EKS-DRM-00138

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00138

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	438.0	2.9E-131	164	484	321

Status

Reviewed

Ensembl Protein

FBpp0289736

UniProt Accession

P49657; Q59E39; Q6AWJ3; Q9I7R8; Q9VX07;

Protein Name

Serine/threonine-protein kinase minibrain

Protein Synonyms/Alias

Gene Name

mnb

Gene Synonyms/Alias

mnb; CG7826;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0259168	FBpp0289736	FBtr0300509
FBgn0259168	FBpp0288894	FBtr0299619
FBgn0259168	FBpp0289735	FBtr0300508
FBgn0259168	FBpp0289737	FBtr0300510

Organism

Drosophila melanogaster

Functional Description

Role in the specific control of proper proliferation ofoptic lobe neuronal progeny.

Protein Length

604

Protein Sequence
(FASTA)

MYRLEDTNSG GVMDKNKQKL SAYGSSGGSV DAAQGSGSGG GRQRHAPLYG RFVDAEDLPA 60

THRDVMHHHS SPSSSSEVRA MQARIPNHFR EPASGPLRKL SVDLIKTYKH INEVYYAKKK 120

RRAQQTQGDD DSSNKKERKL YNDGYDDDNH DYIIKNGEKF LDRYEIDSLI GKGSFGQVVK 180

AYDHEEQCHV AIKIIKNKKP FLNQAQIEVK LLEMMNRADA ENKYYIVKLK RHFMWRNHLC 240

LVFELLSYNL YDLLRNTNFR GVSLNLTRKF AQQLCTALLF LSTPELNIIH CDLKPENILL 300

CNPKRSAIKI VDFGSSCQLG QRIYHYIQSR FYRSPEVLLG IQYDLAIDMW SLGCILVEMH 360

TGEPLFSGCN EVDQMNKIVE VLGMPPKYLL DQAHKTRKFF DKIVADGSYV LKKNQNGRKY 420

KPPGSRKLHD ILGVETGGPG GRRLDEPGHS VSDYLKFKDL ILRMLDFDPK TRVTPYYALQ 480

HNFFKRTADE ATNTSGAGAT ANAGAGGSGS SGAGGSSGGG VGGGLGASNS SSGAVSSSSA 540

AAPTAATAAA TAAGSSGSGS SVGGGSSAAQ QQQAMPLPLP LPLPLPPLAG PGGASDGQCH 600

DDRR 604

Nucleotide Sequence
(FASTA)

ATGTATAGAT TAGAGGATAC GAATAGCGGC GGCGTTATGG ATAAGAATAA ACAGAAACTG 60

TCCGCTTATG GGTCCAGCGG CGGCAGCGTC GACGCAGCGC AGGGCAGCGG AAGCGGGGGC 120

GGAAGACAGC GCCACGCCCC ACTCTACGGG CGATTCGTCG ACGCAGAGGA TCTGCCTGCC 180

ACGCACCGGG ATGTCATGCA CCATCACTCT AGTCCCTCGT CTTCGTCGGA GGTGCGCGCC 240

ATGCAGGCCC GGATTCCCAA CCACTTTCGG GAGCCCGCCT CGGGACCTTT GCGCAAGCTG 300

AGTGTCGATC TGATAAAGAC CTACAAGCAC ATCAACGAGG TTTACTATGC GAAAAAGAAA 360

CGTCGTGCCC AGCAGACGCA AGGAGACGAC GACTCATCTA ACAAAAAGGA GCGAAAACTT 420

TATAACGACG GCTACGACGA CGATAATCAC GACTATATAA TCAAGAATGG CGAAAAGTTT 480

TTGGATCGCT ACGAGATCGA CTCTCTGATC GGCAAAGGCA GTTTTGGCCA GGTGGTGAAG 540

GCTTACGACC ACGAGGAGCA GTGCCACGTG GCGATCAAGA TAATTAAGAA TAAGAAACCG 600

TTCCTAAACC AGGCACAGAT CGAGGTCAAG TTGCTCGAGA TGATGAACCG GGCGGATGCC 660

GAAAACAAAT ACTACATCGT TAAGCTCAAG CGGCACTTCA TGTGGCGCAA CCACCTGTGC 720

CTGGTGTTCG AGCTGCTCTC ATACAACCTG TACGACCTGC TGCGGAACAC CAACTTCCGG 780

GGCGTTTCGC TGAACCTCAC GCGCAAGTTC GCCCAGCAGC TGTGCACCGC ACTGCTCTTC 840

CTCAGCACCC CCGAACTGAA CATAATTCAC TGTGATTTGA AGCCCGAGAA CATCCTGCTC 900

TGCAACCCGA AGCGCTCGGC GATCAAGATC GTTGACTTTG GCAGCTCCTG CCAGTTGGGA 960

CAGCGGATCT ACCACTACAT CCAGTCGCGC TTCTACCGCT CGCCGGAGGT GCTGCTTGGC 1020

ATCCAGTATG ACCTGGCCAT CGATATGTGG TCACTGGGCT GCATCTTGGT CGAGATGCAC 1080

ACCGGCGAGC CGCTCTTCTC CGGCTGCAAC GAGGTGGACC AGATGAACAA GATCGTCGAG 1140

GTGCTGGGCA TGCCGCCCAA GTATCTGCTC GACCAGGCGC ACAAGACCCG CAAGTTCTTC 1200

GACAAGATCG TCGCCGATGG CTCCTATGTG CTGAAGAAGA ATCAGAACGG CAGGAAGTAC 1260

AAGCCGCCAG GATCCCGCAA GCTTCACGAC ATCCTCGGAG TGGAAACAGG CGGTCCAGGG 1320

GGCAGGCGTC TCGATGAGCC GGGCCACTCC GTCTCGGACT ATCTGAAGTT CAAGGATCTG 1380

ATCCTGCGCA TGCTCGACTT TGACCCCAAG ACACGGGTCA CGCCCTACTA TGCCCTGCAG 1440

CACAACTTCT TCAAGCGCAC GGCAGACGAG GCAACCAATA CGAGCGGCGC GGGCGCCACA 1500

GCGAATGCAG GAGCCGGTGG CTCCGGTTCC AGCGGAGCAG GAGGCTCCAG CGGCGGAGGC 1560

GTCGGCGGTG GCCTCGGAGC GAGCAACAGC AGTAGCGGTG CGGTCTCCTC ATCCAGTGCA 1620

GCGGCTCCAA CGGCGGCGAC AGCAGCGGCC ACGGCCGCAG GATCCTCCGG TTCGGGTTCA 1680

AGTGTCGGCG GGGGATCCTC CGCAGCGCAG CAACAGCAGG CGATGCCGCT GCCATTGCCG 1740

CTTCCCTTGC CGTTGCCACC ACTCGCGGGT CCTGGCGGTG CGTCAGATGG CCAATGTCAC 1800

GACGATCGCC GATGA 1815

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d++++ +vaikiiknkk f++qaq+Ev++Le++n++d e+k

Q: 164   YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENK  223

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f++rnhlclvfells+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 224   YYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSt  283

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 284   pELNIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYHYIQSRFYRSPEVLLGIQ  342

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G nevdq+++ivevlg+pp++ll++a+k++kff+k

Q: 343   YDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFFDK  402

         **********************************************************88

S: 239   kea.pkyilktk........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

           a   y+lk++         ++rk + +l+v++ +     p+ ++l e+ ++++d+l f

Q: 403   IVAdGSYVLKKNqngrkykpPGSRKLHDILGVETGG-----PGGRRLDEPGHSVSDYLkF  457

         765156666666666666666666666666666666.....999****************

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++R+tp++al+h+f+

Q: 458   KDLILRMLDFDPKTRVTPYYALQHNFF  484

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD HEEQCHVAIK IIKNKKPFLN QAQIEVKLLE MMNRADAENK 60

YYIVKLKRHF MWRNHLCLVF ELLSYNLYDL LRNTNFRGVS LNLTRKFAQQ LCTALLFLST 120

PELNIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YHYIQSRFYR SPEVLLGIQY 180

DLAIDMWSLG CILVEMHTGE PLFSGCNEVD QMNKIVEVLG MPPKYLLDQA HKTRKFFDKI 240

VADGSYVLKK NQNGRKYKPP GSRKLHDILG VETGGPGGRR LDEPGHSVSD YLKFKDLILR 300

MLDFDPKTRV TPYYALQHNF F 321

Keyword

Alternative splicing; ATP-binding; Complete proteome; Developmental protein; Differentiation; Kinase; Neurogenesis; Nucleotide-binding; Nucleus; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0030154	; P:cell differentiation
GO:0007623	; P:circadian rhythm
GO:0007399	; P:nervous system development
GO:0008355	; P:olfactory learning
GO:0007632	; P:visual behavior

KEGG

dme:Dmel_CG42273

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013