EKS-SCP-00093

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00093

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	161.8	6.2E-48	3329	3646	318

Status

Reviewed

Ensembl Protein

SPBP16F5.03c.1:pep

UniProt Accession

Q9HFE8;

Protein Name

Transcription-associated protein 1

Protein Synonyms/Alias

Gene Name

tra1

Gene Synonyms/Alias

tra1; SPBP16F5.03c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBP16F5.03c	SPBP16F5.03c.1:pep	SPBP16F5.03c.1

Organism

Schizosaccharomyces pombe

Functional Description

Essential component of histone acetyltransferase (HAT)complexes, which serves as a target for activators during recruitment of HAT complexes. Essential for vegetative growth. Functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation (By similarity).

Protein Length

3699

Protein Sequence
(FASTA)

MQLALSHNIP IVIVKYLGKR IRVQLEFKKE LAQRSKHLMD VSQCEHWHNR LCDVGLDSKQ 60

KANTAIEIRD ALDDVLVTEK TNFETFIPLL EDTLSLLEKE RPVFSSLAAT HRLRIALLEL 120

LKKSGSYKGF EAFVNRTFAV LLRIVVNDNE EMAVLALKLV VLLFKDHSSL AKGHVQEFLS 180

IVVENYKSMT TVVSEAFPPR SAPNTPSSHP MSAASSASPA EIGMEHAGPK MIPKASSSFK 240

VTAEFPIIVF LLFQTYKDLI PKMLPLLAPL VLQFISLRPP PQAEARRLAE SQKEVFIGVV 300

PSLRRNHLYN DLISAQIKSF SFLAYLLRSF GAALKQFESS IPICTLQLFM DCPSELYQTR 360

RELLVATRHV LSTDYLRGFL PYVDQLLDTK ILVGSGITSQ HSLRPMAFSM LADMLHYVRM 420

ELSPQQIYKV ILLYFSILMD DFYTSAIQAM ATKLILNLVE RIVALEDFST SRSLLFAILL 480

CLLRKLTSLN FEFMKLRDSL QENADLKQIK IEENKHDLPM FENPTGAAQP SGLDKLKDCI 540

FLFKNTLLGI KPVLFGLKQR NIPLANGSIF TAQEWSEKLH LSSTNEVLLF RRLLVESLKG 600

FSYYQTDEKT GVFKSSKNLA YSQLDSSLTT NPSKLLEEKE LLEMLATLFL HLDPSVFVEI 660

LESEFPNIFE CLVDNLALLH IFQFWMSNEV TSVNCTGIVL SFCCDNLAKI GSGQSTRVSV 720

LLRLFKLAFM TVNVFPEKNA EVLRPHISYI ISTSLELTTD AVEPLNYVYL MKALFRNISG 780

GKFDSLYKEI LPLLQVMLEC FNRLIFTVTS TSQKELYAEL CLTLPIRLSV LLPHMNFLMK 840

PLIVALKGPP EIASQGLRIF ELCLDNLTQE FLDPLLDSIM PDLLICLWNH SRLNQSNNQL 900

HQSAVRILGK MGGRNRQIYL GTFGFDFLQD ENIFPSIQFS FQGSSQNFSL EHSKFLMSSC 960

AVLNNQNSDL EEKKQAFQMV KNSYLLLFAS AKPDEDFWES IDTMCRAVVD RMDKNLQQVS 1020

NGRLCPDKDE SYYLQRSIVS NIFKSLVGSM SCVEFVAEAR ETINRSLEWL IVLDLVNYAD 1080

SLQIKDQNIF DNLQSIKMLD LTTCINGIFE SLCSENENTR SNALSCIDHY LNAHKMLLNT 1140

TLDISKLPSF QNLVTVFCQS CHKELWYQKN AGFLGLKAIL SYDSHHKLWI QDRLHDILKA 1200

LFFILKDTPT DYGVLKLTEV RSFIVDITTQ FCILQDVLAP KERANNIINA FSPFFLELLH 1260

PNDHVRNTVQ QAIENISNNS KLSVVDLLLP IKDRLLSPIF GKPLRALPFT IQIGHIDAIT 1320

YCLHRSPSFL DLTDELYRLF RETIALADAE DEALVTMLKT SQSKDSSSLR KLRATCLHLL 1380

FASLVAHKFD QPQHAQTRTK IIAIFFKDLY SPHKEIYSVA IDALRHVLSQ NQKLPKELLQ 1440

SGLRPILMNL SDHNKLSVNG LEGLSRLLRL LTNYFKVEIG RKLLQHLNVL SDSKVLETAS 1500

LSLLKTNPRI EIIVSLVNVF RDLPPLSAQF LGDLLSSVVN IEAVLRKYSN SPLRKPLYSF 1560

MDLHANDTWM YILNNARNGD LITRFVGALN DPMSEKLRET AGNYWGKLLE LISQPVSVEN 1620

LAPMYAVDII ATVFPYISAN VDAGVISAKF IVLSKSLYGM LSSYNEYLFL PIRRCISSIT 1680

KMLLSSLKKI EKKLEFSLEV FRFKADDDND FLPEYIDSLC GCLITSTSAA EKKSIFLVCC 1740

SIVGDKSVRP FFKAFLLDKV INPLVFKSCG ENNFIDKDVV HSVYTHVWRV SIRDFAEVSG 1800

ATDSFYMGIM CLTTALCKYH SALLNDYRKS VIMSAWNYIK LEDPMVKQAA YATIACFISA 1860

YDTPAKIVTP VYVSILKTYQ PEVRAFIEFS LASLLSVLTA RLSSPSDSTF PLWAKLPRLV 1920

ISEDVQGISQ PLTVYQFICK APDLFFSCCS HFIVPMVNAL PKLVSFSSAS TEPRKLALDI 1980

VQTFINWQRK QNESENSETT LFSNSHIEAI LTFLIKFLSL FPEPVEENPL SKKGLSLFND 2040

LFSFPRWKDC QLNSNFFEKI LVDMDFNDNN YRTVANTLFV FGVILKNRGM EYIQREYSHI 2100

IALIDKSLRC GKLPVTHSLE QIILLLLQSH PTQAEEEEDT NEADDFKQLL LSVIHDNLAA 2160

ATNIESAICY LQIVKSSNPE ALDGLLLPLN KCFQKVARDH IVACMQSAIQ ASGKVTLPSA 2220

SDTVSKLLIS FIEIIRVRMA SLGDQRRWFL SVVVQLLEKS SSFELCEHIL NVTKEWVIVK 2280

RDSFLTVKEK TALLLKMRTF EGRFDNKLYI EACDLLSTIY RDPIFAHTEL TARLKQAFLL 2340

ATASKDTKIR MDFMDIFDSS MSRNVYSRLT FILDATSWDT IPSIYWIKQA NYILLGAINA 2400

KQPVRLTDNS LRFAPVPMTK PILSSLPEVF SKHNGSAIPL GRFTFFKQLD LFLKRNKELT 2460

VQKIIFPLAH IQMLSDADAN KLWQYIFPLA WKILSSDNRS DLSKSLIYLL TRDYHIKQVN 2520

NRPNVISTLV SSFVKCAAKL ELPPHLVKYL GKLYGVYHES VSLLEIQLSD KYDMYQNAKV 2580

QESRADAVAE LYASLNEDDM FYGHWRRNCK YLQTQVALSY EQLGMWGRAQ QLYEQAQTKA 2640

RSEAIPFSES EYNLWEDQWV MCAQKLQQWD VLTELAKHEG SSELLLECAW RISDWSNNRE 2700

SLEVAIKSLS DVPTPRKLTF QCFMTLQKSV SQPLAIKEFQ QVLSEAIQLA LIKWHQLPEK 2760

VNQSHYSLLH LFQQFVELQE AATIYSHLNA INFQNLPTNV QLIKSALQVW QERLPNVWDD 2820

INLWRDLISW RQIVFSMINR VYLPLVPTIQ ANSSADSSNP PNTSFLFRGY HETAWLINRF 2880

AHVARKHKLP SVCLNQLTKI YTLPNIEIQE AFYKLREQVL CYLQNPRDLK TGLEVVTNTN 2940

LMYFNSRQKS EFVTLKGKFL EKLNRGEEAN QMYAAAVQID LGLPKAWAEW GRYNDLLFNK 3000

SPDNLSAACN AISCYLQAAG TYQSSKARKM LARVLWLLSL NDSAGTIVKA FESYKGDIPV 3060

WHWLTFIPQL LNSLSKGDTK CAPVVLKKIA KSYPQALFFT LRTAREDIAQ VKRTEMAAWK 3120

SNTTDENKRN EDILSIQSNF LSTNQSTNAP ATNKEDGLSK KVWEYIDEIM SILKTAYPLL 3180

ALTMETLVDQ IQAKFKCKND GDAFRLVVAL LNDAVQHSIR LGIVTDEMKL PSSTESNLSL 3240

FADNILPDYC KQLFKEDFIV NSNGLKSYIF KLRKWRSYFE RLLSKVPKKQ YLEQYSSFLC 3300

EFHHQKFDEI EVPGQYLLHK DNNNSFSCIE RFLPEVELIV GHGVCYRRLS IRSNGGTIHP 3360

FVIQYPSARN SRREERFMQL TRYLNDALAL NCETRRRCLK FYIPAVIPLS SHIRLLEDQP 3420

SSITLQKIYE IYSERNNFSR DDPKELFTNE LSKHMMELNS QISQESTDAE KLANRKQLFS 3480

RRIGMFENIQ KLYSPSTILK DYFSSIFTNY SDLWLFRKNF SYQYACFSFI TYILSINNRI 3540

PAKLVFSRDS GGVWTTEALP SMVSSTPVYH NGEIVPFRFT PNIKEFIGKT CTEGLLGPSI 3600

MAIARALSKP DFDLDMYLGI FIRDDLFWWL AQQTKGVPAD FSMLNKVNSN TDLIMRRVAS 3660

LSQVAYGNLP VNQTAIDYLA QASSSKVLAQ MDVLWAPWL 3699

Nucleotide Sequence
(FASTA)

ATGCAGCTTG CTCTATCCCA CAACATTCCA ATAGTAATTG TTAAATACTT AGGAAAACGT 60

ATCCGAGTGC AATTGGAATT TAAAAAAGAG CTTGCGCAGA GATCCAAGCA TCTGATGGAT 120

GTATCACAAT GCGAACATTG GCATAATCGG CTTTGTGATG TTGGATTAGA CTCGAAGCAA 180

AAGGCAAACA CAGCAATTGA AATTCGAGAT GCACTGGATG ATGTGTTGGT AACTGAAAAG 240

ACGAATTTTG AAACTTTCAT TCCTCTTTTG GAGGACACGT TGTCTTTGCT TGAAAAGGAA 300

CGTCCTGTAT TTTCATCGTT AGCAGCTACA CATCGTTTAC GCATTGCATT GCTTGAATTG 360

CTCAAGAAAT CTGGATCCTA TAAAGGTTTT GAAGCATTCG TTAATCGGAC TTTTGCCGTG 420

CTTCTTCGTA TAGTCGTTAA TGATAATGAA GAGATGGCAG TGTTGGCATT GAAGCTTGTT 480

GTCCTTCTTT TTAAGGACCA CAGTAGCCTT GCTAAGGGAC ATGTTCAGGA ATTTTTATCC 540

ATTGTCGTTG AAAACTACAA ATCCATGACC ACAGTTGTTT CAGAAGCTTT CCCACCTAGA 600

TCAGCTCCGA ATACTCCATC CTCTCATCCC ATGTCTGCTG CATCTTCTGC ATCTCCTGCT 660

GAAATTGGAA TGGAACATGC AGGTCCAAAA ATGATCCCAA AAGCTTCTTC GAGTTTCAAG 720

GTCACTGCTG AATTTCCCAT TATCGTCTTT CTCCTATTTC AAACATACAA AGATCTTATT 780

CCGAAAATGC TTCCTTTACT TGCTCCGCTT GTACTTCAAT TTATCTCACT TCGTCCTCCA 840

CCTCAAGCCG AAGCTCGTCG ACTTGCAGAA TCTCAAAAAG AGGTTTTTAT TGGTGTAGTC 900

CCTTCTTTGC GTCGAAATCA TCTTTACAAT GACCTTATTT CTGCGCAAAT TAAATCATTC 960

TCTTTTCTCG CCTATTTATT GAGAAGTTTT GGTGCTGCTC TTAAACAGTT TGAAAGCTCG 1020

ATCCCAATAT GTACCTTGCA ATTGTTCATG GACTGTCCTT CCGAATTATA TCAGACTCGA 1080

AGAGAACTTT TGGTAGCTAC AAGGCACGTC TTATCGACGG ATTATTTGAG AGGGTTTCTA 1140

CCGTATGTAG ATCAACTACT TGATACCAAA ATTCTAGTTG GTTCTGGAAT CACTTCTCAG 1200

CATTCATTAC GACCCATGGC TTTTAGCATG CTGGCAGATA TGCTTCATTA TGTGCGTATG 1260

GAATTAAGTC CACAACAAAT TTACAAAGTC ATACTTCTTT ATTTCAGTAT TTTGATGGAC 1320

GACTTTTATA CTTCAGCTAT TCAGGCAATG GCTACAAAGC TTATTTTAAA CTTGGTTGAA 1380

AGAATTGTTG CACTAGAAGA TTTTTCCACT AGCCGATCAC TTCTATTTGC TATACTTTTA 1440

TGTCTCTTAA GAAAATTGAC TTCTCTGAAT TTCGAGTTTA TGAAGCTGAG AGATTCTTTA 1500

CAGGAAAATG CTGACTTAAA GCAAATTAAA ATAGAAGAAA ATAAACATGA TCTTCCTATG 1560

TTTGAGAACC CTACTGGAGC TGCCCAACCT TCAGGTTTGG ATAAGCTAAA AGATTGCATA 1620

TTTCTTTTTA AAAACACCTT ATTAGGTATT AAGCCTGTTT TGTTTGGACT AAAGCAACGA 1680

AATATTCCTC TTGCCAACGG TTCCATTTTT ACAGCTCAGG AATGGTCTGA AAAGTTACAT 1740

CTTAGTTCAA CTAATGAAGT TTTACTGTTT CGAAGATTAC TTGTGGAAAG TTTAAAGGGA 1800

TTCAGTTATT ACCAGACAGA TGAAAAAACC GGTGTATTCA AGTCCTCGAA AAATCTTGCA 1860

TACTCTCAAC TTGATTCTTC GTTGACCACA AACCCTTCTA AACTCTTAGA AGAGAAGGAG 1920

CTCTTAGAAA TGTTAGCAAC TTTATTTTTA CACTTGGACC CATCTGTTTT CGTCGAAATT 1980

TTGGAATCCG AGTTTCCGAA TATATTTGAG TGTCTAGTAG ATAATCTTGC TTTATTGCAT 2040

ATTTTCCAAT TTTGGATGTC TAATGAAGTT ACTTCTGTCA ACTGCACGGG CATCGTGCTG 2100

TCTTTTTGCT GTGACAATCT AGCTAAAATA GGGTCTGGCC AATCCACTCG GGTTTCTGTT 2160

TTATTGCGAT TATTCAAGTT GGCCTTTATG ACTGTGAATG TTTTTCCCGA AAAAAATGCA 2220

GAAGTCCTGC GTCCCCATAT ATCCTATATC ATTTCAACTA GCCTCGAATT GACTACTGAT 2280

GCTGTTGAAC CTTTAAATTA CGTTTATTTA ATGAAAGCTT TGTTTAGAAA TATCAGTGGA 2340

GGAAAATTTG ATTCTCTTTA CAAGGAAATA CTACCACTTC TCCAAGTAAT GCTAGAATGT 2400

TTCAACAGAT TGATTTTTAC TGTTACGTCT ACATCCCAAA AAGAGCTGTA TGCGGAACTT 2460

TGTTTGACTT TACCCATTAG ACTCAGTGTG TTGTTGCCTC ATATGAATTT TTTAATGAAG 2520

CCATTGATTG TTGCATTAAA AGGCCCCCCT GAAATAGCTA GTCAAGGGCT TCGAATATTT 2580

GAACTTTGCT TGGATAATCT TACTCAAGAA TTTTTGGATC CTTTATTGGA CTCAATTATG 2640

CCGGATTTGC TGATATGCCT GTGGAATCAT TCACGCCTTA ATCAATCCAA TAATCAATTG 2700

CATCAAAGTG CTGTGAGAAT ATTAGGAAAA ATGGGTGGTC GAAATAGACA AATATATCTT 2760

GGTACCTTTG GCTTTGATTT TTTGCAAGAT GAAAATATTT TTCCTTCAAT CCAGTTTTCT 2820

TTCCAAGGCT CCTCTCAGAA TTTTAGCTTA GAGCACTCCA AATTTTTAAT GTCTTCATGT 2880

GCTGTTTTAA ACAATCAAAA TTCCGATTTA GAAGAAAAGA AGCAAGCATT TCAAATGGTC 2940

AAGAATTCGT ATTTATTACT CTTTGCGTCT GCGAAGCCCG ATGAAGACTT TTGGGAATCT 3000

ATTGATACAA TGTGCCGAGC AGTTGTAGAT CGCATGGATA AAAACTTACA GCAAGTCTCT 3060

AATGGTAGGT TGTGCCCTGA CAAAGATGAA TCTTATTATC TGCAAAGATC TATTGTCTCA 3120

AACATTTTTA AATCTTTAGT CGGCTCAATG TCTTGTGTGG AATTTGTAGC TGAAGCTCGA 3180

GAAACCATCA ATCGTTCTTT GGAATGGCTC ATTGTTCTTG ATTTGGTTAA TTACGCTGAC 3240

TCTCTGCAAA TAAAAGATCA AAATATTTTT GATAATTTGC AAAGCATTAA AATGCTTGAT 3300

CTTACTACGT GCATCAACGG AATTTTCGAA TCTTTATGTT CTGAAAATGA AAATACCAGG 3360

TCTAATGCTT TATCGTGTAT CGATCATTAT TTGAACGCCC ATAAGATGCT TCTCAACACA 3420

ACATTGGATA TATCAAAGTT GCCTAGTTTT CAAAATCTTG TAACAGTGTT TTGCCAAAGT 3480

TGCCATAAGG AACTGTGGTA CCAAAAGAAT GCTGGATTTC TCGGCTTAAA AGCAATACTT 3540

TCGTATGATT CACATCATAA GCTTTGGATC CAAGATAGAT TACACGACAT ATTGAAGGCT 3600

TTGTTCTTTA TTCTCAAGGA TACTCCAACC GATTATGGGG TTTTAAAATT AACCGAAGTT 3660

CGTTCTTTCA TCGTTGATAT TACAACTCAA TTCTGTATAC TTCAGGATGT GCTTGCACCG 3720

AAAGAGCGTG CTAATAATAT AATTAATGCA TTTTCTCCCT TTTTTTTAGA ACTCCTACAT 3780

CCCAACGATC ATGTTAGGAA TACTGTGCAA CAAGCTATTG AGAACATTTC CAACAATTCT 3840

AAACTTAGTG TGGTTGATCT TCTTCTTCCT ATAAAGGACA GGCTTTTAAG CCCTATTTTT 3900

GGAAAACCCT TAAGAGCGTT ACCTTTTACA ATCCAAATAG GGCATATAGA TGCAATCACT 3960

TACTGCTTGC ACCGCTCTCC CTCTTTTTTG GATTTGACTG ATGAATTGTA CAGATTATTT 4020

CGTGAAACAA TAGCATTAGC TGATGCTGAA GATGAAGCAT TAGTCACCAT GCTTAAAACT 4080

TCTCAAAGCA AAGATAGCTC TTCTTTACGA AAATTAAGGG CTACTTGCTT GCATTTACTA 4140

TTTGCTTCTT TGGTGGCTCA TAAGTTTGAT CAACCTCAAC ATGCTCAAAC TCGTACTAAA 4200

ATCATAGCGA TATTTTTCAA AGATCTATAC TCACCTCACA AAGAAATTTA TTCAGTTGCA 4260

ATAGATGCGT TAAGGCACGT GCTCTCGCAA AACCAAAAGC TTCCTAAAGA ACTTCTTCAA 4320

AGCGGCTTGA GACCAATTTT AATGAATTTA TCGGACCACA ATAAGCTGTC AGTTAACGGT 4380

CTTGAGGGTT TATCCAGACT TTTAAGATTA CTAACTAATT ACTTTAAAGT GGAAATAGGT 4440

CGGAAGCTTC TTCAACACCT TAATGTTCTA TCTGATTCTA AAGTCCTAGA GACTGCCTCA 4500

CTTTCGTTAT TGAAAACCAA CCCAAGGATC GAGATTATTG TGTCTTTGGT TAACGTATTC 4560

AGAGATCTTC CTCCGTTGTC AGCGCAGTTT CTAGGTGACT TGTTGTCGTC GGTCGTAAAC 4620

ATAGAGGCAG TTCTCAGAAA ATATTCTAAC AGCCCATTAA GAAAACCGTT GTATTCTTTT 4680

ATGGATTTGC ATGCAAATGA TACCTGGATG TATATTTTGA ATAATGCACG TAATGGCGAT 4740

TTAATAACTC GATTCGTTGG TGCTTTGAAT GACCCGATGT CTGAAAAACT TCGCGAAACC 4800

GCCGGTAATT ACTGGGGAAA GCTTTTGGAG CTAATTTCGC AACCGGTGTC TGTTGAAAAT 4860

TTGGCTCCAA TGTATGCTGT TGATATTATT GCAACCGTGT TTCCTTACAT TTCTGCCAAT 4920

GTAGATGCAG GAGTTATATC GGCTAAATTT ATTGTTTTAT CAAAGTCCTT GTATGGAATG 4980

CTTAGTTCAT ACAACGAATA TCTATTTCTT CCTATTCGCA GGTGTATATC GTCCATTACA 5040

AAAATGCTTT TATCTAGTTT AAAGAAAATA GAGAAGAAGC TCGAGTTTTC ATTAGAAGTT 5100

TTTAGATTTA AAGCTGACGA TGATAACGAT TTCCTTCCAG AATACATAGA TTCGTTATGT 5160

GGTTGTCTTA TAACCTCAAC AAGTGCAGCT GAAAAGAAAA GTATATTTTT AGTTTGCTGC 5220

AGTATAGTTG GTGACAAGTC AGTTCGACCT TTTTTTAAAG CATTTCTCTT GGATAAAGTA 5280

ATCAATCCGC TTGTATTTAA GTCATGCGGA GAAAATAACT TTATTGATAA GGATGTTGTT 5340

CATTCTGTTT ACACTCATGT TTGGCGTGTT TCAATTCGAG ATTTTGCTGA AGTATCGGGA 5400

GCCACAGATT CCTTTTACAT GGGAATTATG TGCTTGACAA CGGCGCTTTG TAAGTACCAT 5460

TCAGCACTTC TTAATGATTA TCGCAAGAGC GTTATAATGT CAGCTTGGAA CTACATTAAA 5520

CTCGAAGATC CTATGGTAAA ACAAGCCGCT TACGCTACGA TTGCATGTTT TATAAGTGCG 5580

TATGATACAC CTGCTAAGAT TGTGACACCT GTTTATGTTT CTATACTAAA AACATATCAA 5640

CCAGAAGTGA GAGCTTTTAT TGAATTCTCT CTTGCTTCTT TGCTGTCTGT ATTAACCGCT 5700

AGGCTATCGA GTCCTTCCGA TTCAACTTTC CCCCTTTGGG CGAAACTTCC TAGATTAGTT 5760

ATCTCCGAAG ATGTTCAGGG TATATCACAG CCTTTGACAG TTTACCAATT CATATGTAAA 5820

GCACCTGACC TTTTCTTCTC TTGTTGCTCT CATTTTATTG TACCCATGGT TAATGCGCTT 5880

CCAAAGCTTG TGTCGTTTTC TAGTGCTAGT ACAGAACCAC GAAAGTTAGC TTTGGATATT 5940

GTTCAAACCT TTATAAATTG GCAGAGGAAA CAGAATGAAT CAGAAAATTC CGAGACCACG 6000

CTTTTTAGCA ATTCCCATAT TGAAGCTATT CTTACCTTCC TTATAAAATT CCTTTCGCTT 6060

TTTCCCGAAC CAGTTGAAGA AAATCCACTT TCAAAGAAGG GGTTATCATT ATTTAATGAT 6120

CTGTTTAGTT TTCCTCGATG GAAAGACTGT CAGCTGAACT CTAACTTCTT TGAAAAAATC 6180

CTTGTTGATA TGGACTTCAA CGATAATAAC TATCGTACGG TAGCTAACAC ATTGTTTGTG 6240

TTTGGAGTTA TTTTAAAGAA CAGAGGTATG GAGTATATTC AACGTGAATA TAGTCATATA 6300

ATCGCTCTGA TCGACAAAAG TTTGCGTTGT GGTAAATTGC CTGTTACTCA TTCATTGGAG 6360

CAGATTATTT TATTACTGTT ACAAAGCCAT CCAACTCAAG CAGAAGAAGA AGAAGACACG 6420

AATGAGGCTG ATGATTTTAA ACAACTACTA CTTTCAGTTA TTCATGATAA TCTCGCCGCT 6480

GCCACTAACA TTGAGTCTGC TATTTGCTAT TTGCAAATTG TTAAATCCTC TAATCCGGAA 6540

GCGCTTGATG GTCTTCTTCT TCCCTTAAAT AAATGCTTTC AAAAGGTAGC ACGAGACCAT 6600

ATTGTCGCTT GCATGCAATC TGCTATACAA GCATCTGGAA AAGTTACACT TCCTTCTGCA 6660

TCTGATACTG TCTCAAAGCT TTTGATTAGT TTCATTGAAA TTATTAGAGT ACGCATGGCA 6720

AGCTTAGGAG ATCAACGTAG ATGGTTTTTA AGTGTTGTGG TGCAATTGCT CGAAAAGAGT 6780

TCAAGTTTTG AGCTTTGTGA ACATATTCTT AATGTTACAA AGGAATGGGT GATTGTGAAA 6840

AGAGATTCGT TTTTGACAGT CAAAGAAAAA ACTGCACTTT TATTGAAGAT GAGAACTTTT 6900

GAGGGAAGAT TTGACAACAA ACTATACATC GAAGCATGTG ATTTGCTATC CACGATATAC 6960

AGGGATCCCA TTTTTGCGCA TACAGAATTA ACTGCCCGAT TGAAGCAAGC CTTCCTTCTT 7020

GCTACGGCAT CTAAAGATAC CAAAATACGA ATGGATTTTA TGGATATTTT TGATTCCAGC 7080

ATGTCTCGTA ATGTTTATTC TAGATTGACT TTCATACTGG ATGCAACTAG CTGGGATACA 7140

ATTCCTAGCA TTTACTGGAT CAAACAAGCG AATTATATTC TTCTTGGGGC TATAAATGCG 7200

AAACAGCCTG TCCGGCTTAC CGACAATAGT CTTCGATTTG CTCCAGTGCC AATGACAAAA 7260

CCCATATTAA GCTCACTTCC TGAAGTTTTT TCAAAACACA ACGGTTCAGC TATTCCTCTT 7320

GGCAGATTTA CCTTTTTCAA ACAACTGGAT TTGTTCCTAA AAAGAAATAA GGAATTAACT 7380

GTGCAAAAAA TTATTTTTCC GTTGGCACAC ATTCAAATGC TCAGCGATGC AGATGCTAAT 7440

AAGCTTTGGC AATATATTTT TCCTCTTGCA TGGAAAATAC TAAGTTCGGA TAACCGTTCT 7500

GACCTTTCAA AGTCTTTAAT CTATTTACTC ACTCGTGATT ATCACATCAA ACAGGTAAAC 7560

AATCGACCGA ATGTGATCTC TACTTTGGTT TCATCTTTCG TTAAGTGTGC TGCAAAATTA 7620

GAGCTTCCAC CTCATTTGGT AAAATATCTT GGAAAATTGT ACGGTGTATA TCATGAATCC 7680

GTTTCACTTC TCGAAATTCA GCTGAGTGAT AAATATGACA TGTATCAGAA TGCAAAAGTT 7740

CAAGAAAGCC GTGCGGATGC AGTCGCAGAG TTATATGCAT CTTTAAATGA AGATGATATG 7800

TTTTATGGCC ATTGGCGACG AAACTGTAAG TACTTGCAAA CTCAAGTTGC TCTCTCGTAT 7860

GAGCAACTTG GAATGTGGGG AAGGGCTCAA CAACTTTATG AACAGGCACA GACCAAGGCT 7920

CGCAGTGAAG CCATTCCCTT CTCAGAATCA GAATACAACT TGTGGGAGGA TCAGTGGGTA 7980

ATGTGCGCTC AAAAATTACA ACAATGGGAC GTCTTGACAG AGTTGGCGAA GCACGAGGGA 8040

TCTTCTGAAC TATTGCTCGA GTGTGCTTGG AGAATTAGCG ATTGGTCTAA TAATCGTGAA 8100

TCCTTAGAGG TTGCCATTAA GAGCCTTTCT GATGTTCCTA CTCCACGGAA ACTTACCTTT 8160

CAATGCTTTA TGACACTTCA AAAGTCAGTA TCTCAACCTC TTGCCATTAA AGAGTTCCAA 8220

CAAGTATTGT CTGAAGCCAT TCAACTTGCG TTAATTAAGT GGCATCAACT TCCAGAAAAA 8280

GTTAATCAAT CTCATTATTC ACTTTTGCAT CTGTTTCAGC AATTTGTTGA ACTACAAGAA 8340

GCTGCTACAA TTTATTCACA TCTGAATGCT ATCAATTTTC AGAATTTGCC TACTAATGTT 8400

CAGTTGATTA AAAGTGCTCT TCAAGTTTGG CAAGAGCGGT TACCTAATGT CTGGGACGAT 8460

ATTAATCTTT GGCGTGATCT CATTTCTTGG AGACAAATAG TATTCTCTAT GATAAATCGT 8520

GTTTATCTCC CCTTGGTCCC TACGATACAG GCTAATAGTA GTGCTGATTC GTCTAATCCT 8580

CCGAATACCT CTTTCTTATT TAGAGGATAT CATGAAACCG CTTGGCTAAT TAACCGATTC 8640

GCTCATGTTG CCAGAAAACA TAAACTACCT TCCGTATGTC TGAACCAATT AACGAAGATA 8700

TATACTCTTC CAAATATTGA AATTCAAGAA GCTTTTTATA AGCTTCGAGA GCAAGTTTTA 8760

TGTTATCTAC AAAACCCAAG AGATCTGAAA ACAGGTTTGG AGGTTGTTAC AAATACCAAT 8820

CTGATGTACT TCAATTCTAG ACAAAAGTCA GAATTCGTGA CATTAAAAGG AAAATTTTTA 8880

GAAAAACTAA ATCGAGGTGA GGAGGCTAAC CAAATGTATG CTGCAGCAGT ACAAATTGAT 8940

TTAGGGTTGC CAAAGGCATG GGCAGAATGG GGTCGTTACA ACGATTTGCT TTTCAATAAG 9000

TCACCAGATA ATTTGAGTGC AGCATGCAAT GCCATTAGTT GCTATCTTCA AGCTGCTGGT 9060

ACTTACCAAA GTTCTAAAGC TCGTAAGATG CTGGCAAGGG TATTGTGGTT ATTAAGTTTG 9120

AATGACAGCG CCGGTACTAT AGTTAAAGCT TTTGAATCAT ACAAAGGTGA TATACCAGTT 9180

TGGCATTGGC TTACCTTTAT TCCCCAGCTT TTAAATTCAC TTTCTAAAGG GGATACTAAA 9240

TGCGCACCTG TTGTTCTTAA AAAAATTGCT AAATCCTATC CACAGGCACT ATTTTTCACT 9300

TTAAGAACTG CTCGTGAAGA TATTGCACAG GTAAAACGCA CTGAGATGGC AGCATGGAAA 9360

TCAAATACGA CTGATGAAAA TAAAAGAAAT GAGGATATTT TAAGCATACA ATCTAACTTT 9420

CTTTCTACCA ATCAAAGCAC GAATGCTCCA GCAACAAATA AAGAAGATGG ACTTTCTAAA 9480

AAAGTTTGGG AATATATTGA TGAAATTATG TCAATTTTAA AAACTGCTTA TCCTCTATTG 9540

GCTTTGACTA TGGAAACTTT AGTTGATCAA ATTCAAGCGA AGTTTAAATG TAAGAATGAT 9600

GGAGATGCTT TCAGGCTAGT GGTAGCCTTG CTTAATGATG CTGTACAGCA TAGCATTCGT 9660

TTGGGGATCG TAACGGATGA AATGAAACTT CCTTCTTCAA CCGAATCGAA CTTAAGTTTG 9720

TTTGCTGATA ATATTCTCCC TGACTATTGT AAACAACTAT TTAAGGAAGA TTTCATTGTC 9780

AATTCAAACG GTTTGAAATC ATATATTTTC AAACTAAGGA AATGGAGATC ATATTTTGAG 9840

CGGTTATTAT CTAAGGTTCC TAAAAAACAA TATTTGGAAC AATACAGCTC ATTCTTGTGT 9900

GAATTTCATC ATCAAAAATT TGATGAAATA GAAGTTCCTG GACAATATCT TTTGCACAAG 9960

GATAACAACA ATAGTTTTTC TTGCATAGAA AGGTTTCTTC CTGAAGTGGA ATTGATAGTA 10020

GGACATGGCG TTTGCTATAG AAGGTTATCC ATTCGAAGCA ATGGCGGAAC TATACACCCA 10080

TTTGTCATTC AGTATCCTTC AGCACGAAAC AGCCGTAGGG AAGAGCGTTT TATGCAGCTG 10140

ACCAGATACT TAAATGATGC ACTTGCTTTA AATTGTGAGA CTCGAAGACG TTGTTTGAAA 10200

TTTTACATTC CTGCAGTGAT TCCGTTGTCA TCGCACATCC GGCTGTTAGA AGACCAACCG 10260

TCTTCTATTA CTCTCCAAAA AATATACGAA ATTTATTCAG AAAGAAATAA CTTCTCCAGA 10320

GATGATCCGA AAGAGTTGTT TACAAACGAG TTATCAAAAC ATATGATGGA ATTAAACTCC 10380

CAAATTAGTC AGGAATCTAC TGATGCTGAA AAATTAGCTA ATCGTAAACA ATTGTTTAGT 10440

AGGAGAATCG GAATGTTTGA AAATATTCAA AAGCTTTATT CTCCGTCAAC GATTTTAAAA 10500

GATTATTTCT CAAGTATCTT TACTAATTAT TCCGATCTGT GGTTGTTCAG AAAAAATTTT 10560

TCATACCAAT ATGCTTGTTT TTCATTTATT ACATACATAC TAAGTATAAA TAATAGGATA 10620

CCTGCTAAGC TTGTTTTTTC TAGAGACTCT GGCGGTGTTT GGACAACAGA AGCGCTGCCA 10680

TCTATGGTTT CTTCTACTCC AGTTTACCAT AATGGAGAAA TTGTTCCTTT TCGCTTTACC 10740

CCCAACATTA AAGAATTTAT TGGAAAAACT TGTACTGAAG GTTTACTGGG CCCTTCAATA 10800

ATGGCTATAG CTCGCGCGCT CTCCAAACCG GATTTCGATT TGGATATGTA CTTGGGTATC 10860

TTTATTAGAG ATGATCTTTT TTGGTGGCTT GCACAGCAAA CTAAAGGCGT GCCGGCAGAT 10920

TTCAGTATGC TCAACAAAGT CAATAGCAAT ACTGATCTTA TAATGCGAAG GGTTGCATCA 10980

TTAAGTCAGG TTGCTTATGG TAACTTACCA GTCAATCAAA CAGCTATTGA TTATTTGGCG 11040

CAAGCCTCTA GTTCCAAAGT TTTGGCACAG ATGGACGTCT TATGGGCTCC TTGGCTGTGA 11100

Domain Profile

S: 1     iagfderveilask.qkpkklllrGsdgkeypyLv..kgkeDlrqdervlqlfslvNtlL  57

         i +f ++ve++  +    ++l++r + g ++p+ +      ++r++er +ql + +N  L

Q: 3329  IERFLPEVELIVGHgVCYRRLSIRSNGGTIHPFVIqyPSARNSRREERFMQLTRYLNDAL  3388

         678999999999886788*****************877889*******************

S: 58    akdketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyry  117

         a + et+rr Lk+  ++V+pls++++l+e+ +++++L+++++ + e+++   d+p++  +

Q: 3389  ALNCETRRRCLKFYIPAVIPLSSHIRLLEDQPSSITLQKIYEIYSERNNFSRDDPKELFT  3448

         ********************************************************9999

S: 118   kdlstvqar........kpklkhlkls.........levfkevlenlvpkdllkklllek  160

         ++ls+ +           ++++ l            + +f+++++   p ++lk  + +

Q: 3449  NELSKHMMElnsqisqeSTDAEKL--AnrkqlfsrrIGMFENIQKLYSPSTILKDYFSSI  3506

         999888877666666443333333..2558888899************************

S: 161   fpspeewfelrkaytrslAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekak  220

         f++  + + +rk++  + A  s++ yiL +++r +  l++ +++g v   +    + + +

Q: 3507  FTNYSDLWLFRKNFSYQYACFSFITYILSINNRIPAKLVFSRDSGGVWTTEALPSMVSST  3566

         ************************************************999888888888

S: 221   tqlkvpekvPFRLTrnivnalgvtgveGvfrasceavlrvlreskeklltiLevflydpl  280

            +  e+vPFR T+ni +++g t +eG++  s+ a++r+l ++ + l+  L +f++d+l

Q: 3567  PVYHNGEIVPFRFTPNIKEFIGKTCTEGLLGPSIMAIARALSKPDFDLDMYLGIFIRDDL  3626

         77**********************************************************

S: 281   vdwkk.kkktsketeeelae  299

         + w   + k+ + + + l++

Q: 3627  FWWLAqQTKGVPADFSMLNK  3646

         ***97222333333334443

Domain Sequence
(FASTA)

IERFLPEVEL IVGHGVCYRR LSIRSNGGTI HPFVIQYPSA RNSRREERFM QLTRYLNDAL 60

ALNCETRRRC LKFYIPAVIP LSSHIRLLED QPSSITLQKI YEIYSERNNF SRDDPKELFT 120

NELSKHMMEL NSQISQESTD AEKLANRKQL FSRRIGMFEN IQKLYSPSTI LKDYFSSIFT 180

NYSDLWLFRK NFSYQYACFS FITYILSINN RIPAKLVFSR DSGGVWTTEA LPSMVSSTPV 240

YHNGEIVPFR FTPNIKEFIG KTCTEGLLGP SIMAIARALS KPDFDLDMYL GIFIRDDLFW 300

WLAQQTKGVP ADFSMLNK 318

Keyword

Activator; Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Repeat; TPR repeat; Transcription; Transcription regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0070209	; C:ASTRA complex
GO:0000124	; C:SAGA complex
GO:0016773	; F:phosphotransferase activity, alcohol group as acceptor
GO:0016573	; P:histone acetylation
GO:0010389	; P:regulation of G2/M transition of mitotic cell cycle
GO:0006357	; P:regulation of transcription from RNA polymerase II promoter
GO:0007165	; P:signal transduction
GO:0006351	; P:transcription, DNA-dependent

KEGG

spo:SPBP16F5.03c

;

InterPros

IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 2.
PS00915	; PI3_4_KINASE_1; FALSE_NEG.
PS00916	; PI3_4_KINASE_2; FALSE_NEG.
PS50290	; PI3_4_KINASE_3; FALSE_NEG.
PS50005	; TPR; FALSE_NEG.
PS50293	; TPR_REGION; FALSE_NEG.

Prints

Created Date

20-Feb-2013