EKS-DRM-00105

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00105

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/MAST	268.3	1.0E-79	57	208	152

Status

Unreviewed

Ensembl Protein

FBpp0303770

UniProt Accession

Q95TN8; Q9VE35;

Protein Name

Protein Synonyms/Alias

Greatwall; LD35132p;

Gene Name

gwl

Gene Synonyms/Alias

gwl; Pk91C; CG7719, Dmel_CG7719;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0260399	FBpp0083089	FBtr0083674
FBgn0260399	FBpp0303770	FBtr0331352

Organism

Drosophila melanogaster

Functional Description

Protein Length

803

Protein Sequence
(FASTA)

MENADATSQS DVHIDYKTPK KTHSLIDSEQ LLDKINILTT KPENHSQNAK LPTIKDFVII 60

KPISRGAFGK VFLGYKNNDS KRLFAIKVMR KSEMINKNMV SQVITERNAL ALSRSQFCVS 120

LFYSLQSLSY VYLVMEYMVG GDLKSLLAMF GYFDEPTARF YVAEMVMALQ YLHQHGIVHR 180

DIKPDNMLLS SSGHVKLTDF GLSKIDMRRD LEISDLINCS PNLNARTPGQ LLSLTSHLSF 240

GSEKKLNDFG SVSSGQNNGM GSVATGTSHL LQAINKHSLI MELSDSEGDT SLNDAEKTSD 300

SKISGVSPFF SAEEANESIT HTCTTNVNPQ DSSSSCSFHT CNSADLSKCS PPLESKDGAA 360

AGNAIPSKRR VEFVLDAAPC QRNRISKGPE DSGVSSRKGD DYSSCHLNLN SESTASSIEK 420

NVDNLSQSKE DFSCSDYSRS YNVTNGNEMS GINMNSPFRN LSKHFKRPDF LRGMKRKINL 480

VNRSDNMSSM DTDGCSSSNG STNTGLTQEI EILNIGSSTP KKRKARSSPI RGVLKVRSLS 540

DDEMPINHLL GPEANVANVV FSTPVSSQKL PRRDGGLLGK LKATRFALPL SIENKKREHA 600

TADKMSGIQY HLKLSDDPTM SPINHGAGNL PKTPKNVNIN TPFRTPKSVR RGARVSNERI 660

LGTPDYLAPE LLLKQGHGPA VDWWALGVCF YEFMTGIPPF NDETPQKVFD NILNKNIEWP 720

EGDEALSVES MEAVELLLTM DPNERPAAKE VQQMRHFACI DWENIGNTEP PFVPTPDNPT 780

DTGYFDARNN LQHLQLSNFA LEE 803

Nucleotide Sequence
(FASTA)

ATGGAAAACG CCGATGCGAC TTCGCAATCG GATGTCCACA TCGACTACAA AACCCCCAAG 60

AAGACCCACT CGCTGATCGA CAGTGAGCAG TTGCTGGACA AGATCAACAT CCTTACCACC 120

AAGCCGGAGA ATCACTCCCA GAATGCCAAG CTTCCCACTA TCAAGGATTT TGTCATCATT 180

AAGCCAATCA GCCGCGGCGC CTTTGGAAAA GTCTTCCTGG GCTACAAGAA CAACGACTCG 240

AAGCGGCTGT TCGCCATCAA GGTGATGCGC AAGTCAGAGA TGATCAACAA GAACATGGTG 300

TCCCAGGTAA TCACGGAGCG GAATGCCCTG GCCCTCTCCC GCTCTCAGTT CTGTGTCAGT 360

CTCTTCTACT CCCTGCAATC GCTCTCCTAC GTCTACCTGG TGATGGAGTA CATGGTGGGC 420

GGGGATCTCA AGTCACTGCT GGCCATGTTT GGGTATTTTG ACGAGCCCAC GGCCCGGTTC 480

TACGTGGCCG AGATGGTGAT GGCGCTGCAG TATCTGCATC AGCACGGAAT TGTCCACAGA 540

GATATTAAAC CGGACAACAT GTTGCTCTCC TCCAGTGGCC ATGTGAAGCT TACTGATTTT 600

GGGTTGAGCA AAATCGATAT GCGAAGAGAT CTGGAAATAT CAGACCTTAT AAACTGCTCA 660

CCGAATTTAA ACGCCCGCAC GCCGGGCCAG CTTTTGTCGC TTACTTCGCA CCTGTCTTTT 720

GGGTCAGAGA AGAAACTGAA TGACTTCGGT TCTGTTTCAA GTGGACAAAA CAACGGAATG 780

GGCTCGGTGG CCACGGGGAC ATCCCACTTG CTGCAGGCCA TCAACAAGCA TAGTCTGATA 840

ATGGAGCTGT CGGATAGCGA GGGCGACACC TCGCTCAATG ATGCAGAGAA GACGAGCGAT 900

AGCAAGATAT CTGGTGTTTC CCCCTTCTTT TCTGCCGAGG AGGCCAATGA ATCCATTACT 960

CATACCTGCA CTACAAACGT AAATCCCCAG GATAGCAGCT CGTCTTGTTC GTTCCACACT 1020

TGTAACTCGG CCGACCTGAG CAAGTGCTCA CCACCACTGG AGTCAAAGGA CGGTGCTGCT 1080

GCGGGCAATG CGATCCCCAG CAAGCGGCGC GTGGAATTCG TCTTGGATGC GGCACCCTGT 1140

CAGCGAAATC GCATCTCAAA GGGGCCGGAG GATTCAGGGG TGTCCAGTCG CAAGGGCGAC 1200

GACTATTCCA GCTGCCACTT GAATCTGAAT AGCGAGAGCA CGGCTTCGTC GATTGAGAAG 1260

AATGTGGACA ACCTAAGCCA ATCCAAGGAG GATTTTAGCT GTTCAGATTA CTCGCGCAGT 1320

TATAACGTGA CCAACGGCAA CGAGATGAGT GGCATCAACA TGAACTCGCC GTTTCGGAAT 1380

CTGTCCAAGC ACTTTAAACG CCCCGACTTC CTGCGCGGCA TGAAGCGAAA GATCAATTTG 1440

GTCAATCGCT CCGACAACAT GTCCAGCATG GATACCGATG GCTGCAGTTC AAGCAATGGA 1500

AGTACCAACA CCGGACTAAC ACAGGAAATT GAAATCCTTA ATATTGGCAG CAGCACGCCC 1560

AAGAAGCGCA AGGCCCGTTC CTCGCCCATC CGTGGTGTGC TAAAGGTGCG CTCTTTATCC 1620

GATGACGAAA TGCCCATAAA TCATTTGCTT GGTCCGGAAG CAAATGTGGC CAACGTGGTC 1680

TTCTCTACGC CCGTATCTTC ACAGAAGTTG CCACGTCGGG ATGGTGGTCT TCTTGGAAAG 1740

CTCAAGGCCA CTCGGTTCGC TCTTCCGCTG TCCATTGAGA ACAAGAAACG GGAGCATGCG 1800

ACCGCCGATA AGATGTCAGG CATTCAGTAC CATCTGAAAC TGTCCGACGA TCCCACGATG 1860

TCGCCTATCA ATCATGGAGC CGGCAATCTA CCAAAGACGC CGAAAAACGT TAACATCAAT 1920

ACCCCGTTCC GCACACCGAA ATCAGTGCGT CGCGGGGCTC GCGTGTCTAA TGAGCGCATC 1980

TTGGGCACAC CTGATTATCT GGCGCCGGAG TTACTGCTGA AGCAAGGTCA CGGTCCGGCC 2040

GTCGACTGGT GGGCTCTGGG CGTCTGTTTC TACGAGTTCA TGACCGGCAT TCCACCCTTT 2100

AACGACGAGA CACCTCAGAA AGTATTTGAC AACATTCTGA ATAAGAACAT CGAATGGCCA 2160

GAAGGTGATG AGGCATTATC CGTCGAATCC ATGGAGGCTG TGGAACTGCT CCTGACCATG 2220

GATCCCAATG AGCGACCGGC CGCAAAGGAA GTGCAACAAA TGCGTCACTT TGCTTGCATC 2280

GACTGGGAGA ATATAGGCAA TACCGAGCCC CCATTTGTCC CGACACCAGA CAATCCCACT 2340

GATACGGGAT ATTTCGATGC GCGCAACAAT CTTCAGCACC TGCAGCTGTC CAATTTTGCC 2400

CTAGAAGAAT GA 2412

Domain Profile

S: 1     feiiklisrGayGavyl.vrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenp  59

         f iik+isrGa+G+v+l +++++++++fa+k+++k+++i+kn+v+qv++er++lal++++

Q: 57    FVIIKPISRGAFGKVFLgYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQ  116

         89**********************************************************

S: 60    fvvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryG  119

         f+vsl+ysl++ +++ylvmey++GGd+ksll+++G++d+++ar+y+ae+v+al+ylh++G

Q: 117   FCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHG  176

         ************************************************************

S: 120   ivhrdlkPdnllitseGhikltdfGlskvglm  151

         ivhrd+kPdn+l++s+Gh+kltdfGlsk++++

Q: 177   IVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMR  208

         ******************************98

Domain Sequence
(FASTA)

FVIIKPISRG AFGKVFLGYK NNDSKRLFAI KVMRKSEMIN KNMVSQVITE RNALALSRSQ 60

FCVSLFYSLQ SLSYVYLVME YMVGGDLKSL LAMFGYFDEP TARFYVAEMV MALQYLHQHG 120

IVHRDIKPDN MLLSSSGHVK LTDFGLSKID MR 152

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030261	; P:chromosome condensation
GO:0007144	; P:female meiosis I
GO:0040020	; P:regulation of meiosis
GO:0046602	; P:regulation of mitotic centrosome separation

KEGG

dme:Dmel_CG7719

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013