EKS-SCP-00087

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00087

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	391.4	4.0E-118	201	456	256

Status

Reviewed

Ensembl Protein

SPBC106.10.1:pep

UniProt Accession

P40376;

Protein Name

cAMP-dependent protein kinase catalytic subunit

Protein Synonyms/Alias

Gene Name

pka1

Gene Synonyms/Alias

pka1; tpk; SPBC106.10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBC106.10	SPBC106.10.1:pep	SPBC106.10.1

Organism

Schizosaccharomyces pombe

Functional Description

Protein Length

512

Protein Sequence
(FASTA)

MDTTAVASKG STNVGSSTDT LSTSASLHPS MNAGSVNEYS EQQRHGTNSF NGKPSVHDSV 60

GSDASVSNGH NNHNESSLWT SGIPKALEEA TKSKKPDSLV STSTSGCASA HSVGYQNIDN 120

LIPSPLPESA SRSSSQSSHQ RHSRDGRGEL GSEHGERRSA MDGLRDRHIR KVRVSQLLDL 180

QRRRIRPADH TTKDRYGIQD FNFLQTLGTG SFGRVHLVQS NHNRLYYAIK VLEKKKIVDM 240

KQIEHTCDER YILSRVQHPF ITILWGTFQD AKNLFMVMDF AEGGELFSLL RKCHRFPEKV 300

AKFYAAEVIL ALDYLHHNQI VYRDLKPENL LLDRFGHLKI VDFGFAKRVS TSNCCTLCGT 360

PDYLAPEIIS LKPYNKAADW WSLGILIFEM LAGYPPFYSE NPMKLYENIL EGKVNYPSYF 420

SPASIDLLSH LLQRDITCRY GNLKDGSMDI IMHPWFRDIS WDKILTRKIE VPYVPPIQAG 480

MGDSSQFDAY ADVATDYGTS EDPEFTSIFK DF 512

Nucleotide Sequence
(FASTA)

ATGGATACGA CTGCCGTTGC TTCCAAAGGA AGTACTAACG TGGGTTCTTC AACTGACACT 60

CTATCTACAA GTGCCTCTTT GCATCCATCT ATGAATGCCG GCAGCGTTAA TGAATATTCG 120

GAACAGCAGC GACATGGAAC AAATTCTTTT AATGGCAAAC CCTCTGTTCA TGATTCTGTT 180

GGTAGTGATG CAAGTGTAAG CAATGGTCAT AATAACCATA ATGAATCAAG TCTGTGGACT 240

TCGGGCATCC CTAAAGCTTT GGAAGAGGCC ACGAAAAGCA AAAAACCCGA CAGCTTGGTT 300

AGCACCAGTA CGTCTGGCTG TGCAAGTGCC CATTCTGTTG GTTACCAAAA CATCGATAAT 360

TTGATCCCTT CACCTCTTCC TGAAAGCGCG AGTAGAAGTA GTAGCCAAAG CAGCCATCAA 420

AGACATTCGC GGGACGGTCG TGGTGAACTA GGTTCAGAAC ACGGAGAGAG ACGGTCAGCT 480

ATGGATGGGC TACGCGATCG CCATATTCGT AAAGTTCGGG TTAGTCAGCT GCTCGATTTA 540

CAGCGTCGAA GGATTCGTCC TGCTGACCAC ACCACAAAAG ATCGATATGG AATACAAGAT 600

TTCAATTTCT TACAAACATT GGGCACTGGC TCGTTTGGTC GAGTTCATCT CGTTCAGTCG 660

AATCACAATC GCCTGTATTA CGCCATCAAG GTTTTAGAAA AGAAAAAAAT CGTTGATATG 720

AAGCAAATAG AGCACACTTG CGATGAGAGA TACATTTTAT CCCGTGTCCA ACACCCGTTC 780

ATTACCATTC TATGGGGTAC TTTCCAAGAT GCCAAAAATC TGTTTATGGT CATGGATTTT 840

GCTGAAGGAG GAGAGCTTTT TTCTTTGCTT CGTAAATGTC ATCGATTTCC CGAAAAAGTT 900

GCCAAATTTT ATGCAGCAGA AGTGATCCTT GCTCTTGATT ATCTTCACCA CAATCAAATC 960

GTATATCGAG ATTTAAAACC CGAAAATCTT CTTCTTGACC GGTTTGGTCA TTTGAAAATT 1020

GTGGACTTTG GTTTTGCCAA ACGCGTCTCT ACTAGCAACT GTTGTACTCT TTGTGGTACC 1080

CCCGATTATT TAGCCCCGGA AATCATATCT TTAAAACCGT ACAACAAAGC TGCAGATTGG 1140

TGGTCCCTTG GTATTCTTAT CTTTGAAATG CTTGCGGGTT ATCCTCCATT TTACTCTGAG 1200

AATCCAATGA AGTTGTATGA GAATATCCTT GAAGGCAAGG TCAACTATCC ATCGTACTTT 1260

TCTCCTGCTA GTATTGATTT GTTGAGCCAT TTACTTCAGC GAGACATAAC CTGCCGCTAT 1320

GGAAATTTGA AAGATGGTAG CATGGATATT ATTATGCACC CTTGGTTCCG TGATATCAGC 1380

TGGGACAAGA TCCTTACTCG GAAAATTGAG GTTCCGTATG TTCCTCCCAT TCAAGCTGGA 1440

ATGGGTGATT CCAGTCAATT TGACGCTTAT GCTGATGTAG CTACGGATTA TGGAACATCT 1500

GAAGATCCTG AATTTACTTC TATCTTTAAG GACTTTTGA 1539

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         f+ l+tlGtGsfGrv+lv++++++ yya+kvl+k+k+v++kq+eh+ +e+ +l++v++pf

Q: 201   FNFLQTLGTGSFGRVHLVQSNHNRLYYAIKVLEKKKIVDMKQIEHTCDERYILSRVQHPF  260

         56789*******************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         +  l+ +f+d++nl++v+++ eGGelfs+lrk +rf+ek+a+fyaae++lal+ylh+ ++

Q: 261   ITILWGTFQDAKNLFMVMDFAEGGELFSLLRKCHRFPEKVAKFYAAEVILALDYLHHNQI  320

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkd.rtwtlcGtpeylapeiiqskgynkavdw  179

         +yrdlkpenllld+ G++k+ dfGfak+v++    tlcGtp+ylapeii+ k+ynka dw

Q: 321   VYRDLKPENLLLDRFGHLKIVDFGFAKRVSTsNCCTLCGTPDYLAPEIISLKPYNKAADW  380

         *****************************872578*************************

S: 180   walGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrl  239

         w+lG+li+e+laGyppf++++p+k+ye+i++gk+++ps++s +  dll++llq+d t r+

Q: 381   WSLGILIFEMLAGYPPFYSENPMKLYENILEGKVNYPSYFSPASIDLLSHLLQRDITCRY  440

         ************************************************************

S: 240   gnlkngvedikehkwf  255

         gnlk+g+ di  h wf

Q: 441   GNLKDGSMDIIMHPWF  456

         ***************9

Domain Sequence
(FASTA)

FNFLQTLGTG SFGRVHLVQS NHNRLYYAIK VLEKKKIVDM KQIEHTCDER YILSRVQHPF 60

ITILWGTFQD AKNLFMVMDF AEGGELFSLL RKCHRFPEKV AKFYAAEVIL ALDYLHHNQI 120

VYRDLKPENL LLDRFGHLKI VDFGFAKRVS TSNCCTLCGT PDYLAPEIIS LKPYNKAADW 180

WSLGILIFEM LAGYPPFYSE NPMKLYENIL EGKVNYPSYF SPASIDLLSH LLQRDITCRY 240

GNLKDGSMDI IMHPWF 256

Keyword

ATP-binding; cAMP; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005952	; C:cAMP-dependent protein kinase complex
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0051519	; P:activation of bipolar cell growth
GO:0001315	; P:age-dependent response to reactive oxygen species
GO:0019933	; P:cAMP-mediated signaling
GO:0001300	; P:chronological cell aging
GO:0031142	; P:induction of conjugation upon nitrogen starvation
GO:0031138	; P:negative regulation of conjugation with cellular fusion
GO:0045014	; P:negative regulation of transcription by glucose
GO:0006110	; P:regulation of glycolysis

KEGG

spo:SPBC106.10

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013