EPS-SCP-00021

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SCP-00021

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Asp-Based PTP/FCP	164.0	6.9E-49	304	467	164

Status

Reviewed

Ensembl Protein

SPBC3B8.10c.1:pep

UniProt Accession

O59718;

Protein Name

Nuclear envelope morphology protein 1

Protein Synonyms/Alias

Gene Name

nem1

Gene Synonyms/Alias

nem1; SPBC3B8.10c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBC3B8.10c	SPBC3B8.10c.1:pep	SPBC3B8.10c.1

Organism

Schizosaccharomyces pombe

Functional Description

Catalytic component of the nem1-spo7 complex which actsas a phosphatase and may be required for proper nuclear membrane morphology (By similarity).

Protein Length

476

Protein Sequence
(FASTA)

MNSIARLSDE INKAILATPL DDDEADKEKL ANARGRASSA TLRHYNRRRS SYSASSLSSL 60

SSKPTEKEVP TRNEKPKHAN IMRVVVYWIR VFLKRIYTFF VHSARVFLYH FLNEEKEFTL 120

ASFFWGLCRF VFFPVLLSYK RREMLPPQPS VRRPRFYSSY SYPSSHQDPA YSSFKRHRSS 180

NSYSSSSNGN HVRFQPSIAE EEISFNSFSN SLNSEEDVCV SPMKPKEVSL MGKANSNRSG 240

HSHQPQSTQF SPPANDNISK LPSSFTIVND PLKSPSSSRL RIRNITLCAD KIPRPLLNSK 300

LPRKTLVLDL DETLIHSVSR GSRTTSGQPI EVHVPGEHPI LYYIHKRPHL DYFLSNVSQW 360

FRLILFTASV QPYADPIIDY LERDKKIFAK RYYRQHCALV DSSFVKDISI CNIHLSRIMI 420

IDNSPASYNA HKENAIPIEG WISDPSDVDL LNLLSFLHAL QYVHDVRDLL GLRLAK 476

Nucleotide Sequence
(FASTA)

ATGAATTCGA TTGCTAGGCT ATCAGATGAA ATTAATAAAG CAATCCTTGC CACTCCTTTA 60

GACGACGATG AAGCTGACAA AGAAAAACTT GCTAATGCTC GGGGGCGAGC TTCATCAGCT 120

ACTTTGAGGC ATTATAATCG TCGTAGATCG TCTTATTCGG CGTCCAGCCT TAGCAGTTTG 180

TCATCAAAAC CGACGGAAAA GGAAGTTCCT ACAAGGAATG AAAAACCGAA GCATGCCAAC 240

ATTATGCGTG TTGTCGTCTA CTGGATTCGT GTGTTCCTGA AACGAATTTA TACGTTTTTC 300

GTTCATTCCG CTCGTGTATT TTTGTACCAC TTTTTGAATG AAGAGAAAGA GTTTACCCTT 360

GCAAGTTTTT TTTGGGGTCT ATGCCGGTTT GTCTTTTTTC CTGTATTATT ATCGTATAAA 420

CGCCGAGAGA TGCTTCCCCC TCAGCCAAGT GTCCGCCGTC CTAGGTTTTA TTCTTCTTAT 480

TCTTACCCAT CCTCTCACCA GGATCCTGCC TATTCATCTT TCAAACGACA TAGATCTTCT 540

AATTCTTATA GCAGTTCTTC TAATGGAAAT CATGTTCGTT TTCAGCCCTC TATTGCAGAA 600

GAAGAAATTT CTTTCAATTC TTTTTCAAAT TCATTGAATT CAGAAGAAGA TGTGTGTGTT 660

TCTCCTATGA AACCCAAAGA GGTCTCCCTA ATGGGAAAAG CAAATTCCAA TCGTTCAGGA 720

CATTCGCATC AACCTCAATC AACTCAGTTT TCCCCGCCTG CTAATGACAA TATTTCTAAG 780

CTGCCTTCCT CCTTTACGAT AGTTAATGAT CCTCTTAAAT CTCCTTCTTC TTCCCGTCTC 840

CGTATTAGAA ACATTACTCT GTGTGCGGAC AAAATACCGA GGCCTTTGTT GAATAGCAAG 900

TTACCGAGAA AGACCCTTGT ATTAGATTTG GATGAAACAC TTATCCATTC CGTGTCTCGT 960

GGTAGTCGAA CGACTTCTGG ACAGCCAATT GAAGTACATG TGCCTGGTGA ACATCCAATC 1020

CTTTACTATA TTCACAAAAG GCCTCATCTT GACTACTTTT TATCAAATGT GAGTCAATGG 1080

TTTCGCCTTA TTTTGTTCAC AGCATCTGTC CAGCCATATG CTGATCCAAT AATTGATTAT 1140

TTGGAGCGTG ATAAAAAAAT ATTTGCTAAA CGATACTACC GTCAACACTG TGCACTTGTC 1200

GATAGTTCTT TCGTTAAAGA TATTTCCATT TGTAATATTC ATCTTTCACG GATCATGATA 1260

ATTGATAATT CTCCAGCCAG TTACAATGCT CATAAAGAAA ATGCCATACC TATTGAAGGT 1320

TGGATTAGCG ACCCCTCTGA CGTTGATTTA CTAAACTTAC TTTCTTTTCT TCATGCACTG 1380

CAATATGTTC ATGATGTGCG AGATCTTTTG GGGCTTCGTC TCGCAAAATA A 1431

Domain Profile

S: 1     ktLVLDLDetLvhsksekde.e.........e..ektkasvkkRPgldeFLkelskayev  48

         ktLVLDLDetL+hs+s+ +               + + ++++kRP+ld+FL ++s+++++

Q: 304   KTLVLDLDETLIHSVSRGSRtTsgqpievhvPgeHPILYYIHKRPHLDYFLSNVSQWFRL  363

         89*************554444245677776515699************************

S: 49    viftasskeyadavldkldpkkklfkkrlyresctlengkyvKdLsllgrdlskvvivDd  108

         ++ftas ++yad+++d+l+++kk+f kr+yr++c l ++++vKd+s+ + +ls+++i+D+

Q: 364   ILFTASVQPYADPIIDYLERDKKIFAKRYYRQHCALVDSSFVKDISICNIHLSRIMIIDN  423

         ***************************************99*******************

S: 109   sprsfelqpdnlipiepfygdsdkdtellkllpflealeksddvr  153

         sp s++++++n+ipie +++d ++d +ll+ll+fl al+ ++dvr

Q: 424   SPASYNAHKENAIPIEGWISD-PSDVDLLNLLSFLHALQYVHDVR  467

         *********************.*****************999998

Domain Sequence
(FASTA)

KTLVLDLDET LIHSVSRGSR TTSGQPIEVH VPGEHPILYY IHKRPHLDYF LSNVSQWFRL 60

ILFTASVQPY ADPIIDYLER DKKIFAKRYY RQHCALVDSS FVKDISICNI HLSRIMIIDN 120

SPASYNAHKE NAIPIEGWIS DPSDVDLLNL LSFLHALQYV HDVR 164

Keyword

Complete proteome; Endoplasmic reticulum; Glycoprotein; Hydrolase; Membrane; Nucleus; Protein phosphatase; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005783	; C:endoplasmic reticulum
GO:0005789	; C:endoplasmic reticulum membrane
GO:0016021	; C:integral to membrane
GO:0031965	; C:nuclear membrane
GO:0042175	; C:nuclear outer membrane-endoplasmic reticulum membrane network
GO:0008287	; C:protein serine/threonine phosphatase complex
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0030437	; P:ascospore formation
GO:0033554	; P:cellular response to stress
GO:0016311	; P:dephosphorylation
GO:0006998	; P:nuclear envelope organization
GO:0046890	; P:regulation of lipid biosynthetic process

KEGG

spo:SPBC3B8.10c

;

InterPros

IPR011948	; Dullard_phosphatase.
IPR023214	; HAD-like_dom.
IPR004274	; NIF.

Pfam

PF03031

; NIF; 1.

SMARTs

SM00577

; CPDc; 1.

Prosites

PS50969

; FCP1; 1.

Prints

Created Date

20-Feb-2013