EKS-DRM-00044

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-DRM-00044

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	294.3	1.6E-87	1894	2210	317

Status

Reviewed

Ensembl Protein

FBpp0070933

UniProt Accession

Q70PP2; Q6NP14; Q9W3V6;

Protein Name

Serine/threonine-protein kinase Smg1

Protein Synonyms/Alias

Gene Name

Smg1

Gene Synonyms/Alias

Smg1; CG32743;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
FBgn0263968	FBpp0070933	FBtr0070972

Organism

Drosophila melanogaster

Functional Description

Serine/threonine protein kinase involved in mRNAsurveillance. Recognizes the substrate consensus sequence [ST]-Q. Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons, probably by phosphorylating Upf1.

Protein Length

3218

Protein Sequence
(FASTA)

MKNAIHPENC NGAGTEEEAS SAFHAEIDRV LLNNNGNHGD SSNEGGGGNG SGRGGATGSG 60

NIAGLGGSES MWSPGGGKSH DVAQAFANAL LLRNMNHVVG KGQPVVQNHR KAYQCKGDTI 120

NPMANGEDLR LSKIIRRLIN ENNPTVSLEL CSKLDQAVRT PINMGYMTCS FVWILDNMLT 180

LYKQCPPPVL EECSKTLGLI GFINRKSYPI YEEFIVKNYK SSKRMQKYMI MALRATLSCD 240

TKCELHMYAD KIMLLLKDFL ENAESADIFI VVSNTLVQFA ASYAETFECH FTDVVDIVIG 300

WQLEAGQPTD LKTHCAQVLE QLTPFFSKQI DFSYGLLDQF VEDITTLEEG EPANTAERVG 360

AFVGAFNTLL KCLARMQIFV GMPTCECIVK MAVDHLIKIM PTLHLNTEAL VNINELICIC 420

LLNNFTGLDP ILLEQVLLDQ VKRMISLTEL QRQSVLYLLL CTVRRLRARL TPSLVHFIFQ 480

SNPYMTKVRL RSPGETSYKL LLRTCQETLL IRNVPLLQQA YKYLVDDIDA CLEKLLITAP 540

RSKARKASVL LVFHLSALAA LAKQTSSIIG MYACKPSILE LLLTNCRAHE LKFWSKYPAA 600

QQAIFGLLVV HCQANHNFRT NSSLLRDQEL SAENTSPTAN SFASILRFLD SVLGQAHQLA 660

PQNLRVLLQW IQMLLRECRE KIDLLMEQEN FRGICRNIAA TASKLVPLES AACIQTVLDY 720

GLERLEKYPK LLILYRDTAL QQLQMLSTNY HAPYFQIYAQ LPLHLTLTGG ESSMPGMASR 780

RVSVWQQRIS QYSAVRDNVF RDFFDRVQKP EQDSLIHCLR ELFVRSCQVA PQDERQMNLS 840

QCTKRCQRLA IAWLQFEAAR YCVDQRLRTT VGKPQETFLG FEAIIMRHAR LLSGCAKEIE 900

RSALDDLSLE ELLSMQSNLS LLLGFLDALE KLIYNAAEGS AFALRPPEKQ VAAFFRLNNP 960

TCQSWFNRIR IGVVIIAMHV QQPELVIRYA QQILVNSKTQ DPTYSQAIVY MAWSLVSCQE 1020

ADSLRGLRLW ARGKSCKSYK WLKYAADQAA GKRESALAGY RTILAEKELQ SELEPHTRQF 1080

VVSQMMQCLQ DLGQWSQLVE LKQQQMTRPE DRELNPFLQR SNVEVNALER LLAKSEESCS 1140

SMDALGGVFQ QLSLWPSNWD ESVSSSGLSE RASFSSIHMR QRTEDIVLHK LLEDRCVPDQ 1200

AKNLLDTQWR DSLLNPSFDQ RSCKELTLLR HIVQGVSGGQ ELSLLPVSSG RCQNRSKFIS 1260

SAILMRCLAW TQLLRQHCAP GSWETLCLDA AAAAREEGNL QLAETLLTQF FGQPIGEIAA 1320

LFSLEQGVQT DNPEMLRGYS ELVKCLHLQQ QQSQTHSGDL SSSIDVCAAL CLNIQKSNNQ 1380

PAAGADLLLN LADWIAVRTC NGLTTNQSPV LIQLLDQLPE CPLTCDSSQP LAIPQAERMV 1440

ARLVHSCLQQ RPNYAEALIA YGNWCYRWGK KVADSCCVLT QADATAISQA LDIPQPLESE 1500

KLDELLQALS TEQPPANCVE VCPDAARARD DEAAKNRLRR LTFLADKTPE ALDAILQIWR 1560

RAIANTYDYY KDAARSYFQY LSFKSGSGPE KPEGEGVVSQ RERLHVDDSN LVTTTLRLLR 1620

LIVKHASGLQ EVLEQGLHTT PIAPWKVIIP QLFSRLNHHE PYVRKSVCDL LCRLAKSRPQ 1680

LVIFPAVVGA NREQQDATAP PATARPTTED ACCYGYLLGE LSKQAPEAVQ HVKLMVKELR 1740

RVCLLWDEYW IHSLAHIYNT YVSRVSALAT DFRPDDHEGK NNRFNVWRPQ LLADLEALVA 1800

VTSRPPETTY ERSFRKRFDA PIRLTVDALR HRRYPEAWDK LKQLYHILQS NMIRGSGSTL 1860

KMQSISPVLC GIGRMRISMP GLDAHGPDGD QVYIESVESS VCVLPTKTKP KKVAFYGSNG 1920

QRYTFLFKGM EDLHLDERIM QFLSISNAIM ACRSDAPGNG CYRAHHYSVI PLGPQSGLIS 1980

WVDGVTPVFA LYKKWQQRRS QVAGNAGAGA VANVPRRFTD LFYNKLSPLL AKHNMQVSDP 2040

RRQWPISVLL QVLDELSQET PNDLLARELW CQAGNAAEWR QSVRRFVRCM SVMSMIGYVI 2100

GLGDRHLDNV LINLGSGDIV HIDYNVCFEK GRTLRIPEKV PFRLTQNLVQ AMGITGIEGP 2160

FRLGCEYVLK VMRKERETLL TLLEAFVYDP LVDWTTNDDA QALRRSLNAK LQESADGGGA 2220

GGLGVGDLKY HKKDKNKGKP LDSDVKRQPF LSKLGMLQKY WSTNKTELMP QLEEMEQEVG 2280

NLQAAQAKQV VAEEELVKLN QRSALIAEIK SLGTAIESHS FNTASLRNAV RRGHSEALAL 2340

LSTERLPDFG RVQCILRSYG QCLQLYHLLD LQGQLVKLQM ESNSENAREF SALTEALQLS 2400

GLDSMRSQLN ELLGRMDMVA QKSSKHLQEY AGVMNFYPEQ SHRQNLFVRF HDSFATYIQN 2460

GYTADSTTNT NSPSSSIICK ADVVGVAEAM EYSWERLGCQ LHEASKLYAA NQAQALTLGA 2520

PTTALLSMIV QSGCSQLLLK ASLVRTLDRA GGAFAAYEQV ALASHDDGLL HHQLLFIHLV 2580

RTMLQGVLVM TKEEDQHLAQ LESLLSALSH LKKMFEYDLP ANLYRLLLLQ PNLGKLSALC 2640

HLSASSLAQL FLEATMENGH KPPDQFPVER RFLLTLQPVY DQFLLASTSL DSLVSSMQSM 2700

LEDVHDVQTQ QIMELGLMRS CHTELNDECF FGLVSEALES SRTCDVREMA RPMLGFIHRL 2760

QVEKLAGLLP ILTRNFYTAV GPQCLPTASC GDPAQADHLC ESLFISLQSD GALLQQQAEI 2820

ALLSQQVDLH TLAASAQYWA YSEALGSQLR CGPHIVSRPK LTAAIGECWL ELDQKLTALQ 2880

QLQAGLESQL SQLQTQRSNW NRNHIDNLLR MEQCNKQRTM SHVALLQKMT DGAGAVARLE 2940

QNAIVVGEEG QALVDHLEQW LAAHGQWQAS SSRISAVEQS MVELLDPEGA IDHYWLENVQ 3000

GLLEEQTCKV HREIAAIEGE QQSKHRFICT LLKETLRLLE NMPRFHVQSL CSEAQAQGQG 3060

KMEYANVQLL SDHLREGQGL MQSLYMRLQE LRKDICSDRR VLQPSMLQNW RHQLEMILTL 3120

AKQEVNEFFK GLEDFMQHAG ETDSYEIFTH AKGSGNVHEQ KRNAYGVSVW KKIRMKLEGR 3180

DPDSNQRSTV AEQVDYVIRE ACNPENLAVL YEGWTPWV 3218

Nucleotide Sequence
(FASTA)

ATGAAGAACG CGATCCACCC AGAAAACTGC AATGGAGCTG GAACCGAGGA GGAGGCGTCC 60

TCCGCGTTCC ACGCGGAAAT TGACCGCGTT CTGCTGAACA ACAATGGCAA TCACGGTGAC 120

AGCAGCAACG AAGGCGGCGG TGGTAATGGC AGCGGGAGGG GTGGCGCCAC CGGAAGCGGC 180

AATATCGCCG GCTTGGGAGG CAGTGAATCC ATGTGGTCAC CTGGTGGTGG TAAGTCGCAC 240

GACGTTGCGC AGGCGTTCGC CAACGCACTG CTGCTGCGCA ACATGAACCA TGTTGTGGGC 300

AAAGGGCAGC CAGTGGTCCA AAATCACCGA AAGGCTTACC AATGCAAAGG CGATACGATC 360

AACCCGATGG CCAATGGCGA AGATCTGCGT CTGTCCAAGA TCATCCGCAG GCTAATCAAC 420

GAGAACAATC CCACCGTGTC TCTGGAGCTG TGCAGCAAAC TGGATCAAGC AGTGCGCACG 480

CCTATCAACA TGGGCTACAT GACATGCTCC TTCGTGTGGA TTCTGGACAA CATGCTCACC 540

CTATACAAGC AATGCCCGCC GCCGGTTCTA GAGGAGTGCA GCAAGACTCT CGGCCTGATT 600

GGCTTTATCA ACCGCAAGTC GTATCCCATT TACGAGGAGT TTATCGTGAA GAACTACAAG 660

AGTAGCAAGC GCATGCAGAA GTACATGATC ATGGCCCTCC GCGCCACACT GAGCTGCGAC 720

ACCAAGTGCG AGCTGCACAT GTACGCCGAC AAAATCATGC TGCTGCTGAA GGATTTTCTG 780

GAGAATGCAG AGAGCGCCGA TATCTTTATT GTCGTCAGCA ACACGCTAGT GCAGTTTGCA 840

GCCAGCTATG CGGAGACTTT CGAGTGCCAC TTCACCGACG TAGTGGACAT CGTTATCGGC 900

TGGCAACTGG AGGCCGGCCA GCCCACGGAC CTGAAGACCC ACTGTGCCCA GGTACTGGAG 960

CAGTTGACGC CGTTCTTTAG CAAGCAGATC GATTTCAGTT ACGGATTGTT GGACCAGTTT 1020

GTCGAGGATA TCACCACGCT GGAGGAAGGG GAACCCGCAA ACACAGCGGA GCGTGTGGGT 1080

GCCTTCGTTG GTGCCTTTAA CACGCTGCTT AAGTGCCTGG CCCGCATGCA GATATTCGTG 1140

GGCATGCCCA CCTGTGAATG CATCGTAAAG ATGGCCGTGG ATCATCTAAT CAAAATAATG 1200

CCCACCCTGC ACTTGAATAC GGAGGCATTG GTCAATATAA ACGAACTGAT CTGCATCTGT 1260

CTGTTGAATA ACTTTACCGG CCTTGATCCG ATATTGTTGG AGCAGGTGCT GCTTGATCAG 1320

GTCAAACGGA TGATTTCTCT GACAGAGCTG CAGCGTCAGA GTGTCCTTTA TCTGCTGCTT 1380

TGCACGGTGA GAAGGTTGCG AGCACGTTTA ACGCCTAGCC TGGTGCACTT TATATTCCAA 1440

TCCAATCCCT ATATGACGAA GGTGAGGCTC CGATCGCCAG GTGAAACTTC TTACAAGCTG 1500

CTATTGCGCA CATGCCAGGA GACACTGCTC ATCCGGAATG TGCCGCTGCT TCAGCAGGCG 1560

TATAAATATC TTGTAGACGA CATTGACGCC TGTCTAGAAA AACTGCTTAT CACTGCACCG 1620

AGAAGTAAAG CCAGAAAGGC GAGTGTTCTG CTCGTTTTCC ATCTGTCCGC TTTGGCTGCC 1680

CTGGCTAAGC AAACATCTTC CATCATTGGC ATGTACGCAT GCAAGCCCTC GATTCTGGAG 1740

CTGCTCCTCA CCAACTGCAG GGCCCACGAG CTGAAATTCT GGAGCAAATA TCCCGCAGCT 1800

CAACAGGCCA TTTTCGGTCT GCTCGTGGTC CACTGCCAGG CGAATCACAA CTTCCGCACC 1860

AACTCGAGCT TGCTTCGTGA TCAGGAACTA TCGGCAGAGA ATACCTCGCC AACGGCAAAC 1920

AGTTTCGCTA GCATACTTCG CTTCTTGGAT TCGGTTCTCG GACAGGCTCA CCAGCTGGCG 1980

CCGCAAAACC TAAGGGTATT ACTGCAGTGG ATACAGATGC TCTTGAGGGA ATGCCGCGAG 2040

AAGATTGATC TCCTTATGGA ACAGGAGAAC TTCCGTGGAA TATGCCGCAA CATTGCGGCC 2100

ACCGCCTCCA AATTGGTACC CTTGGAAAGT GCTGCATGCA TCCAAACAGT CCTGGACTAC 2160

GGCCTGGAAA GGCTAGAAAA ATATCCGAAG CTACTGATCC TGTACCGCGA TACGGCGCTA 2220

CAGCAGCTAC AGATGCTCTC CACGAATTAC CATGCACCCT ATTTCCAAAT CTACGCCCAG 2280

TTGCCATTGC ATCTTACCCT CACCGGCGGT GAATCATCAA TGCCGGGGAT GGCGAGCAGA 2340

CGAGTTAGCG TTTGGCAGCA AAGGATTAGC CAATATAGTG CAGTACGCGA CAACGTCTTC 2400

CGCGATTTCT TTGACCGTGT ACAGAAACCG GAGCAAGATT CACTGATCCA CTGTCTGCGC 2460

GAGCTGTTCG TTCGTAGCTG CCAGGTGGCT CCGCAGGATG AACGACAAAT GAATCTGTCG 2520

CAGTGCACCA AGCGCTGCCA GCGATTGGCC ATCGCCTGGC TGCAATTCGA AGCAGCCAGA 2580

TACTGTGTGG ATCAGCGACT GCGCACAACT GTGGGAAAGC CTCAGGAAAC GTTCCTCGGA 2640

TTCGAGGCCA TTATCATGCG GCATGCCAGA TTGCTGAGTG GCTGTGCCAA GGAGATAGAG 2700

CGCTCAGCCC TGGACGACCT GTCGTTGGAG GAGCTCCTGA GCATGCAAAG CAATCTCAGT 2760

CTGCTGTTAG GCTTCCTCGA TGCGCTAGAG AAGCTCATCT ACAACGCCGC CGAGGGAAGC 2820

GCCTTTGCGC TGCGTCCCCC GGAAAAGCAA GTGGCTGCCT TCTTCCGCCT GAACAATCCC 2880

ACTTGTCAGT CCTGGTTCAA TCGTATCCGT ATTGGTGTGG TCATCATTGC CATGCATGTG 2940

CAGCAGCCGG AACTGGTTAT CCGATATGCC CAGCAAATTC TGGTTAACTC AAAGACGCAA 3000

GATCCCACCT ACAGTCAGGC CATCGTTTAC ATGGCCTGGT CATTGGTCAG TTGCCAAGAA 3060

GCGGACTCGC TGCGAGGTCT GCGCCTGTGG GCTCGTGGCA AGAGCTGCAA ATCCTACAAG 3120

TGGCTAAAGT ACGCAGCGGA TCAGGCGGCC GGAAAACGGG AATCTGCACT TGCCGGCTAC 3180

AGAACTATCC TGGCCGAGAA GGAGCTGCAA TCCGAACTGG AGCCGCATAC GCGACAGTTT 3240

GTTGTGTCGC AGATGATGCA GTGCTTGCAG GATCTGGGTC AGTGGTCGCA GCTGGTGGAG 3300

CTGAAGCAGC AGCAGATGAC GCGACCGGAG GACAGAGAAC TGAATCCCTT TCTGCAACGC 3360

AGCAATGTGG AGGTAAATGC ACTGGAACGG CTCTTGGCCA AGAGCGAGGA ATCGTGCTCC 3420

TCGATGGACG CGTTAGGAGG AGTCTTCCAG CAGTTGAGCC TCTGGCCAAG CAACTGGGAC 3480

GAGTCTGTGT CATCAAGTGG CTTAAGCGAA CGTGCCAGCT TCTCATCCAT CCATATGCGT 3540

CAACGAACCG AGGATATTGT GCTGCACAAG CTATTAGAAG ATCGTTGTGT GCCAGATCAG 3600

GCGAAAAACC TACTGGACAC CCAATGGCGA GACAGTCTTC TGAATCCCAG CTTTGATCAG 3660

AGATCCTGCA AGGAGCTCAC CCTGCTACGG CACATAGTCC AAGGTGTCAG TGGCGGTCAG 3720

GAGTTGTCCC TGCTGCCCGT GTCCTCGGGG AGATGTCAAA ACCGCTCCAA ATTCATTTCC 3780

AGCGCAATTT TAATGCGCTG CCTGGCATGG ACACAATTGC TCCGTCAGCA TTGTGCGCCT 3840

GGCAGCTGGG AAACGCTTTG CTTGGACGCA GCTGCTGCGG CGCGAGAGGA AGGCAATCTC 3900

CAGCTAGCGG AAACCCTACT CACCCAGTTC TTTGGTCAGC CAATTGGTGA GATAGCCGCT 3960

CTGTTTTCAC TGGAACAGGG AGTGCAGACG GATAATCCGG AAATGCTTCG CGGCTACAGT 4020

GAGCTGGTCA AGTGCCTGCA TCTTCAGCAG CAGCAATCGC AGACACACAG CGGCGATTTA 4080

AGTTCTTCGA TTGATGTATG CGCCGCCCTA TGCCTGAATA TCCAGAAGAG CAACAATCAA 4140

CCGGCCGCGG GTGCTGATCT CTTGCTTAAT CTCGCCGATT GGATAGCCGT CCGGACTTGC 4200

AATGGCTTGA CCACCAATCA GTCGCCAGTA TTGATTCAAC TGCTGGATCA GCTCCCGGAA 4260

TGTCCGCTGA CATGTGACTC CAGCCAACCG TTGGCGATTC CCCAAGCCGA ACGTATGGTT 4320

GCCCGCCTGG TCCATTCTTG TTTACAGCAG CGTCCCAACT ACGCGGAAGC TTTGATAGCC 4380

TACGGCAATT GGTGCTATCG ATGGGGCAAG AAAGTCGCGG ACAGCTGCTG TGTGCTCACC 4440

CAGGCCGATG CGACGGCTAT TAGCCAGGCG CTGGACATTC CCCAGCCGTT GGAAAGCGAA 4500

AAATTGGATG AGCTCCTCCA GGCACTGAGC ACGGAACAGC CTCCGGCGAA CTGTGTAGAG 4560

GTGTGTCCGG ATGCGGCTCG TGCCCGCGAC GATGAGGCGG CCAAGAACCG TCTGCGTCGG 4620

CTGACCTTTT TGGCGGATAA AACGCCGGAA GCGCTGGATG CCATTTTGCA GATCTGGCGA 4680

CGGGCCATAG CCAACACATA TGATTATTAC AAGGATGCAG CGCGTTCGTA CTTCCAATAT 4740

CTTAGCTTTA AATCGGGCTC GGGTCCGGAG AAGCCTGAAG GAGAAGGAGT CGTATCGCAG 4800

CGGGAACGTT TACATGTGGA TGATAGCAAC CTGGTGACAA CGACGCTTCG TCTCCTACGC 4860

TTGATTGTGA AGCACGCCAG CGGTCTGCAG GAAGTTCTGG AACAGGGACT GCACACCACG 4920

CCCATTGCCC CCTGGAAAGT GATCATTCCG CAGCTATTCA GCCGACTGAA TCACCACGAA 4980

CCCTATGTGC GAAAGAGCGT TTGTGATCTG CTCTGTCGCC TGGCCAAGAG TCGCCCCCAG 5040

CTGGTTATCT TTCCGGCCGT CGTCGGTGCC AATAGGGAGC AACAGGATGC AACAGCACCG 5100

CCAGCAACAG CGCGACCAAC CACGGAGGAC GCCTGCTGCT ATGGCTATCT GCTGGGAGAG 5160

CTCTCGAAAC AGGCGCCGGA GGCAGTGCAG CATGTGAAGC TGATGGTGAA GGAGCTGCGT 5220

CGCGTTTGCC TGCTGTGGGA CGAGTACTGG ATCCACTCGC TGGCCCACAT CTACAATACG 5280

TATGTGAGTC GTGTGAGTGC GCTGGCAACC GATTTCCGTC CGGACGATCA CGAGGGCAAG 5340

AATAACCGCT TCAATGTCTG GCGACCGCAA TTGCTCGCCG ATCTGGAAGC CCTGGTCGCG 5400

GTCACCTCTC GTCCGCCGGA GACCACCTAT GAGCGTAGTT TCCGCAAGCG TTTCGATGCT 5460

CCCATACGGC TCACCGTGGA TGCACTGCGT CATCGACGCT ATCCGGAGGC ATGGGATAAG 5520

CTGAAGCAGC TGTACCACAT CTTGCAATCG AACATGATCC GCGGCTCGGG CAGCACGCTC 5580

AAAATGCAGA GCATAAGCCC GGTGCTCTGT GGCATTGGAC GCATGCGTAT CTCCATGCCA 5640

GGCCTGGATG CACATGGGCC GGATGGGGAT CAGGTATATA TCGAGAGCGT CGAGAGTTCG 5700

GTTTGCGTTT TGCCCACCAA GACGAAACCC AAAAAGGTCG CCTTTTACGG CAGCAATGGT 5760

CAGCGCTACA CTTTCCTGTT CAAGGGCATG GAGGATCTCC ATCTGGACGA ACGCATCATG 5820

CAGTTCCTGT CCATCTCGAA TGCCATTATG GCCTGCCGCA GCGACGCACC CGGCAATGGC 5880

TGCTATCGTG CCCACCACTA TTCGGTTATA CCATTGGGAC CGCAATCCGG ACTGATTAGC 5940

TGGGTGGACG GGGTCACACC AGTCTTTGCG CTCTACAAGA AGTGGCAACA GAGACGGTCC 6000

CAAGTTGCTG GGAATGCGGG AGCAGGTGCT GTGGCAAATG TCCCGCGACG TTTCACAGAC 6060

TTGTTCTACA ACAAACTCTC GCCCCTGTTG GCCAAGCACA ATATGCAGGT GAGCGATCCA 6120

CGACGCCAAT GGCCAATATC CGTCCTGCTC CAGGTGCTCG ACGAATTGTC ACAGGAAACA 6180

CCCAATGATC TGCTTGCCCG CGAACTGTGG TGCCAGGCGG GAAATGCCGC CGAGTGGCGG 6240

CAATCGGTGC GTCGCTTTGT CCGCTGCATG TCGGTCATGT CGATGATTGG CTATGTCATT 6300

GGCCTGGGCG ATCGTCATTT GGACAACGTG CTTATCAACC TGGGAAGCGG CGACATCGTG 6360

CATATCGACT ACAACGTGTG CTTCGAGAAG GGCCGCACCC TGCGCATCCC CGAGAAGGTG 6420

CCCTTCCGTC TTACCCAGAA TCTAGTGCAG GCCATGGGCA TCACAGGAAT CGAGGGCCCC 6480

TTCCGCTTGG GCTGTGAATA TGTACTGAAG GTGATGCGCA AGGAGCGCGA AACGCTGCTG 6540

ACCCTGCTGG AGGCCTTCGT CTACGATCCT CTGGTTGATT GGACCACCAA CGACGATGCT 6600

CAGGCACTGC GCCGATCGCT GAACGCCAAA CTCCAGGAGT CGGCTGACGG TGGAGGAGCA 6660

GGTGGTCTGG GTGTCGGAGA TCTTAAGTAC CACAAGAAGG ACAAGAATAA GGGAAAGCCA 6720

CTTGATTCGG ATGTCAAGCG ACAGCCCTTC CTAAGCAAAC TGGGCATGCT GCAAAAGTAC 6780

TGGTCCACCA ACAAGACTGA GCTGATGCCG CAGCTGGAGG AGATGGAGCA GGAGGTGGGC 6840

AACCTGCAGG CGGCACAGGC CAAGCAAGTG GTGGCCGAGG AGGAGCTCGT GAAGCTCAAC 6900

CAGCGCAGCG CCCTAATTGC CGAAATCAAA TCGCTGGGCA CGGCGATCGA GAGCCATAGT 6960

TTCAATACGG CCTCGCTGCG TAATGCCGTT CGTCGTGGTC ACTCGGAGGC ACTGGCATTG 7020

CTTAGTACGG AACGATTGCC GGACTTTGGC CGCGTGCAGT GTATACTCAG AAGTTATGGT 7080

CAATGCCTGC AGCTGTACCA TCTGCTTGAT CTGCAGGGCC AGCTCGTTAA GCTGCAAATG 7140

GAGTCGAATT CCGAGAATGC CAGGGAATTT TCTGCGCTGA CAGAGGCTCT ACAGCTATCC 7200

GGACTGGACA GCATGCGCAG CCAGTTGAAT GAGCTACTGG GCCGCATGGA CATGGTGGCA 7260

CAGAAGAGTT CCAAGCATCT GCAAGAGTAT GCAGGAGTCA TGAACTTCTA TCCGGAACAA 7320

AGCCACCGGC AAAACCTATT CGTTCGCTTT CACGACAGCT TTGCGACGTA CATCCAGAAC 7380

GGTTACACTG CGGACTCAAC CACCAATACC AATTCGCCGT CCAGTTCCAT TATTTGTAAG 7440

GCAGATGTCG TGGGCGTCGC GGAGGCCATG GAGTACTCTT GGGAGCGGCT CGGCTGCCAA 7500

TTGCATGAGG CCTCGAAGCT TTATGCCGCC AATCAGGCGC AGGCTCTAAC TCTCGGTGCA 7560

CCCACGACTG CTTTGCTGAG CATGATTGTC CAGAGTGGCT GCAGCCAGCT GCTGCTCAAG 7620

GCAAGCTTGG TTCGTACTCT GGATCGCGCT GGCGGAGCAT TCGCGGCTTA CGAACAGGTG 7680

GCACTGGCCA GCCACGACGA TGGACTGCTG CATCACCAGC TGCTCTTTAT TCACCTGGTG 7740

CGCACCATGT TGCAAGGAGT TTTGGTGATG ACCAAGGAGG AGGATCAGCA TCTTGCACAA 7800

TTGGAGAGCC TACTTTCAGC GCTGTCGCAT CTGAAGAAGA TGTTTGAGTA CGACTTGCCA 7860

GCCAACTTAT ATCGATTGCT CCTGCTGCAA CCCAATCTGG GCAAATTGAG TGCCTTGTGC 7920

CATTTGAGTG CCTCCAGCCT GGCTCAGCTG TTTTTGGAAG CCACAATGGA GAATGGACAT 7980

AAGCCGCCGG ATCAGTTCCC AGTAGAGCGC AGATTTCTGC TAACTCTGCA GCCCGTCTAC 8040

GATCAGTTCC TTTTGGCCTC CACATCGTTG GACTCGCTGG TTAGCAGCAT GCAATCGATG 8100

CTCGAAGATG TCCACGATGT GCAGACCCAA CAAATAATGG AACTGGGTCT AATGAGGTCC 8160

TGTCATACGG AACTGAACGA CGAGTGCTTC TTCGGCCTGG TCAGTGAGGC ATTGGAGTCC 8220

AGTCGCACTT GTGATGTGCG TGAAATGGCC CGACCTATGT TGGGCTTCAT CCATCGCCTC 8280

CAAGTTGAGA AACTTGCAGG TCTGCTGCCG ATCCTTACGC GAAACTTCTA CACCGCCGTC 8340

GGTCCGCAAT GTCTACCCAC CGCCAGCTGT GGGGACCCAG CTCAAGCGGA CCACCTGTGC 8400

GAGAGTCTCT TCATTTCGCT GCAATCGGAC GGCGCTTTGC TGCAGCAGCA GGCGGAAATT 8460

GCACTGCTCA GTCAGCAAGT GGACCTGCAC ACCCTGGCCG CATCCGCTCA ATATTGGGCC 8520

TATTCGGAGG CACTGGGCAG CCAGTTGCGC TGTGGCCCCC ACATTGTCAG CCGCCCAAAA 8580

CTAACCGCCG CCATTGGCGA ATGTTGGCTG GAGTTGGACC AAAAACTGAC CGCCTTGCAG 8640

CAACTACAAG CTGGCCTCGA GTCGCAACTC AGCCAGTTGC AGACGCAGCG CAGTAACTGG 8700

AATCGTAATC ACATAGACAA CCTGCTGCGC ATGGAGCAGT GTAACAAACA GAGGACAATG 8760

TCTCATGTGG CGCTGTTGCA AAAGATGACT GATGGAGCCG GTGCGGTAGC CCGCCTGGAG 8820

CAAAATGCGA TAGTTGTGGG CGAGGAGGGG CAGGCACTGG TTGACCACTT GGAACAATGG 8880

CTGGCTGCGC ACGGGCAATG GCAGGCGAGC AGCTCAAGGA TCAGCGCCGT GGAGCAGTCG 8940

ATGGTGGAGC TCTTGGACCC GGAAGGTGCC ATCGATCACT ATTGGCTTGA GAATGTGCAG 9000

GGATTGTTGG AGGAGCAGAC CTGCAAGGTG CACCGCGAGA TTGCGGCAAT AGAAGGCGAA 9060

CAGCAGAGCA AGCACCGTTT CATTTGCACC TTGCTCAAGG AGACTCTGCG CCTGCTGGAA 9120

AACATGCCAC GCTTCCATGT ACAAAGCCTG TGCTCCGAGG CCCAGGCACA GGGTCAAGGC 9180

AAAATGGAGT ATGCGAATGT GCAGCTACTA TCCGACCACC TCCGCGAAGG CCAGGGCCTG 9240

ATGCAGTCCC TCTATATGCG GCTGCAGGAG CTGCGAAAGG ATATCTGCTC CGATCGTCGC 9300

GTTCTGCAGC CTTCAATGCT GCAAAACTGG CGTCACCAGC TGGAGATGAT CTTGACGTTA 9360

GCCAAACAGG AGGTAAACGA GTTCTTCAAG GGCCTGGAGG ACTTCATGCA GCACGCAGGC 9420

GAAACGGACT CGTACGAAAT CTTCACGCAT GCCAAAGGTT CTGGCAATGT GCATGAGCAG 9480

AAGCGAAATG CGTATGGCGT GTCTGTGTGG AAGAAGATTA GGATGAAGCT GGAGGGCCGA 9540

GATCCAGATA GCAACCAGCG CAGCACCGTC GCCGAACAGG TGGACTATGT CATTCGCGAG 9600

GCCTGCAATC CGGAAAACCT GGCCGTGCTC TACGAGGGCT GGACGCCATG GGTATAA 9657

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         i +++ +v +l++k+kpkk+ + Gs+g+ y +L+kg eDl+ der++q++s+ N ++a +

Q: 1894  IESVESSVCVLPTKTKPKKVAFYGSNGQRYTFLFKGMEDLHLDERIMQFLSISNAIMACR  1953

         6788999***************************************************88

S: 61    kets.rrkLkirtykVvplstrsgliewventvsLkellkklvekk.avlldqpi.....  113

         +    +    + +y+V+pl+++sgli wv++ +++++l+kk+++++ +v+ +  +

Q: 1954  SDAPgNGCYRAHHYSVIPLGPQSGLISWVDGVTPVFALYKKWQQRRsQVAGNAGAgavan  2013

         8775166799********************************776614554433344433

S: 114   .syrykdlstvqar....kpklkhlkls............levfkevlenlvpkdllkkl  156

          ++r +dl  ++      k++++                 l+v+ e  ++ +p+dll+++

Q: 2014  vPRRFTDLFYNKLSpllaKHNMQ----VsdprrqwpisvlLQVLDELSQE-TPNDLLARE  2068

         33444443333333333333333....2556699**99999999999999.9********

S: 157   llekfpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvaf  216

         l+ +  +++ew ++ + + r + v+s++gy++gLgdrhl+n+li+  +g +vhid++v+f

Q: 2069  LWCQAGNAAEWRQSVRRFVRCMSVMSMIGYVIGLGDRHLDNVLINLGSGDIVHIDYNVCF  2128

         ************************************************************

S: 217   ekaktqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevfl  276

         ek++t l++pekvPFRLT+n+v+a+g+tg+eG+fr  ce vl+v+r+++e+llt+Le+f+

Q: 2129  EKGRT-LRIPEKVPFRLTQNLVQAMGITGIEGPFRLGCEYVLKVMRKERETLLTLLEAFV  2187

         *****.******************************************************

S: 277   ydplvdwkkkkktsketeeelaek  300

         ydplvdw+  + + +   ++l++k

Q: 2188  YDPLVDWTT-NDDAQALRRSLNAK  2210

         ********7.33334444444444

Domain Sequence
(FASTA)

IESVESSVCV LPTKTKPKKV AFYGSNGQRY TFLFKGMEDL HLDERIMQFL SISNAIMACR 60

SDAPGNGCYR AHHYSVIPLG PQSGLISWVD GVTPVFALYK KWQQRRSQVA GNAGAGAVAN 120

VPRRFTDLFY NKLSPLLAKH NMQVSDPRRQ WPISVLLQVL DELSQETPND LLARELWCQA 180

GNAAEWRQSV RRFVRCMSVM SMIGYVIGLG DRHLDNVLIN LGSGDIVHID YNVCFEKGRT 240

LRIPEKVPFR LTQNLVQAMG ITGIEGPFRL GCEYVLKVMR KERETLLTLL EAFVYDPLVD 300

WTTNDDAQAL RRSLNAK 317

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Manganese; Metal-binding; Nonsense-mediated mRNA decay; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007274	; P:neuromuscular synaptic transmission
GO:0000184	; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0006950	; P:response to stress
GO:0050808	; P:synapse organization
GO:0048489	; P:synaptic vesicle transport

KEGG

dme:Dmel_CG32743

;

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR014009	; PIK_FAT.
IPR026683	; TOR/Smg1.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; FALSE_NEG.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013