EKS-DRM-00219

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00219

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/VPS15	482.5	4.8E-145	28	315	288

Status

Unreviewed

Ensembl Protein

FBpp0290464

UniProt Accession

Q9VHH2;

Protein Name

Protein Synonyms/Alias

Immune response deficient 1, isoform A;

Gene Name

ird1

Gene Synonyms/Alias

ird1; CG9746, Dmel_CG9746;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0260935	FBpp0290464	FBtr0301246
FBgn0260935	FBpp0305822	FBtr0333666
FBgn0260935	FBpp0081466	FBtr0081986

Organism

Drosophila melanogaster

Functional Description

Protein Length

851

Protein Sequence
(FASTA)

MGNQLVGIAP SQIYAVEHYF SGQFGSEIAF SSNMGSTRFF KVAKAKTDEG QIVVKVFVKH 60

DPTLPLEDHK ERLEGIKKTL SLANAVNCLP FQRVELIDKA AYIMREYVKH SLYDRVSTRP 120

FLTVLEKKWI TFQILCALNQ CHKQKICHGD IKLENILITS WNWILLSDFA SFKPTYLPED 180

NPADYTYFFD TSRRRTCYIA PERFVKTLAS DDDGGNGNMS VIHTDSIIRL APSYAGNTLL 240

PAMDIFSAGC ALLELWTEGT APFELSQLLA YRRGERDLVE KHLAGIENER LRNLLASMID 300

IHSMNRKSAE DYLDQERGQL FPEYFYSFLQ SYLQMFSSTP IMSPDDKIQC LHKDIGHCIK 360

VLTQAQDLTP EEEEKEEKKD PTLCARLPPE HDGLILIITV VTSCIRGLKQ SNTKIAALEL 420

LQKLSKYTTS ETILDRILPY ILHLAQKSPA KVQVQAIETL TACLGMVKDI PRSDANVFPE 480

YILPSITDLA SETSAVIVRV AFARNIAALA KSAVYFLEET QRNAPNDMPT PRYEAELNAL 540

HDIVRQAVLS LLTDSQPVVK QTLMESGICD LCAFFGKEKA NDVILSHIMT FLNDEDKNLR 600

GAFYDNIAGV AGYVGWQASD ILVPLLQQGF TDREEFVIAK AIRAVTILIE LGHIKKPAVT 660

EIVQETACYL CHPNLWVRHE ICGMIATTAR NLSAIDVQCK IMPAIGAFLK APLIQVEKPH 720

ILLDCVHPPV PRQIFDSVLR FQDIHHFIRA LEARSRVRSQ TRQGALPQYE EMGQTLRNLF 780

RRLSSEGLTD LIEMQLLAMN PFLISMKHKA LQDLDDTASG NGRIVVSRKQ VACHEYPLAD 840

KASKMPLDNR K 851

Nucleotide Sequence
(FASTA)

ATGGGCAATC AACTGGTGGG CATTGCCCCT TCGCAAATTT ATGCGGTGGA ACACTATTTT 60

TCCGGCCAGT TTGGATCCGA GATCGCCTTC AGTTCCAATA TGGGCAGCAC GAGATTCTTC 120

AAGGTGGCCA AGGCTAAAAC GGATGAGGGG CAAATAGTGG TCAAGGTGTT TGTGAAGCAC 180

GATCCCACTT TGCCACTGGA GGATCACAAG GAGCGATTGG AGGGCATCAA GAAGACACTC 240

TCGCTGGCCA ATGCCGTCAA TTGTTTACCC TTTCAGCGGG TCGAGCTTAT CGACAAGGCA 300

GCCTACATAA TGCGGGAGTA TGTGAAGCAC AGTCTCTATG ATCGCGTATC CACACGACCA 360

TTTCTCACCG TATTGGAGAA AAAGTGGATA ACGTTCCAAA TTTTGTGTGC CCTGAATCAG 420

TGCCACAAAC AGAAGATCTG CCACGGGGAC ATCAAGCTGG AGAACATCTT GATTACGTCT 480

TGGAACTGGA TTCTGCTCTC CGACTTTGCC TCCTTTAAGC CCACATATTT GCCGGAGGAC 540

AATCCGGCGG ATTATACGTA CTTCTTCGAT ACGAGTAGAA GGCGAACCTG CTATATTGCA 600

CCCGAACGAT TCGTTAAAAC ACTGGCCTCC GATGATGATG GTGGCAATGG TAATATGTCG 660

GTCATACACA CCGATTCCAT AATTCGACTT GCTCCTAGCT ATGCGGGTAA CACTTTGTTG 720

CCAGCCATGG ACATCTTTTC GGCAGGCTGT GCCTTGCTGG AACTCTGGAC AGAGGGAACT 780

GCGCCCTTTG AACTCTCCCA GCTGCTGGCT TACAGGCGTG GCGAGCGAGA TCTGGTGGAG 840

AAACATCTGG CGGGCATCGA AAACGAAAGG TTGCGCAATC TGCTGGCCTC TATGATTGAC 900

ATACACTCGA TGAACCGAAA GAGCGCCGAG GATTACTTGG ACCAGGAGCG CGGTCAGTTG 960

TTTCCCGAAT ACTTCTACTC CTTCCTGCAG TCGTACTTGC AAATGTTCAG CTCAACACCG 1020

ATCATGTCGC CGGATGACAA GATTCAGTGT CTGCATAAGG ACATTGGGCA CTGTATTAAA 1080

GTGCTGACAC AGGCCCAGGA TTTAACACCG GAAGAGGAGG AAAAGGAAGA AAAGAAGGAT 1140

CCCACGTTGT GTGCCCGACT GCCACCGGAG CATGATGGTC TCATTTTGAT CATCACGGTA 1200

GTCACATCCT GCATACGAGG ACTGAAGCAG TCGAATACCA AAATTGCAGC CTTGGAACTT 1260

CTGCAAAAGC TGTCGAAGTA CACAACATCC GAGACCATCC TGGATCGCAT TTTGCCCTAC 1320

ATTCTCCATT TGGCCCAGAA ATCGCCAGCC AAGGTGCAGG TTCAGGCCAT CGAAACTCTG 1380

ACCGCCTGTT TGGGCATGGT AAAGGACATT CCACGCAGCG ATGCCAACGT GTTTCCCGAG 1440

TACATTCTGC CCTCCATCAC CGATTTGGCC AGCGAGACGA GTGCAGTTAT TGTTCGCGTG 1500

GCCTTTGCCC GGAATATAGC TGCACTGGCC AAGAGCGCTG TCTACTTTTT GGAGGAAACG 1560

CAACGAAATG CTCCTAACGA TATGCCCACT CCACGTTACG AGGCAGAACT GAACGCCCTC 1620

CATGACATAG TTAGACAGGC AGTACTCAGT CTGTTAACGG ATTCCCAACC GGTGGTCAAG 1680

CAAACACTGA TGGAGTCGGG CATCTGCGAT CTCTGTGCCT TCTTTGGCAA GGAAAAAGCG 1740

AACGATGTGA TACTCTCGCA CATCATGACG TTCCTTAATG ATGAGGACAA GAACTTGAGA 1800

GGAGCATTCT ATGACAACAT CGCCGGAGTG GCTGGCTATG TGGGCTGGCA GGCGTCGGAC 1860

ATTCTCGTGC CACTTCTGCA GCAAGGTTTC ACGGATCGCG AGGAGTTCGT CATTGCAAAA 1920

GCCATTCGTG CTGTGACCAT TCTTATCGAA CTGGGTCACA TTAAGAAGCC AGCCGTTACG 1980

GAAATTGTCC AAGAGACAGC CTGTTATCTG TGCCATCCAA ATCTTTGGGT TCGTCACGAA 2040

ATCTGCGGCA TGATTGCCAC CACGGCGCGT AATCTCAGCG CCATCGATGT GCAGTGCAAG 2100

ATTATGCCGG CGATTGGGGC ATTTCTCAAG GCCCCGCTCA TCCAGGTGGA GAAACCGCAC 2160

ATCCTGTTGG ACTGTGTGCA TCCGCCTGTG CCGCGGCAGA TCTTCGACAG CGTTCTGCGC 2220

TTCCAAGACA TTCATCATTT TATCAGAGCA CTGGAGGCAC GATCACGTGT TCGTAGTCAG 2280

ACGAGGCAGG GAGCTCTGCC GCAGTACGAG GAGATGGGAC AGACCTTGCG TAATCTCTTT 2340

AGACGCTTAA GCTCTGAGGG ATTAACGGAT CTAATTGAGA TGCAGCTACT GGCCATGAAC 2400

CCGTTCCTTA TCTCCATGAA GCACAAGGCC CTGCAGGATC TGGACGACAC CGCCTCGGGG 2460

AATGGACGCA TCGTGGTCAG TCGCAAGCAA GTCGCTTGTC ATGAATATCC GCTGGCGGAC 2520

AAAGCTAGCA AAATGCCCCT CGATAACCGT AAGTAA 2556

Domain Profile

S: 1     veyvknlgstrflkvakakteeGeivvkvfvkqdptlslesfkqrleelk..lklakaqn  58

         +++++n+gstrf+kvakakt+eG+ivvkvfvk+dptl+le++k+rle++k  l+la+a+n

Q: 28    IAFSSNMGSTRFFKVAKAKTDEGQIVVKVFVKHDPTLPLEDHKERLEGIKktLSLANAVN  87

         5799*********************************************9777899****

S: 59    clpfqkvlekekaavllrqyvkdnlydrlstrPflneiekkwiafqllkaldqihksgvv  118

         clpfq+v++++kaa+++r+yvk++lydr+strPfl+ +ekkwi+fq+l+al+q+hk++++

Q: 88    CLPFQRVELIDKAAYIMREYVKHSLYDRVSTRPFLTVLEKKWITFQILCALNQCHKQKIC  147

         ************************************************************

S: 119   hGdiktenvlvtswnWvlltdfasfkPtylpednPadftyffdtsrrrtcyiaPerfvsa  178

         hGdik+en+l+tswnW+ll+dfasfkPtylpednPad+tyffdtsrrrtcyiaPerfv++

Q: 148   HGDIKLENILITSWNWILLSDFASFKPTYLPEDNPADYTYFFDTSRRRTCYIAPERFVKT  207

         ************************************************************

S: 179   lasdeklrdgstelvdldsiqrlr.....gelkkamdifsaGcvilelftegrplfelsq  233

         lasd+++++g+++++++dsi+rl+     ++l +amdifsaGc++lel+teg+++felsq

Q: 208   LASDDDGGNGNMSVIHTDSIIRLApsyagNTLLPAMDIFSAGCALLELWTEGTAPFELSQ  267

         ***********************9999999******************************

S: 234   llayrsgef.lvekvlekiededlrnlvlqliqlepekrksaedllkk  280

         llayr+ge+ lvek+l++ie+e+lrnl++++i++++++rksaed+l++

Q: 268   LLAYRRGERdLVEKHLAGIENERLRNLLASMIDIHSMNRKSAEDYLDQ  315

         **********************************************97

Domain Sequence
(FASTA)

IAFSSNMGST RFFKVAKAKT DEGQIVVKVF VKHDPTLPLE DHKERLEGIK KTLSLANAVN 60

CLPFQRVELI DKAAYIMREY VKHSLYDRVS TRPFLTVLEK KWITFQILCA LNQCHKQKIC 120

HGDIKLENIL ITSWNWILLS DFASFKPTYL PEDNPADYTY FFDTSRRRTC YIAPERFVKT 180

LASDDDGGNG NMSVIHTDSI IRLAPSYAGN TLLPAMDIFS AGCALLELWT EGTAPFELSQ 240

LLAYRRGERD LVEKHLAGIE NERLRNLLAS MIDIHSMNRK SAEDYLDQ 288

Keyword

Complete proteome; Reference proteome; Repeat; Transferase; WD repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0034198	; P:cellular response to amino acid starvation
GO:0016236	; P:macroautophagy
GO:0002784	; P:regulation of antimicrobial peptide production

KEGG

dme:Dmel_CG9746

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR020472	; G-protein_beta_WD-40_rep.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015943	; WD40/YVTN_repeat-like_dom.
IPR001680	; WD40_repeat.
IPR019775	; WD40_repeat_CS.
IPR017986	; WD40_repeat_dom.

Pfam

PF00069	; Pkinase; 1.
PF00400	; WD40; 2.

SMARTs

SM00320

; WD40; 6.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00678	; WD_REPEATS_1; 1.
PS50082	; WD_REPEATS_2; 3.
PS50294	; WD_REPEATS_REGION; 2.

Prints

PR00320

; GPROTEINBRPT.

Created Date

20-Feb-2013