EPS-SCP-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SCP-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP2B	407.1	3.1E-123	113	313	201

Status

Reviewed

Ensembl Protein

SPBP4H10.04.1:pep

UniProt Accession

Q12705; Q9P7E4;

Protein Name

Serine/threonine-protein phosphatase 2B catalytic subunit

Protein Synonyms/Alias

Gene Name

ppb1

Gene Synonyms/Alias

ppb1; SPBC1346.01c, SPBP4H10.04;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPBP4H10.04	SPBP4H10.04.1:pep	SPBP4H10.04.1

Organism

Schizosaccharomyces pombe

Functional Description

Calcium-dependent, calmodulin-stimulated proteinphosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape.

Protein Length

554

Protein Sequence
(FASTA)

MTSGPHNLED PIVRAIRQKN QAPSHDFTIF VQEDGSSVST LDRVVKNVQA PATYIPTDVE 60

FFDINEPDKP DLHFLRNHFI REGRLSEEQT LYIIKKATEI LKSEDNLIEV DAPVTVCGDI 120

HGQYYDLMKL FEVGGNPANT QYLFLGDYVD RGYFSIECLL YLWALKIWYP KTLWLLRGNH 180

ECAHLTDYFT FKLECTHKYN IKVYEACLQS FNALPLAAIM NKQFLCVHGG LSPELHTLND 240

IRMINRFCEP PTHGLMCDLL WSDPLEDFGS EKSNKHFIHN NVRGCSYFYS YQAVCTFLEN 300

NNLLSVIRAH EAQDVGYRMY RKTKTTGFPS LMTIFSAPNY LDVYNNKAAV LKYENNVMNI 360

RQFNCSPHPY WLPNFMDVFT WSLPFVGEKV SEMLISMLNI CSKEELYETD LKESAPTQHK 420

QPAPSENENK ADQEIDIEAR RQIIKNKIMA IGRISRVFSV LREERESVSE LKNVSGTQRL 480

PAGTLMLGAE GIKNAINSFD DARKLDIQNE RLPPSNSRRR STDLKAFEEV MNSSEDDTSI 540

DHLVERFADK KSSL 554

Nucleotide Sequence
(FASTA)

ATGACTTCGG GTCCTCATAA TTTAGAAGAC CCAATAGTTC GAGCAATTCG CCAAAAAAAT 60

CAAGCTCCTT CTCATGATTT TACAATATTT GTTCAAGAAG ATGGCTCTAG TGTTAGCACA 120

CTGGATAGAG TAGTGAAAAA TGTTCAAGCA CCAGCAACTT ATATTCCGAC GGACGTGGAG 180

TTTTTTGATA TTAATGAACC TGATAAACCT GACTTGCATT TTCTTCGCAA TCATTTCATT 240

CGGGAAGGCC GTTTATCTGA GGAACAAACG TTGTATATTA TAAAAAAGGC TACAGAAATT 300

TTGAAGTCAG AAGACAACTT GATTGAGGTG GATGCACCTG TCACTGTATG CGGTGACATT 360

CACGGCCAAT ATTATGATCT TATGAAACTA TTTGAAGTTG GAGGTAATCC AGCAAATACC 420

CAATATCTTT TCCTTGGAGA TTACGTGGAT CGAGGATATT TCTCAATTGA GTGTTTATTG 480

TACTTGTGGG CTTTGAAAAT ATGGTATCCG AAAACGCTTT GGTTGCTTCG TGGCAATCAC 540

GAATGCGCTC ATCTTACTGA CTATTTTACC TTCAAGTTAG AATGTACTCA TAAGTATAAT 600

ATTAAAGTTT ATGAAGCTTG TTTACAATCT TTTAATGCCC TTCCTTTGGC AGCTATTATG 660

AATAAGCAAT TTTTATGTGT ACATGGTGGA TTATCACCCG AACTACATAC TTTGAATGAT 720

ATACGAATGA TCAATCGTTT TTGTGAGCCT CCAACTCATG GGTTGATGTG TGATTTACTC 780

TGGTCTGATC CCCTTGAAGA TTTTGGATCG GAAAAATCAA ACAAGCATTT TATTCATAAT 840

AATGTTCGTG GCTGTTCTTA CTTTTATAGT TACCAAGCTG TTTGCACCTT CTTAGAAAAC 900

AATAATCTCC TCTCCGTTAT TCGTGCTCAT GAAGCTCAAG ATGTGGGCTA TCGAATGTAT 960

CGCAAAACTA AAACAACCGG GTTTCCATCT TTGATGACCA TATTTTCAGC ACCCAACTAT 1020

TTGGATGTTT ACAATAATAA AGCTGCTGTT TTGAAATACG AAAATAATGT AATGAATATA 1080

AGACAATTTA ATTGTTCCCC TCATCCTTAC TGGCTTCCTA ACTTTATGGA TGTTTTTACT 1140

TGGAGTCTTC CATTTGTGGG CGAAAAAGTT TCTGAAATGT TGATTTCAAT GCTCAATATA 1200

TGTTCTAAGG AGGAGCTTTA TGAAACGGAT TTGAAAGAAT CGGCTCCGAC TCAGCATAAA 1260

CAGCCTGCTC CATCTGAGAA TGAAAATAAA GCCGACCAAG AAATTGATAT TGAAGCTCGT 1320

AGGCAAATTA TTAAAAACAA GATTATGGCT ATTGGCCGTA TCTCTCGAGT ATTCAGTGTG 1380

CTTAGAGAAG AACGGGAAAG TGTTTCGGAA CTGAAAAACG TGTCAGGTAC GCAAAGATTA 1440

CCTGCGGGTA CTTTAATGTT GGGAGCTGAG GGTATCAAAA ATGCTATCAA TTCCTTCGAT 1500

GATGCTCGTA AGCTGGATAT CCAAAATGAA CGTTTACCGC CATCTAATAG CCGTCGACGT 1560

TCTACGGATT TAAAGGCTTT CGAAGAAGTA ATGAATTCGT CTGAAGATGA TACCTCTATC 1620

GATCATTTGG TAGAACGCTT TGCAGATAAG AAAAGCTCTT TGTAG 1665

Domain Profile

S: 1     pvtvcgdihgqffdllklfevggspantrylflgdyvdrgyfsiecvlylyalkilypkt  60

         pvtvcgdihgq++dl+klfevgg+pant+ylflgdyvdrgyfsiec+lyl+alki+ypkt

Q: 113   PVTVCGDIHGQYYDLMKLFEVGGNPANTQYLFLGDYVDRGYFSIECLLYLWALKIWYPKT  172

         9***********************************************************

S: 61    lfllrgnhecrhlteyftfkqelkikyservydacleafdalplaallnqqflcvhggls  120

         l+llrgnhec hlt+yftfk e+++ky+++vy+acl++f+alplaa++n+qflcvhggls

Q: 173   LWLLRGNHECAHLTDYFTFKLECTHKYNIKVYEACLQSFNALPLAAIMNKQFLCVHGGLS  232

         ************************************************************

S: 121   pelktlddirkldrfkeppayglmcdllwsdpledfgnekseeefvhnsvrgcsyfysyk  180

         pel+tl+dir+++rf+epp++glmcdllwsdpledfg+eks+++f+hn+vrgcsyfysy+

Q: 233   PELHTLNDIRMINRFCEPPTHGLMCDLLWSDPLEDFGSEKSNKHFIHNNVRGCSYFYSYQ  292

         ************************************************************

S: 181   avceflqennllsiiraheaq  201

         avc+fl++nnlls+iraheaq

Q: 293   AVCTFLENNNLLSVIRAHEAQ  313

         ********************8

Domain Sequence
(FASTA)

PVTVCGDIHG QYYDLMKLFE VGGNPANTQY LFLGDYVDRG YFSIECLLYL WALKIWYPKT 60

LWLLRGNHEC AHLTDYFTFK LECTHKYNIK VYEACLQSFN ALPLAAIMNK QFLCVHGGLS 120

PELHTLNDIR MINRFCEPPT HGLMCDLLWS DPLEDFGSEK SNKHFIHNNV RGCSYFYSYQ 180

AVCTFLENNN LLSVIRAHEA Q 201

Keyword

Calmodulin-binding; Cell shape; Complete proteome; Hydrolase; Iron; Manganese; Metal-binding; Protein phosphatase; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005955	; C:calcineurin complex
GO:0032153	; C:cell division site
GO:0005829	; C:cytosol
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0019722	; P:calcium-mediated signaling
GO:0030644	; P:cellular chloride ion homeostasis
GO:0031505	; P:fungal-type cell wall organization
GO:0006470	; P:protein dephosphorylation
GO:0071775	; P:regulation of cell cycle cytokinesis
GO:0008360	; P:regulation of cell shape
GO:0031137	; P:regulation of conjugation with cellular fusion
GO:0032878	; P:regulation of establishment or maintenance of cell polarity
GO:0070631	; P:spindle pole body localization

KEGG

spo:SPBP4H10.04

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF00149

; Metallophos; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS00125

; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013