EPS-SCP-00002

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-SCP-00002

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	247.7	3.9E-74	24	287	264

Status

Reviewed

Ensembl Protein

SPCC1223.11.1:pep

UniProt Accession

Q09172;

Protein Name

Protein phosphatase 2C homolog 2

Protein Synonyms/Alias

PP2C-2;

Gene Name

ptc2

Gene Synonyms/Alias

ptc2; SPCC1223.11;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPCC1223.11	SPCC1223.11.1:pep	SPCC1223.11.1

Organism

Schizosaccharomyces pombe

Functional Description

Has an important role in osmotic stability and cellshape control. It may negatively regulate the osmosensing signal transmitted through wis1 map kinase.

Protein Length

370

Protein Sequence
(FASTA)

MGQTLSEPVL DKHSSSGGDR WLHFGVSHMQ GWRISMEDAH CALLNFTDSN SSNPPTSFFG 60

VFDGHGGDRV AKYCRQHLPD IIKSQPSFWK GNYDEALKSG FLAADNALMQ DRDMQEDPSG 120

CTATTALIVD HQVIYCANAG DSRTVLGRKG TAEPLSFDHK PNNDVEKARI TAAGGFIDFG 180

RVNGSLALSR AIGDFEYKKD SSLPPEKQIV TAFPDVVIHN IDPDDEFLIL ACDGIWDCKS 240

SQQVVEFVRR GIVARQSLEV ICENLMDRCI ASNSESCGIG CDNMTICIVA FLHGRGLEDW 300

YNWITQRVNS GEGPCAPPSY AELRGPNTIA DARNLQLEYD HIASHEYGSG DTYDSDSDDE 360

TIAYDRYYLH 370

Nucleotide Sequence
(FASTA)

ATGGGCCAAA CACTCTCAGA ACCCGTACTC GACAAACATT CGAGTTCTGG CGGGGATCGA 60

TGGCTTCATT TTGGCGTTTC ACACATGCAA GGATGGCGTA TTTCGATGGA AGACGCGCAT 120

TGTGCGTTGC TAAACTTTAC GGATTCCAAT TCTTCTAATC CTCCGACAAG CTTCTTTGGG 180

GTCTTTGATG GGCACGGAGG CGACAGAGTC GCCAAGTACT GCAGGCAGCA CTTACCAGAT 240

ATCATTAAAA GTCAGCCGTC TTTTTGGAAG GGTAACTATG ATGAAGCTTT GAAATCTGGT 300

TTTTTGGCTG CAGACAATGC GTTAATGCAA GATCGGGACA TGCAGGAAGA TCCTTCGGGA 360

TGCACAGCTA CCACTGCCTT GATTGTCGAC CATCAAGTAA TATATTGTGC AAATGCTGGG 420

GACTCGCGAA CGGTCTTAGG TAGAAAGGGA ACTGCGGAAC CACTTTCTTT TGATCACAAA 480

CCAAACAACG ACGTGGAAAA AGCTCGAATC ACGGCTGCAG GGGGATTCAT CGACTTTGGT 540

CGAGTGAATG GTAGTTTGGC TCTTTCTCGT GCCATTGGAG ACTTTGAGTA CAAGAAAGAC 600

AGTTCCTTAC CTCCAGAAAA ACAGATCGTT ACAGCTTTTC CTGATGTCGT TATTCATAAC 660

ATAGATCCAG ATGATGAATT TTTAATTCTG GCCTGTGATG GAATTTGGGA TTGCAAGAGC 720

TCTCAACAAG TCGTGGAGTT TGTAAGAAGA GGCATTGTTG CGCGGCAGTC TTTGGAAGTA 780

ATTTGTGAAA ATCTTATGGA CCGTTGTATT GCTAGTAACA GCGAGTCCTG CGGTATCGGA 840

TGTGACAACA TGACTATTTG CATTGTTGCC TTTTTGCATG GTCGTGGTCT TGAGGATTGG 900

TATAATTGGA TTACACAGCG CGTCAACTCG GGAGAAGGTC CTTGCGCACC TCCATCTTAT 960

GCTGAGTTGC GAGGACCTAA CACTATAGCG GATGCAAGAA ATCTGCAGTT GGAATATGAT 1020

CATATAGCTA GCCATGAGTA TGGAAGCGGT GATACATACG ATAGCGATTC AGATGATGAA 1080

ACCATTGCCT ACGATCGCTA TTACCTTCAT TAA 1113

Domain Profile

S: 3     vgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheila  62

         +gv+ ++g+r +meda+ +  nf +s++++   +ffgv+DGhgg +vak+c+++l +i++

Q: 24    FGVSHMQGWRISMEDAHCALLNFTDSNSSNPPTSFFGVFDGHGGDRVAKYCRQHLPDIIK  83

         6999********************************************************

S: 63    eelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds.klyvan  121

          + +    ++ + ++al+++Fl+ d++l  ++++ +++d+sG+ta++ali d   +y+an

Q: 84    SQPS---FWKGNYDEALKSGFLAADNAL--MQDRDMQEDPSGCTATTALIVDHqVIYCAN  138

         **77...69*******************..999999***********99887659999**

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalGdl  181

         +GdSr+vL+r+g+a +ls dHkp+++ E++Ri +agg +      Rv+G+La+sRa+Gd+

Q: 139   AGDSRTVLGRKGTAEPLSFDHKPNNDVEKARITAAGGFIDFG---RVNGSLALSRAIGDF  195

         ************************************999988...***************

S: 182   ylk.........pyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         ++k         ++vt+ P+v+ h+++++defliLa+DG+wd+ s++++v++vr+ +

Q: 196   EYKkdsslppekQIVTAFPDVVIHNIDPDDEFLILACDGIWDCKSSQQVVEFVRRGIVAR  255

         ************************************************************

S: 233   eaeqeaakkLvklalargsk......dnvsai  258

         ++++ ++++L+++++a +s+      dn+++

Q: 256   QSLEVICENLMDRCIASNSEscgigcDNMTIC  287

         *****************999788888887654

Domain Sequence
(FASTA)

FGVSHMQGWR ISMEDAHCAL LNFTDSNSSN PPTSFFGVFD GHGGDRVAKY CRQHLPDIIK 60

SQPSFWKGNY DEALKSGFLA ADNALMQDRD MQEDPSGCTA TTALIVDHQV IYCANAGDSR 120

TVLGRKGTAE PLSFDHKPNN DVEKARITAA GGFIDFGRVN GSLALSRAIG DFEYKKDSSL 180

PPEKQIVTAF PDVVIHNIDP DDEFLILACD GIWDCKSSQQ VVEFVRRGIV ARQSLEVICE 240

NLMDRCIASN SESCGIGCDN MTIC 264

Keyword

Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0071470	; P:cellular response to osmotic stress
GO:0030968	; P:endoplasmic reticulum unfolded protein response
GO:0000173	; P:inactivation of MAPK activity involved in osmosensory signaling pathway
GO:0006470	; P:protein dephosphorylation

KEGG

spo:SPCC1223.11

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013