EKS-DRM-00070
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-DRM-00070
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Csk452.15.2E-136471715245
StatusUnreviewed
Ensembl ProteinFBpp0289006
UniProt AccessionQ8INJ8;
Protein Name
Protein Synonyms/Alias C-terminal Src kinase, isoform G;
Gene NameCsk
Gene Synonyms/Alias Csk; Dmel_CG42317;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
FBgn0262081FBpp0289007FBtr0299729
FBgn0262081FBpp0289006FBtr0299728
FBgn0262081FBpp0289773FBtr0300546
FBgn0262081FBpp0289774FBtr0300547
FBgn0262081FBpp0289775FBtr0300548
FBgn0262081FBpp0289776FBtr0300549
OrganismDrosophila melanogaster
Functional Description
Protein Length723
Protein Sequence
(FASTA)
MNSHATATQN GQTTVVGHHR GFSQPSVTVA AAAATGSTAG DPWFLQTTGH QMPPTAPLRH 60
NKRPAPQPNA VLGAGSSGTA PGSAVGAVLL HQQQLSQSQP HIVPPSIPPH HHHHRENNVH 120
PIQAGAAAAL HLSSHALNSH NLISSASNHS PKSPSQTQQQ QQTTNQQQQQ QQQQASHSIL 180
STFAPAPTVA AVQPAGSQSV AGTAAAVAAV AQQQQQQHLQ LLANCPPGGA GLMSSSLNAA 240
QMGMHGAERA LPPKSLALSG SQHGSNMLLH TAPQPPQASQ PAAVVGVSGS GSAGMSTSLH 300
SFDINGVTAG SGVNASSAWS SGSTTAMNHA SLSPTALAPQ QGRSRCEVKL NAMPWFHGSI 360
TRDEAEHLLQ PREDGLFLVR ESTNFPGDYT LCVCFQSKVE HYRVKYLENK LTIDDEEYFE 420
NLGQLVAHYE ADADGLCTQL IKCLPKLGKQ EFCINSKDFV DKGWVIPEAE LQLRESIGKG 480
EFGDVMLGIL RNEKVAVKML KDEGAVQKFL AEASVMTTLE HDNLVKFIGL VFTSKHLYLV 540
TEYMSKGSLV DYLRSRGRQH ITKKDQIIFA YDTASGMEYL EAKKVVHRDL AARNVLISED 600
CVAKVSDFGL AREECYNLDV GKLPIKWTAP EALKNGRFSN KSDMWSFGIL LWEIYSFGRV 660
PYPRIPLADV VKHVEVGYKM EAPEGCPPEI YEMMRQAWDL NPAKRPTFAE LKVKLQLLNN 720
ATA 723
Nucleotide Sequence
(FASTA)
ATGAACAGCC ACGCGACTGC CACGCAGAAC GGACAAACCA CGGTCGTCGG ACACCATCGC 60
GGATTCTCGC AGCCCTCGGT GACGGTGGCC GCTGCAGCGG CAACGGGCAG CACGGCTGGT 120
GATCCATGGT TCCTGCAGAC CACCGGTCAC CAGATGCCAC CCACTGCACC GTTGCGGCAC 180
AACAAGCGTC CTGCCCCCCA GCCGAATGCG GTTTTGGGAG CGGGTTCCTC GGGAACAGCG 240
CCTGGATCGG CGGTTGGCGC CGTACTGCTC CACCAACAGC AGCTCAGCCA GTCGCAGCCG 300
CACATTGTGC CGCCCAGCAT ACCGCCGCAC CACCACCACC ATCGCGAGAA CAATGTGCAC 360
CCCATCCAGG CGGGCGCGGC AGCCGCATTG CATTTGTCAT CGCATGCGCT TAATAGTCAT 420
AATTTAATCA GCAGCGCCAG CAATCATTCG CCCAAGTCCC CCAGCCAGAC GCAGCAGCAG 480
CAACAGACGA CGAACCAGCA GCAACAACAG CAGCAGCAGC AGGCGTCCCA CAGCATACTG 540
TCCACGTTTG CGCCCGCCCC CACTGTCGCC GCCGTTCAGC CGGCGGGATC GCAGTCCGTT 600
GCCGGTACCG CTGCCGCAGT GGCCGCCGTT GCCCAGCAGC AGCAACAGCA GCATCTTCAG 660
CTGCTGGCCA ACTGTCCGCC CGGTGGAGCG GGTCTAATGT CCTCCTCCCT GAATGCAGCC 720
CAAATGGGCA TGCATGGCGC CGAGCGAGCG CTGCCGCCAA AGAGTCTGGC GCTGAGTGGC 780
AGCCAGCACG GCAGCAATAT GCTACTGCAC ACAGCACCGC AACCGCCACA GGCATCCCAG 840
CCAGCGGCAG TCGTCGGCGT CAGTGGTAGC GGATCGGCGG GTATGTCCAC CTCGCTGCAC 900
AGCTTCGATA TTAATGGAGT CACGGCAGGC AGCGGGGTGA ATGCGAGCAG CGCGTGGTCA 960
AGCGGATCCA CCACTGCCAT GAACCATGCT TCCCTCTCGC CCACAGCGTT GGCACCGCAA 1020
CAAGGTCGGT CCAGGTGCGA GGTCAAACTG AACGCCATGC CATGGTTCCA TGGCAGCATA 1080
ACGCGGGATG AGGCGGAGCA TCTGCTGCAG CCGCGTGAGG ATGGTTTGTT CCTGGTTCGC 1140
GAGTCCACAA ACTTCCCCGG CGACTACACG CTCTGCGTTT GTTTCCAGTC CAAGGTGGAG 1200
CACTACCGGG TCAAGTACCT AGAGAACAAG CTGACCATCG ACGACGAGGA ATACTTTGAG 1260
AATTTGGGCC AGCTAGTGGC GCACTACGAG GCGGATGCGG ATGGACTGTG CACCCAGCTG 1320
ATTAAATGCT TGCCAAAGCT GGGCAAACAA GAGTTTTGCA TTAACTCCAA AGATTTCGTG 1380
GACAAGGGCT GGGTGATCCC TGAAGCGGAG CTGCAGCTGC GCGAGAGCAT CGGCAAGGGC 1440
GAGTTCGGTG ACGTGATGCT GGGCATATTA CGCAACGAGA AGGTGGCCGT CAAGATGCTG 1500
AAGGACGAGG GCGCCGTGCA GAAGTTTCTG GCTGAGGCCT CGGTCATGAC CACGCTGGAG 1560
CACGACAATT TGGTAAAGTT TATCGGCCTT GTCTTCACCA GCAAGCATCT GTATCTGGTT 1620
ACGGAATATA TGAGTAAGGG ATCACTGGTT GATTACCTGC GATCGCGAGG ACGACAGCAC 1680
ATAACCAAAA AGGATCAAAT CATTTTTGCC TACGACACTG CCTCTGGTAT GGAGTATCTG 1740
GAAGCCAAAA AGGTTGTCCA TCGCGATCTG GCAGCTCGCA ATGTCCTTAT ATCAGAGGAT 1800
TGCGTGGCTA AAGTATCGGA TTTCGGTTTG GCACGCGAGG AATGCTACAA TCTTGACGTT 1860
GGCAAGCTGC CCATAAAATG GACGGCTCCC GAGGCACTTA AAAATGGGCG TTTTTCCAAC 1920
AAATCAGACA TGTGGAGCTT TGGCATACTG CTATGGGAAA TCTACTCCTT TGGACGCGTG 1980
CCCTATCCCA GAATTCCATT AGCCGATGTG GTAAAGCACG TTGAGGTGGG CTACAAAATG 2040
GAAGCGCCCG AGGGCTGTCC ACCGGAGATT TACGAAATGA TGCGGCAGGC CTGGGACCTA 2100
AATCCCGCCA AGCGACCCAC ATTCGCGGAG CTCAAGGTCA AACTGCAGCT ACTGAACAAT 2160
GCCACGGCGT GA 2172
Domain Profile
S: 1     lklgetigkgefgdvllgeyrgekvavkvikndataqafldeasvmtklehenlvkllgv  60
         l+l+e+igkgefgdv+lg +r+ekvavk++k+++++q+fl+easvmt+leh+nlvk++g+
Q: 471   LQLRESIGKGEFGDVMLGILRNEKVAVKMLKDEGAVQKFLAEASVMTTLEHDNLVKFIGL  530
         789*********************************************************
S: 61    ileekglylvteyvakgslvdylrsrgrallekkqllkfaldvaegmeyleskklvhrdl  120
         ++++k+lylvtey++kgslvdylrsrgr++++kk++++fa+d+a+gmeyle+kk+vhrdl
Q: 531   VFTSKHLYLVTEYMSKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDL  590
         ************************************************************
S: 121   aarnvlvsedlvakvsdfglakeeskdldsgklpvkwtapealkekkfstksdvwsfgil  180
         aarnvl+sed+vakvsdfgla+ee+++ld+gklp+kwtapealk+++fs+ksd+wsfgil
Q: 591   AARNVLISEDCVAKVSDFGLAREECYNLDVGKLPIKWTAPEALKNGRFSNKSDMWSFGIL  650
         ************************************************************
S: 181   lweifsfgrvpypriplkdvvkavekgykmeapegcppevyelmkeaweleaakrpsfak  240
         lwei+sfgrvpypripl+dvvk+ve+gykmeapegcppe+ye+m++aw+l++akrp+fa+
Q: 651   LWEIYSFGRVPYPRIPLADVVKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAE  710
         ************************************************************
S: 241   lkekl  245
         lk kl
Q: 711   LKVKL  715
         *9987
Domain Sequence
(FASTA)
LQLRESIGKG EFGDVMLGIL RNEKVAVKML KDEGAVQKFL AEASVMTTLE HDNLVKFIGL 60
VFTSKHLYLV TEYMSKGSLV DYLRSRGRQH ITKKDQIIFA YDTASGMEYL EAKKVVHRDL 120
AARNVLISED CVAKVSDFGL AREECYNLDV GKLPIKWTAP EALKNGRFSN KSDMWSFGIL 180
LWEIYSFGRV PYPRIPLADV VKHVEVGYKM EAPEGCPPEI YEMMRQAWDL NPAKRPTFAE 240
LKVKL 245
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00137
EKS-ANC-00139
EKS-BOT-00146
EKS-CAE-00119
EKS-CAJ-00150
EKS-CAF-00152
EKS-CAP-00145
EKS-CII-00089
EKS-CIS-00181
EKS-DAR-00430
EKS-DIO-00081
EKS-EQC-00143
EKS-FEC-00136
EKS-GAM-00075
EKS-GAG-00122
EKS-GAA-00170
EKS-GOG-00145
EKS-HOS-00150
EKS-ICT-00139
EKS-LAC-00154
EKS-LOA-00144
EKS-MAM-00143
EKS-MAE-00056
EKS-MEG-00113
EKS-MOD-00144
EKS-MUM-00149
EKS-MUP-00149
EKS-MYL-00155
EKS-NOL-00139
EKS-ORN-00178
EKS-ORL-00167
EKS-OTG-00150
EKS-PAT-00135
EKS-PES-00129
EKS-POA-00141
EKS-PRC-00025
EKS-PTV-00137
EKS-RAN-00143
EKS-SAH-00139
EKS-SOA-00023
EKS-SUS-00127
EKS-TAG-00173
EKS-TAR-00188
EKS-TEN-00181
EKS-TUT-00144
EKS-XET-00133
EKS-XIM-00172
Gene Ontology
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004713; F:protein tyrosine kinase activity
GO:0034334; P:adherens junction maintenance
GO:0010669; P:epithelial structure maintenance
GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007293; P:germarium-derived egg chamber formation
GO:0008285; P:negative regulation of cell proliferation
GO:0045926; P:negative regulation of growth
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043068; P:positive regulation of programmed cell death
KEGG
dme:Dmel_CG42317;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013