EKS-DRM-00085

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00085

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	436.4	5.1E-131	182	450	269

Status

Unreviewed

Ensembl Protein

FBpp0292493

UniProt Accession

Q0E974;

Protein Name

Protein Synonyms/Alias

Atypical protein kinase C, isoform D;

Gene Name

aPKC

Gene Synonyms/Alias

aPKC; Dmel_CG10261;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0261854	FBpp0292494	FBtr0303437
FBgn0261854	FBpp0302921	FBtr0329887
FBgn0261854	FBpp0292489	FBtr0303432
FBgn0261854	FBpp0302924	FBtr0329890
FBgn0261854	FBpp0292487	FBtr0303430
FBgn0261854	FBpp0302923	FBtr0329889
FBgn0261854	FBpp0302922	FBtr0329888
FBgn0261854	FBpp0292488	FBtr0303431
FBgn0261854	FBpp0292491	FBtr0303434
FBgn0261854	FBpp0292486	FBtr0303429
FBgn0261854	FBpp0292490	FBtr0303433
FBgn0261854	FBpp0292493	FBtr0303436
FBgn0261854	FBpp0292492	FBtr0303435

Organism

Drosophila melanogaster

Functional Description

Protein Length

498

Protein Sequence
(FASTA)

MIIWSGFCEA AQIYSTQTAT FMSGGASLFP NVPQAPGLSC DGEDRSIYRR GARRWRKLYR 60

VNGHIFQAKR FNRRAFCAYC QDRIWGLGRQ GFKCIQCKLL VHKKCHKLVQ KHCTDQPEPL 120

VKERAEESSD PIPVPLPPLP YEAMSGGAEA CETHDHAHIV APPPPEDPLE PGTQRQYSLN 180

DFELIRVIGR GSYAKVLMVE LRRTRRIYAM KVIKKALVTD DEDIDWVQTE KHVFETASNH 240

PFLVGLHSCF QTPSRLFFVI EFVRGGDLMY HMQRQRRLPE EHARFYAAEI SLALNFLHEK 300

GIIYRDLKLD NVLLDHEGHI KLTDYGMCKE GIRPGDTTST FCGTPNYIAP EILRGEDYGF 360

SVDWWALGVL LYEMLAGRSP FDLAGASENP DQNTEDYLFQ VILEKTIRIP RSLSVRAASV 420

LKGFLNKNPA DRLGCHRESA FMDIVSHPFF KNMDWELIAQ KEVQPPYIPN IDTGDPYVTS 480

NFDVQFTQEP AVLTPDDP 498

Nucleotide Sequence
(FASTA)

ATGATCATCT GGAGTGGCTT CTGCGAGGCG GCCCAAATAT ACAGCACACA AACGGCCACT 60

TTTATGAGCG GCGGAGCATC GTTATTTCCC AATGTTCCTC AAGCGCCGGG ATTGTCTTGC 120

GATGGCGAAG ATCGCAGCAT CTATCGACGC GGTGCTCGAC GCTGGCGCAA GTTGTATCGC 180

GTCAACGGAC ACATCTTCCA GGCCAAGCGT TTCAACCGGC GTGCTTTCTG TGCCTACTGC 240

CAGGATCGAA TCTGGGGTTT GGGACGTCAG GGTTTCAAGT GCATCCAGTG CAAGCTGTTG 300

GTGCACAAGA AGTGCCATAA GCTTGTGCAG AAGCACTGCA CCGACCAGCC GGAGCCGCTG 360

GTCAAGGAGC GGGCGGAGGA GTCCAGTGAC CCTATACCGG TGCCTTTGCC GCCACTTCCC 420

TACGAAGCGA TGAGCGGCGG AGCCGAAGCC TGCGAGACGC ACGACCATGC GCACATAGTG 480

GCGCCACCGC CACCGGAGGA TCCATTGGAG CCGGGCACTC AGCGCCAGTA TTCGCTGAAC 540

GACTTCGAGC TGATACGGGT CATCGGACGC GGCAGCTATG CCAAGGTGCT AATGGTGGAG 600

CTACGACGCA CACGGCGCAT CTACGCCATG AAGGTGATCA AGAAGGCGCT GGTCACCGAC 660

GACGAGGACA TCGACTGGGT GCAAACGGAG AAGCATGTGT TCGAGACGGC CTCGAACCAC 720

CCGTTCCTGG TCGGATTGCA CTCGTGCTTC CAGACGCCCT CGCGGCTCTT CTTTGTCATC 780

GAGTTTGTGC GCGGTGGCGA TTTGATGTAC CACATGCAGC GGCAACGGCG GCTGCCCGAG 840

GAGCACGCCC GTTTCTATGC AGCCGAGATC AGTTTGGCGC TGAATTTCCT TCACGAGAAG 900

GGCATCATTT ATCGCGATCT GAAGCTGGAC AACGTGCTGC TGGATCACGA GGGCCACATC 960

AAGCTAACGG ATTACGGCAT GTGTAAGGAG GGCATTCGAC CTGGAGACAC CACCTCCACA 1020

TTCTGCGGTA CACCCAATTA CATTGCCCCT GAGATACTGA GGGGCGAGGA CTATGGCTTC 1080

TCGGTGGACT GGTGGGCACT AGGCGTCTTG CTCTATGAGA TGTTGGCCGG CCGTAGTCCG 1140

TTTGATCTGG CAGGAGCCTC AGAGAATCCC GATCAGAACA CTGAGGACTA TCTGTTCCAA 1200

GTGATCCTGG AGAAGACGAT TCGTATACCA CGCTCGCTGA GCGTTCGTGC GGCCTCTGTC 1260

TTAAAAGGTT TCCTCAACAA GAATCCCGCT GACCGTTTGG GCTGCCATCG GGAGTCCGCG 1320

TTCATGGATA TCGTCAGCCA TCCCTTCTTT AAGAATATGG ATTGGGAATT GATAGCTCAA 1380

AAGGAGGTGC AACCGCCTTA TATACCGAAC ATAGACACGG GAGATCCCTA TGTGACAAGC 1440

AACTTTGATG TGCAATTTAC CCAAGAACCG GCTGTACTAA CGCCAGATGA TCCGTAA 1497

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         fel++v+G+Gs++kvl++el++t+++ya+kv+kk +v++d+d++++++ek+v+++as++p

Q: 182   FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHP  241

         89**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         flv l+scfqt +rlffv+e+v+GGdlm+h+q++r+l+ee+arfyaaei+lal+flhekg

Q: 242   FLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKG  301

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         iiyrdlkldnvlld+eGhikl+d+G+cke+i  g+ttstfcGtP+yiaPeil++e+yg+s

Q: 302   IIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFS  361

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231

         vdwwalGvllyemlag+sPf+         +++ed+lf++ilek++++P+sls++a+++l

Q: 362   VDWWALGVLLYEMLAGRSPFDlagasenpdQNTEDYLFQVILEKTIRIPRSLSVRAASVL  421

         *****************************99*****************************

S: 232   kglltkdpekrlGvk.eegeedikehaff  259

         kg+l+k+p++rlG++ e++ +di +h+ff

Q: 422   KGFLNKNPADRLGCHrESAFMDIVSHPFF  450

         **************868999********9

Domain Sequence
(FASTA)

FELIRVIGRG SYAKVLMVEL RRTRRIYAMK VIKKALVTDD EDIDWVQTEK HVFETASNHP 60

FLVGLHSCFQ TPSRLFFVIE FVRGGDLMYH MQRQRRLPEE HARFYAAEIS LALNFLHEKG 120

IIYRDLKLDN VLLDHEGHIK LTDYGMCKEG IRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180

VDWWALGVLL YEMLAGRSPF DLAGASENPD QNTEDYLFQV ILEKTIRIPR SLSVRAASVL 240

KGFLNKNPAD RLGCHRESAF MDIVSHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045179	; C:apical cortex
GO:0016324	; C:apical plasma membrane
GO:0016327	; C:apicolateral plasma membrane
GO:0035003	; C:subapical complex
GO:0005524	; F:ATP binding
GO:0004697	; F:protein kinase C activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0045176	; P:apical protein localization
GO:0045167	; P:asymmetric protein localization involved in cell fate determination
GO:0060446	; P:branching involved in open tracheal system development
GO:0046667	; P:compound eye retinal cell programmed cell death
GO:0003382	; P:epithelial cell morphogenesis
GO:0090163	; P:establishment of epithelial cell planar polarity
GO:0000132	; P:establishment of mitotic spindle orientation
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0045196	; P:establishment or maintenance of neuroblast polarity
GO:0016332	; P:establishment or maintenance of polarity of embryonic epithelium
GO:0016334	; P:establishment or maintenance of polarity of follicular epithelium
GO:0007294	; P:germarium-derived oocyte fate determination
GO:0035556	; P:intracellular signal transduction
GO:0030011	; P:maintenance of cell polarity
GO:0035011	; P:melanotic encapsulation of foreign target
GO:0007613	; P:memory
GO:0001738	; P:morphogenesis of a polarized epithelium
GO:0007314	; P:oocyte anterior/posterior axis specification
GO:0002052	; P:positive regulation of neuroblast proliferation
GO:0007416	; P:synapse assembly
GO:0045186	; P:zonula adherens assembly

KEGG

dme:Dmel_CG42783

;

InterPros

IPR000961	; AGC-kinase_C.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR012233	; PKC_zeta.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 1.
PF00564	; PB1; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00666	; PB1; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013