EKS-DRM-00148

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00148

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	365.7	1.5E-109	1175	1435	261

Status

Unreviewed

Ensembl Protein

FBpp0085368

UniProt Accession

Q7KN56;

Protein Name

Protein Synonyms/Alias

LD23835p;

Gene Name

BubR1

Gene Synonyms/Alias

BubR1; Bub1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0263855	FBpp0085368	FBtr0086032

Organism

Drosophila melanogaster

Functional Description

Protein Length

1460

Protein Sequence
(FASTA)

MDFDNAKENI QPLASGRNVS LLQASLSQDS THGQELLAQR KQMEEEVRTY KGADPLGAWY 60

TFICWIEQSY PAGGSGSGLQ TVLHQCLTKF EDDERYRQDK RLIKLFIKFM EKQKDKIEFY 120

QQMYNNGIGT MLADFYIAWA YSYDLSGNMR KADEIFRLGL ECRAEPLEDL KEAHHHFGYT 180

VGQRMLYSTG EEANAVNQEL NERRLALQSL HGRRQQISNS ITVGSIRTGA AVKSGLPGVV 240

QVEPSTTTSR RNVGRNVEVF NDENSEGNIP ISNSETEVKS SLRSIIDSAC SQENIKEPVA 300

WNKANAKRHK HGKIFGSNAS PDLGFDIHVD EQAMPPITNY ERRLEQPFRF PTNFVAKNRP 360

QEPWVTPVTI EDEPNASGLP CYNKCLLYPR PNIEFSPEEY RAYSFLKHRN PQHPFIHRND 420

DWWGTGRVIR GIRCYPNFAR YSKPQDLDEL DKFWKPPLVP GLQVVFDKIY NEVEQKEYQP 480

EELLAAKWME KRNVTVHGDF DMEETVCLPG NKMPRRKSFF PSSFRKSIMP RRVSSVQEED 540

EKKEDEATLI VKDIPSQVAP KIPESPCDQI DEPKIKIFED SGSPRDNFAV PAVPVPKIEI 600

YEDSEEPQPT PKTRPFYDGD ETCSTQMFNM FIKSQAVSTP KGTQKQAPSR QFGTVLKELP 660

LPEEAAHSVE SPVETRSPTL RKQLSTILET SEHGTQSLAT SGTTTKSTIT STSSPGSNAV 720

SKLGSKIEEN TPGQMRLQRV ISAGVSAVLS EPEKPGGDNF LRRELWEPNA PSVPMLKSLR 780

FQEDKTETIP RPLACFQEDK TETLPQMPIA LPENSMDHGS LGAENCFSAP QLPTLEDESD 840

LCGLFGKTPP KTNIFGSPKR NFDPTSQLFK STQGDRRSFA VTGNKLEAAP SISNLQDSFM 900

CDLSFVPETQ PEAVAKSGAI QKFDIFLDDT QPKLTKSKPV ALMVSSFDLD CTLPETQQVA 960

IKEPGTQQEN IGHSHMIASF MKDCTEIGSC PSQMPASVVK TNISSTSNKI KFSNDSMSES 1020

SRKAPVNENV GISKQPDEFF ELNAATEMFA TNISMIKNST LLIPNAKVAE ASELSIYYKT 1080

TPLTPKQSHR SWSQSDLETP PRENFVHPTS NGDQTVLNET LADANKNPFN VELISSLLES 1140

IDFSMYIEKL PHCQLVGHVK RLHPNTHLEV HNEKFEVSKM IGKGAYGSVY VGKHLKSGKK 1200

VALKQERPTN YWEFYICLEI HSRLTSEQMI PSYAHIDYAL VGNNSSVYIS EFSDYGSLIG 1260

VCNKVKSVTN RNMDEYVVMH LSCQMLDIVD HLHAMGIIHA DIKPDNFLLM KPICADPNEV 1320

SLQLIDFGVS IDMKLFPDNQ TFNYVHHDDL FKCIEMRTGR PWTYQLDLYG LVSVMHVLLF 1380

GRYMEVVQRS PSTIWMPKTN VPRYFQRTMW ENIFRTLLNI RDCRTMPNLQ QLRTQLKCAL 1440

AEKEKYVAEA ISKFNTILQK 1460

Nucleotide Sequence
(FASTA)

ATGGACTTTG ACAATGCGAA AGAGAACATT CAGCCGCTGG CCAGCGGTCG CAATGTGAGC 60

CTTCTGCAGG CTTCTCTTAG CCAGGACTCC ACCCACGGCC AGGAACTGCT GGCACAACGC 120

AAGCAAATGG AGGAGGAGGT GCGCACCTAC AAAGGCGCGG ATCCTCTCGG TGCCTGGTAC 180

ACGTTCATCT GCTGGATCGA GCAGAGCTAT CCGGCGGGGG GCAGTGGCTC CGGTCTGCAG 240

ACTGTCCTAC ACCAGTGCCT CACCAAATTT GAAGACGACG AGCGCTACCG TCAGGACAAG 300

CGGCTTATAA AGCTTTTCAT TAAATTCATG GAGAAACAGA AGGACAAGAT CGAGTTTTAT 360

CAGCAGATGT ACAACAACGG GATCGGAACA ATGCTGGCAG ATTTCTACAT TGCTTGGGCC 420

TACAGCTACG ACCTGAGCGG TAACATGCGC AAGGCCGACG AGATCTTTCG CTTAGGTCTA 480

GAGTGCCGCG CAGAGCCCTT AGAGGATCTG AAGGAGGCCC ACCACCACTT TGGCTATACG 540

GTGGGCCAGC GCATGCTCTA CAGCACTGGT GAAGAGGCCA ACGCAGTAAA CCAGGAACTT 600

AACGAGCGAC GGCTAGCACT GCAATCACTT CATGGTCGCC GGCAGCAGAT CTCTAACAGC 660

ATCACCGTGG GCAGCATCCG TACCGGAGCA GCAGTTAAAA GCGGCCTCCC AGGCGTGGTT 720

CAGGTCGAGC CTTCAACCAC CACCAGTAGG CGCAATGTAG GTCGGAACGT TGAGGTGTTT 780

AATGACGAAA ATTCTGAGGG AAATATTCCG ATCTCTAATT CTGAGACGGA GGTGAAGTCA 840

AGCCTGCGAT CCATTATCGA CTCGGCTTGC AGTCAGGAGA ATATAAAAGA ACCGGTGGCC 900

TGGAATAAGG CAAATGCTAA ACGCCACAAA CATGGAAAAA TTTTCGGCAG TAACGCCTCG 960

CCGGATCTGG GCTTTGATAT ACACGTTGAC GAACAAGCAA TGCCACCTAT TACAAACTAC 1020

GAGCGTCGTC TAGAACAACC ATTTAGATTT CCGACAAACT TTGTGGCCAA GAACAGGCCT 1080

CAGGAACCGT GGGTGACGCC AGTTACTATT GAGGACGAGC CAAACGCAAG TGGACTGCCT 1140

TGCTATAACA AGTGTCTCCT CTACCCCCGC CCCAACATCG AGTTCTCGCC CGAAGAGTAT 1200

CGAGCCTATT CCTTTTTGAA GCATCGCAAC CCACAGCATC CATTTATCCA TCGCAATGAT 1260

GATTGGTGGG GCACTGGACG GGTGATCAGA GGAATTCGCT GCTATCCGAA TTTCGCCAGA 1320

TATTCTAAGC CACAAGATCT CGATGAGCTA GACAAGTTTT GGAAACCCCC ACTGGTACCG 1380

GGCCTTCAGG TAGTTTTTGA CAAAATTTAC AACGAAGTTG AGCAAAAGGA GTACCAGCCA 1440

GAGGAGTTGT TGGCAGCTAA ATGGATGGAA AAACGAAATG TGACAGTTCA TGGTGACTTT 1500

GACATGGAAG AAACCGTTTG CTTGCCCGGA AACAAGATGC CACGCCGCAA GAGCTTCTTT 1560

CCCTCTTCCT TCAGAAAATC CATCATGCCA CGCAGAGTTT CGTCTGTGCA GGAGGAGGAT 1620

GAAAAGAAAG AGGATGAAGC CACTTTGATT GTAAAAGATA TACCTTCTCA GGTGGCACCT 1680

AAGATACCTG AATCGCCGTG CGATCAAATA GATGAGCCAA AAATTAAAAT ATTTGAGGAT 1740

TCCGGTTCTC CACGTGACAA TTTTGCTGTA CCGGCCGTTC CTGTTCCGAA AATAGAGATC 1800

TATGAAGACT CTGAAGAGCC GCAGCCAACT CCAAAAACAA GGCCGTTTTA TGACGGAGAT 1860

GAGACCTGCT CCACGCAAAT GTTCAACATG TTCATAAAGT CGCAGGCAGT AAGCACTCCT 1920

AAGGGAACAC AGAAACAGGC TCCGTCACGT CAATTTGGAA CCGTGCTCAA AGAACTACCG 1980

CTACCAGAGG AGGCTGCTCA TTCCGTCGAA TCTCCAGTGG AGACTCGTTC TCCAACTTTG 2040

CGAAAGCAAC TATCTACCAT ATTGGAAACC TCTGAGCACG GCACACAAAG CTTGGCGACG 2100

AGCGGTACCA CCACTAAATC CACTATTACC TCCACGTCTT CACCCGGATC CAATGCTGTT 2160

TCTAAACTAG GCAGCAAGAT TGAAGAGAAC ACTCCTGGAC AAATGCGTCT GCAGCGCGTG 2220

ATAAGTGCTG GTGTATCAGC AGTCCTTTCC GAGCCGGAAA AACCGGGTGG TGACAACTTT 2280

TTGCGCCGTG AGTTATGGGA GCCCAATGCG CCTAGCGTGC CTATGCTTAA GTCGTTGCGC 2340

TTCCAAGAGG ATAAGACAGA GACTATCCCA AGACCTCTTG CTTGCTTTCA GGAAGATAAA 2400

ACTGAAACAC TCCCACAAAT GCCGATCGCA CTGCCGGAGA ATTCTATGGA TCATGGCTCA 2460

CTGGGAGCTG AAAATTGTTT TTCCGCACCG CAACTTCCCA CTTTGGAGGA TGAAAGCGAT 2520

TTGTGTGGAT TGTTTGGAAA GACACCGCCG AAAACAAATA TTTTTGGCTC TCCGAAGCGC 2580

AATTTCGATC CAACTTCACA GCTTTTTAAA TCGACACAGG GCGATCGGAG ATCCTTCGCA 2640

GTGACTGGCA ACAAACTGGA GGCTGCGCCC AGCATCAGCA ATCTGCAGGA TTCCTTTATG 2700

TGCGACCTTT CCTTTGTGCC CGAAACGCAG CCTGAAGCTG TAGCAAAATC AGGGGCGATA 2760

CAGAAGTTTG ATATTTTTCT GGACGACACG CAGCCAAAGC TCACTAAGTC AAAACCAGTA 2820

GCTTTAATGG TCTCCAGCTT TGACTTAGAC TGCACGCTGC CCGAAACGCA ACAGGTGGCA 2880

ATTAAGGAGC CAGGGACTCA ACAGGAAAAT ATTGGGCACT CCCATATGAT TGCCTCGTTT 2940

ATGAAAGATT GCACAGAAAT AGGCAGCTGT CCTTCACAGA TGCCGGCTTC CGTTGTCAAA 3000

ACGAATATTT CAAGCACATC GAATAAGATC AAATTTTCCA ACGATTCCAT GTCAGAATCG 3060

TCAAGGAAAG CCCCTGTGAA TGAAAATGTC GGTATTTCAA AACAACCTGA CGAGTTTTTC 3120

GAGCTTAACG CAGCTACTGA AATGTTTGCA ACAAATATCA GTATGATAAA AAATTCCACA 3180

CTGCTGATCC CTAACGCAAA GGTAGCAGAG GCGTCGGAAC TAAGCATCTA CTATAAGACA 3240

ACTCCACTGA CGCCGAAGCA ATCGCACCGT TCCTGGTCGC AGTCTGATTT AGAAACTCCT 3300

CCGCGGGAAA ACTTTGTTCA CCCCACCTCA AACGGAGATC AAACTGTTTT GAACGAAACG 3360

CTGGCAGACG CTAATAAAAA CCCTTTCAAT GTAGAACTGA TCAGCTCGCT ACTCGAATCA 3420

ATTGACTTTT CTATGTACAT CGAAAAGCTG CCCCATTGTC AACTGGTTGG ACACGTTAAG 3480

CGCCTACATC CTAACACCCA CCTGGAAGTG CACAACGAAA AGTTTGAGGT GTCTAAAATG 3540

ATAGGAAAGG GGGCTTATGG CTCGGTTTAT GTAGGAAAGC ATCTGAAATC TGGCAAGAAG 3600

GTCGCGCTCA AGCAGGAACG GCCCACTAAC TACTGGGAGT TCTACATTTG TCTAGAGATT 3660

CACAGCCGGC TAACTAGTGA GCAAATGATT CCATCCTATG CACATATTGA CTATGCACTG 3720

GTAGGAAATA ATTCCAGTGT ATACATCTCA GAGTTTTCAG ACTATGGTTC TCTGATCGGT 3780

GTATGCAACA AGGTTAAGAG TGTCACTAAC AGGAATATGG ACGAGTATGT GGTAATGCAT 3840

CTGAGTTGCC AAATGCTCGA TATTGTGGAT CACCTGCACG CCATGGGTAT AATCCACGCC 3900

GACATCAAGC CGGATAACTT TCTACTTATG AAACCGATAT GTGCGGATCC CAACGAAGTC 3960

AGCCTGCAGC TTATTGATTT CGGTGTGTCT ATTGACATGA AGCTGTTTCC GGACAATCAG 4020

ACATTCAACT ATGTTCATCA TGATGACCTA TTCAAGTGCA TTGAGATGAG AACGGGACGC 4080

CCATGGACTT ACCAATTGGA TTTATATGGT CTCGTAAGCG TTATGCATGT GCTGCTTTTC 4140

GGCCGCTATA TGGAAGTAGT GCAGCGGTCT CCGAGCACGA TTTGGATGCC GAAAACAAAC 4200

GTGCCACGCT ACTTTCAGCG CACAATGTGG GAAAACATCT TCCGCACTCT GCTTAACATT 4260

AGAGATTGTC GCACCATGCC TAATCTGCAG CAACTGCGTA CGCAGCTTAA ATGTGCGTTG 4320

GCCGAAAAGG AAAAATATGT TGCCGAGGCA ATCAGCAAGT TTAACACGAT ATTGCAGAAA 4380

TAG 4383

Domain Profile

S: 1     leiekeigeGayakvykaehdsksgelvalKvekpansWefYIclqlkeRlkeeellksi  60

         +e++k+ig+Gay++vy  +h  ksg++valK+e+p+n+WefYIcl++++Rl++e++++s+

Q: 1175  FEVSKMIGKGAYGSVYVGKH-LKSGKKVALKQERPTNYWEFYICLEIHSRLTSEQMIPSY  1233

         689****************6.***************************************

S: 61    ieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiveklH  120

         ++i +al+ +++s++++e+++yg+l+ ++nkvk+vtn++mde++v++l++q+l+iv++lH

Q: 1234  AHIDYALVGNNSSVYISEFSDYGSLIGVCNKVKSVTNRNMDEYVVMHLSCQMLDIVDHLH  1293

         ************************************************************

S: 121   eveIiHgDlkPdnfllgnrimdkadkdkeekglkliDfgrsiDmkllpdgtkfkgkaktd  180

         +++IiH+D+kPdnfll    m+++++d +e +l+liDfg+siDmkl+pd+++f++++++d

Q: 1294  AMGIIHADIKPDNFLL----MKPICADPNEVSLQLIDFGVSIDMKLFPDNQTFNYVHHDD  1349

         ****************....****************************************

S: 181   afeciemlagkswsYqvDlfglaavihvllfgkyleviqeggs..wklkqkikrllkkel  238

          f+ciem++g++w+Yq+Dl+gl++v+hvllfg+y+ev+q+++s  w++k++++r++++++

Q: 1350  LFKCIEMRTGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPStiWMPKTNVPRYFQRTM  1409

         ***************************************776667***************

S: 239   wekiferlLNisdastlpsleelveek  265

         we+if++lLNi+d++t+p+l++l++ +

Q: 1410  WENIFRTLLNIRDCRTMPNLQQLRT-Q  1435

         ***********************94.4

Domain Sequence
(FASTA)

FEVSKMIGKG AYGSVYVGKH LKSGKKVALK QERPTNYWEF YICLEIHSRL TSEQMIPSYA 60

HIDYALVGNN SSVYISEFSD YGSLIGVCNK VKSVTNRNMD EYVVMHLSCQ MLDIVDHLHA 120

MGIIHADIKP DNFLLMKPIC ADPNEVSLQL IDFGVSIDMK LFPDNQTFNY VHHDDLFKCI 180

EMRTGRPWTY QLDLYGLVSV MHVLLFGRYM EVVQRSPSTI WMPKTNVPRY FQRTMWENIF 240

RTLLNIRDCR TMPNLQQLRT Q 261

Keyword

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0000940	; C:condensed chromosome outer kinetochore
GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007066	; P:female meiosis sister chromatid cohesion
GO:0007065	; P:male meiosis sister chromatid cohesion
GO:0051754	; P:meiotic sister chromatid cohesion, centromeric
GO:0007094	; P:mitotic cell cycle spindle assembly checkpoint
GO:0007052	; P:mitotic spindle organization
GO:0022008	; P:neurogenesis
GO:0007096	; P:regulation of exit from mitosis
GO:0035415	; P:regulation of mitotic prometaphase
GO:0010965	; P:regulation of mitotic sister chromatid separation
GO:0000819	; P:sister chromatid segregation
GO:0070193	; P:synaptonemal complex organization
GO:0035186	; P:syncytial blastoderm mitotic cell cycle

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013