EPS-SCP-00007

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SCP-00007

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	93.3	5.3E-27	1017	1272	256

Status

Reviewed

Ensembl Protein

SPBC19C7.03.1:pep

UniProt Accession

P14605;

Protein Name

Adenylate cyclase

Protein Synonyms/Alias

ATP pyrophosphate-lyase; Adenylyl cyclase;

Gene Name

cyr1

Gene Synonyms/Alias

cyr1; SPBC19C7.03;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBC19C7.03	SPBC19C7.03.1:pep	SPBC19C7.03.1

Organism

Schizosaccharomyces pombe

Functional Description

Plays essential roles in regulation of cellularmetabolism by catalyzing the synthesis of a second messenger, cAMP.

Protein Length

1692

Protein Sequence
(FASTA)

MDQSKRLLKS AVPNPPEHFK TGISWLDDLD EKDDDSATSV NYDIPEITEA NLCNDSHEAL 60

SPCTQPVGNS GRPVEAFKTY PSTPAVPSKS VLFHFYEPDE NFSLSDTGRT KSDTALAARE 120

SSEKSEVPRD TRSAGIKPYK ENNSSNCAIS KEAGLRRLID KDRESFDKNL NQSFTNLTFP 180

EPISDDSDSV EFQRDSLNNN WPASLEGSIH ELPRNSDDDG IPASAAHILD LDYHRDSYDS 240

PWKKFLPYPS ILSDDSWKAP ESWGTSLPTE AIPKQVFTTR FFARPSLGNR KKEFFLRVYR 300

DDRTSVSFIC PIGIQTHEVI KLLARLFFLP SSANFYLLLI QFNTERILLP HEQPCIIFER 360

LLSLFGCKVT SDEEINEEDN YSVARLVFTT MDIGADVLRK FSEKKITANL DISRSNLEVI 420

PVKIYPYAHE LISLNVSHNL SLDLPLDFME RCVKLKRLDI SNNLRSPRGK PITALRQLEV 480

LNMSRNDIYE LDPLIFSGLS RNSLKELNIA NNKLFFLPHS TRYLVNLTYL DLSYNNFVTF 540

PLIITELSQL ETLNFSHNLL SQISSKIGSL VKLKHLYLQF NDLSNRLPQE IGLLKNLETI 600

DLSYNAITNI ASLSECPKLN SINVACNLLS FYEYSNPSAT FIDFSFCPLT TIDPAFSYSN 660

LVYFDISHAK LIGLKDSVIE TLVNVETVKV NYNHFTSISD AISAMQNLKY LSCTNCEMSY 720

VSPNLGKLKH LVHLDLHANN IKIFPEEVWQ VSSLKVVNLS SNILEKIKLP VATSKKLTRT 780

ISQLKIMRTL SGNPVSSLSS QEFVMPTVEE LYLVDNRLGN DCFTALEYFK CLKVLNLSYN 840

YLTEIPSKFF QNFSDLKHLF VSGNELANLS ISSTAQVLLE TLYANGNRLS SFPKNEALSK 900

SLRFLDISTN NLQNLAVEKA EKKSLTKLPQ LEYLNLSGNT WFRFSEHEDT NFTKSYLKNL 960

KFLSIMDLNT KFSNAPSDVL NHFIQRNSPQ PNILRYGVCG YLSRSIPVIS ACELVVNNFL 1020

HPQSSLYCVL DSDISAGKNN RVLKFVYDNL ASCLAHEINA ADSSSEQICN ALRRGFLRLN 1080

KKLGNVIHYD LRKSSEGDVD SNYVTTMNIS EKGYSMDSSC LDIGVSIILV YVRDTRAFVA 1140

NVGTSMAIMS TRNDSEPTTL SVMHDVYNRD EIRRIVDSCG FISGEIKSTT TRAIGRLSQF 1200

PGVQAVPYVN VQYLSELNEF IILANQEFWS VLSKRTVIDV VRANRHSPLL ASTKLRDYAI 1260

AYGAEKNVLV VIVELNGLFE ENSLNFNQLR GDEKTLAISE KNDNMSFVQD LPDDSSLARM 1320

NREVSPPKGC IAMVFTDIKN STLLWERHPI AMRSAIKTHN TIMRRQLRAT GGYEVKTEGD 1380

AFMVCFQTVP AALLWCFSVQ LQLLSADWPN EIVESVQGRL VLGSKNEVLY RGLSVRIGVN 1440

YGVTVSELDP ITRRMDYYGP VVNRTSRVVS VADGGQIAVS AEVVSVLNQL DSETMSSEKT 1500

NVNEMEVRAL KQIGYIIHNL GEFKLKGLDT TEMISLVYPV QLQGRLERLI KSRSLGTPTA 1560

LPETQTYTPV RSRSNSLRPM LARLSDSKSV HGEEGGSGKR SVSSLRNVSP SESTGGYEGC 1620

IFDDQQYQLL YELCERLEDH AAILHGFPEP PPCDTGLAAP VNQAEEYSLF YRLTLRIENT 1680

IYCVSQMLGH TG 1692

Nucleotide Sequence
(FASTA)

ATGGATCAAA GCAAGCGATT GTTAAAGTCA GCTGTTCCAA ACCCGCCTGA ACATTTTAAA 60

ACAGGTATAT CCTGGCTTGA TGACCTTGAC GAGAAGGACG ATGACTCAGC GACGTCTGTG 120

AACTATGATA TACCAGAAAT AACCGAAGCA AATCTCTGTA ATGACTCCCA TGAAGCTCTT 180

TCACCTTGCA CTCAACCTGT CGGTAATTCT GGACGACCTG TCGAAGCTTT TAAGACCTAT 240

CCTAGCACTC CTGCAGTACC TAGCAAAAGC GTGCTTTTCC ATTTTTATGA ACCGGATGAG 300

AACTTTAGCT TATCTGACAC GGGACGTACT AAATCGGATA CCGCCTTAGC TGCAAGAGAA 360

AGCTCTGAAA AGTCTGAAGT GCCACGTGAT ACCCGTAGTG CTGGGATAAA GCCATACAAA 420

GAAAATAACT CGTCTAATTG TGCAATTTCT AAAGAAGCAG GCCTTCGAAG ACTTATTGAT 480

AAGGACAGAG AATCTTTCGA CAAAAACCTG AATCAGTCAT TTACCAATCT AACTTTTCCA 540

GAACCGATTT CTGATGACAG TGACAGTGTG GAGTTTCAAC GTGATTCTCT TAATAACAAT 600

TGGCCAGCTA GTTTGGAAGG TAGCATACAC GAATTACCCA GGAATAGTGA TGATGATGGA 660

ATCCCTGCTT CTGCGGCTCA TATCCTGGAC CTCGATTATC ATAGAGATAG TTATGATAGC 720

CCTTGGAAGA AGTTTTTACC GTACCCTTCC ATTTTATCCG ATGATTCTTG GAAAGCTCCG 780

GAGAGTTGGG GAACTAGTTT GCCCACTGAG GCTATTCCAA AGCAGGTTTT TACTACTAGA 840

TTTTTTGCTC GTCCTTCCCT GGGCAATAGA AAGAAAGAGT TCTTTCTTCG AGTATACCGT 900

GATGATCGAA CTTCCGTATC ATTCATTTGC CCTATTGGCA TACAAACTCA TGAAGTGATT 960

AAGCTGTTAG CAAGGTTATT TTTTCTTCCC TCGTCTGCTA ATTTTTACCT CTTATTAATC 1020

CAATTCAATA CAGAACGTAT TTTGTTGCCT CATGAACAGC CATGCATTAT ATTTGAACGA 1080

TTATTGAGTT TGTTTGGGTG TAAGGTAACT TCCGATGAAG AAATAAATGA AGAAGATAAT 1140

TATAGTGTTG CTAGATTGGT GTTTACTACG ATGGATATTG GAGCGGATGT ATTGCGTAAA 1200

TTCTCTGAAA AAAAAATTAC TGCGAACCTT GACATTAGTA GGTCAAACCT GGAGGTTATT 1260

CCGGTAAAGA TCTATCCCTA TGCCCATGAA CTTATCTCGT TGAATGTTTC GCACAATTTA 1320

TCGCTGGACC TGCCTTTAGA TTTCATGGAG CGCTGTGTCA AGCTTAAGCG GTTAGACATT 1380

TCCAATAATT TAAGGTCTCC AAGAGGAAAA CCGATTACTG CTCTTCGCCA ATTGGAAGTT 1440

TTGAACATGT CTCGTAACGA TATATATGAA TTGGATCCTC TTATATTCTC TGGGCTTAGT 1500

CGAAATTCTC TGAAAGAATT GAATATAGCT AATAATAAGC TGTTCTTCCT TCCCCATTCT 1560

ACTAGATATT TGGTGAATCT AACCTATCTT GATTTATCCT ACAATAATTT TGTGACTTTC 1620

CCTTTAATAA TTACTGAGTT GTCCCAATTG GAGACTCTTA ACTTTTCGCA TAATTTATTG 1680

TCACAGATAT CTAGCAAAAT TGGCTCTCTT GTTAAATTGA AGCATCTATA TCTACAATTT 1740

AATGATTTAT CTAATCGGCT TCCACAGGAA ATAGGCTTGC TAAAAAATCT GGAAACAATT 1800

GACCTTAGTT ATAATGCGAT TACTAACATC GCCAGTTTAT CTGAATGTCC GAAACTAAAT 1860

AGCATCAATG TAGCTTGCAA TTTACTTTCT TTTTACGAAT ATTCCAATCC GTCAGCTACA 1920

TTCATCGACT TCTCGTTTTG TCCACTGACT ACAATTGATC CGGCATTTAG CTATAGCAAT 1980

CTCGTCTACT TTGATATCTC ACATGCGAAG CTTATTGGGC TCAAGGATTC TGTCATTGAA 2040

ACTTTAGTAA ATGTAGAAAC AGTGAAAGTG AATTACAACC ACTTTACTAG CATTTCCGAT 2100

GCAATTTCTG CTATGCAAAA TTTGAAATAT TTGTCTTGCA CGAACTGTGA AATGTCTTAT 2160

GTTTCACCAA ACCTTGGCAA ATTAAAGCAT TTAGTTCACC TGGATTTACA TGCAAATAAT 2220

ATCAAAATAT TCCCTGAGGA AGTATGGCAA GTCTCTTCAC TAAAAGTTGT TAACCTGTCT 2280

TCCAATATCC TGGAGAAAAT CAAGTTACCA GTTGCAACGT CAAAAAAATT AACTAGGACA 2340

ATTAGCCAAT TAAAAATCAT GCGTACTTTA TCAGGAAATC CGGTATCGAG CCTCTCCTCC 2400

CAAGAATTTG TTATGCCTAC CGTTGAAGAA TTATACTTGG TGGACAACAG ATTGGGCAAT 2460

GACTGTTTTA CGGCTTTAGA ATACTTTAAG TGTTTAAAAG TCTTAAATTT ATCTTACAAT 2520

TATTTAACGG AAATTCCAAG CAAGTTTTTC CAAAATTTTT CTGATCTTAA ACACCTTTTT 2580

GTGTCAGGAA ATGAGCTTGC AAATCTTTCC ATTTCCAGTA CAGCGCAGGT CCTACTTGAA 2640

ACTTTGTACG CGAATGGAAA TCGTCTTTCC TCTTTTCCTA AAAATGAAGC TTTGTCTAAA 2700

AGTTTAAGAT TTTTGGACAT AAGTACCAAT AATCTGCAGA ATTTAGCAGT AGAAAAAGCT 2760

GAAAAGAAGA GTTTAACTAA ACTTCCTCAA TTGGAATACC TTAATCTATC TGGTAACACA 2820

TGGTTTCGAT TCTCTGAGCA TGAAGATACA AACTTTACAA AATCATATTT GAAGAATTTA 2880

AAGTTTTTGA GCATCATGGA TTTGAATACA AAATTTTCTA ATGCGCCTTC TGATGTTCTA 2940

AACCATTTTA TTCAACGCAA CTCTCCTCAA CCTAACATTT TGAGGTATGG AGTATGTGGA 3000

TACCTTTCTC GTTCTATTCC CGTCATCTCT GCATGTGAAT TAGTTGTTAA CAACTTTTTG 3060

CATCCTCAAT CATCTTTATA CTGTGTGCTT GACAGTGACA TCAGCGCTGG AAAAAACAAC 3120

CGGGTTTTAA AATTTGTGTA CGACAATTTG GCTTCATGCC TAGCGCATGA GATTAATGCA 3180

GCAGATTCCT CTTCTGAACA AATTTGTAAC GCTTTGAGAA GAGGATTTCT TCGTTTAAAC 3240

AAAAAATTAG GAAATGTCAT TCATTATGAC CTTAGGAAGT CTTCAGAAGG AGACGTGGAT 3300

AGTAATTACG TTACCACTAT GAATATTTCA GAAAAGGGTT ATTCTATGGA CAGTTCTTGC 3360

TTGGATATAG GAGTTAGCAT TATCTTAGTG TACGTCAGGG ATACAAGAGC TTTCGTTGCC 3420

AATGTGGGCA CATCAATGGC TATAATGTCT ACGAGAAATG ATTCGGAACC TACAACTTTA 3480

AGTGTCATGC ATGATGTGTA CAATAGGGAT GAAATTCGTC GCATAGTTGA TTCATGTGGT 3540

TTCATATCTG GTGAAATAAA ATCGACCACT ACACGTGCTA TTGGTCGTTT GTCTCAATTT 3600

CCTGGCGTCC AAGCAGTTCC CTATGTTAAT GTGCAGTACT TATCTGAACT AAACGAATTT 3660

ATCATTCTAG CAAATCAGGA ATTTTGGAGC GTATTATCAA AACGCACAGT AATTGACGTT 3720

GTTCGTGCCA ACAGACATTC TCCTCTATTA GCCTCTACGA AGCTACGTGA CTATGCTATT 3780

GCATATGGTG CAGAAAAAAA TGTTCTTGTA GTTATCGTCG AATTGAACGG ATTGTTTGAA 3840

GAGAATTCCC TTAATTTCAA CCAACTACGG GGGGATGAAA AAACTTTAGC AATTTCTGAA 3900

AAGAACGATA ATATGTCATT TGTCCAAGAT TTACCCGATG ATTCTTCTTT AGCACGAATG 3960

AATAGAGAAG TCTCTCCCCC GAAAGGTTGT ATTGCCATGG TTTTTACTGA TATTAAGAAT 4020

TCCACATTAT TGTGGGAAAG ACATCCTATT GCAATGAGAT CTGCGATCAA AACTCATAAT 4080

ACTATTATGC GTCGGCAACT CCGTGCAACT GGAGGCTATG AAGTAAAAAC CGAAGGAGAT 4140

GCGTTTATGG TTTGTTTTCA AACAGTTCCT GCTGCATTAC TTTGGTGTTT TTCAGTACAA 4200

TTACAGTTAC TTTCGGCAGA TTGGCCCAAC GAAATAGTTG AGTCAGTGCA AGGACGGTTG 4260

GTACTCGGCT CAAAAAATGA GGTGTTATAT CGAGGGCTTA GTGTTCGAAT TGGTGTCAAT 4320

TATGGTGTAA CCGTGAGTGA ACTAGATCCC ATCACTAGAC GTATGGACTA TTACGGGCCT 4380

GTAGTAAACA GAACATCTAG GGTTGTATCA GTCGCTGATG GTGGTCAAAT TGCTGTTTCT 4440

GCTGAGGTGG TATCTGTATT GAATCAGCTT GATTCAGAAA CAATGTCATC AGAGAAGACG 4500

AATGTCAACG AAATGGAAGT TCGTGCTCTT AAACAAATCG GTTATATTAT CCATAACCTT 4560

GGAGAATTTA AGTTAAAAGG TTTGGATACT ACTGAAATGA TTTCATTGGT TTATCCTGTG 4620

CAATTGCAAG GAAGACTGGA GAGATTGATA AAGAGCCGAA GTTTGGGAAC ACCCACAGCC 4680

CTCCCGGAAA CTCAGACTTA TACTCCCGTT CGTAGTAGAA GCAACAGCTT GCGACCCATG 4740

TTAGCAAGAT TGAGTGATTC AAAATCTGTC CATGGAGAGG AGGGTGGTTC TGGGAAGAGA 4800

TCGGTTTCAT CCTTGCGCAA CGTATCACCA TCAGAGAGTA CTGGTGGATA TGAAGGTTGT 4860

ATTTTTGATG ACCAACAGTA TCAATTACTT TATGAACTTT GTGAGCGTCT TGAAGACCAT 4920

GCCGCTATAC TGCATGGGTT TCCTGAACCA CCGCCTTGCG ATACCGGTCT GGCAGCTCCC 4980

GTAAACCAGG CCGAGGAGTA TTCATTGTTC TACCGTCTGA CTTTGCGTAT CGAGAATACT 5040

ATTTATTGTG TCAGTCAAAT GCTTGGACAC ACTGGCTAA 5079

Domain Profile

S: 23    pnflkspekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalaka  82

         +nfl ++++ +   ++      ++++v kf+ ++l ++la e+++ +s+++++++al+++

Q: 1017  NNFLHPQSSLY-CVLDSDISAGKNNRVLKFVYDNLASCLAHEINAADSSSEQICNALRRG  1075

         55555554433.34445455556788999*******************************

S: 83    Flstdeel.......................kvleeksldidk....sGstavvalikds  115

         Fl++ ++l                       ++++ek  ++d+     G +  +++++d+

Q: 1076  FLRLNKKLgnvihydlrkssegdvdsnyvttMNISEKGYSMDSscldIGVSIILVYVRDT  1135

         *************************9999997777777776667888*************

S: 116   klyvanvGdSravLcr.ng.kavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

           +vanvG S a+++  n+ ++ +ls+ H + + dE++Ri +  g +  +    ++

Q: 1136  RAFVANVGTSMAIMSTrNDsEPTTLSVMHDVYNRDEIRRIVDSCGFISGE----IKS--T  1189

         ***************978878**********************9998866....655..7

S: 174   vsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekke  233

          +Ra+G l   p v + P v +  l++ +ef+iLa    w v+s+ +++++vr

Q: 1190  TTRAIGRLSQFPGVQAVPYVNVQYLSELNEFIILANQEFWSVLSKRTVIDVVRANRH---  1246

         8***************************************************98887...

S: 234   aeqeaakkLvklalargskdnvsaiv  259

         ++  a++kL ++a+a+g+++nv +++

Q: 1247  SPLLASTKLRDYAIAYGAEKNVLVVI  1272

         9*********************6665

Domain Sequence
(FASTA)

NNFLHPQSSL YCVLDSDISA GKNNRVLKFV YDNLASCLAH EINAADSSSE QICNALRRGF 60

LRLNKKLGNV IHYDLRKSSE GDVDSNYVTT MNISEKGYSM DSSCLDIGVS IILVYVRDTR 120

AFVANVGTSM AIMSTRNDSE PTTLSVMHDV YNRDEIRRIV DSCGFISGEI KSTTTRAIGR 180

LSQFPGVQAV PYVNVQYLSE LNEFIILANQ EFWSVLSKRT VIDVVRANRH SPLLASTKLR 240

DYAIAYGAEK NVLVVI 256

Keyword

ATP-binding; cAMP biosynthesis; Complete proteome; Cytoplasm; Leucine-rich repeat; Lyase; Magnesium; Metal-binding; Nucleotide-binding; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0004016	; F:adenylate cyclase activity
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0007188	; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0019933	; P:cAMP-mediated signaling
GO:0045014	; P:negative regulation of transcription by glucose
GO:0031137	; P:regulation of conjugation with cellular fusion

KEGG

spo:SPBC19C7.03

;

InterPros

IPR001054	; A/G_cyclase.
IPR013716	; Adenylate_cyclase_G-a-bd.
IPR001611	; Leu-rich_rpt.
IPR025875	; Leu-rich_rpt_4.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR001932	; PP2C-like.
IPR000159	; Ras-assoc.

Pfam

PF08509	; Ad_cyc_g-alpha; 1.
PF00211	; Guanylate_cyc; 1.
PF12799	; LRR_4; 1.
PF00481	; PP2C; 1.
PF00788	; RA; 1.

SMARTs

SM00044	; CYCc; 1.
SM00369	; LRR_TYP; 1.
SM00332	; PP2Cc; 1.
SM00314	; RA; 1.

Prosites

PS50125	; GUANYLATE_CYCLASE_2; 1.
PS51450	; LRR; 14.
PS50200	; RA; 1.

Prints

Created Date

20-Feb-2013