EKS-CAE-00376

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00376

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	466.6	3.6E-140	83	351	269

Status

Unreviewed

Ensembl Protein

K08B12.5.1

UniProt Accession

O01583;

Protein Name

Protein Synonyms/Alias

Protein MRCK-1;

Gene Name

mrck-1

Gene Synonyms/Alias

mrck-1; tag-59;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
K08B12.5	K08B12.5.1	K08B12.5.1
K08B12.5	K08B12.5.2	K08B12.5.2

Organism

Caenorhabditis elegans

Functional Description

Protein Length

1592

Protein Sequence
(FASTA)

MAEPPPDDSA PVRLKTLENI YMDGPSKKPE ALSFETLIDS LICLYDECCN STLRKEKCIA 60

EFVESVKTVI SKAKKLRLSR DDFEVLKVIG KGAFGEVAVV RMRGVGEIYA MKILNKWEMV 120

KRAETACFRE ERDVLVYGDR RWITNLHYAF QDEKNLYFVM DYYIGGDMLT LLSKFVDHIP 180

ESMAKFYIAE MVLAIDSLHR LGYVHRDVKP DNVLLDMQGH IRLADFGSCL RILADGSVAS 240

NVAVGTPDYI SPEILRAMED GRGRYGKECD WWSLGICMYE MLYGTTPFYS ERLVDTYGKI 300

MSHQDMLDFP DDEIDWVVSE EAKDLIRQLI CSSDVRFGRN GLSDFQLHPF FEGIDWNTIR 360

DSNPPYVPEV SSPEDTSNFD VDVCEDDFTP CLQETQPPRV LAAFTGNHLP FVGFSYTHGS 420

LLSDARSLTD EIRAIAQRCQ GDAELMEKSV DGFMVELENE KAELVQKLKE AQTIIAQHVA 480

ENPRSEEDRN YESTIAQLKD EIQILNKRLE DEALAQQQQK PKDEIVAESE KKLKELKERN 540

KQLVMEKSEI QRELDNINDH LDQVLVEKAT VVQQRDDMQA ELADVGDSLL TEKDSVKRLQ 600

DEAEKAKKQV ADFEEKLKEI ETEKIALIKK QEEVTIEARK SVETDDHLSE EVVAAKNTIA 660

SLQATNEERE TEIKKLKQRM DEERASHTAQ SEQEMKQLEA HYERAQKMLQ DNVEQMNVEN 720

RGLRDEIEKL SQQMAALPRG GLNEQQLHEI FNWVSEEKAT REEMENLTRK ITGEVESLKN 780

NSPLTTSNYI QNTPSGWGSR RMNNVARKDG LDLQRQLQAE IDAKLKLKAE LKNSQEQYLT 840

SAARLDDTEK RMASLMREVA MLKQQKNIEN SSDSAFSSTM GRGDLMISMN NDYEMSNSSL 900

MRQEMISRQS TPSYENAILL HDHQVPKRVD DLRYKQKPMK TASGIFSPVS ISAMERGHNF 960

ERMKIKTPTK CGHCTSILIG LDRQGLFCQS CQYACHVSCA ERVSQSCPVP EEERRPLGID 1020

PTRGVGTAYE GLVKTPRAGG VRKGWQTAYV VVCDFKLYLY DCTVDRQNKM QDVKNEIRLV 1080

LDMRDPDFTV CGVSEADVIH AQKGDIPKIF RVTTTQILNS SSEYSSSSKF YTLFMAETEE 1140

EKRKWVVALS ELKTLLRRSK LADRKAFLVK EVFDVTTLPS IRVAQCCAII DRSKIVIGFS 1200

DHGLYCIEIS RQLLIPVGGE KENKQRCVET VEYDEAEQLL MMIVGPAKDR HVRIVPSAAL 1260

DGRDLKWIKV NDTKGCHLLA VGTNNPGGRA GFFAVAFKKS VTIFQIDRSE KRHKKWKDLA 1320

MPGTPQSIAI FNGRLYVGFS HSFRSWSLVG VDSSPVGSGD ASGAVLQHIS LVNMEDTSLQ 1380

FLNQQTSYEA KLIVNVPGSP DEYLLVFNMI GLYVNEMGRR SRLPEVMFPT QAKYFAYHEP 1440

YLCVFSENEV DIFNVTLAEW VQTINLRSAK PLSGDGILST CLCNDSPIFV LLQNVLQDQD 1500

SIEVPVNLAS GSTDGRKVTR RKFTFRTIGK DDRSASERRS HIQISTPSDF MHIVHMGPAP 1560

VMELQQNFID LQSNHSHTSS DKDSLNRSVN ND 1592

Nucleotide Sequence
(FASTA)

ATGGCTGAAC CACCGCCCGA TGATTCGGCG CCGGTTCGCC TCAAAACCCT TGAAAATATT 60

TATATGGATG GCCCGAGCAA AAAACCCGAG GCACTTTCAT TTGAAACTTT AATAGATTCC 120

CTTATTTGTT TATACGATGA ATGCTGCAAC AGTACGTTAC GGAAGGAGAA GTGTATCGCA 180

GAATTTGTTG AATCAGTGAA AACAGTGATC AGCAAAGCGA AGAAGCTACG ATTGTCTCGA 240

GATGACTTCG AAGTTCTCAA AGTTATCGGA AAAGGAGCAT TCGGAGAAGT TGCCGTCGTA 300

AGAATGCGTG GTGTTGGTGA AATTTACGCG ATGAAAATAC TGAACAAGTG GGAAATGGTA 360

AAAAGAGCAG AAACTGCGTG TTTTCGAGAA GAACGCGATG TTCTTGTGTA CGGAGATCGA 420

CGATGGATCA CTAATTTGCA TTACGCTTTT CAAGATGAGA AGAATTTGTA TTTCGTAATG 480

GACTACTACA TTGGCGGAGA TATGCTTACT CTTTTATCAA AATTCGTAGA TCACATACCA 540

GAATCAATGG CCAAATTCTA CATTGCTGAA ATGGTTCTTG CGATTGATTC ACTTCATCGG 600

TTAGGATATG TGCATCGGGA CGTGAAGCCT GACAATGTGC TTCTCGATAT GCAAGGACAC 660

ATTCGGCTCG CTGATTTCGG AAGTTGTCTG AGGATCTTAG CCGATGGATC TGTTGCGTCG 720

AATGTTGCTG TAGGAACACC TGATTATATT TCACCTGAAA TACTCAGAGC AATGGAAGAC 780

GGCCGCGGGC GGTACGGAAA AGAATGTGAT TGGTGGTCAC TTGGTATTTG TATGTATGAA 840

ATGCTGTACG GTACAACACC GTTCTATTCG GAACGACTCG TTGACACTTA CGGTAAAATT 900

ATGAGCCATC AAGACATGCT CGACTTCCCC GATGATGAAA TCGATTGGGT TGTGTCGGAA 960

GAGGCAAAGG ATCTTATACG ACAACTTATC TGTTCGAGTG ATGTTCGATT CGGACGAAAT 1020

GGTCTCAGTG ATTTCCAGTT GCATCCGTTC TTTGAGGGAA TCGATTGGAA TACGATTCGA 1080

GATTCGAATC CACCATATGT ACCCGAGGTT TCAAGTCCTG AAGATACTTC AAATTTTGAT 1140

GTGGACGTTT GTGAGGATGA TTTTACGCCT TGTCTTCAGG AAACACAACC TCCTCGAGTA 1200

CTCGCCGCTT TCACTGGAAA TCATCTTCCG TTTGTTGGCT TCTCATATAC CCACGGTAGT 1260

TTACTATCCG ATGCTCGATC ACTTACGGAT GAAATACGAG CGATAGCACA GCGATGTCAA 1320

GGAGACGCAG AATTAATGGA GAAAAGTGTC GATGGGTTTA TGGTAGAACT CGAGAATGAG 1380

AAGGCCGAGC TTGTGCAAAA ACTGAAAGAA GCTCAAACAA TTATTGCACA ACATGTCGCT 1440

GAAAATCCCC GATCTGAAGA AGATAGGAAT TATGAATCGA CGATAGCACA GCTGAAAGAC 1500

GAAATACAAA TTCTCAATAA ACGATTGGAA GATGAAGCTC TTGCTCAACA ACAACAAAAG 1560

CCGAAAGATG AAATTGTGGC GGAAAGTGAA AAGAAATTGA AGGAATTGAA AGAACGAAAT 1620

AAGCAGTTGG TTATGGAGAA AAGTGAGATT CAAAGAGAGT TGGACAATAT CAACGATCAT 1680

TTGGATCAAG TTTTGGTGGA GAAAGCTACA GTAGTACAGC AACGAGATGA TATGCAAGCT 1740

GAACTGGCTG ATGTTGGAGA TTCTTTATTA ACCGAAAAAG ATTCTGTGAA ACGGTTACAA 1800

GATGAAGCTG AAAAGGCCAA AAAGCAAGTG GCAGATTTCG AAGAGAAGCT GAAAGAAATT 1860

GAAACAGAGA AAATTGCATT GATTAAAAAG CAAGAAGAGG TCACAATTGA AGCTCGAAAG 1920

TCGGTTGAAA CTGATGATCA TCTTTCGGAA GAAGTTGTCG CTGCAAAGAA TACCATTGCC 1980

TCATTACAAG CAACCAACGA AGAGCGAGAG ACTGAAATTA AGAAGCTCAA GCAGAGAATG 2040

GACGAAGAAC GAGCATCTCA TACCGCCCAA TCAGAACAAG AAATGAAGCA ACTGGAAGCT 2100

CACTACGAAC GAGCACAGAA AATGCTTCAG GACAATGTTG AGCAAATGAA CGTCGAAAAT 2160

CGTGGTCTTC GTGATGAAAT CGAGAAGCTC TCTCAACAAA TGGCCGCTCT TCCACGTGGA 2220

GGTCTCAATG AACAGCAACT CCACGAGATT TTCAATTGGG TCAGTGAAGA GAAGGCTACC 2280

CGTGAGGAAA TGGAGAATTT GACGAGAAAG ATCACCGGAG AAGTTGAGTC TTTGAAAAAT 2340

AATTCTCCAT TGACCACGTC CAACTACATT CAAAATACAC CATCCGGATG GGGATCACGA 2400

AGAATGAATA ACGTTGCCAG GAAAGACGGG TTGGATTTAC AACGACAACT TCAAGCTGAA 2460

ATTGATGCAA AGTTGAAGCT GAAAGCTGAG CTTAAGAACT CCCAAGAACA ATACCTAACA 2520

TCAGCTGCCA GATTAGACGA CACTGAAAAA CGAATGGCTT CTCTGATGCG TGAAGTGGCG 2580

ATGCTTAAGC AACAGAAAAA TATTGAAAAC TCTTCGGACA GCGCATTCTC GTCAACGATG 2640

GGACGTGGTG ATTTGATGAT CAGCATGAAC AACGATTACG AGATGTCAAA TTCATCATTG 2700

ATGAGACAGG AAATGATATC TCGCCAATCC ACTCCTTCCT ACGAAAACGC GATACTTCTT 2760

CATGACCATC AAGTGCCAAA GCGAGTTGAT GACTTGAGAT ATAAACAAAA ACCAATGAAA 2820

ACGGCTAGTG GAATCTTCTC TCCAGTATCG ATATCAGCTA TGGAACGAGG TCATAACTTT 2880

GAGAGAATGA AGATCAAAAC ACCCACCAAA TGCGGGCATT GTACATCGAT TCTCATTGGT 2940

CTTGATCGTC AAGGATTATT CTGTCAAAGC TGTCAGTATG CATGCCACGT GTCATGTGCA 3000

GAGCGGGTGT CTCAATCGTG TCCTGTGCCA GAAGAAGAAC GTCGACCACT GGGAATCGAT 3060

CCGACACGCG GAGTTGGAAC AGCTTACGAA GGTCTTGTGA AGACACCTCG TGCTGGAGGA 3120

GTTCGGAAAG GATGGCAAAC TGCATACGTT GTAGTATGCG ATTTCAAACT TTACCTCTAC 3180

GATTGTACTG TGGACAGACA AAACAAAATG CAAGATGTAA AGAATGAGAT TCGATTGGTG 3240

CTTGACATGC GTGATCCTGA TTTCACCGTT TGTGGAGTCA GTGAAGCCGA TGTTATTCAC 3300

GCTCAGAAAG GTGATATTCC AAAAATTTTC CGAGTCACGA CAACTCAAAT TTTGAATTCA 3360

TCATCTGAAT ATTCGTCTTC ATCGAAGTTC TATACATTGT TCATGGCTGA AACTGAAGAA 3420

GAAAAACGAA AATGGGTGGT TGCTCTGAGT GAACTGAAGA CATTGCTGAG AAGATCAAAG 3480

CTGGCGGATC GAAAAGCATT CCTTGTGAAA GAAGTTTTCG ATGTGACAAC ACTTCCATCT 3540

ATCCGAGTTG CTCAATGCTG TGCGATCATT GATCGATCGA AAATAGTCAT AGGATTCTCG 3600

GATCACGGAT TATACTGCAT CGAGATTAGT CGCCAATTGC TGATCCCTGT TGGTGGTGAG 3660

AAAGAGAACA AACAGCGGTG TGTTGAAACA GTTGAGTACG ACGAAGCCGA GCAATTGCTC 3720

ATGATGATTG TTGGTCCAGC CAAGGATCGT CATGTTCGGA TAGTTCCAAG TGCAGCACTG 3780

GACGGTCGAG ACTTGAAATG GATCAAAGTG AACGATACGA AAGGATGTCA TTTGCTGGCT 3840

GTTGGTACCA ATAATCCTGG TGGAAGAGCT GGTTTCTTTG CTGTTGCCTT CAAAAAGAGT 3900

GTCACCATCT TCCAAATAGA TCGGTCAGAG AAACGGCACA AAAAGTGGAA GGATCTCGCC 3960

ATGCCAGGCA CTCCCCAATC AATTGCTATT TTCAACGGCC GTCTATACGT TGGATTCTCC 4020

CACAGCTTCC GTTCCTGGTC ACTTGTTGGA GTTGACTCAT CGCCAGTCGG AAGTGGTGAT 4080

GCAAGTGGAG CCGTTCTTCA GCATATCTCT CTTGTCAACA TGGAGGACAC TTCACTGCAA 4140

TTCCTCAACC AACAAACATC CTACGAGGCA AAATTGATTG TGAATGTACC AGGTTCTCCA 4200

GATGAATATC TCCTCGTGTT CAATATGATT GGTCTTTATG TCAACGAAAT GGGCCGTCGA 4260

TCTAGGCTAC CAGAAGTGAT GTTCCCGACA CAGGCCAAAT ATTTCGCCTA CCACGAGCCG 4320

TATTTATGTG TGTTCTCGGA GAATGAAGTC GACATTTTCA ATGTGACCCT TGCTGAATGG 4380

GTTCAAACAA TCAATTTGAG ATCGGCAAAA CCACTTTCTG GTGATGGAAT TCTCTCAACA 4440

TGCCTTTGCA ATGACTCTCC AATATTCGTA CTTCTTCAAA ATGTGCTCCA AGATCAAGAT 4500

TCAATAGAAG TTCCAGTGAA TTTGGCATCT GGAAGCACTG ATGGACGGAA AGTGACGCGA 4560

CGGAAGTTCA CCTTCCGAAC AATCGGAAAA GATGATAGGA GTGCTTCGGA GCGTCGGAGT 4620

CACATACAAA TCTCGACCCC ATCGGATTTC ATGCATATAG TTCATATGGG TCCCGCACCG 4680

GTCATGGAGC TACAACAAAA TTTCATTGAC TTGCAGTCGA ATCATTCGCA TACTTCATCC 4740

GATAAGGATT CACTGAACAG ATCTGTAAAT AACGACTAA 4779

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fe+lkviG+Gafgevavvr++ ++++yamkil+k+e++krae+a+freerdvlv +d++w

Q: 83    FEVLKVIGKGAFGEVAVVRMRGVGEIYAMKILNKWEMVKRAETACFREERDVLVYGDRRW  142

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqdek+ly+vm+y++GGd+ltllsk+ d++pe++a+fy+ae+vla+ds+h+lg

Q: 143   ITNLHYAFQDEKNLYFVMDYYIGGDMLTLLSKFVDHIPESMAKFYIAEMVLAIDSLHRLG  202

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrd+kpdn+lld++Ghi+ladfGscl++ +dg+v+s+vavGtpdyispe+l+a+e+g+

Q: 203   YVHRDVKPDNVLLDMQGHIRLADFGSCLRILADGSVASNVAVGTPDYISPEILRAMEDGR  262

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede...kvseea  237

         g+ygkecdwwslG+++ye+l+g+tpfy+e+lv+ty+ki++h+++l+fp+de    vseea

Q: 263   GRYGKECDWWSLGICMYEMLYGTTPFYSERLVDTYGKIMSHQDMLDFPDDEidwVVSEEA  322

         *************************************************999889*****

S: 238   kdlikklltsreerlgregiedlkkhpff  266

         kdli++l++s++ r+gr+g++d++ hpff

Q: 323   KDLIRQLICSSDVRFGRNGLSDFQLHPFF  351

         ****************************9

Domain Sequence
(FASTA)

FEVLKVIGKG AFGEVAVVRM RGVGEIYAMK ILNKWEMVKR AETACFREER DVLVYGDRRW 60

ITNLHYAFQD EKNLYFVMDY YIGGDMLTLL SKFVDHIPES MAKFYIAEMV LAIDSLHRLG 120

YVHRDVKPDN VLLDMQGHIR LADFGSCLRI LADGSVASNV AVGTPDYISP EILRAMEDGR 180

GRYGKECDWW SLGICMYEML YGTTPFYSER LVDTYGKIMS HQDMLDFPDD EIDWVVSEEA 240

KDLIRQLICS SDVRFGRNGL SDFQLHPFF 269

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0010172	; P:embryonic body morphogenesis
GO:0035556	; P:intracellular signal transduction
GO:0040011	; P:locomotion
GO:0002119	; P:nematode larval development
GO:0040010	; P:positive regulation of growth rate

KEGG

cel:CELE_K08B12.5

;

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013