EPS-SCP-00026
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-SCP-00026
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
PPP/PP2A395.31.1E-11951243193
StatusReviewed
Ensembl ProteinSPAC823.15.1:pep
UniProt AccessionP23635;
Protein NameMinor serine/threonine-protein phosphatase PP2A-1 catalytic subunit
Protein Synonyms/Alias
Gene Nameppa1
Gene Synonyms/Alias ppa1; SPAC823.15;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
SPAC823.15SPAC823.15.1:pepSPAC823.15.1
OrganismSchizosaccharomyces pombe
Functional DescriptionEssential role in cell cycle control. PP2A may beinvolved in controlling the entry into mitosis, possibly acting as an inhibitor.
Protein Length309
Protein Sequence
(FASTA)
MSVSGKIGEV DRWIEQLSRC EPLSEEDVIQ MCDLAKEVLS VESNVQSVRC PVTVCGDIHG 60
QFHDLMELFN IGGPSPDTNY LFMGDYVDRG YHSVETVSLL IAFKIRYPQR ITILRGNHES 120
RQITQVYGFY DECLRKYGNA NVWQYFTDLF DYLPLTALIE DRIFCLHGGL SPSIDTLDHV 180
RILDRVQEVP HEGPICDLLW SDPDDRPGWG ISPRGAGYTF GPDIAEAFNH NNGLDLIARA 240
HQLVMEGYNW TTNHNVVTIF SAPNYCYRCG NQAAIMGIDD HINYAFIQYD TAPRKEELHV 300
TRRTPDYFL 309
Nucleotide Sequence
(FASTA)
ATGTCTGTCT CTGGAAAAAT TGGAGAGGTC GATCGTTGGA TTGAACAGTT GAGTCGATGC 60
GAACCTCTTT CAGAGGAAGA TGTCATTCAA ATGTGTGATC TCGCAAAAGA GGTACTTTCT 120
GTAGAATCAA ACGTTCAAAG CGTCCGATGC CCTGTAACGG TTTGTGGTGA TATTCATGGA 180
CAATTCCATG ACTTAATGGA GTTGTTCAAT ATTGGCGGCC CTTCACCTGA TACAAATTAT 240
TTGTTTATGG GAGATTATGT TGACAGAGGA TATCACAGTG TAGAAACAGT TTCTCTACTG 300
ATTGCTTTTA AAATTCGATA TCCCCAGCGT ATAACAATAT TACGTGGAAA CCATGAATCT 360
AGGCAAATTA CACAAGTTTA TGGATTTTAT GATGAATGCC TTAGAAAGTA TGGAAATGCG 420
AATGTTTGGC AGTACTTTAC AGATCTTTTT GACTATTTGC CTCTCACCGC CCTAATTGAA 480
GATCGAATTT TTTGCCTTCA CGGAGGTCTT TCTCCTAGTA TTGATACACT TGACCATGTT 540
CGTATATTAG ATCGTGTGCA AGAGGTTCCT CATGAAGGTC CGATATGCGA CTTGTTATGG 600
TCAGATCCTG ATGACCGACC TGGTTGGGGT ATTTCTCCTC GAGGTGCTGG GTATACGTTT 660
GGCCCGGATA TTGCTGAAGC ATTTAACCAT AATAACGGTT TAGATTTAAT AGCAAGAGCT 720
CATCAGCTAG TTATGGAAGG TTATAATTGG ACTACAAACC ATAATGTTGT TACTATTTTT 780
TCTGCTCCCA ATTATTGTTA TCGATGTGGA AACCAAGCAG CCATTATGGG AATTGATGAC 840
CACATAAATT ACGCATTTAT CCAATATGAT ACTGCTCCCC GAAAGGAGGA ATTACATGTC 900
ACCAGAAGAA CACCCGATTA CTTCTTATAA 930
Domain Profile
S: 1     pvtvcgdvhgqfhdllelfriggkspdtnylflgdyvdrgyysvetvtllvalkvryrer  60
         pvtvcgd+hgqfhdl+elf+igg spdtnylf+gdyvdrgy+svetv+ll+a+k+ry++r
Q: 51    PVTVCGDIHGQFHDLMELFNIGGPSPDTNYLFMGDYVDRGYHSVETVSLLIAFKIRYPQR  110
         9***********************************************************
S: 61    itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdgkifclhggl  120
         itilrgnhesrqitqvygfydeclrkygnanvw+yftdlfdylpltal++++ifclhggl
Q: 111   ITILRGNHESRQITQVYGFYDECLRKYGNANVWQYFTDLFDYLPLTALIEDRIFCLHGGL  170
         ************************************************************
S: 121   spsidtldeiraldrlqevphegplcdllwsdpddregwgisprgagytfgqdiseqfnh  180
         spsidtld++r ldr+qevphegp+cdllwsdpddr gwgisprgagytfg di+e fnh
Q: 171   SPSIDTLDHVRILDRVQEVPHEGPICDLLWSDPDDRPGWGISPRGAGYTFGPDIAEAFNH  230
         ************************************************************
S: 181   angleliarahql  193
         +ngl+liarahql
Q: 231   NNGLDLIARAHQL  243
         ************8
Domain Sequence
(FASTA)
PVTVCGDIHG QFHDLMELFN IGGPSPDTNY LFMGDYVDRG YHSVETVSLL IAFKIRYPQR 60
ITILRGNHES RQITQVYGFY DECLRKYGNA NVWQYFTDLF DYLPLTALIE DRIFCLHGGL 120
SPSIDTLDHV RILDRVQEVP HEGPICDLLW SDPDDRPGWG ISPRGAGYTF GPDIAEAFNH 180
NNGLDLIARA HQL 193
KeywordCell cycle; Cell division; Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Methylation; Mitosis; Protein phosphatase; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Petromyzon marinus"; ?>Tetraodon nigroviridis"; ?>
EPS-PEM-00054
EPS-TEN-00089
Gene Ontology
GO:0005634; C:nucleus
GO:0046872; F:metal ion binding
GO:0004721; F:phosphoprotein phosphatase activity
GO:0051301; P:cell division
GO:0007067; P:mitosis
GO:0006470; P:protein dephosphorylation
GO:2000765; P:regulation of cytoplasmic translation
GO:0007346; P:regulation of mitotic cell cycle
GO:0007165; P:signal transduction
KEGG
spo:SPAC823.15;
InterPros
IPR004843; Metallo_PEstase_dom.
IPR006186; Ser/Thr-sp_prot-phosphatase.
Pfam
PF00149; Metallophos; 1.
SMARTs
SM00156; PP2Ac; 1.
Prosites
PS00125; SER_THR_PHOSPHATASE; 1.
Prints
PR00114; STPHPHTASE.
Created Date20-Feb-2013