EKS-ORS-01408

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORS-01408

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	320.2	5.4E-95	2308	2627	320

Status

Reviewed

Ensembl Protein

LOC_Os06g50910.1

UniProt Accession

Q5Z987;

Protein Name

Serine/threonine-protein kinase ATR

Protein Synonyms/Alias

Gene Name

Gene Synonyms/Alias

Os06g0724700, LOC_Os06g50910; P0535F09.39, P0548E04.6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
LOC_Os06g50910	LOC_Os06g50910.2	LOC_Os06g50910.2
LOC_Os06g50910	LOC_Os06g50910.1	LOC_Os06g50910.1
LOC_Os06g50910	LOC_Os06g50910.3	LOC_Os06g50910.3

Organism

Oryza sativa

Functional Description

Probable serine/threonine kinase. Seems to play acentral role in cell-cycle regulation by transmitting DNA damage signals to downstream effectors of cell-cycle progression. May recognize the substrate consensus sequence [ST]-Q and phosphorylate histone variant H2AX to form H2AXS139ph at sites of DNA damage, thereby regulating DNA damage response mechanism (By similarity).

Protein Length

2653

Protein Sequence
(FASTA)

MANFSSHIQE LRELIAASST TTSTSAPASV HFEVKLREVL PNLLRDYVVP SSPTGAADGR 60

EATAVLKLLS YTAGKFPGVF FHGRAADVIR VIGRVLPFFA EPNFRSRHEI IFDTVWSLLS 120

LLRTGDREAY RQFFLDVMVA VQDVLYVVAS MHGDRPSGVL TERYLVKCLC GSFSDILDSP 180

GIFSDLPDSC QPKNGPGVLV DLTDGTLYVE GLVNMPFVSA ACSIICYGDE SLHKVCFDFA 240

RIVATVITVE ILPVENIIRS IMCILSQDVN GLSDIRDADY DFSMGACLHA LHSSCPGYIV 300

AITASDIVNV FQRAVHTSRS SELQVAMCNA YKRIVELCSP RVWKPEILLK LLCLPKPCAK 360

LIECIRLVVD KSGQSFLSSD DRDDGSSLLA KSEGLDLPKV GQKRIALDEE NSFPKRLKMT 420

EPRFSSGSFM VDELSAGVGQ ELEKDHGCDF RVQLYSLINC LSPDNHMAYP LEPAISIQVL 480

SLLCLSLSVY PKTNLFSRIS KQVLSWIPWI CKQTTKICMF SFDVSLYFEA VQTVMLLQSF 540

LPGHTKLFED EPLLIGNGCT DFEYPRYADL INLLKLVSDD GYLTSQTCSE KLKCLAVQII 600

AKIGSRQNAE CDLQVLELAI QSETGELQNE ALMSLPIIVL YSGPRMLGAM FRKLETIGTL 660

GCKKLWKSIA ISLGFLSCLN GTTDCTDKVG NHCKLFLAKH CEQPILTLNL LRGFWCPQCD 720

VRTVHIEDQV PIVDIALSED KNIDFKINMF KAHSLFFKFL YAETSEECIV SIVEVLPRIL 780

KHSSRDVLLD MKFQWVQCVD FLLLHEMKAV RDAFSSVVSC FLETNAMDIL FSDGTGMSGG 840

TSRVKFMDKI KSAFTEAEDP QILLTLLEST AAIVKASDIH GEVFFCSFVL LIGQLGNHDY 900

IVRVTALRLL QRCCTYCFKG GLELFLSKYF HVRDNLYDYL SSRLLTHPVV ISEFAESVLG 960

VKTEELIRRM VPSIIPKLIV SHQNNDQAVV TLNELASHLN RTDSKEIFSA ALPTLLDEII 1020

CFPGESDQIE TDRRMAKISP TIQNIARILT GNDNLPEFLK NDFVRLLNSI DKKMLHSSDV 1080

NLQKQALQRI RKLVEMMGPY LSTHAPKIMV LLIFAIDKET LQMDGLDVLH FFIKRLAEVS 1140

CTSIKYVMSQ VVAAFIPSLE RCRERPLVHL GKIVEILEEL VVKNIILLKQ HIRELPLLPS 1200

LPSLSGVNKV IQEARGLMTL QDHLKDAVNG LNHESLNVRY MVACELNKLF NDRRGDITSL 1260

IIGEDIADLD IISSLIMSLL KGCAEESRTV VGQRLKLVCA DCLGALGAVD PAKFKVMSCE 1320

RFKIECSDDD LIFELIHKHL ARAFRAASDT TVQDSAALAI QELLKLSGCQ SLPNESSSCK 1380

MSKRGQKLWG RFSSYVKEII APCLTSRFHL PSVNDATLAG PIYRPTMSFR RWIYYWIRKL 1440

TSHATGSRSG IFGACRGIVR HDMPTAIYLL PYLVLNVVCY GTPEARQSIT EEILSVLNAA 1500

ASESSGAIVH GITGGQSEVC IQAVFTLLDN LGQWVDDLKQ EIALSQSNYA MAGRQGGKLR 1560

DESNSMYDQD QLLVQCSNVA ELLAAIPKVT LAKASFRCQA HARALMYFES HVREKSGSSN 1620

PAADCSGAFS DDDISFLMEI YGGLDEPDGL LGLANLRKSS TLQDQLIINE KAGNWAEVLT 1680

LCEQSLQMEP DSVHRHCDVL NCLLNMCHLQ AMIAHVDGLV YRIPQSKKTW CMQGVQAAWR 1740

LGRWDLMDEY LAEADKGLVC RSSENNASFD MGLAKIFNAM MKKDQFMVAE KIAQSKQALL 1800

VPLAAAGMDS YMRAYPYIVK LHMLRELEDF NSLLGDESFL EKPFAADDPK FLKLTKDWEN 1860

RLRCTQPSLW AREPLLAFRR MVYNLSHMNA QAGNCWLQYA RLCRLAGHYE TAHRAILEAD 1920

ASGAPNAHME KAKYLWNIRK SDSAIAELQQ TLLNMPADVL GPTVLSSLSS LSLALPNAPL 1980

SVTQASKENP DVSKTLLLYT RWIHYTGQKQ SNDIKSLYSR VADLRPKWEK GFFCIAKFYD 2040

DLLVDARRRQ EDKKIASGVG PVPPSSTGSL TTATEEKPWW DMLPVVLIQY ARGLHRGHKN 2100

LFQALPRLLT LWFEFGSIYI QDGSSFNKPM KEVHIRLLGI MRGCLKDLPP YQWLTVLSQL 2160

ISRICHQNIE VVKLVKCIVT SILREYPQQA LWMMAAVSKS TVAARRDAAA EILQSAKKGS 2220

RRGSDSNALF MQFPSLIDHL IKLCFHPGQP KARAINISTE FSSLKRMMPL GIILPIQQAL 2280

TVTLPSYDTN MTDQSTFRPF SVSEHPTIAG IADDAEILNS LQKPKKVVFI GSDGISRPFL 2340

CKPKDDLRKD SRMMEFNAMI NRLLSKVPES RRRKLYIRTF AVVPLTEDCG MVEWVPNTRG 2400

LRQILQDIYI TCGKFDRMKT NPQIKKIYDQ LQGKMPEEML KAKILPMFPP VFHKWFLTTF 2460

SEPAAWIRAR AAYAHTTAVW SMVGHIVGLG DRHGENILLD STTGDCIHVD FSCLFDKGLL 2520

LEKPEVVPFR FTQNMVDGLG ITGYEGVFVK VCEITLSVLR THKEALMTVL ETFIHDPLVE 2580

WTKSHKSSGV EVRNPHAQRA ISNITERLQG VVVGVNAAPS LPLSVEGQAR RLIAEAVSHS 2640

NLGKMYVWWM AWF 2653

Nucleotide Sequence
(FASTA)

ATGGCCAACT TTTCCAGCCA CATCCAGGAG CTCCGCGAGC TCATCGCGGC GTCCTCCACC 60

ACCACCTCCA CCTCCGCCCC CGCATCCGTC CACTTCGAGG TCAAGCTCCG CGAGGTCCTC 120

CCCAACCTCC TCCGCGACTA CGTCGTCCCC TCATCCCCCA CCGGTGCAGC GGACGGGAGG 180

GAGGCCACCG CGGTGCTCAA GCTGCTCTCC TACACCGCGG GGAAGTTCCC GGGGGTCTTC 240

TTCCACGGCC GCGCCGCCGA CGTCATCCGC GTCATTGGCC GTGTCCTCCC CTTCTTCGCG 300

GAGCCCAACT TCCGGTCAAG GCATGAGATT ATATTTGATA CAGTTTGGTC TCTTCTCTCG 360

CTTCTTCGCA CAGGTGACCG AGAAGCCTAC CGGCAGTTCT TCTTGGATGT CATGGTTGCA 420

GTACAAGATG TGCTATATGT GGTGGCATCA ATGCATGGGG ACAGGCCAAG TGGCGTGCTT 480

ACTGAAAGAT ATTTAGTTAA ATGCCTCTGC GGATCCTTCT CAGATATCTT GGATTCACCT 540

GGGATTTTTA GTGATCTCCC AGACAGTTGC CAGCCTAAGA ATGGACCCGG AGTACTGGTT 600

GATCTGACAG ATGGGACCCT GTATGTCGAG GGACTTGTTA ACATGCCATT TGTTTCTGCT 660

GCCTGTTCTA TTATCTGCTA TGGGGATGAA TCCCTACACA AGGTTTGTTT TGATTTTGCA 720

CGGATTGTTG CAACGGTGAT CACTGTTGAG ATTCTTCCTG TGGAAAACAT TATCCGTTCG 780

ATAATGTGCA TTTTGAGCCA AGATGTTAAC GGACTTTCTG ATATCAGAGA TGCAGATTAC 840

GACTTTTCAA TGGGTGCCTG TCTTCATGCA CTGCATTCTT CCTGCCCAGG CTATATTGTT 900

GCAATTACGG CTTCTGACAT TGTTAATGTT TTTCAAAGAG CAGTGCATAC CAGCAGAAGC 960

TCAGAGCTTC AGGTTGCTAT GTGCAATGCA TACAAGAGAA TAGTTGAACT CTGCTCCCCA 1020

CGAGTGTGGA AACCAGAAAT ACTTCTAAAG CTGCTTTGCT TGCCAAAGCC TTGTGCTAAA 1080

TTGATAGAAT GCATTCGACT GGTCGTTGAC AAATCTGGCC AGAGTTTTTT ATCTTCTGAT 1140

GACAGGGATG ATGGAAGCAG CCTACTGGCA AAATCTGAGG GATTAGATTT GCCAAAAGTT 1200

GGGCAGAAAC GAATAGCTCT GGACGAGGAA AATAGTTTCC CCAAACGTTT AAAGATGACA 1260

GAACCAAGAT TTTCTTCTGG TTCATTTATG GTCGATGAAC TTTCTGCTGG CGTTGGACAG 1320

GAGCTAGAAA AGGATCATGG TTGTGATTTT CGTGTGCAAC TATATTCACT TATTAATTGC 1380

CTGTCACCTG ACAATCATAT GGCTTATCCA TTGGAGCCGG CAATTTCTAT TCAAGTGCTT 1440

AGTCTGCTAT GCCTTTCATT ATCTGTTTAT CCAAAGACAA ATCTGTTTAG TAGAATTTCC 1500

AAGCAAGTCC TTTCCTGGAT TCCTTGGATT TGCAAGCAGA CAACCAAGAT ATGCATGTTT 1560

TCCTTTGATG TGTCACTCTA TTTTGAAGCT GTTCAGACTG TAATGCTTCT CCAATCTTTT 1620

CTTCCTGGAC ACACAAAACT GTTTGAAGAT GAACCTCTGT TGATTGGTAA TGGTTGTACA 1680

GATTTCGAGT ATCCAAGATA TGCTGATCTT ATTAACTTGC TGAAACTGGT GTCGGATGAT 1740

GGTTATCTTA CTTCTCAAAC ATGTTCGGAG AAGTTAAAAT GCCTTGCAGT ACAAATTATT 1800

GCTAAAATAG GCAGCAGGCA GAATGCTGAG TGTGATCTTC AAGTCCTTGA ATTGGCTATC 1860

CAAAGTGAAA CTGGGGAGCT TCAAAACGAG GCTCTTATGT CATTACCCAT TATTGTATTG 1920

TACTCTGGTC CCAGGATGCT TGGAGCAATG TTCAGGAAAC TTGAGACAAT TGGTACTTTA 1980

GGATGCAAGA AACTGTGGAA AAGTATTGCC ATTTCACTTG GTTTTCTTTC TTGCTTAAAT 2040

GGAACCACTG ATTGCACTGA CAAAGTGGGA AATCATTGCA AACTTTTCCT GGCCAAGCAC 2100

TGTGAACAGC CAATCTTGAC ATTAAATCTC TTAAGAGGTT TCTGGTGCCC GCAGTGTGAT 2160

GTCAGAACTG TCCACATTGA AGATCAAGTT CCTATTGTGG ACATTGCACT TTCGGAAGAT 2220

AAAAATATTG ACTTCAAAAT TAACATGTTC AAGGCCCATT CTCTTTTCTT CAAGTTCCTT 2280

TATGCTGAGA CTTCCGAGGA GTGTATAGTT TCTATAGTTG AAGTATTGCC ACGAATATTG 2340

AAACATTCTA GCAGGGACGT TCTGCTTGAT ATGAAATTTC AGTGGGTACA GTGTGTTGAT 2400

TTTCTCCTAC TACATGAAAT GAAAGCTGTC CGAGATGCAT TCTCTAGTGT AGTGTCCTGC 2460

TTCTTGGAAA CAAACGCGAT GGATATTTTG TTTTCTGATG GAACGGGAAT GAGTGGAGGG 2520

ACCAGCAGAG TTAAATTTAT GGACAAAATA AAGAGTGCTT TCACTGAAGC TGAAGATCCC 2580

CAGATACTAC TTACTCTTTT GGAATCGACT GCAGCAATTG TGAAAGCTAG TGATATTCAT 2640

GGGGAAGTTT TTTTCTGCTC ATTTGTATTG CTAATTGGTC AGCTTGGTAA TCACGATTAT 2700

ATTGTAAGGG TTACTGCATT GAGATTACTT CAAAGATGTT GCACCTACTG TTTCAAGGGA 2760

GGATTGGAAC TCTTCCTTTC AAAGTATTTC CATGTTAGAG ATAATCTGTA TGATTATCTG 2820

TCATCTAGAC TTTTGACTCA TCCTGTAGTG ATTAGTGAAT TTGCTGAATC TGTTCTTGGG 2880

GTTAAGACTG AAGAGCTGAT CAGGAGAATG GTTCCATCAA TTATACCAAA ACTTATTGTG 2940

TCTCACCAAA ACAATGACCA AGCAGTTGTT ACTCTGAATG AACTGGCGAG TCATCTAAAC 3000

AGAACTGATA GCAAAGAGAT ATTTTCAGCT GCTTTGCCAA CACTGCTTGA TGAAATCATA 3060

TGTTTTCCTG GTGAATCTGA CCAGATCGAG ACAGATAGAA GGATGGCAAA AATTTCACCA 3120

ACTATTCAGA ATATCGCAAG AATTTTGACA GGCAACGATA ACCTTCCTGA GTTTTTGAAG 3180

AATGATTTTG TTCGGCTTCT CAACAGTATT GACAAGAAAA TGCTTCATTC CAGTGATGTG 3240

AATCTTCAGA AGCAAGCCCT CCAGCGTATA AGGAAATTAG TTGAGATGAT GGGCCCTTAT 3300

TTGAGTACAC ATGCACCAAA GATTATGGTT CTGTTGATTT TTGCCATTGA TAAAGAAACT 3360

CTGCAAATGG ATGGGCTAGA TGTACTACAT TTTTTCATCA AGCGACTGGC CGAGGTATCG 3420

TGTACCAGTA TCAAGTATGT TATGTCCCAA GTTGTAGCTG CATTTATTCC CTCTTTAGAA 3480

AGGTGCAGAG AACGTCCTCT TGTGCATCTG GGCAAAATTG TTGAAATCCT GGAAGAACTT 3540

GTAGTTAAAA ACATTATCTT GCTTAAACAA CATATACGTG AATTGCCGTT GTTACCTAGC 3600

TTACCATCTT TGTCAGGAGT GAACAAAGTA ATACAAGAAG CCAGAGGGTT AATGACTCTG 3660

CAAGATCATC TAAAGGATGC TGTCAATGGT CTTAACCATG AGAGCTTAAA TGTAAGGTAC 3720

ATGGTGGCAT GTGAGTTAAA TAAACTATTC AATGATAGAA GGGGGGACAT TACTTCTCTC 3780

ATTATTGGTG AAGATATTGC TGATTTGGAT ATAATAAGCT CTTTAATAAT GTCTTTACTA 3840

AAAGGATGTG CAGAGGAATC AAGGACAGTT GTTGGCCAGA GATTGAAACT AGTTTGTGCA 3900

GATTGTCTTG GTGCACTTGG AGCTGTTGAT CCTGCTAAGT TTAAGGTAAT GTCATGCGAG 3960

CGCTTTAAGA TTGAATGTTC AGATGACGAT CTTATATTTG AGTTGATCCA CAAGCATCTT 4020

GCAAGGGCAT TCAGAGCTGC TTCTGACACC ACAGTACAGG ATTCTGCTGC ATTGGCTATT 4080

CAAGAGCTAC TAAAACTGTC AGGTTGTCAA TCTTTACCTA ATGAATCAAG TAGTTGCAAG 4140

ATGAGCAAAA GGGGCCAGAA GTTGTGGGGG CGTTTTTCTA GTTATGTTAA GGAAATTATT 4200

GCACCATGCT TGACTTCAAG ATTTCATCTT CCTAGTGTGA ATGATGCTAC TTTAGCTGGT 4260

CCAATATACC GCCCAACAAT GTCTTTTAGG AGGTGGATAT ATTATTGGAT TAGGAAGTTA 4320

ACATCCCATG CAACTGGATC GCGTAGTGGT ATATTTGGTG CATGTCGTGG AATTGTTCGG 4380

CATGACATGC CAACTGCAAT ATATCTCCTA CCGTACTTGG TCTTGAATGT TGTTTGCTAT 4440

GGAACTCCCG AGGCTCGTCA AAGTATTACT GAGGAAATCT TGTCTGTTCT CAATGCTGCT 4500

GCTTCAGAAA GTAGTGGAGC TATTGTTCAT GGAATTACTG GAGGACAGAG TGAAGTCTGT 4560

ATTCAAGCTG TCTTCACTTT ACTTGATAAT CTTGGGCAAT GGGTTGATGA CCTCAAACAG 4620

GAAATTGCTT TATCCCAATC TAATTATGCA ATGGCTGGAA GACAGGGAGG TAAACTGAGA 4680

GATGAAAGCA ACTCTATGTA TGACCAAGAT CAATTGCTAG TGCAGTGCAG CAACGTTGCT 4740

GAGCTGTTGG CTGCTATTCC TAAAGTCACT CTAGCTAAGG CATCATTTAG ATGTCAAGCT 4800

CATGCTCGTG CTCTAATGTA CTTTGAATCT CATGTCCGTG AAAAGTCTGG CTCCTCAAAT 4860

CCAGCTGCAG ACTGTAGTGG TGCCTTTTCA GATGATGACA TCTCTTTTCT GATGGAAATA 4920

TATGGAGGAC TGGATGAGCC CGATGGCCTC CTAGGTTTAG CTAATCTGAG GAAATCATCA 4980

ACCCTACAAG ATCAACTAAT CATCAATGAG AAAGCGGGGA ATTGGGCTGA AGTGCTAACA 5040

TTATGTGAAC AGTCTTTGCA AATGGAACCT GATTCTGTCC ATAGACATTG TGATGTTCTC 5100

AATTGTTTGC TAAACATGTG CCATCTTCAA GCCATGATTG CACATGTGGA TGGTTTGGTG 5160

TATAGAATAC CTCAATCTAA GAAAACTTGG TGCATGCAAG GGGTACAAGC AGCTTGGAGA 5220

TTAGGGAGAT GGGATCTCAT GGATGAATAT CTAGCCGAGG CAGACAAAGG TCTGGTGTGC 5280

AGAAGTTCTG AGAACAATGC TTCTTTTGAC ATGGGTCTTG CTAAGATATT CAACGCGATG 5340

ATGAAAAAAG ATCAGTTTAT GGTTGCTGAA AAAATTGCCC AGTCCAAGCA AGCATTGCTT 5400

GTACCTTTAG CTGCAGCTGG CATGGACTCA TACATGCGTG CATATCCTTA CATAGTTAAG 5460

CTCCATATGC TGCGTGAGTT AGAAGACTTC AACTCCCTGC TGGGAGATGA GTCATTTCTT 5520

GAAAAGCCAT TTGCTGCAGA TGATCCTAAG TTTCTGAAAT TGACAAAGGA TTGGGAAAAC 5580

CGTCTGAGAT GTACACAACC ATCTCTGTGG GCAAGGGAGC CATTGCTTGC TTTCCGAAGG 5640

ATGGTTTATA ATCTGAGTCA TATGAATGCT CAAGCTGGGA ACTGCTGGCT TCAGTATGCA 5700

AGGCTCTGCC GTTTGGCTGG CCATTACGAG ACTGCCCACC GTGCAATACT GGAAGCAGAC 5760

GCTTCAGGTG CTCCTAATGC TCACATGGAA AAGGCTAAGT ACCTCTGGAA TATACGGAAG 5820

TCTGATAGTG CTATAGCTGA ACTTCAGCAA ACACTTCTAA ACATGCCTGC GGATGTTTTG 5880

GGACCTACTG TCCTTTCATC CCTTTCTAGC CTTTCTCTTG CTTTGCCAAA TGCACCCCTC 5940

TCTGTGACAC AGGCATCAAA AGAGAATCCA GATGTGTCCA AAACTCTCCT TCTCTACACT 6000

AGATGGATCC ACTATACAGG GCAAAAGCAG AGCAATGACA TCAAATCTCT ATATTCTAGG 6060

GTAGCAGATT TGCGGCCCAA GTGGGAAAAG GGGTTCTTCT GCATAGCAAA GTTCTATGAT 6120

GATTTGCTTG TTGATGCTAG GAGACGCCAA GAAGATAAGA AAATTGCAAG TGGAGTTGGA 6180

CCTGTCCCTC CTAGCTCTAC TGGTTCTTTA ACTACAGCAA CTGAAGAGAA GCCTTGGTGG 6240

GATATGCTTC CAGTAGTCTT AATACAGTAT GCAAGAGGAC TTCACAGAGG ACATAAAAAT 6300

CTTTTTCAAG CGTTACCGCG ATTGCTTACT CTTTGGTTTG AATTCGGAAG CATATATATC 6360

CAGGATGGAT CTTCCTTCAA TAAACCCATG AAAGAAGTTC ATATAAGGTT GTTAGGCATT 6420

ATGCGCGGGT GTTTGAAAGA TCTACCACCA TATCAGTGGT TAACTGTGCT GTCTCAGTTG 6480

ATCTCCCGCA TCTGTCATCA AAATATTGAA GTTGTCAAAC TTGTCAAATG CATCGTCACA 6540

TCTATTTTAC GGGAGTACCC TCAGCAGGCT CTATGGATGA TGGCTGCAGT GTCAAAGTCA 6600

ACAGTTGCTG CAAGACGAGA TGCTGCTGCT GAAATATTAC AATCAGCAAA GAAGGGCAGT 6660

CGGCGTGGTA GTGACAGCAA TGCATTATTC ATGCAGTTTC CTTCTTTGAT AGATCATCTG 6720

ATCAAGCTGT GCTTTCATCC GGGGCAGCCA AAGGCAAGGG CAATAAATAT CTCAACAGAG 6780

TTCAGTTCCT TGAAAAGAAT GATGCCGTTA GGAATCATCT TACCCATCCA GCAGGCTCTA 6840

ACTGTGACTC TACCATCATA TGATACAAAT ATGACAGATC AATCAACTTT TCGTCCCTTT 6900

TCAGTTTCCG AGCACCCTAC TATAGCCGGA ATAGCTGATG ATGCAGAGAT CCTTAACTCT 6960

CTTCAGAAAC CAAAGAAGGT TGTTTTCATT GGAAGTGATG GAATTTCTCG ACCATTTCTG 7020

TGCAAACCAA AGGATGATCT TAGGAAAGAT TCGCGCATGA TGGAGTTCAA TGCAATGATC 7080

AACCGCCTTC TCTCCAAAGT CCCTGAGAGC CGCAGGAGAA AGCTTTATAT TAGAACCTTT 7140

GCAGTGGTTC CGCTTACAGA AGATTGTGGA ATGGTAGAGT GGGTGCCCAA TACTCGTGGT 7200

CTTCGGCAAA TTCTTCAGGA TATCTACATA ACTTGTGGCA AATTCGATAG GATGAAAACA 7260

AACCCACAAA TCAAGAAGAT ATATGATCAA TTGCAGGGTA AAATGCCTGA GGAGATGCTG 7320

AAGGCTAAAA TCCTTCCAAT GTTCCCCCCA GTTTTCCACA AATGGTTCTT GACTACATTT 7380

TCTGAGCCAG CTGCATGGAT CCGTGCCAGG GCAGCTTATG CGCATACAAC CGCAGTTTGG 7440

TCAATGGTTG GGCATATTGT TGGGCTTGGT GACAGACATG GTGAAAACAT CCTTCTCGAT 7500

TCAACTACTG GGGACTGTAT TCATGTGGAT TTCAGCTGCT TGTTTGACAA GGGCTTGCTG 7560

CTCGAGAAGC CTGAGGTGGT GCCATTCAGG TTTACACAAA ACATGGTTGA TGGCTTGGGC 7620

ATCACTGGTT ATGAGGGCGT GTTTGTGAAG GTCTGTGAAA TTACTCTATC GGTTCTGAGA 7680

ACTCACAAGG AGGCACTCAT GACTGTTCTT GAGACCTTTA TCCATGATCC GCTAGTAGAG 7740

TGGACCAAAT CTCATAAATC CAGTGGAGTG GAAGTCCGAA ACCCACATGC ACAGAGGGCC 7800

ATCAGTAACA TCACAGAAAG GCTCCAGGGA GTTGTGGTAG GCGTTAACGC CGCTCCTTCT 7860

CTGCCACTTT CTGTGGAAGG CCAAGCACGC CGCCTGATTG CTGAAGCAGT CTCCCACAGC 7920

AACCTCGGCA AGATGTACGT CTGGTGGATG GCTTGGTTCT AA 7962

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iag+++  eil+s+qkpkk+++ Gsdg ++p+L+k+k+Dlr+d r+++++ ++N lL k

Q: 2308  IAGIADDAEILNSLQKPKKVVFIGSDGISRPFLCKPKDDLRKDSRMMEFNAMINRLLSKV  2367

         899*********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rrkL irt++Vvpl++ +g++ewv+nt +L+++l++++   +         r+k +

Q: 2368  PESRRRKLYIRTFAVVPLTEDCGMVEWVPNTRGLRQILQDIYITCGKFD------RMKTN  2421

         **************************************76654443333......44555

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         ++++    +l+  + + e++k+   ++ p+ +++k++l +f +p++w + r ay+  +Av

Q: 2422  PQIKKIYDQLQGKMPE-EMLKAKILPMFPP-VFHKWFLTTFSEPAAWIRARAAYAHTTAV  2479

         5555555555555555.8899999999997.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

          s+vg+i+gLgdrh en+l+d++tg ++h+df + f+k+   l+ pe vPFR T+n+v++

Q: 2480  WSMVGHIVGLGDRHGENILLDSTTGDCIHVDFSCLFDKGLL-LEKPEVVPFRFTQNMVDG  2538

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeelaek  300

         lg+tg eGvf + ce +l vlr +ke l+t+Le+f++dplv+w+k  ++++   e++++

Q: 2539  LGITGYEGVFVKVCEITLSVLRTHKEALMTVLETFIHDPLVEWTK--SHKSSGVEVRNPH  2596

         ********************************************8..5556666777888

S: 301   akaealkikkllskvekaenavatrdlllle  331

         a+    +i+++l++v  ++na   ++l++++

Q: 2597  AQRAISNITERLQGVVVGVNAAPSLPLSVEG  2627

         888999999********99999888888775

Domain Sequence
(FASTA)

IAGIADDAEI LNSLQKPKKV VFIGSDGISR PFLCKPKDDL RKDSRMMEFN AMINRLLSKV 60

PESRRRKLYI RTFAVVPLTE DCGMVEWVPN TRGLRQILQD IYITCGKFDR MKTNPQIKKI 120

YDQLQGKMPE EMLKAKILPM FPPVFHKWFL TTFSEPAAWI RARAAYAHTT AVWSMVGHIV 180

GLGDRHGENI LLDSTTGDCI HVDFSCLFDK GLLLEKPEVV PFRFTQNMVD GLGITGYEGV 240

FVKVCEITLS VLRTHKEALM TVLETFIHDP LVEWTKSHKS SGVEVRNPHA QRAISNITER 300

LQGVVVGVNA APSLPLSVEG 320

Keyword

ATP-binding; Cell cycle; Complete proteome; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Arabidopsis lyrata"; ?>Arabidopsis thaliana"; ?>Brachypodium distachyon"; ?>Brassica rapa"; ?>Chlamydomonas reinhardtii"; ?>Cyanidioschyzon merolae"; ?>Glycine max"; ?>Hordeum vulgare"; ?>Musa acuminata"; ?>Oryza brachyantha"; ?>Oryza glaberrima"; ?>Oryza indica"; ?>Physcomitrella patens"; ?>Populus trichocarpa"; ?>Selaginella moellendorffii"; ?>Setaria italica"; ?>Solanum lycopersicum"; ?>Vitis vinifera"; ?>Zea mays"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007049	; P:cell cycle
GO:0006281	; P:DNA repair

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013