EKS-DRM-00146
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00146
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/IRE449.35.8E-135436700265
StatusUnreviewed
Ensembl ProteinFBpp0112161
UniProt AccessionA8JR46;
Protein Name
Protein Synonyms/Alias Ire-1, isoform B;
Gene NameIre1
Gene Synonyms/Alias Ire1; ire-1; Dmel_CG4583;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0261984FBpp0112160FBtr0113248
FBgn0261984FBpp0112161FBtr0113249
OrganismDrosophila melanogaster
Functional Description
Protein Length962
Protein Sequence
(FASTA)
MGSLKKLPYT IPQLVANAPC RSSDGILYSG KKSDTWYMVD PKTGRREKVM GFGDATVDGK 60
EGEQIGWATS RAIYLGRTQY TVMMYDSLAK NKDAKPWNIT FYDYNAVSAP PELAKEYEYI 120
HLTTTTNGQI VTLDRKHGKF LWQRDLSSPV VAAFLLGPDG LLSVPFTTVS DEAYQAILEE 180
SKTGNVNTVK LFQSLYVGEH QKGLYALPSL VDKNTPRIST APPIKLLDGP TGDQNSNQET 240
DPRTIYINDV LQEHAGIMLG HYNMPNEGNG NLQLSPTTAS SKVVQSLATI HNYNDGYGLL 300
ANNEKNAADI GVQTDPELVE IGIDQRTNGN TINRTKTIIL QNSNKVQAFI NEWFMEHPSG 360
KVHQILIVIV LGMIALFWYT CSTMRELQKQ SENGSKTFAI AQNGSNGSTG SNGSNANAED 420
LVDLGNGQVR VGKISFSTNE VLGKGCEGTF VFKGTFEERF VAVKRLLPEC FTFADREVAL 480
LRESDAHENV VRYFCTEQDR QFRYIAVELC AATLQDYTEG DRSLELQNHI DVWQVLSQAA 540
SGLSHLHSLD IVHRDIKPQN VLISLPDAKG KVRVMISDFG LCKKLNFGKT SFSRRSGVTG 600
TDGWIAPEMM RSQRTTTAVD IFSLGCVYYY VLSGGHHAFG DNLKRQANIL SHEYNLAKLR 660
PEDDSEDSRI ILAEQLISDM IHKDPQSRPP ARCIGNHPLF WDEPKMLSFL QDVSDRVEKL 720
QFHAEPLKSL EKNGRIVVLD DWNVHLDPMI TDDLRKYRGY MGASVRDLLR ALRNKKHHYH 780
ELTPAAQKML GCIPHEFTNY WVDRFPQLIS HAYHAFSICS NEPIFKPYYS AGYLFTRPWY 840
FDADDALFPM LMLDPKPLPK IGSPKKTPSP ASSQAQQLKQ RKGLYNFRKP NDELPIPGVG 900
LQRNLELDGQ SLEPDGKRDV FANFKFRRYS KPGNNRNYNG GHKEAQDKEK YVIWTLPPST 960
QD 962
Nucleotide Sequence
(FASTA)
ATGGGCAGTC TTAAGAAGTT ACCGTACACC ATTCCCCAAC TGGTGGCCAA TGCTCCCTGT 60
CGTTCCTCCG ATGGAATCCT GTACTCAGGG AAAAAGAGCG ACACCTGGTA TATGGTGGAT 120
CCTAAGACGG GCAGACGCGA AAAGGTTATG GGCTTTGGCG ATGCCACAGT GGATGGTAAG 180
GAGGGCGAGC AGATCGGCTG GGCCACTTCG CGGGCCATCT ATCTAGGCCG GACTCAGTAC 240
ACGGTCATGA TGTACGACAG CCTGGCTAAG AACAAGGATG CTAAGCCATG GAATATCACA 300
TTTTACGACT ACAATGCTGT GAGTGCTCCT CCTGAGCTGG CCAAGGAATA TGAGTATATA 360
CATCTGACCA CCACCACCAA TGGACAAATT GTGACTCTGG ATCGAAAACA CGGTAAATTT 420
CTGTGGCAGC GCGATCTGAG CAGCCCAGTG GTGGCTGCAT TCCTTTTGGG ACCAGACGGG 480
CTACTCAGTG TGCCATTCAC CACGGTCTCT GATGAGGCTT ACCAGGCCAT CCTCGAGGAG 540
TCGAAAACAG GAAATGTGAA CACCGTGAAG CTATTCCAAT CCCTTTATGT GGGCGAACAT 600
CAAAAGGGCT TGTATGCCCT GCCTTCGCTG GTGGACAAGA ACACGCCTCG TATTTCCACA 660
GCACCACCTA TAAAACTCCT GGATGGACCT ACAGGAGACC AGAACAGCAA CCAAGAGACA 720
GATCCGCGCA CCATTTACAT TAACGATGTG CTGCAAGAGC ATGCAGGAAT TATGTTGGGA 780
CACTACAACA TGCCCAATGA GGGTAATGGT AACCTGCAGC TGTCACCGAC GACAGCCAGC 840
AGCAAGGTGG TTCAAAGTCT GGCCACCATT CACAACTATA ACGATGGCTA CGGCCTGTTG 900
GCCAATAATG AAAAGAACGC CGCCGACATT GGCGTGCAAA CGGATCCCGA GCTGGTCGAA 960
ATTGGCATTG ATCAGCGGAC GAATGGGAAC ACCATTAATC GGACGAAGAC AATAATACTG 1020
CAGAACAGCA ATAAGGTGCA GGCCTTTATC AACGAGTGGT TTATGGAGCA TCCTAGCGGA 1080
AAGGTGCATC AGATTCTAAT TGTTATCGTT CTGGGTATGA TTGCCTTGTT CTGGTACACC 1140
TGCAGCACAA TGAGGGAGCT GCAAAAGCAG AGCGAGAATG GTTCAAAAAC CTTTGCCATA 1200
GCCCAAAATG GATCCAATGG AAGCACTGGC AGCAATGGTA GCAATGCGAA CGCTGAAGAC 1260
CTAGTGGACT TGGGTAATGG ACAAGTGCGT GTGGGCAAGA TCAGCTTCAG CACAAATGAA 1320
GTGCTGGGAA AGGGCTGCGA GGGTACTTTT GTCTTTAAGG GCACATTCGA GGAACGTTTC 1380
GTAGCCGTAA AACGGCTGCT GCCCGAATGC TTCACCTTTG CTGATCGCGA GGTGGCCCTA 1440
TTGCGAGAAT CGGACGCGCA CGAAAATGTG GTGCGCTACT TCTGCACCGA ACAGGATCGC 1500
CAGTTCCGCT ACATAGCCGT CGAGCTGTGC GCGGCCACTC TGCAGGACTA CACCGAAGGA 1560
GATCGCTCGC TGGAACTTCA AAATCACATC GATGTTTGGC AAGTGTTGAG CCAGGCTGCA 1620
TCTGGACTTA GTCATCTTCA CTCTCTCGAC ATTGTGCATC GCGACATTAA GCCGCAAAAT 1680
GTTCTTATTT CTCTGCCAGA CGCCAAGGGC AAAGTACGTG TCATGATCTC CGATTTTGGG 1740
CTGTGCAAGA AGCTGAATTT TGGCAAGACT AGTTTCTCAC GCCGATCGGG TGTAACAGGC 1800
ACCGATGGAT GGATAGCCCC AGAAATGATG AGATCACAGC GAACGACAAC TGCTGTGGAT 1860
ATATTTTCCT TGGGCTGCGT TTATTATTAT GTTTTAAGTG GCGGTCACCA CGCCTTTGGT 1920
GACAATCTGA AGCGACAGGC CAACATACTC TCCCACGAAT ACAATCTGGC CAAGCTGCGC 1980
CCAGAGGACG ACAGTGAGGA CAGCCGAATT ATCCTTGCTG AGCAATTAAT ATCGGATATG 2040
ATACACAAGG ATCCGCAATC GCGACCTCCA GCTCGTTGTA TCGGAAATCA TCCGCTCTTT 2100
TGGGATGAGC CTAAAATGCT CTCGTTCCTC CAGGATGTCA GCGATCGTGT GGAGAAGTTG 2160
CAATTCCATG CTGAACCGCT CAAGTCGCTG GAGAAGAACG GGCGGATAGT CGTTTTAGAC 2220
GATTGGAATG TCCATCTGGA CCCCATGATC ACGGATGATT TGAGGAAGTA CCGCGGATAT 2280
ATGGGCGCCA GTGTACGAGA TTTGCTCCGT GCTCTGCGCA ACAAAAAGCA TCATTATCAC 2340
GAGCTAACGC CAGCCGCCCA GAAGATGCTG GGCTGCATTC CGCACGAATT CACCAACTAC 2400
TGGGTGGATC GCTTCCCGCA GCTCATTTCA CACGCCTACC ACGCGTTCAG TATTTGCTCA 2460
AATGAGCCGA TATTCAAGCC TTACTACAGT GCCGGCTATC TTTTTACACG TCCGTGGTAC 2520
TTTGATGCGG ACGATGCGCT GTTTCCCATG CTGATGCTGG ATCCCAAGCC CCTGCCCAAG 2580
ATTGGTAGTC CTAAAAAGAC ACCTTCGCCG GCAAGCAGCC AAGCTCAGCA GCTGAAGCAA 2640
AGAAAAGGGC TCTACAACTT TCGTAAGCCC AACGATGAGC TGCCGATTCC TGGCGTTGGT 2700
CTGCAGCGTA ATCTAGAGCT AGATGGACAA TCACTGGAGC CCGATGGCAA GCGGGATGTG 2760
TTTGCTAACT TTAAGTTTCG GCGCTACTCG AAGCCGGGAA ACAATCGCAA TTACAACGGT 2820
GGGCACAAGG AAGCGCAGGA CAAGGAAAAG TACGTAATCT GGACGCTGCC ACCTTCAACG 2880
CAGGATTAG 2889
Domain Profile
S: 1     fspkdvlGkGaeGtvvfrGsfegrevavkrllsefvdlakrevkllresdehpnviryfc  60
         fs+++vlGkG+eGt+vf+G+fe+r vavkrll+e++++a+rev+llresd+h+nv+ryfc
Q: 436   FSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFADREVALLRESDAHENVVRYFC  495
         789*********************************************************
S: 61    tekdrqfryialelcaaslqdyve.dkdlelqkelepisllkqiasGlahlhslkivhrd  119
         te+drqfryia+elcaa+lqdy+e d++lelq++++++++l+q+asGl+hlhsl+ivhrd
Q: 496   TEQDRQFRYIAVELCAATLQDYTEgDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRD  555
         ************************9***********************************
S: 120   lkpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleeltk  179
         +kpqn+lislpdakgk+rv+isdfGlckkl++Gk+sfsrrsgv+Gt+Gwiape+++   +
Q: 556   IKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMR---S  612
         ********************************************************...9
S: 180   erltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdee....vi  235
         +r+t+avdifslGcv+yyvls+G+h+fGd+lkrqanils+e++l+kl++e+d+e    ++
Q: 613   QRTTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEdsriIL  672
         *************************************************99988889899
S: 236   aedliskmidkdplkrpsakkvlkhplf  263
         ae+lis+mi+kdp++rp+a+++ +hplf
Q: 673   AEQLISDMIHKDPQSRPPARCIGNHPLF  700
         ***************************9
Domain Sequence
(FASTA)
FSTNEVLGKG CEGTFVFKGT FEERFVAVKR LLPECFTFAD REVALLRESD AHENVVRYFC 60
TEQDRQFRYI AVELCAATLQ DYTEGDRSLE LQNHIDVWQV LSQAASGLSH LHSLDIVHRD 120
IKPQNVLISL PDAKGKVRVM ISDFGLCKKL NFGKTSFSRR SGVTGTDGWI APEMMRSQRT 180
TTAVDIFSLG CVYYYVLSGG HHAFGDNLKR QANILSHEYN LAKLRPEDDS EDSRIILAEQ 240
LISDMIHKDP QSRPPARCIG NHPLF 265
KeywordComplete proteome; Hydrolase; Reference proteome; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00269
EKS-ANC-00278
EKS-BOT-00287
EKS-CAE-00246
EKS-CAJ-00293
EKS-CAF-00293
EKS-CAP-00322
EKS-CII-00169
EKS-CIS-00050
EKS-DAR-00632
EKS-ECT-00032
EKS-EQC-00279
EKS-FEC-00273
EKS-GAM-00181
EKS-GAG-00240
EKS-GAA-00355
EKS-GOG-00286
EKS-HOS-00293
EKS-ICT-00272
EKS-LAC-00301
EKS-LOA-00297
EKS-MAM-00290
EKS-MEG-00229
EKS-MIM-00023
EKS-MOD-00282
EKS-MUM-00318
EKS-MUP-00283
EKS-MYL-00290
EKS-NOL-00265
EKS-OCP-00029
EKS-ORN-00373
EKS-ORA-00253
EKS-ORC-00269
EKS-ORL-00346
EKS-OTG-00293
EKS-PAT-00272
EKS-PES-00256
EKS-POA-00279
EKS-PTV-00113
EKS-RAN-00303
EKS-SAH-00269
EKS-SUS-00253
EKS-TAG-00301
EKS-TAR-00376
EKS-TEN-00371
EKS-TUB-00026
EKS-XET-00360
EKS-XIM-00366
EKS-SAC-00054
EKS-SCP-00051
Gene Ontology
GO:0005524; F:ATP binding
GO:0004521; F:endoribonuclease activity
GO:0016891; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004672; F:protein kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0007030; P:Golgi organization
GO:0070055; P:HAC1-type intron splice site recognition and cleavage
GO:0006402; P:mRNA catabolic process
GO:0043484; P:regulation of RNA splicing
KEGG
dme:Dmel_CG4583;
InterPros
IPR010513; KEN_RNase_activator.
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR006567; PUG-dom.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF06479; Ribonuc_2-5A; 1.
SMARTs
SM00564; PQQ; 5.
SM00580; PUG; 1.
Prosites
PS51392; KEN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013