EKS-SCP-00083
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SCP-00083
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PDHK152.71.5E-45285415131
StatusReviewed
Ensembl ProteinSPAC644.11c.1:pep
UniProt AccessionQ9P6P9;
Protein Name[Pyruvate dehydrogenase [lipoamide]] kinase, mitochondrial
Protein Synonyms/Alias Pyruvate dehydrogenase kinase;
Gene Namepkp1
Gene Synonyms/Alias SPAC644.11c;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
SPAC644.11cSPAC644.11c.1:pepSPAC644.11c.1
OrganismSchizosaccharomyces pombe
Functional DescriptionInhibits the mitochondrial pyruvate dehydrogenasecomplex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism (By similarity).
Protein Length425
Protein Sequence
(FASTA)
MSVLGKTLQE KVNLLAQYPQ TGLSLKQLVY FGKNPTPGTL FRAGLFLRDE LPIRLARRIQ 60
DLQNLSPMLR SMKRISSVKA AYGRSMEEII ELKGVELPKC LPKHARYHNA PKWRSSLMDS 120
EILHNPSLAN THLDSSKGRY FETDFSDQDN GVDCNWPESL LKFNSNFAYL LNTIRTRHDN 180
VAVEIALDIQ EYRRKTNQID NSIQIFLDRF YMSRIGIRML LGQYIALVSE PPRENYVGVI 240
STRANIYQII EGAAENAKYI CRLAYGLFEA PEIQIICDPS LEMMYVESHL NHAVFEILKN 300
SLRATVEFHG VDSDFFPPIK VIVAKGQEDI TIKISDEGGG ISRRNIPLVW SYMFTTASPT 360
LTDDPHDIVS ANSTTPMAGF GFGLPLARLY TRYFGGDLEL ISMEGYGTDV YIHLNRLCES 420
AEPLQ 425
Nucleotide Sequence
(FASTA)
ATGTCAGTGC TCGGGAAAAC TTTACAGGAG AAAGTCAATC TCTTGGCTCA ATATCCTCAA 60
ACAGGGTTGT CTTTAAAGCA ATTAGTGTAT TTTGGCAAGA ACCCTACACC AGGAACACTT 120
TTCCGGGCTG GCTTGTTTTT GCGAGATGAA TTGCCCATTC GCTTGGCTCG GCGCATCCAA 180
GACCTGCAGA ATCTTTCACC GATGCTACGA AGTATGAAGC GTATATCTTC CGTAAAGGCT 240
GCTTACGGTA GATCTATGGA GGAAATTATT GAACTGAAAG GAGTGGAACT ACCGAAATGT 300
CTTCCAAAGC ACGCTCGATA TCACAATGCC CCGAAATGGA GGTCAAGTTT AATGGACTCT 360
GAAATTCTTC ATAATCCCTC GCTTGCAAAT ACTCATTTAG ACTCTTCAAA AGGTCGCTAT 420
TTTGAAACAG ATTTTTCTGA CCAAGATAAT GGCGTTGATT GTAATTGGCC CGAATCTTTG 480
TTAAAATTTA ATAGTAATTT TGCATACCTT TTAAATACCA TTCGAACTAG ACACGATAAC 540
GTTGCAGTCG AAATTGCTTT GGACATACAA GAATACCGAA GGAAGACTAA CCAAATTGAC 600
AACAGTATTC AAATATTTTT GGATAGGTTT TACATGTCTC GTATTGGAAT TCGAATGCTG 660
TTAGGTCAAT ATATAGCACT TGTCTCTGAA CCGCCGCGTG AGAATTACGT TGGTGTGATA 720
AGTACACGTG CAAATATTTA TCAAATAATA GAAGGTGCTG CTGAAAATGC CAAGTACATT 780
TGCAGGCTTG CGTACGGATT GTTTGAAGCA CCTGAGATTC AAATTATTTG CGATCCTTCA 840
CTTGAAATGA TGTATGTAGA GTCCCATTTA AATCACGCAG TCTTTGAAAT TCTCAAAAAC 900
AGTCTTCGTG CAACCGTAGA ATTTCATGGT GTAGACAGTG ATTTCTTTCC TCCCATAAAG 960
GTCATTGTTG CAAAAGGACA AGAGGATATA ACCATCAAAA TCTCTGATGA AGGAGGCGGT 1020
ATATCCCGTC GAAATATCCC TTTAGTTTGG TCATACATGT TTACAACTGC CTCTCCTACA 1080
TTGACAGATG ATCCTCACGA TATCGTTAGC GCAAATTCTA CTACTCCTAT GGCTGGCTTC 1140
GGGTTTGGTC TTCCTCTCGC TCGACTTTAT ACTAGGTATT TTGGTGGAGA TCTTGAGCTA 1200
ATTTCAATGG AGGGGTACGG AACCGATGTA TACATACACC TAAATCGTCT TTGCGAAAGT 1260
GCTGAACCGC TTCAGTGA 1278
Domain Profile
S: 1     yvpshlyyllfellknamratvesh.edkkvlpdvkvlvalgkedliikisdrGGGvplr  59
         yv shl++ +fe+lkn++ratve h  d++ +p++kv+va+g+ed++ikisd+GGG+++r
Q: 285   YVESHLNHAVFEILKNSLRATVEFHgVDSDFFPPIKVIVAKGQEDITIKISDEGGGISRR  344
         899********************98357788*****************************
S: 60    kidrlldymystapapskdd.......araaplaGfGyGlpisrlyakylqGdlkllsle  112
         +i  + +ym++ta  + +dd         ++p+aGfG+Glp++rly++y++Gdl+l s+e
Q: 345   NIPLVWSYMFTTASPTLTDDphdivsaNSTTPMAGFGFGLPLARLYTRYFGGDLELISME  404
         *************888777779999988899*****************************
S: 113   GiGtdaviylk  123
         G+Gtd+ i+l+
Q: 405   GYGTDVYIHLN  415
         ******88875
Domain Sequence
(FASTA)
YVESHLNHAV FEILKNSLRA TVEFHGVDSD FFPPIKVIVA KGQEDITIKI SDEGGGISRR 60
NIPLVWSYMF TTASPTLTDD PHDIVSANST TPMAGFGFGL PLARLYTRYF GGDLELISME 120
GYGTDVYIHL N 131
KeywordATP-binding; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Kinase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Transit peptide.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00419
EKS-ANC-00433
EKS-BOT-00447
EKS-CAE-00378
EKS-CAJ-00453
EKS-CAF-00448
EKS-CAP-00481
EKS-CHH-00030
EKS-CII-00254
EKS-DAR-00851
EKS-DAN-00024
EKS-DIO-00091
EKS-DRM-00211
EKS-ECT-00054
EKS-EQC-00439
EKS-ERE-00045
EKS-FEC-00428
EKS-GAM-00258
EKS-GAG-00376
EKS-GAA-00541
EKS-GOG-00441
EKS-HOS-00456
EKS-ICT-00429
EKS-LAC-00461
EKS-LOA-00455
EKS-MAM-00445
EKS-MAE-00061
EKS-MEG-00369
EKS-MOD-00437
EKS-MUM-00479
EKS-MUP-00441
EKS-MYL-00441
EKS-NOL-00408
EKS-OCP-00110
EKS-ORN-00565
EKS-ORA-00391
EKS-ORC-00419
EKS-ORL-00516
EKS-OTG-00452
EKS-PAT-00424
EKS-PES-00394
EKS-PEM-00247
EKS-POA-00436
EKS-PRC-00053
EKS-PTV-00154
EKS-RAN-00461
EKS-SAH-00415
EKS-SOA-00041
EKS-SUS-00396
EKS-TAG-00512
EKS-TAR-00556
EKS-TAS-00061
EKS-TEN-00562
EKS-TUB-00042
EKS-TUT-00159
EKS-VIP-00082
EKS-XET-00598
EKS-XIM-00560
Gene Ontology
GO:0005967; C:mitochondrial pyruvate dehydrogenase complex
GO:0005524; F:ATP binding
GO:0016887; F:ATPase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0004740; F:pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate
GO:0006006; P:glucose metabolic process
KEGG
spo:SPAC644.11c;
InterPros
IPR003594; ATPase-like_ATP-bd.
IPR018955; BCDHK/PDK_N.
IPR004358; Sig_transdc_His_kin-like_C.
IPR005467; Sig_transdc_His_kinase_core.
Pfam
PF10436; BCDHK_Adom3; 1.
PF02518; HATPase_c; 1.
SMARTs
SM00387; HATPase_c; 1.
Prosites
PS50109; HIS_KIN; 1.
Prints
PR00344; BCTRLSENSOR.
Created Date20-Feb-2013