EKS-SCP-00094

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00094

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	471.2	1.9E-142	11	271	261

Status

Reviewed

Ensembl Protein

SPBC3H7.15.1:pep

UniProt Accession

P40235;

Protein Name

Casein kinase I homolog hhp1

Protein Synonyms/Alias

Gene Name

hhp1

Gene Synonyms/Alias

hhp1; SPBC3H7.15;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBC3H7.15	SPBC3H7.15.1:pep	SPBC3H7.15.1

Organism

Schizosaccharomyces pombe

Functional Description

Involved in DNA repair. Has a probable role in repairingalkylated DNA and may regulate the activity of protein(s) involved in double strand break repair caused by gamma rays.

Protein Length

365

Protein Sequence
(FASTA)

MALDLRIGNK YRIGRKIGSG SFGDIYLGTN VVSGEEVAIK LESTRAKHPQ LEYEYRVYRI 60

LSGGVGIPFV RWFGVECDYN AMVMDLLGPS LEDLFNFCNR KFSLKTVLLL ADQLISRIEF 120

IHSKSFLHRD IKPDNFLMGI GKRGNQVNII DFGLAKKYRD HKTHLHIPYR ENKNLTGTAR 180

YASINTHLGI EQSRRDDLES LGYVLVYFCR GSLPWQGLKA TTKKQKYEKI MEKKISTPTE 240

VLCRGFPQEF SIYLNYTRSL RFDDKPDYAY LRKLFRDLFC RQSYEFDYMF DWTLKRKTQQ 300

DQQHQQQLQQ QLSATPQAIN PPPERSSFRN YQKQNFDEKG GDINTTVPVI NDPSATGAQY 360

INRPN 365

Nucleotide Sequence
(FASTA)

ATGGCTTTGG ACCTCCGGAT TGGGAACAAG TATCGCATTG GTCGTAAAAT TGGCAGTGGA 60

TCTTTCGGAG ACATTTATCT TGGGACTAAT GTCGTTTCTG GTGAAGAGGT CGCTATCAAG 120

CTAGAATCAA CTCGTGCTAA ACACCCTCAA TTGGAGTATG AATACAGAGT TTATCGCATT 180

TTGTCAGGAG GGGTCGGAAT CCCGTTTGTT CGTTGGTTCG GTGTAGAATG TGATTACAAC 240

GCTATGGTGA TGGATTTATT GGGTCCTTCG TTGGAAGACT TGTTTAATTT TTGCAATCGA 300

AAGTTTTCTT TGAAAACAGT TCTTCTCCTT GCGGACCAGC TCATTTCTCG AATTGAATTC 360

ATTCATTCAA AATCTTTTCT TCATCGTGAT ATTAAGCCTG ATAACTTTTT AATGGGAATA 420

GGTAAAAGAG GAAATCAAGT TAACATAATT GATTTCGGAT TGGCTAAGAA GTATCGTGAT 480

CACAAAACTC ACCTGCACAT TCCTTATCGC GAGAACAAGA ATCTTACAGG TACTGCACGC 540

TATGCTAGCA TCAATACTCA TTTAGGTATT GAACAATCCC GCCGTGATGA CCTCGAATCT 600

TTAGGTTATG TGCTCGTCTA CTTTTGTCGT GGTAGCCTGC CTTGGCAGGG ATTGAAGGCT 660

ACCACGAAAA AGCAAAAGTA TGAAAAGATT ATGGAGAAGA AGATCTCTAC GCCTACAGAG 720

GTCTTATGTC GGGGATTCCC TCAGGAGTTC TCAATTTATC TCAATTACAC GAGATCTTTA 780

CGTTTCGATG ACAAACCTGA TTACGCCTAC CTTCGCAAGC TTTTCCGAGA TCTTTTTTGT 840

CGGCAATCTT ATGAGTTTGA CTATATGTTT GATTGGACCT TGAAGAGAAA GACTCAACAA 900

GACCAACAAC ATCAGCAGCA ATTACAGCAA CAACTGTCTG CAACTCCTCA AGCTATTAAT 960

CCGCCGCCAG AGAGGTCTTC ATTTAGAAAT TATCAAAAAC AAAACTTTGA TGAAAAAGGC 1020

GGAGACATTA ATACAACCGT TCCTGTTATA AATGATCCAT CTGCAACCGG AGCTCAATAT 1080

ATCAACAGAC CTAATTGA 1098

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         yr+++kiGsGsfGdiylg+n+ sgeevaikles+++k+pql++e+rvy+il+ggvgiP v

Q: 11    YRIGRKIGSGSFGDIYLGTNVVSGEEVAIKLESTRAKHPQLEYEYRVYRILSGGVGIPFV  70

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         r+fg e +yn++v+dllGpsledlf++c+rkfslktvllladqlisrie++hsk++++rd

Q: 71    RWFGVECDYNAMVMDLLGPSLEDLFNFCNRKFSLKTVLLLADQLISRIEFIHSKSFLHRD  130

         ************************************************************

S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180

         ikPdnfl+gig++g++v +idfGlakkyrd+kt+ hipyre+k+ltGtaryasinthlg+

Q: 131   IKPDNFLMGIGKRGNQVNIIDFGLAKKYRDHKTHLHIPYRENKNLTGTARYASINTHLGI  190

         ************************************************************

S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240

         eqsrrddleslgyvl+yf+rgslPWqglka+tkkqkyeki+ekk+st+ evlc+gfP+ef

Q: 191   EQSRRDDLESLGYVLVYFCRGSLPWQGLKATTKKQKYEKIMEKKISTPTEVLCRGFPQEF  250

         ************************************************************

S: 241   atylkyvrklkfeekPdyeyl  261

         + yl+y+r+l+f++kPdy yl

Q: 251   SIYLNYTRSLRFDDKPDYAYL  271

         *******************97

Domain Sequence
(FASTA)

YRIGRKIGSG SFGDIYLGTN VVSGEEVAIK LESTRAKHPQ LEYEYRVYRI LSGGVGIPFV 60

RWFGVECDYN AMVMDLLGPS LEDLFNFCNR KFSLKTVLLL ADQLISRIEF IHSKSFLHRD 120

IKPDNFLMGI GKRGNQVNII DFGLAKKYRD HKTHLHIPYR ENKNLTGTAR YASINTHLGI 180

EQSRRDDLES LGYVLVYFCR GSLPWQGLKA TTKKQKYEKI MEKKISTPTE VLCRGFPQEF 240

SIYLNYTRSL RFDDKPDYAY L 261

Keyword

ATP-binding; Complete proteome; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0032153	; C:cell division site
GO:0005829	; C:cytosol
GO:0033551	; C:monopolin complex
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051519	; P:activation of bipolar cell growth
GO:0051455	; P:attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
GO:0006281	; P:DNA repair
GO:0006282	; P:regulation of DNA repair
GO:0007165	; P:signal transduction

KEGG

spo:SPBC3H7.15

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013