| Tag | Content |
|---|
| EKPD ID | EKS-SCP-00063 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 305.7 | 7.1E-92 | 5 | 319 | 315 |
|
| Status | Reviewed |
| Ensembl Protein | SPAC23H4.17c.1:pep |
| UniProt Accession | O13958; |
| Protein Name | Serine/threonine-protein kinase srb10 |
| Protein Synonyms/Alias | Cyclin-dependent kinase 8; Suppressor of RNA polymerase B srb10; |
| Gene Name | srb10 |
| Gene Synonyms/Alias | srb10; cdk8, prk1; SPAC23H4.17c; |
| Ensembl Information | |
| Organism | Schizosaccharomyces pombe |
| Functional Description | Catalytic component of the Cdk8 module/Srb8-11 modulewhich is a regulatory module of the Mediator complex that regulates basal RNA polymerase II transcription. The Cdk8 module may sterically hinder the interaction between Mediator and RNA polymerase II leading to transcriptional repression of a subset of genes regulated by Mediator. |
| Protein Length | 369 |
Protein Sequence
(FASTA) | | MKDGYKIIGF ISSGTYGKVY KAVSSNSNDK RLFAIKKFKA ESKQVSSNAQ QTGVSQSAIR 60 | | EMMLCREIQH ENIVSLVQVL LKDGTISMVF EYAEHDLLQI IHFHSRSRTR QIPPSILKSI 120 | | LWQIINGVAY LHENWIMHRD LKPANIMITA TGKVKIGDLG LGRLIRDPIL PFYSSDRVVV 180 | | TIWYRAPELL LGAHDYTPAI DVWAIGCIYG EMLALSPLFK GDEIKMEDKK VVPFQSTQML 240 | | RIMELLGTPT EERWPGLKNY PEYYQLSSFE VRYWNNLLPQ WYQTVKNRDP QGLDLLMKML 300 | | QYDPKSRITA KQALEHVFFT SDKLWTTSPF LNQPIHYPER RISEDDSEVS SKRVLSTSLR 360 | | SESKRFKGN 369 |
|
Nucleotide Sequence
(FASTA) | | ATGAAAGACG GTTATAAAAT TATTGGGTTT ATCTCATCTG GAACTTATGG AAAGGTTTAT 60 | | AAAGCGGTTT CATCTAATTC GAATGATAAA CGACTGTTTG CAATTAAAAA GTTCAAAGCT 120 | | GAGTCAAAGC AAGTAAGCTC GAATGCTCAA CAAACCGGCG TTTCTCAAAG TGCTATTCGT 180 | | GAAATGATGC TGTGTAGAGA AATTCAGCAT GAAAATATAG TTAGCTTGGT TCAAGTTTTA 240 | | CTCAAAGATG GCACAATTAG CATGGTTTTT GAATACGCCG AACACGATCT GTTGCAAATT 300 | | ATTCATTTCC ATAGCCGATC TAGAACAAGA CAAATTCCAC CATCAATTTT AAAAAGTATT 360 | | CTATGGCAGA TCATTAATGG TGTAGCATAC CTACATGAAA ACTGGATTAT GCATCGAGAT 420 | | TTGAAACCAG CAAACATAAT GATTACAGCT ACAGGCAAGG TAAAAATTGG GGACCTAGGG 480 | | CTGGGAAGGC TCATTCGGGA TCCCATATTA CCATTTTATT CCAGCGATCG TGTAGTAGTT 540 | | ACTATTTGGT ATCGTGCGCC AGAGCTACTT TTGGGAGCTC ACGATTATAC CCCAGCAATA 600 | | GATGTTTGGG CAATTGGTTG TATTTATGGA GAAATGCTTG CTCTTTCTCC TCTTTTCAAA 660 | | GGAGATGAAA TAAAAATGGA AGATAAAAAA GTCGTTCCTT TTCAGAGTAC TCAAATGCTA 720 | | CGCATAATGG AGTTACTAGG CACACCAACA GAAGAACGCT GGCCAGGTCT CAAAAATTAT 780 | | CCAGAGTACT ATCAATTATC ATCATTTGAA GTTCGTTACT GGAATAATTT GCTTCCTCAG 840 | | TGGTATCAAA CCGTAAAAAA TCGGGATCCG CAAGGGTTAG ATCTACTGAT GAAAATGCTA 900 | | CAATACGATC CAAAATCACG CATAACTGCT AAGCAAGCTT TGGAACACGT TTTTTTTACT 960 | | TCCGATAAAT TATGGACCAC TAGCCCATTT TTAAATCAAC CTATTCATTA TCCAGAAAGG 1020 | | AGAATTTCAG AAGATGATTC CGAGGTTTCC TCCAAACGCG TACTATCTAC TTCACTAAGG 1080 | | TCCGAAAGTA AACGTTTTAA AGGAAATTGA 1110 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdke..tgevvAlKkirlekek.......egvpitalrEisl 51 | y+ + i Gtygkvyka + + ++++ A+Kk++ e+++ +gv+++a+rE+ l | Q: 5 YKIIGFISSGTYGKVYKAVSSNsnDKRLFAIKKFKAESKQvssnaqqTGVSQSAIREMML 64 | 788899************9855115568******99988766666667************ |
| S: 52 lkelkhknivkLlevvakdkkklyLvfefleqdLkkllkkkkkk...klsleevkslllq 108 | ++e++h+niv+L++v+ ++ ++ +vfe++e+dL ++++ ++++ +++++ +ks+l+q | Q: 65 CREIQHENIVSLVQVLL-KDGTISMVFEYAEHDLLQIIHFHSRSrtrQIPPSILKSILWQ 123 | *****************.99*******************999888889************ |
| S: 109 lleglaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk...tytkevvTlw 165 | +++g+aylH+n+i+HRDlKp+N++i+++gk+k++D+Gl r + p + +++vvT+w | Q: 124 IINGVAYLHENWIMHRDLKPANIMITATGKVKIGDLGLGRLIRDPILpfySSDRVVVTIW 183 | ******************************************9998843345689***** |
| S: 166 YraPelLlgakeYstavDiWsvgcilaelltrkplfqgkse...........idqlerif 214 | YraPelLlga++Y+ a+D+W++gci e+l+ +plf+g++ q+ ri+ | Q: 184 YRAPELLLGAHDYTPAIDVWAIGCIYGEMLALSPLFKGDEIkmedkkvvpfqSTQMLRIM 243 | **************************************9988999******999****** |
| S: 215 kllgtpsekvwpevsklpeyk..ksfpkkkkk....klkekvkklkekaldllekllald 268 | +llgtp+e+ wp+++++pey +sf+ + + ++ ++vk+ + ++ldll k+l++d | Q: 244 ELLGTPTEERWPGLKNYPEYYqlSSFEVRYWNnllpQWYQTVKNRDPQGLDLLMKMLQYD 303 | *******************99644454433332023344444555578************ |
| S: 269 pkkRisakealqhkyf 284 | pk+Ri+ak+al+h +f | Q: 304 PKSRITAKQALEHVFF 319 | *************998 |
|
Domain Sequence
(FASTA) | | YKIIGFISSG TYGKVYKAVS SNSNDKRLFA IKKFKAESKQ VSSNAQQTGV SQSAIREMML 60 | | CREIQHENIV SLVQVLLKDG TISMVFEYAE HDLLQIIHFH SRSRTRQIPP SILKSILWQI 120 | | INGVAYLHEN WIMHRDLKPA NIMITATGKV KIGDLGLGRL IRDPILPFYS SDRVVVTIWY 180 | | RAPELLLGAH DYTPAIDVWA IGCIYGEMLA LSPLFKGDEI KMEDKKVVPF QSTQMLRIME 240 | | LLGTPTEERW PGLKNYPEYY QLSSFEVRYW NNLLPQWYQT VKNRDPQGLD LLMKMLQYDP 300 | | KSRITAKQAL EHVFF 315 |
|
| Keyword | Activator; ATP-binding; Complete proteome; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome; Repressor; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |