EKS-CAE-00355

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00355

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/IRAK	366.8	1.2E-109	145	436	292

Status

Unreviewed

Ensembl Protein

K09B11.1b

UniProt Accession

G5ECP4;

Protein Name

Protein Synonyms/Alias

Pelle IRAK-like kinase 1; Protein PIK-1, isoform a;

Gene Name

pik-1

Gene Synonyms/Alias

pik-1; CELE_K09B11.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
K09B11.1	K09B11.1a	K09B11.1a
K09B11.1	K09B11.1b	K09B11.1b

Organism

Caenorhabditis elegans

Functional Description

Protein Length

445

Protein Sequence
(FASTA)

MPGIELRDVE GCKRYSSYNQ SPSELLLRIW SSKGYSTTHL YQLFAKTKLI RLMRMMRSQV 60

HEKYHYLENK VTNSTSRVSK QMVQPPGSQS ASRLKKTEIK ESSPSPAAAA ASQLSRSNTD 120

DTLRVAIEGT LPVTYCELLE ATNGFAVSNV IGKGGYGTVY KGELKGTGGI VAVKRLHSGN 180

DTSQNGSRER LRQSLTELRT LARFRHDNIL PIYAYSLEGS EPCLVYQFMS NGSLEDRLLC 240

RKGSVPLTWI QRKEISIGAG RGLGFLHSFG KTPIIHGDIK TANILLDKHM EPKIGDFGLC 300

RDGHVEAEAM EKHPLIASHI KGTLAYLAPE FITSKILTTK LDVYSFGIVL LEIASGQRAY 360

SDSRETRGLV EYCQVNKELA AHRKIPVREI FIDRRAPPLV GDEEKSFLDA LIEVGLAGAN 420

NDRKVRPTMS QIVEYLCKNS IPPVV 445

Nucleotide Sequence
(FASTA)

ATGCCCGGAA TTGAGTTGAG AGATGTTGAA GGTTGCAAGA GATATTCAAG TTATAACCAA 60

AGTCCATCGG AGTTACTTTT AAGAATATGG AGCTCGAAAG GATACTCGAC AACTCATCTT 120

TATCAACTTT TTGCGAAAAC AAAATTGATT CGATTGATGA GAATGATGAG GTCACAAGTA 180

CATGAGAAGT ATCATTATTT GGAGAACAAG GTCACAAATT CGACGTCTCG AGTTTCGAAA 240

CAAATGGTCC AACCGCCGGG GTCTCAAAGT GCGTCTCGTT TGAAAAAAAC TGAAATAAAA 300

GAGTCATCTC CGTCACCAGC AGCAGCAGCA GCTTCTCAGT TATCCAGAAG TAACACTGAC 360

GATACACTTC GTGTAGCAAT CGAAGGAACA CTTCCAGTAA CTTATTGTGA ACTTCTCGAA 420

GCAACTAACG GCTTTGCTGT GAGCAATGTA ATTGGAAAAG GTGGATATGG AACAGTATAT 480

AAAGGAGAAT TAAAAGGAAC TGGAGGAATT GTTGCAGTGA AAAGATTACA TTCAGGAAAT 540

GATACATCAC AGAATGGATC ACGAGAACGA CTTCGACAGA GTTTAACAGA ATTACGAACA 600

CTGGCAAGAT TTAGACATGA TAATATTCTA CCAATTTATG CATATTCATT GGAAGGATCT 660

GAACCATGTC TTGTATATCA ATTTATGTCA AATGGATCAT TGGAGGATCG ATTGTTGTGT 720

AGAAAAGGAA GTGTACCTCT CACGTGGATT CAACGAAAAG AAATCAGTAT TGGAGCAGGT 780

CGAGGACTCG GATTTCTTCA TTCTTTCGGA AAAACTCCAA TAATTCATGG CGATATAAAA 840

ACAGCGAATA TTCTTCTCGA CAAGCATATG GAACCGAAAA TCGGCGATTT TGGTCTGTGT 900

AGAGATGGAC ATGTTGAAGC TGAAGCAATG GAAAAGCATC CATTAATTGC TTCACATATC 960

AAGGGAACAC TTGCTTATCT TGCACCAGAA TTCATTACAT CAAAGATTCT TACCACAAAA 1020

CTTGATGTCT ATAGTTTTGG AATAGTACTT TTGGAAATTG CATCTGGTCA ACGGGCATAT 1080

TCGGATTCTC GTGAAACTCG GGGGCTCGTT GAATATTGTC AGGTTAATAA GGAATTGGCA 1140

GCACATCGGA AGATTCCAGT CAGAGAGATT TTTATTGATC GACGAGCGCC GCCACTTGTT 1200

GGTGATGAGG AAAAATCATT TTTGGATGCT CTGATTGAAG TTGGATTAGC TGGAGCGAAT 1260

AACGATCGGA AAGTTCGACC GACTATGTCA CAAATTGTTG AATATCTTTG TAAAAATTCA 1320

ATTCCGCCAG TTGTCTAA 1338

Domain Profile

S: 1     fsednrigeGgfgevyrgelknt..avavkklkeeadlslkelkqsf...ltElkvlarf  55

         f+ +n+ig+Gg+g+vy+gelk+t  +vavk+l++ +d+s++ +++++   ltEl++larf

Q: 145   FAVSNVIGKGGYGTVYKGELKGTggIVAVKRLHSGNDTSQNGSRERLrqsLTELRTLARF  204

         7889******************9999***************99999987789********

S: 56    rHdnilellgysaeseklcLvYqymknGsLedrLqcqkgsepLsWpqRlsillGtaraie  115

         rHdnil++++ys+e++++cLvYq+m+nGsLedrL c+kgs pL+W qR +i++G++r++

Q: 205   RHDNILPIYAYSLEGSEPCLVYQFMSNGSLEDRLLCRKGSVPLTWIQRKEISIGAGRGLG  264

         ************************************************************

S: 116   fLHeasp.slihgdiksaNiLLDekltpKlgDfglar.fapesekqsstvlrtskvrgtl  173

         fLH++ + ++ihgdik+aNiLLD++++pK+gDfgl+r  ++e+e+++++ l++s+++gtl

Q: 265   FLHSFGKtPIIHGDIKTANILLDKHMEPKIGDFGLCRdGHVEAEAMEKHPLIASHIKGTL  324

         ******99*****************************99*********************

S: 174   aYlpeefirvgqltvkvDvySfGiVllEvltGlravdedrktkyLkdll...keeieeek  230

         aYl++efi+++ lt+k+DvySfGiVllE+++G+ra++++r+t+ L++++   ke ++++k

Q: 325   AYLAPEFITSKILTTKLDVYSFGIVLLEIASGQRAYSDSRETRGLVEYCqvnKELAAHRK  384

         *************************************************9999*******

S: 231   veilekfldkkagkl....eeellealielalaclaekakkrPtmsqvlell  278

         + ++e f+d++a++l    e+++l+alie++la++++++k+rPtmsq++e+l

Q: 385   IPVREIFIDRRAPPLvgdeEKSFLDALIEVGLAGANNDRKVRPTMSQIVEYL  436

         **************9999999****************************987

Domain Sequence
(FASTA)

FAVSNVIGKG GYGTVYKGEL KGTGGIVAVK RLHSGNDTSQ NGSRERLRQS LTELRTLARF 60

RHDNILPIYA YSLEGSEPCL VYQFMSNGSL EDRLLCRKGS VPLTWIQRKE ISIGAGRGLG 120

FLHSFGKTPI IHGDIKTANI LLDKHMEPKI GDFGLCRDGH VEAEAMEKHP LIASHIKGTL 180

AYLAPEFITS KILTTKLDVY SFGIVLLEIA SGQRAYSDSR ETRGLVEYCQ VNKELAAHRK 240

IPVREIFIDR RAPPLVGDEE KSFLDALIEV GLAGANNDRK VRPTMSQIVE YL 292

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

cel:CELE_K09B11.1

;

InterPros

IPR000488	; Death.
IPR011029	; DEATH-like.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00531	; Death; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013