY 60

LEKQKETSRR FLNITVPRVV PISPQMRLAE DNPNSISLLK IFKKCCQSMQ VDYDMPIVKY 120

YDRLSEVQAR GTPTTHTLLR EIFSEIQWTM VPKTLLKHWA LKTFLAATDF WHFRKMLTLQ 180

LALAFLCEHA LNLTRLNADM MYLHQDSGLM NISYFKFDVN DDKCQLNQHR PVPFRLTPNV 240

GEFITHFGIT GPLSAAIVAT ARCFIQPNYK LSSILQTILR DEIIALQKKG FRECKLIEGS 300

EDRYSDGNCM EHSVNIVNSA VDIIMTR 327

Keyword

Activator; Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005875	; C:microtubule associated complex
GO:0035267	; C:NuA4 histone acetyltransferase complex
GO:0005703	; C:polytene chromosome puff
GO:0000124	; C:SAGA complex
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor
GO:0000910	; P:cytokinesis
GO:0016573	; P:histone acetylation
GO:0043486	; P:histone exchange
GO:0006911	; P:phagocytosis, engulfment
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0006355	; P:regulation of transcription, DNA-dependent
GO:0006351	; P:transcription, DNA-dependent
GO:0035222	; P:wing disc pattern formation

KEGG

dme:Dmel_CG33554

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; FALSE_NEG.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013