EKS-CAE-00233

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00233

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PDK1	361.9	3.6E-108	69	362	294

Status

Reviewed

Ensembl Protein

H42K12.1a

UniProt Accession

Q9Y1J3; Q9UA36;

Protein Name

3-phosphoinositide-dependent protein kinase 1

Protein Synonyms/Alias

Pdk-class protein kinase 1;

Gene Name

pdk-1

Gene Synonyms/Alias

pdk-1; H42K12.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
H42K12.1	H42K12.1a	H42K12.1a
H42K12.1	H42K12.1b	H42K12.1b

Organism

Caenorhabditis elegans

Functional Description

Involved in the daf-2/insulin receptor-like transductionpathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates and activates sgk-1, akt-1 and akt-2.

Protein Length

632

Protein Sequence
(FASTA)

MEDLTPTNTS LDTTTTNNDT TSDREAAPTT LNLTPTASES ENSLSPVTAE DLIAKSIKEG 60

CPKRTSNDFM FLQSMGEGAY SQVFRCREVA TDAMFAVKVL QKSYLNRHQK MDAIIREKNI 120

LTYLSQECGG HPFVTQLYTH FHDQARIYFV IGLVENGDLG ESLCHFGSFD MLTSKFFASE 180

ILTGLQFLHD NKIVHRDMKP DNVLIQKDGH ILITDFGSAQ AFGGLQLSQE GFTDANQASS 240

RSSDSGSPPP TRFYSDEEEE NTARRTTFVG TALYVSPEML ADGDVGPQTD IWGLGCILFQ 300

CLAGQPPFRA VNQYHLLKRI QELDFSFPEG FPEEASEIIA KILVRDPSTR ITSQELMAHK 360

FFENVDWVNI ANIKPPVLHA YIPATFGEPE YYSNIGPVEP GLDDRALFRL MNLGNDASAS 420

QPSTPSNVEH RGDPFVSEIA PRANSEAEKN RAARAQKLEE QRVKNPFHIF TNNSLILKQG 480

YLEKKRGLFA RRRMFLLTEG PHLLYIDVPN LVLKGEVPWT PCMQVELKNS GTFFIHTPNR 540

VYYLFDLEKK ADEWCKAIND VRKRYSVTIE KTFNSAMRDG TFGSIYGKKK SRKEMMREQK 600

ALRRKQEKEE KKALKAEQVS KKLSMQMDKK SP 632

Nucleotide Sequence
(FASTA)

ATGGAGGATC TCACACCAAC TAACACGTCG CTCGACACCA CAACTACTAA CAATGACACG 60

ACATCGGATC GTGAAGCGGC GCCAACGACG CTCAACTTAA CACCAACAGC AAGTGAATCG 120

GAGAACAGCT TATCCCCAGT CACCGCCGAA GATCTCATAG CTAAAAGCAT TAAAGAAGGA 180

TGTCCGAAGA GAACTTCCAA CGACTTCATG TTTCTTCAGA GTATGGGCGA AGGAGCCTAC 240

AGCCAGGTAT TCCGATGTCG CGAAGTGGCA ACAGATGCGA TGTTCGCCGT CAAAGTGCTC 300

CAGAAGTCGT ACCTCAACCG CCATCAAAAA ATGGACGCAA TCATTCGCGA GAAGAATATC 360

TTAACATACC TGTCACAAGA ATGCGGTGGT CATCCGTTTG TCACACAGCT CTACACACAT 420

TTTCACGACC AGGCTAGAAT TTATTTCGTG ATCGGACTTG TTGAAAATGG TGATCTTGGC 480

GAGTCGCTGT GCCATTTTGG ATCATTCGAC ATGCTCACCT CAAAATTCTT TGCCTCGGAA 540

ATCCTCACCG GACTGCAATT CCTACACGAC AACAAAATTG TGCACAGAGA CATGAAGCCG 600

GACAATGTGC TCATCCAGAA AGACGGTCAC ATTCTCATCA CAGATTTTGG AAGTGCCCAG 660

GCGTTTGGCG GTCTCCAACT GTCACAGGAG GGCTTTACGG ATGCGAATCA GGCAAGCTCG 720

CGATCTTCGG ATTCTGGATC GCCGCCGCCA ACTCGATTCT ATTCGGATGA GGAGGAAGAG 780

AACACTGCTC GACGTACCAC ATTTGTTGGA ACTGCTCTCT ACGTGAGCCC GGAGATGCTA 840

GCTGACGGAG ATGTGGGACC ACAAACCGAC ATTTGGGGAT TGGGATGTAT CCTTTTCCAG 900

TGTCTAGCCG GACAGCCACC ATTCAGAGCC GTCAACCAGT ACCATCTTTT GAAAAGAATC 960

CAGGAGTTGG ATTTCTCGTT CCCAGAAGGA TTTCCAGAGG AAGCGTCGGA AATTATCGCA 1020

AAGATTTTGG TGCGCGACCC GAGTACCCGT ATCACCAGTC AAGAACTTAT GGCTCACAAG 1080

TTTTTTGAAA ACGTTGACTG GGTGAACATT GCAAATATCA AGCCACCAGT CCTGCACGCC 1140

TACATTCCAG CCACATTTGG CGAGCCGGAG TACTACTCTA ACATTGGGCC TGTCGAGCCG 1200

GGACTTGATG ATCGTGCCTT GTTCCGTTTG ATGAATTTGG GAAATGATGC TAGCGCATCA 1260

CAGCCATCAA CACCGTCTAA CGTGGAACAT CGCGGAGACC CATTTGTTTC GGAAATTGCA 1320

CCACGCGCCA ATTCGGAAGC CGAAAAGAAC CGCGCCGCAC GTGCGCAGAA GCTCGAAGAG 1380

CAACGTGTCA AAAACCCATT CCACATCTTC ACCAACAACT CGCTCATTTT GAAACAAGGA 1440

TATTTGGAAA AGAAGCGAGG ATTGTTTGCC AGACGCCGAA TGTTCCTGTT GACCGAAGGA 1500

CCGCATCTCT TGTACATTGA TGTGCCGAAT CTTGTGCTCA AAGGAGAGGT ACCATGGACG 1560

CCGTGCATGC AGGTGGAGCT AAAAAACTCG GGAACTTTCT TTATACATAC GCCCAACCGC 1620

GTCTACTACT TGTTTGATCT CGAAAAGAAA GCAGATGAGT GGTGTAAGGC TATCAATGAT 1680

GTTCGCAAGC GGTACTCGGT GACTATCGAA AAGACTTTTA ACTCTGCGAT GCGTGACGGA 1740

ACATTTGGCA GCATTTATGG AAAGAAAAAG TCCAGAAAGG AAATGATGCG TGAACAGAAG 1800

GCGCTGCGCC GCAAACAAGA AAAGGAGGAG AAAAAGGCGC TAAAAGCCGA GCAAGTGAGC 1860

AAGAAGCTTT CAATGCAAAT GGACAAGAAG TCGCCTTGA 1899

Domain Profile

S: 1     fkfekelgeGsystvvlarekeskkeyaikvlekryiikekkvkyvtrekevlakl....  56

         f+f +++geG+ys v+++re+++++++a+kvl+k+y+++++k+++++rek++l++l

Q: 69    FMFLQSMGEGAYSQVFRCREVATDAMFAVKVLQKSYLNRHQKMDAIIREKNILTYLsqec  128

         678899**************************************************9998

S: 57    nehpgivkLyatfqDeeslyfvleyakkGdllellkkvgsfdeactryyaaellsalefl  116

          +hp++++Ly++f+D++++yfv+ ++++Gdl e+l+++gsfd+++++++a+e+l++l+fl

Q: 129   GGHPFVTQLYTHFHDQARIYFVIGLVENGDLGESLCHFGSFDMLTSKFFASEILTGLQFL  188

         99**********************************************************

S: 117   hkkgiihrDlkpeniLldkdgkilitDfGsakvl..epklkedskkeeeesarsk.....  169

         h+++i+hrD+kp+n+L++kdg+ilitDfGsa+++   + ++e  ++ ++ s+rs+

Q: 189   HDNKIVHRDMKPDNVLIQKDGHILITDFGSAQAFggLQLSQEGFTDANQASSRSSdsgsp  248

         *********************************976233333334444555555556666

S: 170   ..................sfvGtaeyvsPelLtdsevskssDlWalgcilyqllaGkpPf  211

                           +fvGta yvsPe+L+d++v++++D+W+lgcil+q+laG+pPf

Q: 249   pptrfysdeeeentarrtTFVGTALYVSPEMLADGDVGPQTDIWGLGCILFQCLAGQPPF  308

         666666666666666666******************************************

S: 212   raeneylifkkilkleyafpegfpekakdlveklLvkdakerltleeikahkff  265

         ra+n+y+++k+i++l+++fpegfpe+a+++++k+Lv+d+++r+t++e++ahkff

Q: 309   RAVNQYHLLKRIQELDFSFPEGFPEEASEIIAKILVRDPSTRITSQELMAHKFF  362

         *****************************************************9

Domain Sequence
(FASTA)

FMFLQSMGEG AYSQVFRCRE VATDAMFAVK VLQKSYLNRH QKMDAIIREK NILTYLSQEC 60

GGHPFVTQLY THFHDQARIY FVIGLVENGD LGESLCHFGS FDMLTSKFFA SEILTGLQFL 120

HDNKIVHRDM KPDNVLIQKD GHILITDFGS AQAFGGLQLS QEGFTDANQA SSRSSDSGSP 180

PPTRFYSDEE EENTARRTTF VGTALYVSPE MLADGDVGPQ TDIWGLGCIL FQCLAGQPPF 240

RAVNQYHLLK RIQELDFSFP EGFPEEASEI IAKILVRDPS TRITSQELMA HKFF 294

Keyword

Alternative splicing; ATP-binding; Coiled coil; Complete proteome; Cytoplasm; Developmental protein; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0030424	; C:axon
GO:0005737	; C:cytoplasm
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0040024	; P:dauer larval development
GO:0007611	; P:learning or memory
GO:0050920	; P:regulation of chemotaxis

KEGG

cel:CELE_H42K12.1

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00233	; PH; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013