EKS-SCP-00101

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00101

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	410.1	1.1E-123	39	327	289

Status

Reviewed

Ensembl Protein

SPAC31G5.09c.1:pep

UniProt Accession

P27638;

Protein Name

Mitogen-activated protein kinase spk1

Protein Synonyms/Alias

MAP kinase spk1; MAPK;

Gene Name

spk1

Gene Synonyms/Alias

spk1; SPAC31G5.09c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPAC31G5.09c	SPAC31G5.09c.1:pep	SPAC31G5.09c.1

Organism

Schizosaccharomyces pombe

Functional Description

Involved in mating signal transduction pathway.

Protein Length

372

Protein Sequence
(FASTA)

MASATSTPTI ADGNSNKESV ATSRSPHTHD LNFELPEEYE MINLIGQGAY GVVCAALHKP 60

SGLKVAVKKI HPFNHPVFCL RTLREIKLLR HFRHENIISI LDILPPPSYQ ELEDVYIVQE 120

LMETDLYRVI RSQPLSDDHC QYFTYQILRA LKAMHSAGVV HRDLKPSNLL LNANCDLKVA 180

DFGLARSTTA QGGNPGFMTE YVATRWYRAP EIMLSFREYS KAIDLWSTGC ILAEMLSARP 240

LFPGKDYHSQ ITLILNILGT PTMDDFSRIK SARARKYIKS LPFTPKVSFK ALFPQASPDA 300

IDLLEKLLTF NPDKRITAEE ALKHPYVAAY HDASDEPTAS PMPPNLVDLY CNKEDLEIPV 360

LKALIFREVN FR 372

Nucleotide Sequence
(FASTA)

ATGGCGAGCG CTACTTCCAC GCCTACTATT GCGGATGGGA ATTCCAACAA GGAGTCAGTA 60

GCTACAAGTC GAAGCCCACA CACGCATGAT CTAAACTTTG AGCTACCAGA GGAATACGAA 120

ATGATCAATC TCATCGGTCA AGGTGCTTAT GGAGTTGTAT GTGCCGCGCT TCACAAACCC 180

AGCGGCCTAA AGGTGGCTGT TAAAAAAATA CATCCTTTCA ATCATCCTGT GTTTTGTCTA 240

AGAACTTTAA GGGAAATCAA GTTACTCAGA CATTTTCGTC ATGAAAATAT AATTTCAATT 300

CTAGACATCC TTCCACCACC GAGCTACCAG GAATTGGAAG ATGTTTATAT TGTACAAGAG 360

CTTATGGAAA CGGATTTGTA CCGTGTTATA CGTTCGCAGC CCTTAAGCGA TGATCATTGT 420

CAATACTTTA CGTATCAAAT TTTGCGCGCT CTGAAAGCCA TGCATAGTGC TGGAGTTGTT 480

CATAGAGACC TGAAGCCATC AAACTTACTA CTAAATGCCA ATTGTGATCT CAAAGTTGCC 540

GATTTCGGTT TGGCACGTTC CACCACAGCT CAAGGCGGAA ATCCTGGCTT TATGACTGAG 600

TATGTCGCAA CTCGTTGGTA TCGAGCACCG GAAATTATGC TGAGTTTCCG AGAATACAGC 660

AAAGCTATTG ATTTATGGAG TACTGGTTGT ATACTTGCTG AGATGCTTTC TGCTCGACCA 720

TTGTTCCCAG GAAAGGACTA TCATAGTCAA ATTACTTTAA TCCTTAACAT TCTAGGAACG 780

CCTACTATGG ACGATTTTTC AAGAATTAAA TCTGCACGTG CGAGGAAATA TATTAAAAGT 840

CTTCCATTTA CTCCTAAAGT ATCATTCAAA GCACTCTTTC CTCAGGCATC ACCAGATGCT 900

ATTGACCTTT TAGAAAAATT ACTGACATTT AATCCTGATA AGCGTATAAC TGCAGAAGAG 960

GCTCTAAAGC ACCCGTATGT AGCTGCTTAT CATGATGCCA GTGATGAGCC TACAGCATCC 1020

CCCATGCCTC CCAACCTCGT CGATTTATAC TGTAACAAAG AAGATCTCGA AATACCGGTA 1080

TTGAAGGCCT TAATATTTCG TGAAGTAAAT TTCAGATAA 1119

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         ye ++ +g+Gaygvv++a +k ++ +va+kk+  pf++ + + rtlRE+kll++++heNi

Q: 39    YEMINLIGQGAYGVVCAALHKPSGLKVAVKKIH-PFNHPVFCLRTLREIKLLRHFRHENI  97

         778899**************************9.**************************

S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120

         i++ld++ p + ++el+dvY+v+elmetdL++vi+sq lsd+h++++ yqilr+lk +Hs

Q: 98    ISILDILPPPS-YQELEDVYIVQELMETDLYRVIRSQPLSDDHCQYFTYQILRALKAMHS  156

         *******9998.************************************************

S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekk..lteyvatrwYraPeillsl  178

         a+v+HrDlKPsNll+n++c+lk++dFGlars++++  +   +teyvatrwYraPei+ls

Q: 157   AGVVHRDLKPSNLLLNANCDLKVADFGLARSTTAQGGNPgfMTEYVATRWYRAPEIMLSF  216

         *******************************9999877799*******************

S: 179   keytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearn  238

         +ey+ka+D+Ws GCIlaE+l+ +plfpgkd+ +q+++il++lgtp+ +++++i+s +ar+

Q: 217   REYSKAIDLWSTGCILAEMLSARPLFPGKDYHSQITLILNILGTPTMDDFSRIKSARARK  276

         ************************************************************

S: 239   yikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         yikslp ++k +f++lfp+as++a+dLleklL+++pdkRi++eeaL+hpY+

Q: 277   YIKSLPFTPKVSFKALFPQASPDAIDLLEKLLTFNPDKRITAEEALKHPYV  327

         **************************************************7

Domain Sequence
(FASTA)

YEMINLIGQG AYGVVCAALH KPSGLKVAVK KIHPFNHPVF CLRTLREIKL LRHFRHENII 60

SILDILPPPS YQELEDVYIV QELMETDLYR VIRSQPLSDD HCQYFTYQIL RALKAMHSAG 120

VVHRDLKPSN LLLNANCDLK VADFGLARST TAQGGNPGFM TEYVATRWYR APEIMLSFRE 180

YSKAIDLWST GCILAEMLSA RPLFPGKDYH SQITLILNIL GTPTMDDFSR IKSARARKYI 240

KSLPFTPKVS FKALFPQASP DAIDLLEKLL TFNPDKRITA EEALKHPYV 289

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005816	; C:spindle pole body
GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000751	; P:cell cycle arrest in response to pheromone
GO:0032005	; P:signal transduction involved in conjugation with cellular fusion

KEGG

spo:SPAC31G5.09c

;

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR008352	; MAPK_p38.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01773

; P38MAPKINASE.

Created Date

20-Feb-2013