EPS-SCP-00005

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SCP-00005

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	155.8	4.4E-46	92	379	288

Status

Reviewed

Ensembl Protein

SPAC10F6.17c.1:pep

UniProt Accession

O14189; O42655;

Protein Name

Protein phosphatase 2C homolog C10F6.17c

Protein Synonyms/Alias

Pyruvate dehydrogenase (Lipoamide) phosphatase C10F6.17c;

Gene Name

SPAC10F6.17c

Gene Synonyms/Alias

SPAC10F6.17c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPAC10F6.17c	SPAC10F6.17c.1:pep	SPAC10F6.17c.1

Organism

Schizosaccharomyces pombe

Functional Description

Involved in regulation of pyruvate dehydrogenaseactivity (By similarity).

Protein Length

444

Protein Sequence
(FASTA)

MNFFTSAVGS KVFKRNNFKY VAIAASSIGL AAYHIRKDAI ALDIPNSTYQ HVSKNRVPPT 60

DGDGITKRLK EFERTVTVNK DGIFRYDFNQ VASNDPCEDD HVEVIDRNID EGNWYFWGIF 120

DGHSGWNTSL FLRQHLVPAV VRELQKCTAS YYHQNACPSS LALDKSISEA FAKVDHQIVH 180

EHVSHVFNNP ESLQVAASLL LPALSGSCAL LTSYSAKSKS LQVACTGDSR AVLGECTPDG 240

SWEAIPLSRD QTGMNPDEAS RLEVEHPGEE VLRNNRILGR LMPSRAFGDA RYKWSQEISE 300

RLHREYFSAS PIPVKTPPYV TAVPEIESIT VNPKKHRFLI MASDGLWDTM SSEQAVQLVG 360

EWADTVLGKT TNEKNTTQDD KQSWSLFKKT SKVIDDNAAT HLIRHSLGGS DQRISALLTL 420

TYPISRRYRD DITVTVIFFD EKTL 444

Nucleotide Sequence
(FASTA)

ATGAATTTTT TTACCTCAGC CGTTGGTTCG AAAGTGTTTA AGCGTAACAA CTTTAAATAT 60

GTCGCTATAG CCGCTTCCTC CATTGGATTA GCTGCTTACC ATATTCGTAA GGATGCGATT 120

GCCTTGGACA TACCTAATAG CACTTATCAG CATGTTTCTA AAAATCGGGT TCCTCCCACG 180

GATGGGGATG GTATCACAAA ACGCCTGAAA GAGTTTGAGC GAACGGTAAC CGTCAACAAA 240

GATGGCATCT TTCGCTACGA CTTCAATCAG GTTGCCAGCA ATGATCCTTG CGAAGACGAT 300

CATGTAGAGG TAATAGATCG AAACATCGAT GAAGGGAATT GGTATTTTTG GGGTATTTTT 360

GACGGACATT CCGGTTGGAA TACTTCTCTT TTCTTACGCC AGCACCTAGT TCCAGCAGTC 420

GTTAGGGAAT TGCAAAAGTG TACTGCATCT TACTATCATC AAAATGCTTG TCCTTCATCT 480

CTTGCGCTCG ATAAGTCGAT CAGTGAGGCA TTTGCCAAAG TTGACCATCA AATTGTACAC 540

GAGCATGTCT CCCATGTATT CAACAATCCA GAGTCACTCC AAGTAGCCGC TAGTCTATTG 600

TTACCCGCTC TATCAGGATC GTGCGCTCTT CTTACTTCGT ATTCAGCAAA ATCTAAGAGT 660

CTTCAGGTTG CCTGTACTGG TGATTCGCGG GCTGTTCTTG GAGAATGTAC GCCCGATGGC 720

TCTTGGGAAG CTATCCCACT TAGTCGCGAT CAAACTGGAA TGAATCCTGA TGAAGCATCT 780

CGCTTGGAAG TTGAGCATCC AGGCGAAGAA GTCCTTCGTA ATAACAGGAT TCTTGGACGT 840

CTTATGCCTT CAAGAGCCTT TGGCGACGCT CGTTACAAAT GGTCCCAGGA AATTAGCGAG 900

AGACTACACA GAGAATATTT TTCCGCTTCA CCCATCCCTG TTAAAACTCC TCCATATGTT 960

ACTGCGGTCC CTGAAATTGA AAGTATCACC GTGAATCCAA AGAAGCATCG CTTTCTAATT 1020

ATGGCTTCCG ATGGCCTTTG GGACACTATG TCCAGTGAAC AAGCAGTACA ATTGGTCGGA 1080

GAATGGGCAG ATACAGTTTT GGGTAAAACT ACCAACGAAA AGAACACAAC TCAGGATGAC 1140

AAACAATCAT GGTCGCTGTT TAAGAAAACA TCAAAGGTCA TTGATGATAA TGCTGCCACG 1200

CACCTTATTC GACATTCTTT GGGTGGAAGC GACCAAAGAA TATCTGCTTT ATTAACCTTG 1260

ACTTATCCAA TTTCAAGAAG GTATCGTGAC GACATAACTG TTACGGTGAT CTTTTTCGAC 1320

GAAAAAACTT TGTAG 1335

Domain Profile

S: 25    flkspekkdr............laffgvyDGhggsevakfcseklheilaeele......  66

         + ++p++ d+            ++f g++DGh g +++ f++++l  ++ +el+

Q: 92    ASNDPCEDDHvevidrnidegnWYFWGIFDGHSGWNTSLFLRQHLVPAVVRELQkctasy  151

         5555555555666666666666********************************998888

S: 67    ...sseseerkvkkalakaFlstdeel............kvleeksldidk.........  102

            +  +++  ++k + +aF+++d ++            +          +

Q: 152   yhqNACPSSLALDKSISEAFAKVDHQIvhehvshvfnnpE----------Slqvaaslll  201

         8876667777888**************9977775554441..........1333345666

S: 103   ...sGstavvalikds..klyvanvGdSravLcrng.k....avelssdHkpsredEleR  152

            sGs+a++  ++ +  +l va +GdSravL+    +    a++ls+d +  ++dE +R

Q: 202   palSGSCALLTSYSAKskSLQVACTGDSRAVLGECTpDgsweAIPLSRDQTGMNPDEASR  261

         677******999887767**************8733234578******************

S: 153   ieeag..gsvilkdgaRvlGvLavsRalGdlylk........................py  186

         +e ++   +v +++  R+lG L++sRa+Gd ++k                        py

Q: 262   LEVEHpgEEVLRNN--RILGRLMPSRAFGDARYKwsqeiserlhreyfsaspipvktpPY  319

         **999866777777..********************************************

S: 187   vtpePevtshrltsede.fliLasDGlwdvvsneeavslvrdvle..............k  231

         vt+ Pe+ s++++++++ fli+asDGlwd++s+e+av+lv ++ +

Q: 320   VTAVPEIESITVNPKKHrFLIMASDGLWDTMSSEQAVQLVGEWADtvlgkttneknttqD  379

         *******************************************99888777665544441

Domain Sequence
(FASTA)

ASNDPCEDDH VEVIDRNIDE GNWYFWGIFD GHSGWNTSLF LRQHLVPAVV RELQKCTASY 60

YHQNACPSSL ALDKSISEAF AKVDHQIVHE HVSHVFNNPE SLQVAASLLL PALSGSCALL 120

TSYSAKSKSL QVACTGDSRA VLGECTPDGS WEAIPLSRDQ TGMNPDEASR LEVEHPGEEV 180

LRNNRILGRL MPSRAFGDAR YKWSQEISER LHREYFSASP IPVKTPPYVT AVPEIESITV 240

NPKKHRFLIM ASDGLWDTMS SEQAVQLVGE WADTVLGKTT NEKNTTQD 288

Keyword

Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0004741	; F:[pyruvate dehydrogenase (lipoamide)] phosphatase activity
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006091	; P:generation of precursor metabolites and energy

KEGG

spo:SPAC10F6.17c

;

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013