EKS-DRM-00078

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00078

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	586.7	8.3E-177	672	951	280

Status

Unreviewed

Ensembl Protein

FBpp0305894

UniProt Accession

B7Z126;

Protein Name

Protein Synonyms/Alias

Tousled-like kinase, isoform G;

Gene Name

tlk

Gene Synonyms/Alias

tlk; Dmel_CG34412;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0086899	FBpp0305895	FBtr0333753
FBgn0086899	FBpp0099673	FBtr0070596
FBgn0086899	FBpp0290873	FBtr0301659
FBgn0086899	FBpp0288854	FBtr0299579
FBgn0086899	FBpp0111592	FBtr0112680
FBgn0086899	FBpp0288856	FBtr0299581
FBgn0086899	FBpp0288855	FBtr0299580
FBgn0086899	FBpp0288858	FBtr0299583
FBgn0086899	FBpp0288857	FBtr0299582
FBgn0086899	FBpp0305894	FBtr0333752
FBgn0086899	FBpp0305893	FBtr0333751

Organism

Drosophila melanogaster

Functional Description

Protein Length

1011

Protein Sequence
(FASTA)

MDQFQTSLNP RKLELLESRI TGVRMSPGAH LQMSPQNTSS LSQHHPHQQQ QLQPPQQQQQ 60

HFPNHHSAQQ QSQQQQQQEQ QNPQQQAQQQ QQILPHQHLQ HLHKHPHQLQ LHQQQQQQLH 120

QQQQQHFHQQ SLQGLHQGSS NPDSNMSTGS SHSEKDVNDM LSGGAATPGA AAAAIQQQHP 180

AFAPTLGMQQ PPPPPPQHSN NGGEMGYLSA GTTTTTSVLT VGKPRTPAER KRKRKMPPCA 240

TSADEAGSGG GSGGAGATVV NNSSLKGKSL AFRDMPKVNM SLNLGDRLGG SAGSGVGAGG 300

AGSGGGGAGS GSGSGGGKSA RLMLPVSDNK KINDYFNKQQ TGVGVGVPGG AGGNTAGLRG 360

SHTGGGSKSP SSAQQQQTAA QQQGSGVATG GSAGGSAGNQ VQVQTSSAYA LYPPASPQTQ 420

TSQQQQQQQP GSDFHYVNSS KAQQQQQRQQ QQTSNQMVPP HVVVGLGGHP LSLASIQQQT 480

PLSQQQQQQQ QQQQQQQLGP PTTSTASVVP THPHQLGSLG VVGMVGVGVG VGVGVNVGVG 540

PPLPPPPPMA MPAAIITYSK ATQTEVSLHE LQEREAEHES GKVKLDEMTR LSDEQKSQIV 600

GNQKTIDQHK CHIAKCIDVV KKLLKEKSSI EKKEARQKCM QNRLRLGQFV TQRVGATFQS 660

RFNNHPVLND RYLLLMLLGK GGFSEVHKAF DLKEQRYVAC KVHQLNKDWK EDKKANYIKH 720

ALREYNIHKA LDHPRVVKLY DVFEIDANSF CTVLEYCDGH DLDFYLKQHK TIPEREARSI 780

IMQVVSALKY LNEIKPPVIH YDLKPGNILL TEGNVCGEIK ITDFGLSKVM DDENYNPDHG 840

MDLTSQGAGT YWYLPPECFV VGKNPPKISS KVDVWSVGVI FYQCLYGKKP FGHNQSQATI 900

LEENTILKAT EVQFSNKPTV SNEAKSFIRG CLAYRKEDRM DVFALARHEY IQPPIPKHGR 960

GSLNQQQQAQ QQQQQQQQQQ QQQSSTSQAN STGQTSFSAH MFGNMNQSSS S 1011

Nucleotide Sequence
(FASTA)

ATGGATCAAT TTCAAACTTC ACTAAATCCG CGGAAACTCG AGCTTCTGGA GTCTCGAATT 60

ACTGGAGTGC GGATGTCCCC CGGCGCCCAT TTGCAGATGT CCCCGCAGAA CACTTCGTCC 120

CTAAGTCAAC ACCATCCACA TCAACAGCAA CAGTTACAAC CCCCACAGCA GCAACAACAG 180

CATTTCCCTA ACCATCACAG CGCCCAGCAA CAGTCGCAGC AGCAGCAGCA ACAGGAGCAA 240

CAGAATCCCC AGCAGCAGGC GCAACAGCAG CAGCAGATAC TCCCACATCA ACATTTGCAG 300

CACCTGCACA AGCATCCGCA TCAGCTGCAA CTGCATCAGC AGCAGCAACA ACAACTCCAC 360

CAGCAACAGC AGCAACACTT CCACCAGCAG TCGCTGCAAG GGCTGCATCA GGGTAGCAGC 420

AATCCGGATT CGAATATGAG CACTGGCTCC TCGCATAGCG AGAAGGATGT CAATGATATG 480

CTGAGTGGCG GTGCAGCAAC GCCAGGAGCT GCAGCAGCAG CGATTCAACA GCAACATCCC 540

GCCTTTGCGC CCACACTGGG AATGCAGCAA CCACCGCCGC CCCCACCTCA ACACTCCAAT 600

AATGGAGGCG AGATGGGCTA CTTGTCGGCA GGCACGACCA CGACGACGTC GGTGTTAACG 660

GTAGGCAAGC CTCGGACGCC AGCGGAGCGG AAACGGAAGC GAAAAATGCC TCCATGTGCC 720

ACTAGTGCGG ATGAGGCGGG GAGTGGCGGT GGCTCTGGCG GAGCAGGAGC AACCGTTGTT 780

AACAACAGCA GCCTGAAGGG CAAATCATTG GCCTTTCGTG ATATGCCCAA GGTAAACATG 840

AGCCTGAATC TGGGCGATCG TCTGGGAGGA TCTGCAGGAA GCGGAGTAGG AGCCGGTGGC 900

GCCGGAAGCG GGGGAGGTGG CGCTGGTTCC GGTTCTGGAA GCGGTGGCGG CAAAAGCGCC 960

CGCCTGATGC TGCCAGTCAG CGACAACAAG AAGATCAACG ACTATTTCAA TAAGCAGCAA 1020

ACGGGCGTGG GCGTCGGTGT GCCAGGTGGT GCGGGAGGCA ATACCGCTGG CCTTCGAGGA 1080

TCACATACGG GAGGTGGCAG CAAGTCACCC TCATCCGCCC AGCAGCAGCA AACGGCGGCA 1140

CAGCAGCAGG GAAGCGGTGT TGCGACGGGA GGCAGTGCAG GCGGTTCCGC TGGCAACCAG 1200

GTGCAAGTGC AAACGAGCAG CGCTTACGCC CTTTACCCAC CAGCTAGTCC CCAAACCCAG 1260

ACGTCACAGC AACAGCAGCA GCAGCAACCG GGATCAGACT TTCACTATGT CAACTCCAGC 1320

AAGGCGCAGC AACAACAGCA GCGTCAACAG CAACAGACTT CCAATCAAAT GGTTCCTCCA 1380

CACGTGGTCG TTGGCCTTGG TGGTCATCCA CTGAGCCTCG CGTCCATTCA GCAGCAGACG 1440

CCCTTATCCC AGCAGCAACA GCAGCAACAA CAGCAGCAGC AACAGCAGCA ACTGGGACCA 1500

CCGACCACAT CGACGGCCTC CGTCGTGCCA ACGCATCCGC ATCAACTCGG ATCCCTGGGA 1560

GTTGTTGGGA TGGTCGGTGT GGGTGTTGGC GTGGGCGTTG GAGTAAATGT GGGTGTGGGA 1620

CCACCACTGC CACCACCACC GCCGATGGCC ATGCCAGCGG CCATTATCAC TTATAGTAAG 1680

GCCACTCAAA CGGAGGTGTC GCTGCATGAA TTGCAGGAGC GCGAAGCGGA GCACGAATCG 1740

GGCAAGGTGA AGCTAGACGA GATGACACGG CTGTCCGATG AACAAAAGTC CCAAATTGTT 1800

GGCAACCAGA AGACGATTGA CCAGCACAAG TGCCACATAG CCAAGTGTAT TGATGTGGTC 1860

AAGAAGCTGT TGAAGGAGAA GAGCAGCATC GAGAAGAAGG AGGCGCGACA GAAGTGCATG 1920

CAGAATCGCC TCAGGCTCGG ACAGTTTGTT ACCCAACGAG TGGGCGCCAC ATTCCAGTCC 1980

CGCTTTAACA ATCATCCCGT GCTGAATGAT CGCTATCTTC TGTTGATGCT CCTGGGCAAG 2040

GGCGGCTTCT CAGAGGTCCA CAAGGCCTTC GACCTGAAGG AGCAACGCTA TGTCGCATGT 2100

AAGGTGCACC AATTAAACAA GGATTGGAAG GAGGATAAGA AAGCTAATTA TATCAAACAC 2160

GCTTTGCGGG AATACAACAT TCACAAGGCA CTGGATCATC CGCGGGTCGT CAAGCTATAC 2220

GATGTCTTCG AGATCGATGC GAATTCCTTT TGCACAGTGC TCGAATACTG TGATGGCCAC 2280

GATCTGGACT TCTATTTGAA GCAACATAAG ACTATACCCG AGCGTGAAGC GCGCTCGATA 2340

ATAATGCAGG TTGTATCTGC ACTCAAGTAT CTAAATGAGA TTAAGCCTCC AGTTATCCAC 2400

TACGATCTGA AGCCCGGCAA CATTCTGCTT ACCGAGGGCA ACGTCTGCGG CGAGATTAAG 2460

ATCACCGACT TCGGTCTGTC AAAGGTGATG GACGACGAGA ATTACAATCC CGATCACGGC 2520

ATGGATCTGA CCTCTCAGGG GGCGGGAACC TACTGGTATC TGCCACCCGA GTGCTTTGTC 2580

GTGGGCAAAA ATCCGCCGAA AATCTCCTCC AAAGTGGACG TATGGAGTGT GGGTGTTATC 2640

TTCTACCAGT GTCTGTACGG CAAAAAGCCC TTCGGTCACA ATCAGTCGCA GGCCACGATT 2700

CTCGAGGAGA ATACGATCCT GAAGGCCACC GAAGTGCAGT TCTCCAACAA GCCAACCGTT 2760

TCTAACGAGG CCAAGAGTTT CATTCGGGGA TGCTTGGCCT ATCGCAAGGA GGATCGCATG 2820

GATGTGTTCG CACTGGCCAG GCACGAGTAC ATTCAGCCAC CGATACCGAA ACATGGGCGC 2880

GGTTCGCTCA ATCAGCAACA GCAGGCGCAA CAACAGCAGC AGCAACAACA GCAACAGCAG 2940

CAGCAACAGT CGTCGACGTC ACAGGCCAAT TCTACAGGCC AGACATCTTT CTCTGCCCAC 3000

ATGTTTGGCA ATATGAATCA GTCGAGTTCG TCCTAG 3036

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llgkggfsev+kafdlkeqryva+k+hqlnkdwk++kk+ny+khalrey+ihk+l

Q: 672   YLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKAL  731

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhpr+vklyd++++d++sfctvley++g+dldfylkqhk+++e+earsiimq+vsalkyl

Q: 732   DHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYL  791

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikpp+ihydlkpgnill+eg++cgeikitdfglsk+mdd++y+ d+g++ltsqgagty

Q: 792   NEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTY  851

         ************************************************************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgk+ppkis+kvdvwsvgvifyqclygkkpfghnqsq++ileentilkate

Q: 852   WYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATE  911

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqf++kp+vs+eak+fir clayrkedr+dv+ la++ey+

Q: 912   VQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYI  951

         *************************************996

Domain Sequence
(FASTA)

YLLLMLLGKG GFSEVHKAFD LKEQRYVACK VHQLNKDWKE DKKANYIKHA LREYNIHKAL 60

DHPRVVKLYD VFEIDANSFC TVLEYCDGHD LDFYLKQHKT IPEREARSII MQVVSALKYL 120

NEIKPPVIHY DLKPGNILLT EGNVCGEIKI TDFGLSKVMD DENYNPDHGM DLTSQGAGTY 180

WYLPPECFVV GKNPPKISSK VDVWSVGVIF YQCLYGKKPF GHNQSQATIL EENTILKATE 240

VQFSNKPTVS NEAKSFIRGC LAYRKEDRMD VFALARHEYI 280

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0019730	; P:antimicrobial humoral response
GO:0007155	; P:cell adhesion
GO:0007059	; P:chromosome segregation
GO:0016572	; P:histone phosphorylation
GO:0045448	; P:mitotic cell cycle, embryonic
GO:0046777	; P:protein autophosphorylation
GO:0051726	; P:regulation of cell cycle
GO:0008360	; P:regulation of cell shape

KEGG

dme:Dmel_CG34412

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013