EKS-SCP-00090

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00090

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	323.1	5.3E-97	2051	2334	284

Status

Reviewed

Ensembl Protein

SPBC216.05.1:pep

UniProt Accession

Q02099; Q92391; Q9UUM1;

Protein Name

Protein kinase rad3

Protein Synonyms/Alias

DNA repair protein rad3;

Gene Name

rad3

Gene Synonyms/Alias

rad3; SPBC216.05;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBC216.05	SPBC216.05.1:pep	SPBC216.05.1

Organism

Schizosaccharomyces pombe

Functional Description

Serine/threonine kinase which activates checkpointsignaling upon genotoxic stresses. Involved in G2 arrest following DNA damage where it phosphorylates chk1. It is also involved in the dependence of mitosis on the completion of DNA replication.

Protein Length

2386

Protein Sequence
(FASTA)

MSQHAKRKAG SLDLSPRGLD DRQAFGQLLK EVLALDKEHE LGRSNSLPSM TSELVEVLIE 60

VGLLAFKHDD SKSEFISPKM LKEAHLSLQA LMLILKRSPT VLREIKSSVT LLDWILPRTI 120

SLFADIRFIK LFDSLKEFHK LIYQLISEKS FLWDLYASFM RYWKYYITNV SSIVLQITNA 180

TFPYKMPSPN SQPLQSITPN YPTHREDKFD LLIINIEEAC TFFFESAHFF AQCSYLKKSN 240

FPSPPLFTAW TWIKPCFFNF VILLKRISIG DSQLFLHLHS RIVQTLCCFS LNFIYHGLPI 300

CEKSKHILMS SINLTLGSLK KTYTVANTAI SLFFLSLFVL PKTVAGLFYP FGVSLLSDFK 360

VLEQLEPDSD LKKAIILFKC RYQSSEIDQT TLRAFGEICT GKLENTLFSN SELNLFLLHY 420

LSLDNDLSNI LKVDFQNGHN ICTFAKWCIN NNLDEPSNLK HFREMLDYYS SHNVTISEDD 480

LKNFSLVLCT HVAKVNEKTN SIFRTYEVHG CEVCNSFCLL FDERSLFKIP YHELFCALLK 540

NPDIISSSVK QSLLLDGFFR WSQHCSNFNK ESMLSLREFI MKALASTSRC LRVVAAKVLP 600

IFIKGPNNLD IVEFHKESKA LIFNTLKILA VENTAILETV ILSWISLSRV VEEEELHFVL 660

LEVISSVINS GIFYQGIGLS ALQQIASTRH ISVWQLLSPY WPTVSVAIVQ GMGKKPNIAS 720

LFAQLMNISE GDFLIRTQAY TLPFLVLTKN KALIVRIAEL SQSDVATLCL TNMHKILASL 780

LTTDHPNLEE SVMLLLSLAT SDFEKVDLTS LLRSDPISIT VELLQLYQND VPHEKIENAL 840

RKVAMIVSQV VNDEDLSNKE LLYDFFNNHI LGILAEFSNI LNDLKGKTSI NEKIKTIVGI 900

EKMLSLCGGA VKLGLPQILS NLQSAFQNEH LRFYAIKAWF SLILATKEPE YSSIAGLSLV 960

ILPPLFPYLE PQEAELVIQI FDFISSDTHK CLQGLKWAIP TSLDSACFSL KAKEIFCSLQ 1020

NEDFYSELQS IIKCLTNENE PVCYLGLQKL ELFFQAKVDE LHDTLNLDIS NEVLDQLLRC 1080

LLDCCVKYAS TNMQISYLAA KNLGELGAID PSRAKAQHII KETVVLDNFE NGEESLKFIL 1140

DFMQSQLIPA FLVTTDTKAQ GFLAYALQEF LKLGGFKSAV INKKKGLTVV TEHWMSLPDL 1200

SKRVLIPFLT SKYHLTPIPK IDIRYPIYKE NVTIHTWMQL FSLKLMEYAH SQNAEKIFGI 1260

CSKVVKDQEV NIPCFLLPFL VLNVILTESE LEVNKVIEEF QLVINQPGPD GLNSVGQQRY 1320

TSFVDVFFKI VDYLNKWLRM RKKRNWDRRS AIARKENRYM SVEDATSRES SISKVESFLS 1380

RFPSKTLGIV SLNCGFHARA LFYWEQHIRN ATAPYAALES DYRVLQEIYA GIDDPDEIEA 1440

VSLNFHDYSF DQQLLLHENS GTWDSALSCY EIIIQKDPEN KKAKIGLLNS MLQSGHYESL 1500

VLSLDSFIIN DNHEYSKMLN LGIEASWRSL SIDSLKKCLS KSNLESFEAK LGSIFYQYLR 1560

KDSFAELTER LQPLYVDAAT AIANTGAHSA YDCYDILSKL HAINDFSRIA ETDGIVSDNL 1620

DIVLRRRLSQ VAPYGKFKHQ ILSTHLVGYE KFENTKKTAE IYLEIARISR KNGQFQRAFN 1680

AILKAMDLDK PLATIEHAQW WWHQGQHRKA ISELNFSLNN NMFDLVDEHE ERPKNRKETL 1740

GNPLKGKVFL KLTKWLGKAG QLGLKDLETY YHKAVEIYSE CENTHYYLGH HRVLMYEEEQ 1800

KLPVNEQSER FLSGELVTRI INEFGRSLYY GTNHIYESMP KLLTLWLDFG AEELRLSKDD 1860

GEKYFREHII SSRKKSLELM NSNVCRLSMK IPQYFFLVAL SQMISRVCHP NNKVYKILEH 1920

IIANVVASYP GETLWQLMAT IKSTSQKRSL RGKSILNVLH SRKLSMSSKV DIKALSQSAI 1980

LITEKLINLC NTRINSKSVK MSLKDHFRLS FDDPVDLVIP AKSFLDITLP AKDANRASHY 2040

PFPKTQPTLL KFEDEVDIMN SLQKPRKVYV RGTDGNLYPF LCKPKDDLRK DARLMEFNNL 2100

ICKILRKDQE ANRRNLCIRT YVVIPLNEEC GFIEWVNHTR PFREILLKSY RQKNIPISYQ 2160

EIKVDLDFAL RSPNPGDIFE KKILPKFPPV FYEWFVESFP EPNNWVTSRQ NYCRTLAVMS 2220

IVGYVLGLGD RHGENILFDE FTGEAIHVDF NCLFDKGLTF EKPEKVPFRL THNMVDAMGP 2280

TGYEGGFRKA SEITMRLLRS NQDTLMSVLE SFLHDPLVEW NRKKSSSKYP NNEANEVLDI 2340

IRKKFQGFMP GETIPLSIEG QIQELIKSAV NPKNLVEMYI GWAAYF 2386

Nucleotide Sequence
(FASTA)

ATGAGCCAAC ACGCAAAAAG GAAAGCTGGG TCACTCGATC TTTCACCCAG AGGCTTAGAT 60

GACAGACAGG CTTTCGGACA GCTTTTGAAA GAAGTATTAG CATTAGACAA AGAACATGAG 120

TTAGGTAGAA GTAATTCTTT ACCATCTATG ACCTCCGAGC TTGTTGAAGT TTTAATTGAA 180

GTTGGTCTTC TAGCTTTTAA ACATGATGAT TCAAAATCTG AATTTATCTC TCCTAAGATG 240

CTAAAAGAAG CCCATCTCTC TCTACAAGCG TTAATGCTAA TCTTAAAAAG GTCTCCGACA 300

GTTTTGCGGG AGATTAAATC ATCTGTTACT CTTTTGGATT GGATTTTACC CAGGACTATA 360

TCATTGTTTG CTGATATTCG TTTTATTAAG TTATTTGACT CATTAAAAGA GTTTCATAAG 420

CTAATTTATC AGCTAATCAG TGAAAAGTCA TTCCTATGGG ACTTATATGC TTCGTTTATG 480

CGTTATTGGA AATATTATAT TACAAACGTT TCTTCTATAG TTCTCCAAAT CACTAATGCT 540

ACATTCCCTT ACAAGATGCC CTCACCCAAT TCTCAACCAT TGCAGAGTAT CACCCCAAAT 600

TATCCAACCC ATCGAGAGGA CAAATTTGAT TTACTTATCA TTAATATAGA GGAGGCTTGT 660

ACATTTTTCT TTGAAAGTGC CCATTTTTTT GCACAATGCT CATATTTAAA GAAATCCAAT 720

TTTCCTAGTC CACCTCTCTT TACAGCGTGG ACTTGGATCA AGCCATGTTT TTTTAATTTT 780

GTTATTTTAT TAAAACGAAT CAGCATCGGA GACTCACAGC TCTTTCTACA TTTGCATTCA 840

CGTATAGTCC AAACTTTATG CTGTTTTTCC TTGAATTTTA TATATCATGG CCTTCCCATT 900

TGTGAAAAAT CTAAACATAT TTTAATGTCC TCCATCAACT TAACATTGGG ATCATTGAAG 960

AAAACTTATA CAGTTGCTAA TACTGCTATA TCTCTTTTTT TTCTCTCTTT ATTTGTTTTA 1020

CCCAAAACTG TAGCTGGTCT ATTCTATCCT TTTGGGGTTT CCTTACTTTC TGACTTCAAG 1080

GTATTAGAGC AACTTGAACC AGATTCTGAT CTCAAAAAGG CAATAATATT ATTTAAGTGC 1140

AGATACCAAA GTTCAGAAAT AGATCAAACA ACTCTCCGTG CTTTTGGCGA AATTTGTACT 1200

GGTAAACTTG AAAACACGTT GTTTTCTAAC TCTGAATTAA ACCTTTTTCT TTTACATTAT 1260

CTTTCCTTGG ACAATGACTT GTCAAATATT CTTAAAGTGG ATTTCCAGAA TGGTCATAAC 1320

ATATGTACAT TTGCAAAATG GTGTATAAAC AACAACTTAG ATGAACCGTC TAATTTAAAG 1380

CACTTTCGTG AAATGTTAGA TTATTATAGC TCTCATAATG TTACAATAAG TGAGGACGAC 1440

CTGAAGAACT TCTCTTTAGT TTTGTGTACT CATGTTGCAA AGGTGAATGA GAAAACAAAT 1500

AGTATTTTCC GCACATATGA AGTACATGGT TGTGAAGTTT GTAACTCATT TTGTTTACTA 1560

TTTGATGAGC GGTCGCTCTT TAAAATTCCT TATCACGAAT TGTTTTGTGC ATTGCTAAAA 1620

AATCCCGACA TAATTTCCTC TTCTGTTAAA CAATCATTGT TGCTTGATGG CTTTTTTCGG 1680

TGGAGCCAGC ATTGCTCAAA CTTTAATAAA GAATCAATGT TAAGTTTAAG AGAATTTATT 1740

ATGAAAGCAT TAGCCAGTAC TTCAAGATGT TTACGTGTTG TTGCTGCAAA AGTTTTGCCC 1800

ATTTTCATTA AGGGACCTAA TAATCTTGAT ATAGTTGAAT TTCACAAGGA AAGTAAAGCC 1860

TTGATTTTTA ATACGTTGAA AATATTGGCG GTGGAAAATA CAGCTATTTT AGAAACGGTC 1920

ATTCTTTCCT GGATCTCCTT ATCTAGAGTG GTAGAAGAAG AAGAATTACA TTTTGTACTA 1980

TTGGAAGTTA TATCTTCTGT GATAAACAGC GGAATATTTT ATCAAGGCAT TGGTCTCAGC 2040

GCTCTGCAAC AAATTGCCTC GACGCGTCAT ATATCCGTTT GGCAATTACT TTCTCCATAT 2100

TGGCCAACAG TGTCCGTTGC GATTGTCCAA GGTATGGGTA AAAAACCGAA CATAGCCAGT 2160

TTATTTGCTC AGCTTATGAA TATTTCCGAG GGCGATTTTC TTATTCGAAC ACAGGCGTAC 2220

ACTTTACCAT TCCTTGTACT TACTAAAAAC AAAGCGTTAA TAGTACGTAT AGCTGAACTT 2280

TCACAAAGTG ATGTTGCTAC TTTGTGCCTT ACCAATATGC ATAAAATCCT TGCTTCGCTA 2340

CTTACTACGG ATCATCCTAA TTTGGAAGAG AGTGTGATGC TTCTTCTTTC ACTGGCCACT 2400

TCTGATTTTG AAAAAGTTGA TTTAACGTCT TTGTTACGCT CTGATCCTAT TTCTATTACT 2460

GTGGAGTTGT TACAGCTTTA TCAGAATGAT GTTCCTCATG AAAAAATTGA AAATGCTTTA 2520

AGAAAGGTAG CAATGATTGT CTCTCAAGTG GTTAATGACG AAGACTTGAG CAATAAGGAA 2580

TTACTTTATG ATTTTTTTAA TAATCACATT TTGGGTATCT TAGCAGAATT TTCTAATATC 2640

CTTAACGACC TGAAAGGAAA GACTTCAATT AATGAAAAGA TTAAGACAAT TGTCGGCATT 2700

GAAAAAATGT TATCTTTATG TGGAGGTGCA GTCAAACTTG GATTACCACA GATACTTTCT 2760

AATTTACAAA GTGCTTTTCA AAATGAGCAC TTAAGGTTTT ATGCAATCAA AGCTTGGTTC 2820

AGTTTGATAT TAGCAACCAA GGAGCCCGAG TATAGTTCAA TTGCTGGTTT AAGTCTTGTA 2880

ATTTTACCTC CTTTATTCCC TTATTTAGAA CCACAAGAAG CAGAGCTAGT AATTCAAATA 2940

TTTGATTTTA TTTCTTCTGA CACACACAAG TGCCTACAAG GATTAAAGTG GGCTATCCCC 3000

ACCAGTCTGG ATTCAGCGTG CTTTAGCCTT AAGGCTAAAG AAATATTCTG TTCGCTTCAA 3060

AATGAAGATT TTTACTCTGA GCTTCAAAGT ATAATTAAGT GTTTAACTAA CGAAAATGAG 3120

CCAGTTTGTT ATTTAGGTTT ACAAAAATTA GAACTTTTTT TTCAAGCCAA GGTGGACGAG 3180

TTACATGACA CACTAAATTT GGACATATCC AACGAAGTTC TGGACCAATT ACTAAGATGC 3240

CTTTTAGATT GTTGTGTAAA ATATGCTTCA ACAAATATGC AAATATCATA TCTTGCTGCA 3300

AAAAATCTTG GTGAATTGGG TGCGATAGAT CCCAGCCGCG CCAAGGCTCA ACATATTATT 3360

AAAGAAACAG TTGTTCTTGA TAACTTTGAA AACGGAGAAG AAAGTTTGAA GTTTATTCTA 3420

GATTTTATGC AATCGCAGTT AATTCCAGCT TTCCTTGTTA CTACTGATAC TAAAGCACAA 3480

GGTTTTCTTG CCTATGCTCT GCAAGAGTTT CTAAAGCTTG GTGGATTCAA GTCCGCAGTG 3540

ATTAATAAAA AAAAGGGACT AACTGTGGTA ACAGAACATT GGATGTCTTT GCCTGATTTA 3600

TCCAAACGTG TGCTTATACC ATTTTTAACT TCCAAGTATC ATTTAACACC AATCCCCAAA 3660

ATTGACATTC GGTACCCTAT TTATAAAGAA AATGTTACTA TTCATACTTG GATGCAGTTG 3720

TTTTCTCTTA AATTGATGGA GTACGCCCAT TCGCAAAACG CTGAAAAAAT ATTTGGTATT 3780

TGTTCGAAAG TAGTGAAAGA CCAAGAGGTT AACATTCCCT GTTTTCTTCT TCCCTTTCTT 3840

GTTTTAAATG TTATTTTAAC CGAGTCAGAA CTGGAAGTTA ATAAAGTCAT TGAAGAATTC 3900

CAGCTTGTTA TTAATCAACC GGGACCTGAT GGATTAAATT CCGTGGGGCA ACAAAGATAC 3960

ACCTCATTTG TAGATGTATT TTTTAAGATT GTGGATTACC TTAACAAATG GCTTCGCATG 4020

CGAAAGAAGA GGAATTGGGA TAGACGTTCT GCCATTGCAA GGAAAGAGAA CCGTTATATG 4080

TCGGTGGAAG ATGCTACCTC TCGAGAATCA TCGATCTCAA AAGTTGAGTC ATTTCTTTCT 4140

CGATTTCCTT CAAAAACATT AGGTATTGTC TCTTTAAATT GTGGATTTCA TGCTCGTGCA 4200

TTGTTTTATT GGGAGCAACA CATACGTAAT GCTACAGCTC CATATGCAGC TTTAGAGTCC 4260

GATTATAGAG TTTTGCAGGA AATATATGCT GGAATTGATG ATCCAGATGA AATCGAAGCA 4320

GTGTCTTTAA ATTTCCATGA TTACTCGTTT GATCAACAAC TCCTTTTACA TGAAAATTCA 4380

GGAACATGGG ACTCGGCTTT GAGTTGTTAC GAAATTATTA TTCAAAAGGA TCCTGAAAAT 4440

AAAAAGGCGA AAATCGGTTT GCTTAACAGC ATGCTGCAAT CGGGGCATTA TGAATCTCTT 4500

GTTTTGAGTT TAGATTCTTT TATAATCAAT GACAACCACG AGTATTCGAA GATGTTAAAT 4560

TTGGGTATTG AAGCTTCATG GCGTTCGCTA TCTATTGATT CGTTAAAAAA GTGTCTTTCA 4620

AAAAGCAACT TGGAATCTTT CGAAGCTAAA TTGGGTAGCA TATTTTACCA ATACCTACGG 4680

AAGGATTCTT TTGCTGAATT GACGGAGCGG CTGCAACCCT TGTACGTTGA TGCTGCTACA 4740

GCAATTGCAA ACACAGGCGC CCATTCAGCC TATGATTGTT ATGATATTTT ATCTAAGCTG 4800

CACGCAATTA ATGACTTTAG TAGGATTGCT GAAACTGACG GAATTGTTTC CGACAATCTT 4860

GATATTGTTC TTCGCCGTCG GCTTAGCCAA GTAGCTCCGT ACGGTAAATT CAAGCACCAA 4920

ATCCTGTCCA CTCACTTAGT TGGCTATGAA AAATTTGAAA ACACGAAGAA AACTGCTGAA 4980

ATATATCTCG AGATTGCAAG AATATCTCGA AAAAATGGTC AATTTCAAAG AGCCTTCAAT 5040

GCCATCCTCA AAGCAATGGA TTTAGATAAA CCGCTAGCAA CAATAGAGCA CGCACAATGG 5100

TGGTGGCATC AAGGGCAACA TCGTAAAGCT ATTTCTGAAT TGAATTTTTC GCTTAATAAC 5160

AACATGTTTG ATTTGGTTGA TGAGCATGAA GAAAGACCTA AAAATCGTAA AGAAACTTTA 5220

GGAAATCCAC TTAAAGGAAA AGTGTTCTTG AAACTTACAA AATGGCTCGG AAAAGCTGGC 5280

CAACTGGGAT TGAAGGATTT GGAGACGTAT TATCATAAAG CGGTAGAGAT TTACTCAGAA 5340

TGTGAGAATA CGCATTATTA TCTTGGCCAT CATCGAGTTT TAATGTATGA AGAAGAACAA 5400

AAGCTCCCAG TTAATGAACA GAGCGAACGA TTTTTAAGTG GTGAGTTAGT AACTCGCATA 5460

ATTAACGAAT TTGGTCGATC TTTGTACTAT GGTACAAATC ATATATATGA AAGTATGCCA 5520

AAATTGCTCA CACTGTGGCT TGATTTTGGG GCCGAAGAAC TTCGCTTATC TAAAGATGAC 5580

GGCGAAAAGT ACTTTCGTGA ACACATTATC TCTTCGAGAA AAAAATCTTT GGAACTTATG 5640

AATTCGAATG TTTGTCGCCT TTCTATGAAA ATTCCTCAAT ACTTTTTTCT GGTTGCATTA 5700

TCCCAAATGA TATCCAGAGT ATGCCATCCA AATAATAAAG TTTATAAAAT TTTGGAACAT 5760

ATAATTGCAA ACGTTGTAGC ATCTTATCCT GGGGAGACGC TATGGCAATT AATGGCAACA 5820

ATAAAATCGA CTTCTCAAAA GCGCTCGCTT CGTGGAAAAA GCATTTTAAA TGTTTTACAT 5880

TCTAGGAAGC TTTCTATGTC TTCCAAAGTT GATATAAAAG CACTCAGTCA ATCTGCAATT 5940

CTCATTACTG AAAAGTTAAT CAATTTGTGC AATACAAGGA TTAACAGTAA ATCTGTAAAA 6000

ATGAGCTTAA AGGATCATTT TCGGCTTTCT TTTGATGATC CGGTAGATTT AGTCATTCCT 6060

GCTAAATCAT TTTTAGACAT TACTTTACCA GCTAAAGATG CTAACAGAGC TAGTCATTAT 6120

CCATTTCCAA AAACTCAGCC TACTCTGTTG AAATTTGAGG ATGAGGTGGA TATAATGAAC 6180

TCTCTTCAAA AACCAAGAAA AGTGTACGTT AGAGGTACGG ATGGCAACTT ATACCCATTC 6240

TTGTGCAAAC CCAAAGATGA TCTTCGTAAG GATGCTAGAT TGATGGAATT TAATAATCTT 6300

ATTTGTAAAA TATTGAGGAA AGATCAAGAA GCGAACAGAA GGAACTTGTG TATTAGAACT 6360

TATGTTGTTA TTCCTTTAAA TGAAGAATGC GGATTTATCG AATGGGTAAA TCATACTCGT 6420

CCATTTAGAG AAATTTTGTT AAAAAGCTAT AGACAGAAAA ACATTCCCAT ATCATATCAA 6480

GAAATCAAAG TTGATTTAGA CTTTGCACTG CGAAGTCCTA ACCCTGGTGA TATATTTGAA 6540

AAGAAAATCT TACCGAAATT TCCTCCAGTT TTTTATGAGT GGTTTGTTGA ATCTTTCCCA 6600

GAACCAAATA ATTGGGTTAC TAGTAGACAA AACTATTGCC GAACTTTAGC AGTAATGTCA 6660

ATAGTTGGCT ACGTTTTGGG TTTGGGAGAT CGCCATGGCG AAAACATATT GTTTGATGAA 6720

TTTACAGGTG AAGCTATCCA TGTCGATTTC AACTGTCTTT TTGATAAAGG TCTTACTTTT 6780

GAAAAACCTG AAAAGGTGCC GTTCAGATTA ACTCATAATA TGGTAGATGC AATGGGTCCG 6840

ACAGGTTATG AAGGGGGTTT CAGGAAAGCT AGCGAAATAA CGATGCGGCT TCTTCGCTCA 6900

AACCAAGATA CATTGATGAG CGTACTAGAG TCTTTCCTAC ATGATCCTTT AGTCGAGTGG 6960

AATAGAAAGA AGTCGTCAAG CAAGTACCCG AATAATGAAG CAAATGAAGT TTTGGATATA 7020

ATTCGCAAAA AATTTCAAGG CTTTATGCCA GGGGAGACGA TACCTTTATC TATTGAAGGG 7080

CAAATTCAAG AATTGATCAA ATCTGCTGTC AACCCAAAAA ACCTGGTAGA AATGTACATT 7140

GGTTGGGCTG CTTATTTCTA G 7161

Domain Profile

S: 3     gfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdke  62

         +f+++v+i++s+qkp+k+++rG dg  yp+L+k+k+Dlr+d+r++++++l+ ++L+kd+e

Q: 2051  KFEDEVDIMNSLQKPRKVYVRGTDGNLYPFLCKPKDDLRKDARLMEFNNLICKILRKDQE  2110

         699*********************************************************

S: 63    tsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls.  121

          +rr+L irty V+pl++++g iewv++t + +e+l k + +k++  +    y+  +

Q: 2111  ANRRNLCIRTYVVIPLNEECGFIEWVNHTRPFREILLKSYRQKNIPIS----YQEIKVDl  2166

         *****************************************9999886....43333330

S: 122   tvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvi  181

          +  r p+        ++f++   +  p+ ++ ++++e+fp+p++w ++r++y+r lAv+

Q: 2167  DFALRSPNP------GDIFEKKILPKFPP-VFYEWFVESFPEPNNWVTSRQNYCRTLAVM  2219

         333333333......36666555554665.******************************

S: 182   slvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnal  241

         s+vgy+LgLgdrh en+l+d+ tge +h+df++ f+k+ t ++ pekvPFRLT+n+v+a+

Q: 2220  SIVGYVLGLGDRHGENILFDEFTGEAIHVDFNCLFDKGLT-FEKPEKVPFRLTHNMVDAM  2278

         ****************************************.*******************

S: 242   gvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkkkkktsketeeel  297

         g+tg eG fr++ e ++r+lr+++++l+++Le fl+dplv+w+ kk++sk  ++e

Q: 2279  GPTGYEGGFRKASEITMRLLRSNQDTLMSVLESFLHDPLVEWNRKKSSSKYPNNEA  2334

         *******************************************9666555444444

Domain Sequence
(FASTA)

KFEDEVDIMN SLQKPRKVYV RGTDGNLYPF LCKPKDDLRK DARLMEFNNL ICKILRKDQE 60

ANRRNLCIRT YVVIPLNEEC GFIEWVNHTR PFREILLKSY RQKNIPISYQ EIKVDLDFAL 120

RSPNPGDIFE KKILPKFPPV FYEWFVESFP EPNNWVTSRQ NYCRTLAVMS IVGYVLGLGD 180

RHGENILFDE FTGEAIHVDF NCLFDKGLTF EKPEKVPFRL THNMVDAMGP TGYEGGFRKA 240

SEITMRLLRS NQDTLMSVLE SFLHDPLVEW NRKKSSSKYP NNEA 284

Keyword

ATP-binding; Complete proteome; DNA damage; DNA repair; DNA synthesis; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0000228	; C:nuclear chromosome
GO:0043234	; C:protein complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006281	; P:DNA repair
GO:0006260	; P:DNA replication
GO:0031573	; P:intra-S DNA damage checkpoint
GO:0007131	; P:reciprocal meiotic recombination
GO:0007346	; P:regulation of mitotic cell cycle

KEGG

spo:SPBC216.05

;

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013