EKS-SCP-00065

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00065

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	404.6	5.9E-122	33	316	284

Status

Reviewed

Ensembl Protein

SPAC1687.15.1:pep

UniProt Accession

Q10452; O94456;

Protein Name

Protein kinase gsk3

Protein Synonyms/Alias

Protein kinase skp1;

Gene Name

gsk3

Gene Synonyms/Alias

gsk3; skp1; SPAC1687.15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPAC1687.15	SPAC1687.15.1:pep	SPAC1687.15.1

Organism

Schizosaccharomyces pombe

Functional Description

Interacts with cdc14 which is thought to play a role inthe initiation and completion of mitosis. Involved in the positive regulation of mis12.

Protein Length

387

Protein Sequence
(FASTA)

MNHGTKIPVD PFRIIKETAR DGSTGEVKQL SYTSSKVVGS GSFGVVMQVH LIESDSKAAI 60

KRVLQDKRFK NRELQIMRIM KHPNIVDLIA YYYTTGDNSD EVYLNLVLEF MPETIYRASR 120

LYTRQKLSMP MLEVKLYIYQ LLRSLAYIHA SGICHRDIKP QNLLLDPENG ILKLCDFGSA 180

KILVAGEPNV SYICSRYYRA PELIFGATDY THAIDIWSTG CVMAELMLGH PLFPGESGID 240

QLVEIIKILG TPSREQIKTM NPNYMEHRFP QIRPQPLSRV FSRSVPLDAL DLLSKMLQYT 300

PTDRLTAAEA MCHPFFDELR DPNTKLHNSR NPDASPRHLP ELFNFSPFEL SIRPDLNQKL 360

IPSHARDALP VKLDDFVPIP IHRARID 387

Nucleotide Sequence
(FASTA)

ATGAATCATG GTACTAAAAT TCCTGTGGAC CCCTTTCGTA TTATAAAGGA AACCGCTCGT 60

GATGGGTCAA CGGGAGAGGT GAAGCAACTT TCTTACACTT CGAGTAAAGT TGTGGGCTCT 120

GGAAGCTTTG GCGTGGTCAT GCAGGTTCAT TTAATTGAAT CAGACAGCAA AGCCGCTATA 180

AAACGCGTTT TGCAAGATAA ACGGTTTAAG AATAGGGAGT TACAAATTAT GCGAATTATG 240

AAGCATCCAA ATATTGTCGA TTTAATTGCC TACTATTATA CCACCGGTGA TAATTCCGAT 300

GAAGTCTATC TAAATTTGGT TCTAGAGTTT ATGCCTGAAA CGATTTATCG TGCTTCTCGT 360

CTATATACTC GTCAAAAACT TTCTATGCCA ATGCTGGAAG TCAAATTGTA TATATATCAG 420

CTTTTGCGTT CTTTAGCCTA CATTCATGCT AGCGGTATTT GCCATCGTGA TATCAAACCT 480

CAAAATCTAC TATTAGATCC GGAAAACGGA ATATTAAAGC TTTGTGATTT TGGTAGCGCA 540

AAAATCTTGG TTGCTGGTGA ACCAAATGTC TCTTATATAT GTTCTCGTTA TTATCGAGCT 600

CCAGAATTGA TTTTTGGAGC TACTGATTAT ACTCACGCTA TTGACATCTG GTCTACTGGA 660

TGCGTGATGG CTGAGCTTAT GCTTGGACAT CCTCTTTTTC CCGGTGAAAG TGGCATTGAT 720

CAGTTGGTAG AGATTATCAA AATTCTCGGT ACTCCTAGTC GAGAACAAAT AAAGACTATG 780

AATCCTAATT ATATGGAACA TCGATTCCCA CAAATACGTC CACAGCCTCT TTCACGAGTG 840

TTTTCTCGAA GTGTTCCCCT TGATGCATTG GATCTCTTAT CAAAAATGCT TCAATATACA 900

CCTACTGATC GCCTTACTGC TGCTGAGGCA ATGTGCCATC CCTTTTTTGA TGAGCTTCGG 960

GATCCTAATA CTAAGCTTCA TAACTCTCGT AATCCCGATG CTTCTCCTCG TCATTTACCC 1020

GAATTGTTTA ATTTTTCCCC CTTCGAACTA TCCATTCGTC CTGACCTTAA CCAAAAACTA 1080

ATTCCGTCCC ATGCTCGCGA TGCTTTACCC GTGAAACTTG ATGATTTTGT TCCAATTCCA 1140

ATTCATCGTG CCCGAATTGA TTAA 1164

Domain Profile

S: 2     eelkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyf  61

         ++ k++gsGsFg+V+q +l+e+++k  aiK+vlqdk++kn+El+i+r +kH+niv+L+ +

Q: 33    TSSKVVGSGSFGVVMQVHLIESDSK-AAIKRVLQDKRFKNRELQIMRIMKHPNIVDLIAY  91

         6789*******************99.**********************************

S: 62    fsksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsl  121

         ++++ +++d+vylnlvle++Pet+++  r ++++k ++++levkly+yQl+r+lay+h++

Q: 92    YYTTGDNSDEVYLNLVLEFMPETIYRASRLYTRQKLSMPMLEVKLYIYQLLRSLAYIHAS  151

         ************************************************************

S: 122   eivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeyt  181

         +i+HrDiKPqNll+d+e+g+lKlcDfGsak+l+ +epnvsYi+sRyYRaPEL++ga++yt

Q: 152   GICHRDIKPQNLLLDPENGILKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATDYT  211

         ************************************************************

S: 182   tkiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkk  241

          +iD+Ws+gcv+aEl++g++lf+g+s+ dql++i+k+lGtp++e+ik+mn++y+e++f++

Q: 212   HAIDIWSTGCVMAELMLGHPLFPGESGIDQLVEIIKILGTPSREQIKTMNPNYMEHRFPQ  271

         ************************************************************

S: 242   ikkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         i+ ++l++v+++  + +a+dll+k+l+y+p+ Rl+a e+++hpff

Q: 272   IRPQPLSRVFSRSVPLDALDLLSKMLQYTPTDRLTAAEAMCHPFF  316

         ********************************************9

Domain Sequence
(FASTA)

TSSKVVGSGS FGVVMQVHLI ESDSKAAIKR VLQDKRFKNR ELQIMRIMKH PNIVDLIAYY 60

YTTGDNSDEV YLNLVLEFMP ETIYRASRLY TRQKLSMPML EVKLYIYQLL RSLAYIHASG 120

ICHRDIKPQN LLLDPENGIL KLCDFGSAKI LVAGEPNVSY ICSRYYRAPE LIFGATDYTH 180

AIDIWSTGCV MAELMLGHPL FPGESGIDQL VEIIKILGTP SREQIKTMNP NYMEHRFPQI 240

RPQPLSRVFS RSVPLDALDL LSKMLQYTPT DRLTAAEAMC HPFF 284

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0051519	; P:activation of bipolar cell growth
GO:0051301	; P:cell division
GO:0007067	; P:mitosis
GO:0051984	; P:positive regulation of chromosome segregation
GO:0071775	; P:regulation of cell cycle cytokinesis
GO:0007165	; P:signal transduction

KEGG

spo:SPAC1687.15

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013