EKS-SCP-00080

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00080

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	399.1	2.4E-120	683	942	260

Status

Reviewed

Ensembl Protein

SPBC12D12.04c.1:pep

UniProt Accession

P36583; Q9UU42;

Protein Name

Protein kinase C-like 2

Protein Synonyms/Alias

Gene Name

pck2

Gene Synonyms/Alias

pck2; pkc1, sts6; SPBC12D12.04c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBC12D12.04c	SPBC12D12.04c.1:pep	SPBC12D12.04c.1

Organism

Schizosaccharomyces pombe

Functional Description

Involved in the control of the cell shape. Target of theinhibitor staurosporine.

Protein Length

1016

Protein Sequence
(FASTA)

MDMIDEAITE VVRKIERERS VIHGALSMKR LTQNQTVHQQ LHSNIEESKK SIIYLEERLE 60

KLKLRKNGVR KSNSEKPSVG IEKNPSFSTT KSAKSFSSTS SNIDSNLDLL NYDTPLTISK 120

ISFLLQQLEF KLSVEEQYRK GIEKMAKLYE REHDRRSIAE AEKKYVESAQ KITLLKQALK 180

RYHDLHIEID EEDVPSTESR GNLNARRPQS GLLKITVGSL RNVTHSAGIS KQTEMIVAIR 240

AEDLERARTR PSRTDRFNET FEIDLEKTNE VEIVVYEKKN EKLLLPVGLL WIRLSDLVEK 300

QRRKKVEQEV SDKGWVSADK MINQRLSIFL PSALNNISKP ESTDRPNTAS GNQSVSAWFS 360

LEPMGQINLT MNFTKHNTRK RPMDAGLGRQ GAIRQRKESV HEVYGHKFLQ HQFYQIMRCA 420

LCGEFLKNAA GMQCIDCHYT CHKKCYPKVV TKCISKSSDS ASSEYEKINH RIPHHFESHT 480

NIGANWCCHC GYILPLGRKT ARKCTECGIT AHAQCVHLVP DFCGMSMEMA NRVISEIRTT 540

KIYKAQQHKQ KSSHHKHHHH KKSKSSSSKH KENDKASVSI TTTTTPSITP ADPVPTSPKP 600

LAIEPVKRKP VHAGNLEVTS VSDNKLGATV QVVEQKVDDK ADALTKPPSL DAVKEPIPVP 660

SVETSVVAQD LTHKAKRIGL EDFTFLSVLG KGNFGKVMLA ELKSEKQLYA IKVLKKEFIL 720

ENDEVESTKS EKRVFLVANR ERHPFLVNLH SCFQTETRIY FVMDFVSGGD LMLHIQQEQF 780

SRRRAQFYAA EVCLALKYFH DNGIIYRDLK LDNILLSPDG HVKVADYGLC KEDMWHDNTT 840

ATFCGTPEFM APEILLEQQY TRSVDWWAFG VLIYQMLLGQ SPFRGEDEEE IFDAILSDEP 900

LYPIHMPRDS VSILQQLLTR DPKKRLGSGP NDAEDVMTHP FFSNINWDDI YHKRTQPPYI 960

PSLNSPTDTK YFDEEFTREL PVLTPVNSIL TKEMQQHFEG FSYSCEDDKP STTDNA 1016

Nucleotide Sequence
(FASTA)

ATGGATATGA TTGATGAGGC TATAACAGAA GTTGTTAGGA AAATTGAAAG AGAAAGATCA 60

GTTATTCATG GCGCCCTTTC CATGAAGCGC TTGACTCAGA ATCAGACAGT TCACCAACAA 120

CTTCATAGCA ATATTGAAGA ATCAAAAAAG AGCATTATTT ATTTAGAAGA ACGCTTAGAA 180

AAACTAAAGC TTCGCAAAAA TGGTGTCCGA AAGAGTAATT CTGAGAAACC GTCCGTTGGC 240

ATTGAGAAGA ATCCATCCTT TAGCACTACA AAATCCGCTA AAAGCTTTTC CTCTACTTCT 300

TCTAATATCG ATTCTAACTT GGATTTGCTA AATTATGATA CCCCTCTTAC TATTTCAAAG 360

ATATCATTCT TATTACAACA ATTGGAGTTC AAATTATCTG TTGAGGAACA ATATCGAAAA 420

GGTATTGAAA AGATGGCAAA GCTCTATGAG CGTGAACATG ACCGTCGTAG TATAGCTGAA 480

GCAGAGAAGA AGTATGTAGA AAGTGCTCAA AAGATTACCT TACTCAAGCA AGCTTTGAAG 540

CGATACCATG ACTTGCATAT CGAAATCGAT GAGGAAGATG TTCCCAGTAC GGAAAGTAGA 600

GGTAACTTAA ATGCCCGTCG TCCCCAGTCT GGTCTCCTTA AAATTACCGT AGGATCTCTA 660

AGGAACGTCA CGCATTCTGC TGGAATCTCC AAGCAAACGG AAATGATAGT TGCAATTCGT 720

GCAGAGGATC TTGAGCGTGC ACGTACTCGT CCAAGCCGCA CCGACCGTTT TAATGAAACT 780

TTTGAAATTG ATCTGGAGAA GACTAATGAG GTCGAAATAG TTGTTTACGA AAAGAAAAAT 840

GAAAAATTGC TATTACCTGT TGGTTTACTT TGGATACGGT TATCGGATTT AGTAGAAAAA 900

CAAAGGCGAA AAAAGGTTGA ACAAGAGGTT TCAGATAAAG GTTGGGTTAG TGCCGACAAA 960

ATGATTAATC AAAGACTTTC AATATTTTTA CCTTCTGCTC TTAATAATAT TTCAAAGCCT 1020

GAAAGTACTG ACCGCCCCAA CACAGCTAGC GGTAATCAAA GTGTGAGTGC TTGGTTTTCT 1080

CTTGAACCCA TGGGACAAAT TAATTTGACC ATGAATTTCA CAAAGCATAA TACAAGGAAG 1140

AGACCTATGG ATGCTGGCCT CGGTCGTCAA GGTGCTATCC GTCAACGCAA GGAAAGCGTA 1200

CACGAAGTTT ATGGTCACAA ATTTCTACAA CATCAATTTT ATCAAATTAT GCGTTGTGCT 1260

TTATGTGGAG AGTTTTTGAA GAATGCTGCT GGTATGCAGT GCATTGATTG TCATTACACC 1320

TGTCATAAAA AATGCTATCC AAAGGTAGTT ACTAAATGCA TTTCAAAGTC TAGCGATTCT 1380

GCTTCTAGCG AATACGAGAA AATCAACCAT AGAATTCCTC ATCATTTTGA ATCTCACACA 1440

AACATAGGTG CTAATTGGTG CTGTCACTGT GGCTACATCC TTCCTTTAGG AAGAAAAACT 1500

GCCAGGAAAT GTACGGAGTG TGGAATAACT GCGCACGCTC AGTGTGTTCA TCTTGTTCCG 1560

GATTTCTGTG GTATGTCTAT GGAGATGGCT AACCGGGTTA TTTCTGAGAT TCGTACAACT 1620

AAAATTTATA AAGCTCAACA ACATAAACAG AAAAGTTCAC ATCACAAGCA TCATCATCAT 1680

AAAAAGTCTA AGTCTTCATC TTCGAAACAT AAGGAAAATG ACAAAGCATC CGTTTCTATT 1740

ACAACCACCA CAACACCATC TATCACTCCT GCAGACCCTG TTCCAACTTC TCCAAAACCA 1800

CTGGCAATTG AACCGGTTAA AAGAAAGCCT GTACATGCCG GTAATTTAGA AGTGACATCA 1860

GTCTCTGATA ATAAACTTGG CGCTACAGTT CAGGTTGTCG AGCAGAAAGT GGATGACAAA 1920

GCTGATGCGT TGACGAAACC TCCTTCCCTA GATGCTGTGA AAGAGCCAAT CCCAGTACCA 1980

TCAGTTGAAA CCTCTGTTGT TGCTCAAGAC CTAACGCATA AAGCTAAGCG TATCGGACTT 2040

GAAGACTTTA CTTTCTTATC TGTGCTAGGC AAAGGAAATT TCGGTAAAGT AATGCTGGCT 2100

GAGCTTAAAA GTGAAAAGCA ATTGTATGCT ATTAAAGTTT TGAAAAAGGA ATTCATCTTA 2160

GAAAACGATG AAGTCGAAAG CACTAAATCC GAAAAACGCG TTTTTCTCGT TGCCAACCGA 2220

GAGCGTCATC CATTTTTGGT AAACCTGCAT TCTTGCTTTC AAACCGAAAC CCGTATTTAC 2280

TTTGTCATGG ATTTTGTGAG TGGTGGTGAT TTGATGCTTC ACATTCAACA GGAACAATTT 2340

TCACGTAGAA GGGCACAGTT TTATGCTGCT GAGGTGTGTC TTGCTCTAAA ATACTTTCAT 2400

GATAACGGTA TCATATACCG TGATCTTAAG CTTGATAATA TCCTTTTAAG CCCAGATGGT 2460

CATGTTAAAG TGGCCGATTA TGGTTTGTGT AAGGAAGACA TGTGGCATGA TAACACTACT 2520

GCCACGTTTT GCGGTACTCC TGAATTTATG GCACCGGAAA TCTTATTAGA ACAGCAATAT 2580

ACGAGAAGCG TTGACTGGTG GGCTTTTGGT GTACTAATTT ACCAAATGCT GCTTGGTCAA 2640

TCTCCATTTA GAGGAGAAGA CGAAGAAGAA ATTTTTGATG CAATTTTATC TGATGAACCT 2700

TTGTATCCTA TTCATATGCC AAGGGATTCC GTTTCTATAT TACAACAACT TTTGACTCGC 2760

GATCCTAAAA AACGACTTGG ATCTGGCCCT AACGATGCAG AAGATGTCAT GACTCATCCA 2820

TTTTTTAGTA ACATTAATTG GGATGACATC TATCATAAGC GAACTCAACC ACCGTACATT 2880

CCAAGTTTGA ATTCACCTAC GGACACCAAG TATTTCGATG AGGAATTTAC CCGAGAACTC 2940

CCAGTTCTTA CTCCTGTTAA TTCTATTCTG ACGAAAGAGA TGCAGCAACA TTTTGAAGGT 3000

TTTTCTTATT CATGCGAGGA TGATAAACCC TCGACTACCG ATAATGCTTA G 3051

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlal..ask  58

         f++l vlGkG+fgkv+laelk++++lyaikvlkk+ +l++d+ve+t+ ekrv+ +   ++

Q: 683   FTFLSVLGKGNFGKVMLAELKSEKQLYAIKVLKKEFILENDEVESTKSEKRVFLVanRER  742

         89**************************************************98833568

S: 59    kpflvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhe  118

         +pflv+l+scfqte r++fv+++v+GGdlm hiq+  +++ +ra+fyaae++lalk++h+

Q: 743   HPFLVNLHSCFQTETRIYFVMDFVSGGDLMLHIQQE-QFSRRRAQFYAAEVCLALKYFHD  801

         9*********************************97.9**********************

S: 119   kgiiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeyg  178

         +giiyrdlkldn+ll  +Gh+k+ad+Glcke++++++tt+tfcGtP+++aPeil e++y+

Q: 802   NGIIYRDLKLDNILLSPDGHVKVADYGLCKEDMWHDNTTATFCGTPEFMAPEILLEQQYT  861

         ************************************************************

S: 179   ksvdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkd  238

         +svdwwa+Gvl+y+ml+gqsPf gede+e+f++il++e+lyP ++ +++v+il++llt+d

Q: 862   RSVDWWAFGVLIYQMLLGQSPFRGEDEEEIFDAILSDEPLYPIHMPRDSVSILQQLLTRD  921

         ************************************************************

S: 239   pekrlGvkeegeedikehaff  259

         p+krlG+ +++ ed+++h+ff

Q: 922   PKKRLGSGPNDAEDVMTHPFF  942

         ********9999********9

Domain Sequence
(FASTA)

FTFLSVLGKG NFGKVMLAEL KSEKQLYAIK VLKKEFILEN DEVESTKSEK RVFLVANRER 60

HPFLVNLHSC FQTETRIYFV MDFVSGGDLM LHIQQEQFSR RRAQFYAAEV CLALKYFHDN 120

GIIYRDLKLD NILLSPDGHV KVADYGLCKE DMWHDNTTAT FCGTPEFMAP EILLEQQYTR 180

SVDWWAFGVL IYQMLLGQSP FRGEDEEEIF DAILSDEPLY PIHMPRDSVS ILQQLLTRDP 240

KKRLGSGPND AEDVMTHPFF 260

Keyword

ATP-binding; Cell shape; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0032153	; C:cell division site
GO:0030428	; C:cell septum
GO:0051286	; C:cell tip
GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0051519	; P:activation of bipolar cell growth
GO:0035556	; P:intracellular signal transduction
GO:0050850	; P:positive regulation of calcium-mediated signaling
GO:0032949	; P:regulation of alpha-glucan biosynthetic process
GO:0008360	; P:regulation of cell shape
GO:0090334	; P:regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
GO:0032878	; P:regulation of establishment or maintenance of cell polarity

KEGG

spo:SPBC12D12.04c

;

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF02185	; HR1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00742	; Hr1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

Created Date

20-Feb-2013