EKS-ORS-01406

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORS-01406

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	366.1	5.9E-109	934	1230	297

Status

Reviewed

Ensembl Protein

LOC_Os05g14550.1

UniProt Accession

Q0DJS1; B7F5Y4; Q6ATH2;

Protein Name

Serine/threonine-protein kinase TOR

Protein Synonyms/Alias

Protein TARGET OF RAPAMYCIN; OsTOR;

Gene Name

TOR

Gene Synonyms/Alias

TOR; Os05g0235300, LOC_Os05g14550; OSJNBa0093E24.9;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
LOC_Os05g14550	LOC_Os05g14550.1	LOC_Os05g14550.1

Organism

Oryza sativa

Functional Description

Essential cell growth regulator that controls plantdevelopment. Acts through the phosphorylation of downstream effectors that are recruited by the binding partner RAPTOR. Acts by activating transcription, protein synthesis and ribosome biogenesis, and inhibiting mRNA degradation and autophagy (By similarity).

Protein Length

1350

Protein Sequence
(FASTA)

MRYRKWDEIE NRLLRREPLI SENLSVQKYT QCPPEVISDP LDDFGGVPSE EADETQRQPR 60

SHQVNDVRLR SAGEASQRST REDWAEWMRH FSIALLKESP SPALRTCARL AQLQPSVGRE 120

LFAAGFASCW AQMNETSQEQ LVRSLKTAFS SQNIPPEILA TLLNLAEFME HDEKPLPIDT 180

RLLGALAEKC RAFAKALHYK EMEFEAVCSK KMGANPVTVV ESLIHINNQL HQHEAAIGIL 240

TYSQQHLEVQ LKESWYEKLH RWDEALKAYK AKSSQASGPL QNLDATLGRM RCLAALARWE 300

DLSALCREQW TGSEPSARLE MAPMAANAAW HMGEWDHMAE YVSRLDDGDE NKLRILGNTT 360

ASGDGSSNGA FFRAVLSVRC KKYEEARVYV ERARRCLATE LAALVLESYE RAYNNMVRVQ 420

QLSELEEVID YCTLPMESPI ADSRRELIRN MWNERIKGTK RNVEVWQALL AVRELVLPPN 480

EDRDTWIKFA KLCWKSGRIS QAKSTLVKLL QFDPESSPEL TLYHGHPQVV LAYLKYQYAV 540

GDELKRRDAF CRLQDLSVQL ATATNSYSGT LASQVATSNA GVPLIARVYL TLASWKRALS 600

PGLDDDSIQE ILVSYKNATL NAKDWGKAWH LWALFNTEVM SRYTLRGRPD IAGKYVVAAV 660

TGYFYSIACA STTKGVDDSL QDILRLLTLW FNHGATSEVQ MALQKGFSLV NIEMWLVVLP 720

QIIARIHSNN KIVRELIQSL LVRIGKDHPQ ALMYPLLVAC KSISILRQRA AQEVVDKIRQ 780

HSGGLVDQAQ LVSKELIRVA ILWHEMWHEA LEEASRMYFG EHNIEGMLAV LEPLHAMLER 840

GPETIKENTF IQAYGHELLE AHECCLKYRA TGEDAELTKA WDLYYHVFRR IDKQLPSLTT 900

LDLHSVSPEL LECRKLELAV PGTYSADAPL VTIEYFVPQL IVITSKQRPR KLTIHGSDGN 960

DYAFLLKGHE DLRQDERVMQ LFGLVNTLLE NSRKTSEKDL SIQRYAVIPL SPNSGLIGWV 1020

PNCDTLHALI REYRDARKIF LNQEHRCMLS FAPDYDHLPL IAKVEVFQHA LENSEGNDLA 1080

KVLWLKSRTS EVWLERRTNY TRSLAVMSMV GYLLGLGDRH PSNLMLDRYS GKILHIDFGD 1140

CFEASMNREK FPEKVPFRLT RMLVKAMEVS GIEGTFRTTC ENVMQVLRTN KDSVMAMMEA 1200

FVHDPLINWR LFNFNEVPQV TNYGNAHSHT VVNSEEAANR ELMQPPRGAR ERELLQAVNQ 1260

LGDANEVLNE RAVAVMARMS HKLTGRDFSS GSSLSGAGSS TQHGNEHLAS GDTREVEPGL 1320

SVKVQVQRLI LQATSHENLC QNYVGWCPFW 1350

Nucleotide Sequence
(FASTA)

ATGCGGTATA GAAAATGGGA TGAGATTGAA AATCGATTAC TAAGGCGAGA GCCACTCATC 60

TCTGAGAACT TATCAGTACA AAAGTACACA CAATGCCCGC CTGAAGTCAT TAGTGACCCT 120

CTTGATGATT TTGGTGGTGT TCCTTCTGAG GAGGCTGATG AAACACAGCG GCAACCAAGA 180

AGTCATCAAG TCAATGATGT TCGACTGAGA AGTGCCGGTG AGGCTTCTCA AAGGAGCACT 240

AGAGAAGATT GGGCTGAATG GATGAGGCAC TTCAGTATTG CGCTTCTCAA AGAATCACCA 300

TCTCCTGCTT TACGCACTTG CGCAAGACTA GCACAACTTC AGCCTTCTGT TGGTCGTGAG 360

TTGTTTGCTG CGGGCTTTGC AAGTTGCTGG GCCCAAATGA ATGAAACATC CCAGGAGCAA 420

CTTGTGAGAA GTCTCAAGAC TGCATTCTCA TCTCAGAACA TACCTCCAGA AATTCTTGCC 480

ACACTGCTGA ACTTGGCAGA GTTTATGGAA CATGATGAGA AGCCGCTTCC AATTGATACA 540

AGACTGCTCG GTGCACTTGC TGAAAAGTGT CGAGCATTTG CAAAAGCACT GCATTATAAA 600

GAAATGGAGT TTGAAGCTGT ATGTTCCAAG AAGATGGGTG CAAATCCTGT TACTGTTGTT 660

GAATCTCTTA TTCATATTAA CAACCAATTA CACCAGCATG AGGCAGCTAT TGGGATATTG 720

ACTTACTCAC AACAACATTT AGAAGTTCAA TTGAAGGAGT CCTGGTACGA AAAATTGCAC 780

CGTTGGGATG AGGCCTTGAA GGCATACAAA GCAAAGTCAT CTCAAGCATC TGGGCCATTA 840

CAAAACTTGG ATGCTACATT AGGTCGAATG AGGTGTCTAG CAGCCTTGGC CCGTTGGGAA 900

GATTTAAGTG CATTATGCAG GGAGCAATGG ACTGGCTCAG AACCATCTGC CCGACTAGAA 960

ATGGCTCCGA TGGCTGCCAA TGCTGCTTGG CATATGGGTG AGTGGGACCA CATGGCTGAA 1020

TATGTTTCTC GTCTGGATGA TGGGGATGAA AACAAGCTCC GGATATTGGG TAACACAACA 1080

GCTAGTGGTG ACGGAAGCAG CAATGGTGCT TTCTTTAGGG CTGTTCTTTC AGTTCGTTGC 1140

AAAAAGTATG AAGAAGCTCG TGTATATGTT GAGAGAGCTC GGCGGTGTTT GGCTACAGAA 1200

CTTGCAGCAT TGGTACTTGA GAGTTATGAG CGTGCTTATA ATAATATGGT GCGGGTTCAA 1260

CAGCTTTCTG AGCTGGAAGA GGTGATTGAT TACTGCACTC TTCCAATGGA AAGTCCAATA 1320

GCTGACAGCC GGAGGGAACT TATCCGTAAT ATGTGGAATG AGCGTATTAA AGGAACAAAA 1380

CGGAATGTTG AGGTGTGGCA AGCCTTACTT GCTGTTAGAG AGTTGGTTCT CCCTCCTAAT 1440

GAAGACAGAG ACACCTGGAT AAAATTTGCC AAACTTTGCT GGAAGAGTGG CCGCATTAGT 1500

CAGGCTAAAT CTACCTTAGT CAAACTCTTA CAGTTTGATC CAGAATCTTC CCCTGAATTG 1560

ACGCTGTATC ATGGACATCC TCAAGTAGTC CTGGCATACC TGAAGTACCA GTATGCTGTT 1620

GGAGATGAGC TTAAACGAAG GGACGCGTTT TGCAGGCTAC AGGATTTGTC TGTGCAGCTT 1680

GCTACCGCAA CAAATAGTTA TTCTGGAACA TTAGCAAGCC AGGTTGCCAC ATCAAATGCT 1740

GGAGTACCAC TTATTGCTCG CGTCTATTTG ACACTTGCTA GCTGGAAGAG AGCATTATCA 1800

CCTGGGTTAG ACGATGATTC TATTCAAGAA ATATTGGTCT CTTACAAAAA TGCCACACTT 1860

AATGCCAAGG ACTGGGGCAA GGCATGGCAC TTATGGGCCT TGTTCAACAC TGAAGTCATG 1920

TCCCGCTATA CTTTGCGTGG TCGACCAGAT ATTGCAGGAA AATATGTTGT TGCAGCAGTA 1980

ACTGGGTATT TCTACTCTAT TGCTTGCGCA TCCACGACAA AAGGTGTTGA TGATAGCTTA 2040

CAGGATATCC TTCGTCTCTT GACTCTTTGG TTTAATCATG GGGCTACCTC AGAGGTTCAA 2100

ATGGCACTGC AGAAAGGCTT TTCACTTGTC AATATAGAAA TGTGGTTGGT TGTCCTTCCC 2160

CAGATAATTG CAAGGATCCA TTCAAATAAT AAAATAGTGA GAGAACTGAT ACAGTCATTG 2220

CTGGTTCGAA TTGGAAAGGA TCATCCACAG GCATTGATGT ATCCTCTGTT GGTTGCTTGC 2280

AAATCAATAA GCATATTAAG ACAACGAGCG GCGCAAGAGG TCGTCGATAA GATCCGCCAA 2340

CATAGTGGAG GTCTTGTTGA TCAGGCACAG CTTGTTTCAA AGGAACTGAT ACGAGTTGCC 2400

ATTCTGTGGC ATGAGATGTG GCATGAGGCT CTTGAGGAAG CTAGCAGGAT GTATTTTGGT 2460

GAGCACAATA TTGAGGGAAT GCTTGCAGTG CTTGAACCAT TGCATGCAAT GCTCGAGAGG 2520

GGTCCTGAGA CAATAAAAGA AAATACTTTC ATTCAGGCTT ATGGTCATGA ATTACTGGAA 2580

GCCCACGAAT GCTGTTTAAA ATATCGGGCT ACAGGAGAGG ATGCTGAGTT AACTAAGGCA 2640

TGGGATTTGT ATTACCATGT TTTCAGAAGA ATAGACAAAC AGCTTCCAAG TCTTACAACT 2700

TTGGATTTGC ACTCTGTGTC ACCCGAGCTT CTTGAGTGTC GAAAGTTGGA GCTTGCTGTA 2760

CCAGGAACTT ATTCTGCAGA TGCACCACTT GTGACAATTG AGTATTTTGT TCCTCAATTG 2820

ATTGTTATAA CATCTAAACA AAGACCAAGA AAACTGACAA TTCATGGAAG TGATGGCAAC 2880

GATTATGCAT TCTTGCTGAA AGGCCATGAA GATTTACGGC AGGATGAGCG TGTAATGCAG 2940

CTTTTTGGCC TGGTGAATAC TCTGCTGGAG AACTCTAGGA AAACTTCAGA GAAAGATCTG 3000

TCAATCCAAA GATATGCTGT CATACCTTTG TCTCCTAACA GTGGTTTAAT TGGATGGGTT 3060

CCAAATTGTG ACACACTTCA TGCCCTGATC CGTGAATATA GAGATGCCAG GAAGATTTTC 3120

TTAAATCAGG AGCACCGATG TATGTTGAGT TTTGCACCTG ATTATGACCA CTTACCCCTC 3180

ATCGCCAAAG TAGAAGTATT TCAGCATGCC CTAGAAAACA GTGAAGGAAA TGACCTTGCA 3240

AAGGTTCTCT GGCTTAAAAG CCGAACCTCT GAAGTATGGC TTGAGCGGCG CACAAATTAT 3300

ACGAGAAGTC TGGCTGTTAT GAGCATGGTT GGCTATTTGC TTGGTTTAGG AGATCGGCAT 3360

CCAAGTAATC TTATGTTAGA TCGTTATAGT GGAAAAATAT TACATATTGA CTTTGGCGAT 3420

TGCTTTGAGG CTTCAATGAA TCGTGAAAAG TTTCCCGAAA AGGTTCCATT TCGCTTGACT 3480

AGAATGCTTG TGAAAGCCAT GGAAGTTAGT GGTATTGAGG GTACCTTCAG AACCACTTGC 3540

GAAAATGTGA TGCAAGTACT TCGAACAAAC AAGGATAGCG TTATGGCTAT GATGGAGGCA 3600

TTTGTGCATG ACCCATTAAT CAATTGGCGT CTGTTCAATT TCAATGAAGT CCCTCAAGTT 3660

ACAAACTATG GAAATGCTCA CAGTCACACA GTTGTCAATA GCGAAGAAGC TGCTAATCGG 3720

GAGCTCATGC AACCACCCCG GGGAGCTCGG GAGAGAGAAC TGCTACAGGC GGTCAATCAA 3780

CTCGGTGATG CTAACGAGGT TTTGAATGAG CGTGCCGTAG CTGTGATGGC ACGAATGAGT 3840

CATAAGCTCA CAGGGCGCGA TTTCTCTTCC GGATCATCGT TGTCGGGGGC GGGAAGCTCC 3900

ACCCAACATG GTAACGAGCA TCTGGCTTCA GGAGACACTC GAGAGGTGGA ACCTGGTTTA 3960

TCCGTGAAGG TTCAGGTTCA GAGGCTTATA CTTCAAGCGA CTTCGCATGA AAACTTGTGC 4020

CAAAACTACG TCGGGTGGTG CCCGTTTTGG TGA 4053

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdk  61

           f +++ +++skq+p+kl+++Gsdg  y++L+kg+eDlrqderv+qlf+lvNtlL++

Q: 934   EYFVPQLIVITSKQRPRKLTIHGSDGNDYAFLLKGHEDLRQDERVMQLFGLVNTLLENSR  993

         668999******************************************************

S: 62    etsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls  121

         +ts++ L+i++y+V+pls++sgli+wv+n+++L++l++++++ +++ l+       ++++

Q: 994   KTSEKDLSIQRYAVIPLSPNSGLIGWVPNCDTLHALIREYRDARKIFLN-------QEHR  1046

         ************************************************9.......99**

S: 122   tvqarkpklkhlkls..levfkevlenlvpkdllkklllekfpspeewfelrkaytrslA  179

          + + +p+++hl l   +evf+++len    + l+k+l+ k+ ++e+w+e+r++ytrslA

Q: 1047  CMLSFAPDYDHLPLIakVEVFQHALEN-SEGNDLAKVLWLKSRTSEVWLERRTNYTRSLA  1105

         ************99888**********.6669****************************

S: 180   vislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivn  239

         v+s+vgy LgLgdrh++nl++d+ +g+++hidfg +fe  + ++k+pekvPFRLTr++v+

Q: 1106  VMSMVGYLLGLGDRHPSNLMLDRYSGKILHIDFGDCFEASMNREKFPEKVPFRLTRMLVK  1165

         ************************************************************

S: 240   algvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeelae  299

         a++v g+eG fr +ce+v++vlr +k+++++++e+f++dpl++w+  + ++  + ++  +

Q: 1166  AMEVSGIEGTFRTTCENVMQVLRTNKDSVMAMMEAFVHDPLINWRLFNFNEVPQVTNYGN  1225

         *********************************************944444333333333

S: 300   kakae  304

+++

Q: 1226  AHSHT  1230

Domain Sequence
(FASTA)

EYFVPQLIVI TSKQRPRKLT IHGSDGNDYA FLLKGHEDLR QDERVMQLFG LVNTLLENSR 60

KTSEKDLSIQ RYAVIPLSPN SGLIGWVPNC DTLHALIREY RDARKIFLNQ EHRCMLSFAP 120

DYDHLPLIAK VEVFQHALEN SEGNDLAKVL WLKSRTSEVW LERRTNYTRS LAVMSMVGYL 180

LGLGDRHPSN LMLDRYSGKI LHIDFGDCFE ASMNREKFPE KVPFRLTRML VKAMEVSGIE 240

GTFRTTCENV MQVLRTNKDS VMAMMEAFVH DPLINWRLFN FNEVPQVTNY GNAHSHT 297

Keyword

ATP-binding; Complete proteome; Developmental protein; Growth regulation; Kinase; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Arabidopsis lyrata"; ?>Arabidopsis thaliana"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Chlamydomonas reinhardtii"; ?>Cyanidioschyzon merolae"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Solanum tuberosum"; ?>Vitis vinifera"; ?>Zea mays"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008144	; F:drug binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0009793	; P:embryo development ending in seed dormancy
GO:0040008	; P:regulation of growth

KEGG

dosa:Os05t0235300-01	;
osa:4338174	;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR024585	; DUF3385_TOR.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR009076	; Rapamycin-bd_dom.
IPR026683	; TOR/Smg1.

Pfam

PF11865	; DUF3385; 1.
PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08771	; Rapamycin_bind; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; FALSE_NEG.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013