EKS-CAE-00214
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAE-00214
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Abl511.56.2E-154296546251
StatusReviewed
Ensembl ProteinM79.1c
UniProt AccessionP03949; Q9U3A2; Q9U3A3;
Protein NameTyrosine-protein kinase abl-1
Protein Synonyms/Alias
Gene Nameabl-1
Gene Synonyms/Alias abl-1; M79.1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
M79.1M79.1aM79.1a
M79.1M79.1cM79.1c
M79.1M79.1bM79.1b
OrganismCaenorhabditis elegans
Functional Description
Protein Length1209
Protein Sequence
(FASTA)
MIMNPCFRER SQKRTKKRAK NRAKSRSTMY LSKVGDSSLA MSRSLPSVAL PMHYLHHKLA 60
ESICFITATI DSLEDLVACS SMNSVNNVHD MNTVSSSSSS SAPLFVALYD FHGVGEEQLS 120
LRKGDQVRIL GYNKNNEWCE ARLYSTRKND ASNQRRLGEI GWVPSNFIAP YNSLDKYTWY 180
HGKISRSDSE AILGSGITGS FLVRESETSI GQYTISVRHD GRVFHYRINV DNTEKMFITQ 240
EVKFRTLGEL VHHHSVHADG LICLLMYPAS KKDKGRGLFS LSPNAPDEWE LDRSEIIMHN 300
KLGGGQYGDV YEGYWKRHDC TIAVKALKED AMPLHEFLAE AAIMKDLHHK NLVRLLGVCT 360
HEAPFYIITE FMCNGNLLEY LRRTDKSLLP PIILVQMASQ IASGMSYLEA RHFIHRDLAA 420
RNCLVSEHNI VKIADFGLAR FMKEDTYTAH AGAKFPIKWT APEGLAFNTF SSKSDVWAFG 480
VLLWEIATYG MAPYPGVELS NVYGLLENGF RMDGPQGCPP SVYRLMLQCW NWSPSDRPRF 540
RDIHFNLENL ISSNSLNDEV QKQLKKNNDK KLESDKRRSN VRERSDSKSR HSSHHDRDRD 600
RESLHSRNSN PEIPNRSFIR TDDSVSFFNP STTSKVTSFR AQGPPFPPPP QQNTKPKLLK 660
SVLNSNARHA SEEFERNEQD DVVPLAEKNV RKAVTRLGGT MPKGQRIDAY LDSMRRVDSW 720
KESTDADNEG AGSSSLSRTV SNDSLDTLPL PDSMNSSTYV KMHPASGENV FLRQIRSKLK 780
KRSETPELDH IDSDTADETT KSEKSPFGSL NKSSIKYPIK NAPEFSENHS RVSPVPVPPS 840
RNASVSVRPD SKAEDSSDET TKDVGMWGPK HAVTRKIEIV KNDSYPNVEG ELKAKIRNLR 900
HVPKEESNTS SQEDLPLDAT DNTNDSIIVI PRDEKAKVRQ LVTQKVSPLQ HHRPFSLQCP 960
NNSTSSAISH SEHADSSETS SLSGVYEERM KPELPRKRSN GDTKVVPVTW IINGEKEPNG 1020
MARTKSLRDI TSKFEQLGTA STIESKIEEA VPYREHALEK KGTSKRFSML EGSNELKHVV 1080
PPRKNRNQDE SGSIDEEPVS KDMIVSLLKV IQKEFVNLFN LASSEITDEK LQQFVIMADN 1140
VQKLHSTCSV YAEQISPHSK FRFKELLSQL EIYNRQIKFS HNPRAKPVDD KLKMAFQDCF 1200
DQIMRLVDR 1209
Nucleotide Sequence
(FASTA)
ATGATCATGA ATCCGTGCTT TCGGGAACGA TCTCAGAAAC GAACCAAAAA GAGAGCGAAG 60
AATCGTGCCA AATCGCGTAG CACAATGTAC CTATCCAAGG TCGGTGATTC ATCACTTGCC 120
ATGTCGCGAA GTCTACCATC TGTCGCATTA CCAATGCACT ACTTGCATCA CAAACTAGCC 180
GAGAGCATAT GTTTTATCAC GGCTACAATC GACTCATTAG AGGATCTAGT AGCATGTAGC 240
TCAATGAATT CGGTAAACAA CGTGCACGAT ATGAATACAG TTTCCTCTTC ATCATCATCA 300
TCTGCACCAC TTTTTGTAGC TCTCTATGAT TTCCACGGTG TCGGCGAAGA GCAGCTTTCG 360
TTACGAAAGG GTGATCAGGT GCGAATTCTG GGTTACAACA AAAACAATGA GTGGTGTGAG 420
GCACGATTAT ACTCAACGAG AAAAAATGAT GCGAGCAATC AGCGAAGGTT AGGCGAAATT 480
GGATGGGTGC CAAGTAATTT TATTGCTCCG TACAACTCTT TGGATAAGTA CACGTGGTAT 540
CATGGCAAAA TCTCAAGGAG CGATTCTGAG GCTATACTAG GCAGTGGAAT CACTGGCTCA 600
TTTTTGGTAC GAGAAAGTGA AACAAGTATA GGACAGTATA CAATCTCTGT TCGCCATGAT 660
GGTCGAGTGT TTCACTACCG GATCAATGTA GATAATACAG AAAAGATGTT CATCACACAA 720
GAAGTCAAAT TCCGCACACT TGGAGAGTTA GTGCACCATC ATAGTGTTCA CGCTGATGGG 780
CTGATATGTC TTTTAATGTA CCCAGCGAGT AAAAAGGACA AGGGACGTGG ACTGTTCTCA 840
CTGTCGCCTA ACGCGCCAGA CGAATGGGAA CTAGATAGAT CCGAAATCAT CATGCATAAC 900
AAATTGGGCG GTGGACAGTA CGGAGACGTG TACGAGGGAT ACTGGAAACG ACATGACTGC 960
ACAATTGCAG TGAAAGCGTT GAAGGAAGAT GCAATGCCAC TTCATGAATT TTTAGCAGAA 1020
GCTGCTATCA TGAAAGATTT GCACCACAAA AACCTTGTTC GACTGCTTGG AGTATGCACT 1080
CACGAGGCAC CGTTCTATAT TATCACCGAG TTTATGTGCA ATGGAAATTT GCTCGAGTAC 1140
CTGAGGAGGA CCGATAAAAG CTTGCTGCCA CCTATAATCC TTGTTCAAAT GGCTAGTCAG 1200
ATTGCGTCCG GCATGTCGTA CCTGGAAGCC AGACACTTCA TTCATAGGGA TTTGGCCGCA 1260
AGGAATTGCT TAGTATCCGA GCATAATATT GTAAAAATTG CCGACTTTGG GTTGGCAAGA 1320
TTCATGAAGG AAGACACCTA TACAGCACAT GCTGGAGCCA AGTTTCCTAT CAAATGGACT 1380
GCCCCAGAGG GGCTTGCATT CAACACCTTC AGCTCTAAAT CTGATGTTTG GGCGTTTGGA 1440
GTTCTGCTCT GGGAAATTGC CACGTATGGA ATGGCTCCCT ATCCAGGCGT CGAGCTGTCA 1500
AATGTTTATG GGCTTTTGGA AAACGGGTTC CGTATGGATG GCCCGCAAGG GTGCCCTCCA 1560
TCGGTGTATC GCCTTATGCT TCAGTGCTGG AACTGGTCTC CGTCGGATCG TCCTCGTTTC 1620
CGAGATATTC ATTTCAACTT GGAAAATCTA ATTTCAAGCA ATTCCTTGAA CGACGAGGTG 1680
CAAAAACAAT TGAAAAAGAA TAATGATAAG AAACTGGAAA GTGACAAAAG AAGGTCTAAC 1740
GTTAGAGAAC GAAGTGACTC TAAATCCAGA CATTCTTCAC ATCACGACCG TGACCGTGAC 1800
CGGGAATCTC TTCATTCTCG GAACTCAAAT CCTGAAATTC CCAATAGAAG TTTTATAAGA 1860
ACCGACGACA GTGTATCATT CTTCAATCCA TCAACCACAA GTAAAGTAAC GTCGTTTCGT 1920
GCTCAAGGAC CACCGTTCCC ACCACCGCCA CAACAAAACA CAAAACCGAA ACTATTGAAG 1980
TCAGTTCTGA ATAGTAACGC TCGTCATGCA TCAGAGGAGT TTGAGAGAAA CGAACAAGAT 2040
GACGTGGTTC CTTTGGCCGA GAAAAATGTG CGGAAAGCGG TTACCAGGCT GGGTGGAACT 2100
ATGCCGAAAG GACAAAGGAT AGATGCATAT TTAGACTCGA TGAGAAGGGT TGACAGTTGG 2160
AAAGAAAGCA CTGACGCTGA CAATGAAGGG GCGGGATCAT CATCGCTGAG CAGAACTGTA 2220
TCGAATGATT CTCTTGACAC ACTTCCTCTG CCAGATTCTA TGAACTCGAG TACGTATGTT 2280
AAAATGCATC CTGCATCCGG CGAGAACGTT TTCCTGAGAC AAATTCGTTC AAAACTGAAG 2340
AAACGAAGTG AGACACCAGA GTTGGATCAT ATTGATTCAG ATACTGCCGA TGAAACAACA 2400
AAATCGGAAA AGTCACCCTT TGGATCTTTG AATAAATCTT CTATCAAATA TCCAATTAAA 2460
AACGCGCCCG AATTTAGTGA GAATCACTCT AGAGTCAGCC CTGTCCCGGT GCCACCATCT 2520
CGTAACGCTT CTGTAAGTGT AAGACCCGAT TCGAAAGCAG AAGACTCATC GGATGAGACA 2580
ACAAAAGATG TTGGAATGTG GGGTCCTAAG CATGCCGTGA CGCGGAAAAT TGAAATTGTC 2640
AAGAATGATT CGTATCCAAA TGTAGAAGGC GAGTTGAAAG CAAAAATTCG AAATTTACGT 2700
CATGTACCCA AAGAAGAGAG CAACACAAGT AGTCAAGAAG ATTTGCCACT TGATGCGACA 2760
GACAACACAA ATGACAGCAT CATTGTGATT CCAAGAGATG AAAAAGCAAA AGTTCGTCAA 2820
CTGGTGACAC AAAAAGTATC TCCTCTTCAA CATCATCGGC CATTCTCACT GCAATGTCCA 2880
AACAATTCTA CAAGCTCTGC AATATCGCAT TCTGAACACG CGGATAGCTC AGAAACATCT 2940
TCACTTTCCG GTGTCTATGA GGAACGTATG AAACCTGAAC TTCCAAGAAA ACGGAGTAAT 3000
GGCGATACAA AAGTGGTGCC AGTAACATGG ATTATCAATG GAGAAAAGGA ACCCAATGGT 3060
ATGGCTCGAA CAAAATCTCT ACGTGATATT ACATCAAAGT TCGAACAGCT TGGAACAGCT 3120
TCCACGATTG AAAGTAAGAT TGAAGAAGCC GTCCCATATC GTGAGCATGC ATTGGAAAAG 3180
AAAGGAACTT CAAAACGATT TTCAATGCTG GAAGGAAGTA ATGAGTTGAA GCATGTTGTC 3240
CCACCGCGTA AAAACCGAAA CCAAGACGAA TCTGGCTCAA TTGATGAAGA ACCAGTGAGC 3300
AAGGACATGA TTGTATCGTT GCTCAAAGTA ATCCAAAAGG AATTTGTGAA TCTTTTCAAT 3360
TTGGCGAGCT CAGAGATCAC TGATGAAAAA CTACAACAAT TTGTAATAAT GGCTGATAAT 3420
GTACAAAAAC TTCATTCCAC GTGTTCCGTC TATGCAGAAC AAATCTCACC GCATAGTAAA 3480
TTTCGGTTCA AAGAACTTCT TTCTCAACTT GAAATCTACA ATCGACAAAT TAAATTTTCC 3540
CACAACCCTC GAGCGAAGCC AGTTGATGAC AAACTTAAAA TGGCGTTCCA GGACTGTTTC 3600
GACCAAATCA TGAGGCTGGT GGATCGCTGA 3630
Domain Profile
S: 1     iimkhklgggqygevyegvwkkysltvavktlkedtmeveeflkeaavmkelkhpnlvql  60
         iim++klgggqyg+vyeg+wk++++t+avk+lked+m+++efl+eaa+mk+l+h+nlv+l
Q: 296   IIMHNKLGGGQYGDVYEGYWKRHDCTIAVKALKEDAMPLHEFLAEAAIMKDLHHKNLVRL  355
         89**********************************************************
S: 61    lgvctreppfyiitefmsygnlldylreadreeveavvllymatqissameylekknfih  120
         lgvct+e+pfyiitefm++gnll+ylr++d++ +++++l++ma+qi+s+m+yle+++fih
Q: 356   LGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYLEARHFIH  415
         ************************************************************
S: 121   rdlaarnclvgenklvkvadfglsrlmkedtytahagakfpikwtapeslaynkfsiksd  180
         rdlaarnclv+e+++vk+adfgl+r+mkedtytahagakfpikwtape+la+n+fs+ksd
Q: 416   RDLAARNCLVSEHNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSKSD  475
         ************************************************************
S: 181   vwafgvllweiatygmspypgidlsqvyellekgyrmerpegcppkvyelmracwkwsps  240
         vwafgvllweiatygm+pypg++ls+vy lle+g+rm+ p+gcpp+vy+lm++cw+wsps
Q: 476   VWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPS  535
         ************************************************************
S: 241   drpsfaeihqa  251
         drp+f++ih++
Q: 536   DRPRFRDIHFN  546
         *********86
Domain Sequence
(FASTA)
IIMHNKLGGG QYGDVYEGYW KRHDCTIAVK ALKEDAMPLH EFLAEAAIMK DLHHKNLVRL 60
LGVCTHEAPF YIITEFMCNG NLLEYLRRTD KSLLPPIILV QMASQIASGM SYLEARHFIH 120
RDLAARNCLV SEHNIVKIAD FGLARFMKED TYTAHAGAKF PIKWTAPEGL AFNTFSSKSD 180
VWAFGVLLWE IATYGMAPYP GVELSNVYGL LENGFRMDGP QGCPPSVYRL MLQCWNWSPS 240
DRPRFRDIHF N 251
KeywordAlternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00218
EKS-ANC-00228
EKS-BOT-00257
EKS-CAJ-00243
EKS-CAF-00245
EKS-CAP-00293
EKS-CII-00141
EKS-CIS-00017
EKS-DAR-00593
EKS-DAN-00005
EKS-DRM-00121
EKS-EQC-00230
EKS-FEC-00244
EKS-GAG-00198
EKS-GAA-00320
EKS-GOG-00256
EKS-HOS-00245
EKS-ICT-00225
EKS-LAC-00270
EKS-LOA-00268
EKS-MAM-00260
EKS-MEG-00204
EKS-MIM-00012
EKS-MOD-00237
EKS-MUM-00242
EKS-MUP-00256
EKS-MYL-00237
EKS-NOL-00239
EKS-ORN-00335
EKS-ORA-00227
EKS-ORC-00245
EKS-ORL-00286
EKS-OTG-00264
EKS-PAT-00226
EKS-PES-00229
EKS-PEM-00134
EKS-POA-00231
EKS-PTV-00011
EKS-RAN-00271
EKS-SAH-00243
EKS-SUS-00223
EKS-TAG-00253
EKS-TAR-00332
EKS-TAS-00010
EKS-TEN-00296
EKS-TUT-00026
EKS-XET-00313
EKS-XIM-00328
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0050832; P:defense response to fungus
GO:0050829; P:defense response to Gram-negative bacterium
GO:0000077; P:DNA damage checkpoint
GO:0043066; P:negative regulation of apoptotic process
GO:0030336; P:negative regulation of cell migration
GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:1901075; P:negative regulation of engulfment of apoptotic cell
GO:0010212; P:response to ionizing radiation
GO:0007283; P:spermatogenesis
KEGG
cel:CELE_M79.1;
InterPros
IPR015015; F-actin_binding.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00808; FABD; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013