EKS-SCP-00028
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SCP-00028
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/RAN246.31.1E-7321297277
StatusReviewed
Ensembl ProteinSPBC19C2.05.1:pep
UniProt AccessionP08092; Q9UUD5;
Protein NameNegative regulator of sexual conjugation and meiosis
Protein Synonyms/Alias
Gene Nameran1
Gene Synonyms/Alias ran1; pat1; SPBC19C2.05;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
SPBC19C2.05SPBC19C2.05.1:pepSPBC19C2.05.1
OrganismSchizosaccharomyces pombe
Functional DescriptionThis protein is a negative regulator of both sexualconjugation and meiosis. It phosphorylates mei2. It blocks the onset of meiosis until conjugation takes place.
Protein Length470
Protein Sequence
(FASTA)
MMRENPELLL GQVLGDSLRF VSIIGAGAYG VVYKAEDIYD GTLYAVKALC KDGLNEKQKK 60
LQARELALHA RVSSHPYIIT LHRVLETEDA IYVVLQYCPN GDLFTYITEK KVYQGNSHLI 120
KTVFLQLISA VEHCHSVGIY HRDLKPENIM VGNDVNTVYL ADFGLATTEP YSSDFGCGSL 180
FYMSPECQRE VKKLSSLSDM LPVTPEPIES QSSSFATAPN DVWALGIILI NLCCKRNPWK 240
RACSQTDGTY RSYVHNPSTL LSILPISREL NSLLNRIFDR NPKTRITLPE LSTLVSNCKN 300
LTRRLRPAPL VSSRYLAYQQ QQQQQQMNLQ QGIQGYPHQG YMPTQNIGFP WPPTPQFVSN 360
WNHCATPTIP VSLQVLTPNS SLKVDPTTPL TAPIHATESF WPSAAAAAAA VHNNANSYMP 420
ITPTPYPNNA KIFGYPNQPP LTPIPFTGFV LHPAPVGRAA DAVDPSRKSL 470
Nucleotide Sequence
(FASTA)
ATGATGCGCG AAAATCCAGA ACTCCTTTTG GGTCAGGTCT TGGGTGATTC TTTACGATTT 60
GTTTCTATCA TCGGTGCCGG TGCTTATGGT GTCGTGTACA AAGCAGAAGA CATTTACGAC 120
GGTACCTTGT ATGCAGTAAA GGCTTTATGT AAGGATGGCT TAAATGAAAA GCAGAAGAAG 180
TTACAAGCTC GCGAACTTGC CTTACATGCT CGTGTTTCTT CACATCCTTA TATTATTACA 240
TTGCACCGCG TGTTAGAAAC GGAAGACGCC ATTTATGTCG TTCTCCAGTA TTGTCCGAAT 300
GGCGACCTTT TTACTTACAT CACGGAGAAA AAGGTATATC AAGGGAATAG TCATTTAATT 360
AAAACCGTTT TTTTACAGCT TATTTCTGCT GTTGAACATT GTCACTCAGT TGGCATATAT 420
CATCGAGATC TTAAACCCGA AAACATTATG GTTGGAAATG ATGTAAACAC CGTATACTTA 480
GCTGATTTTG GTCTGGCTAC TACAGAACCC TATTCAAGTG ACTTTGGATG TGGTAGTCTG 540
TTTTACATGT CTCCAGAATG TCAACGGGAG GTGAAAAAAC TTAGTTCGCT GTCAGATATG 600
CTACCGGTAA CTCCTGAACC TATAGAATCA CAATCATCCA GCTTTGCTAC AGCGCCAAAT 660
GACGTCTGGG CTCTGGGAAT TATATTAATT AATCTGTGTT GTAAGAGGAA CCCTTGGAAG 720
CGTGCATGTT CTCAAACTGA TGGTACTTAC CGTTCCTACG TTCACAATCC ATCAACCCTT 780
TTATCCATTT TACCCATCAG TAGAGAGCTC AATTCTCTAC TCAATCGAAT TTTTGATAGG 840
AATCCCAAAA CCCGAATCAC ATTACCCGAA CTTTCCACGC TAGTATCAAA CTGTAAGAAC 900
CTTACACGAC GTTTACGACC TGCTCCCCTT GTTTCATCTC GTTATCTCGC ATACCAACAA 960
CAACAACAAC AGCAACAAAT GAATTTGCAA CAAGGAATTC AAGGTTACCC TCATCAAGGC 1020
TATATGCCGA CTCAAAACAT TGGCTTTCCC TGGCCTCCGA CTCCCCAGTT TGTAAGTAAT 1080
TGGAATCATT GTGCTACTCC AACGATCCCT GTCTCCTTAC AAGTCCTTAC ACCAAATTCT 1140
TCACTTAAAG TAGATCCGAC TACACCTCTT ACAGCACCTA TTCATGCAAC CGAATCATTC 1200
TGGCCTTCTG CCGCAGCGGC GGCAGCAGCT GTCCATAACA ATGCTAACTC ATATATGCCT 1260
ATTACACCCA CACCCTATCC GAATAATGCA AAAATTTTCG GTTATCCTAA TCAACCTCCG 1320
CTGACTCCCA TACCTTTTAC TGGATTCGTT TTGCATCCTG CACCAGTTGG TCGTGCTGCT 1380
GATGCCGTAG ATCCATCTCG AAAATCGCTC TAA 1413
Domain Profile
S: 4     ieqigeGayGlvyraldirtdreyavkavvksysvedlkklehykeislqlrvqrhkniv  63
         ++ ig GayG+vy+a di +   yavka+ k  ++++ +k  + +e++l+ rv +h  i+
Q: 21    VSIIGAGAYGVVYKAEDIYDGTLYAVKALCK-DGLNEKQKKLQARELALHARVSSHPYII  79
         6789***************************.7777777767789***************
S: 64    aihevlesavatfivmdyys.tdlftsivddkhfvkkgllikkvflqicsaleyvhekGi  122
         ++h vle+  a ++v++y++ +dlft i ++k +  ++ lik vflq++sa+e++h  Gi
Q: 80    TLHRVLETEDAIYVVLQYCPnGDLFTYITEKKVYQGNSHLIKTVFLQLISAVEHCHSVGI  139
         *******************999**************************************
S: 123   yhcdikPenllldted.nvflcdfGlsttskyikpnvcvGssyymsPerilf..vsssks  179
         yh+d+kPen+++ ++  +v+l+dfGl+tt+ y + +   Gs +ymsPe       +ss s
Q: 140   YHRDLKPENIMVGNDVnTVYLADFGLATTEPY-SSDFGCGSLFYMSPECQREvkKLSSLS  198
         ***********9766459*************7.679999*********554423344444
S: 180   sgl.....klkevceslpsakgdlwslGiilinltcirnPflkadkkedntfyyfakdrn  234
         + l      ++   +s+ +a  d+w+lGiilinl c rnP+ +a  + d t+  + +++ 
Q: 199   DMLpvtpePIESQSSSFATAPNDVWALGIILINLCCKRNPWKRACSQTDGTYRSYVHNPS  258
         4431111157889999****************************9999************
S: 235   vlkdilplsddlfsvlskilqvnPknrldlkelmkevss  273
          l  ilp+s +l s+l++i+  nPk+r+ l el + vs+
Q: 259   TLLSILPISRELNSLLNRIFDRNPKTRITLPELSTLVSN  297
         ********************************9998875
Domain Sequence
(FASTA)
VSIIGAGAYG VVYKAEDIYD GTLYAVKALC KDGLNEKQKK LQARELALHA RVSSHPYIIT 60
LHRVLETEDA IYVVLQYCPN GDLFTYITEK KVYQGNSHLI KTVFLQLISA VEHCHSVGIY 120
HRDLKPENIM VGNDVNTVYL ADFGLATTEP YSSDFGCGSL FYMSPECQRE VKKLSSLSDM 180
LPVTPEPIES QSSSFATAPN DVWALGIILI NLCCKRNPWK RACSQTDGTY RSYVHNPSTL 240
LSILPISREL NSLLNRIFDR NPKTRITLPE LSTLVSN 277
KeywordATP-binding; Complete proteome; Conjugation; Kinase; Meiosis; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Saccharomyces cerevisiae"; ?>
EKS-SAC-00037
Gene Ontology
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0000746; P:conjugation
GO:0007126; P:meiosis
GO:0031138; P:negative regulation of conjugation with cellular fusion
GO:0045835; P:negative regulation of meiosis
GO:0007165; P:signal transduction
KEGG
spo:SPBC19C2.05;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013