EKS-SCP-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-SCP-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/WEE258.91.2E-77566839274
StatusReviewed
Ensembl ProteinSPCC18B5.03.1:pep
UniProt AccessionP07527; Q9UU00;
Protein NameMitosis inhibitor protein kinase wee1
Protein Synonyms/Alias P107 protein kinase homolog;
Gene Namewee1
Gene Synonyms/Alias wee1; SPCC18B5.03;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
SPCC18B5.03SPCC18B5.03.1:pepSPCC18B5.03.1
OrganismSchizosaccharomyces pombe
Functional DescriptionProtein kinase that acts both on serines and ontyrosines. It acts as a dosage-dependent negative regulator of entry into mitosis (G2 to M transition). Phosphorylates and inhibits cdc2.
Protein Length877
Protein Sequence
(FASTA)
MSSSSNTSSH RSYGLRRSQR SMNLNRATLL APPTPSSLYD ANNSTSSTSS QKPNTSFTSL 60
FGPRKQTTSS PSFSHAAPLH PLSPPSFTHS QPQIQAQPVP RRPSLFDRPN LVSRSSSRLG 120
DSPSLSPVAQ VANPIHHTAP SPSDVRAFPI HKNASTGVKR SFFSSSMSNG AMSPPSHSPS 180
PFLQSSQHIP PSTPAQKLRK KNNFDSFRIS NSHISPFASG SFSPFATSSP NFLSTSTPAP 240
PNSNNANPST LFSSIPSSRH TTSNHFPSNS AQSSLFSPTA RPLTARKLGF ASSQTKSAVS 300
NNHSRNSSKD ASFMMKSFIP SNRSHPQTQQ NESSLFSDNS MVNSSSNSFS LFPNATLPNP 360
PSSELLTTPF QQIKPPSQVF MSTGLLSKQH RPRKNINFTP LPPSTPSKPS TFVRPHSSST 420
DSPPSPSTPS NTQTDSYFIQ RENTPTNHNS IPTIQLEKSS MDFLRFDPPP SAVKTSHNYG 480
LPFLSNQRCP ATPTRNPFAF ENTVSIHMDG RQPSPIKSRN NNQMSFAMEE EADVSQPSSS 540
SFTLSFPSAL TSSKVSSSTS HLLTRFRNVT LLGSGEFSEV FQVEDPVEKT LKYAVKKLKV 600
KFSGPKERNR LLQEVSIQRA LKGHDHIVEL MDSWEHGGFL YMQVELCENG SLDRFLEEQG 660
QLSRLDEFRV WKILVEVALG LQFIHHKNYV HLDLKPANVM ITFEGTLKIG DFGMASVWPV 720
PRGMEREGDC EYIAPEVLAN HLYDKPADIF SLGITVFEAA ANIVLPDNGQ SWQKLRSGDL 780
SDAPRLSSTD NGSSLTSSSR ETPANSIIGQ GGLDRVVEWM LSPEPRNRPT IDQILATDEV 840
CWVEMRRKAG AIIYEGIHGS SSNPQGDQMM EDWQVNV 877
Nucleotide Sequence
(FASTA)
ATGAGCTCTT CTTCTAATAC CAGCAGTCAT AGATCTTATG GCTTACGGCG GTCCCAACGC 60
TCCATGAATC TAAATCGTGC TACTTTGCTC GCTCCTCCAA CTCCATCGAG CCTGTATGAT 120
GCTAACAATT CTACTTCATC TACCTCTTCG CAAAAGCCAA ATACCTCTTT CACTAGCTTA 180
TTCGGTCCTC GCAAACAGAC CACTTCCTCC CCTTCCTTCT CTCATGCCGC CCCTCTTCAC 240
CCTCTTTCTC CTCCTTCTTT TACACATTCA CAACCCCAGA TACAGGCACA ACCTGTACCT 300
CGGCGGCCTT CCCTTTTTGA TAGACCCAAT CTGGTATCAC GCTCTTCCTC TCGGTTAGGT 360
GATTCTCCAT CTCTTTCTCC TGTTGCCCAG GTGGCTAATC CCATCCACCA TACTGCCCCT 420
TCACCCTCAG ACGTTCGTGC GTTTCCCATT CATAAAAATG CATCTACTGG TGTAAAACGA 480
AGTTTCTTTT CTTCCTCCAT GTCAAACGGT GCAATGTCCC CTCCTTCCCA CTCTCCATCT 540
CCCTTCCTTC AAAGCTCTCA ACACATACCT CCTTCTACTC CTGCTCAGAA GCTGCGAAAG 600
AAAAACAATT TTGATTCTTT TCGTATCTCA AATTCCCACA TCTCTCCATT TGCATCGGGC 660
TCCTTCTCTC CTTTTGCAAC TTCATCGCCT AATTTTTTAT CGACTTCCAC ACCCGCTCCT 720
CCTAATTCAA ATAATGCTAA TCCTTCTACC CTTTTTTCGT CCATACCATC CTCTCGACAC 780
ACTACCTCTA ATCATTTCCC TTCTAACTCC GCTCAATCCT CTTTGTTTTC TCCTACCGCT 840
CGTCCACTTA CTGCACGCAA GCTTGGGTTT GCCTCCAGCC AAACTAAGTC TGCCGTATCT 900
AACAACCATT CACGAAATAG CTCTAAGGAT GCATCATTTA TGATGAAAAG TTTCATCCCT 960
TCTAATCGCT CACATCCTCA AACCCAACAA AATGAATCTT CCCTCTTTTC TGATAACAGT 1020
ATGGTTAACT CCTCTTCTAA TTCATTCTCC CTTTTCCCCA ATGCTACTCT ACCTAACCCA 1080
CCCTCATCTG AGTTGTTAAC TACTCCCTTT CAACAAATCA AACCTCCTTC CCAAGTTTTT 1140
ATGAGTACAG GTCTTTTATC CAAGCAACAT CGTCCGCGAA AGAATATTAA CTTTACACCT 1200
CTCCCTCCTA GTACTCCTTC AAAACCCTCT ACCTTTGTTC GTCCACATTC TTCCTCCACA 1260
GATTCGCCTC CATCACCCTC GACTCCTTCC AATACACAAA CCGACTCTTA TTTTATTCAA 1320
CGGGAAAACA CTCCTACAAA TCACAATTCC ATTCCTACTA TTCAGTTGGA GAAAAGTTCC 1380
ATGGACTTTT TGAGGTTCGA TCCTCCTCCT TCTGCTGTAA AAACTTCTCA CAACTATGGA 1440
TTACCATTTC TATCTAATCA GAGGTGTCCC GCTACGCCTA CTCGTAACCC ATTTGCGTTT 1500
GAAAATACTG TTTCCATTCA CATGGACGGT CGGCAACCTT CGCCTATCAA ATCGAGAAAT 1560
AATAATCAAA TGTCATTTGC CATGGAGGAA GAAGCTGATG TATCTCAACC CTCTTCTTCA 1620
AGCTTTACAT TATCCTTTCC TTCTGCTCTC ACCTCGTCCA AAGTATCATC ATCTACTTCA 1680
CATTTGCTTA CACGGTTTAG AAATGTTACT TTACTAGGAA GTGGAGAGTT TAGTGAGGTT 1740
TTTCAAGTTG AAGACCCTGT GGAAAAAACT TTAAAGTATG CAGTGAAAAA GCTCAAGGTA 1800
AAGTTTAGTG GACCAAAAGA ACGTAATCGA CTACTTCAGG AAGTCTCTAT TCAACGAGCC 1860
CTTAAAGGCC ATGATCACAT TGTAGAGCTT ATGGACTCAT GGGAACATGG GGGGTTTCTT 1920
TATATGCAAG TCGAATTGTG TGAAAATGGT AGTTTGGATC GTTTTCTTGA AGAGCAAGGA 1980
CAACTTTCAA GGCTCGATGA ATTTAGGGTA TGGAAAATAT TAGTAGAAGT AGCTCTTGGG 2040
CTACAGTTTA TTCATCATAA AAATTATGTT CATTTGGATT TAAAGCCTGC TAATGTTATG 2100
ATAACATTCG AGGGTACCTT GAAGATTGGT GATTTTGGAA TGGCCAGTGT TTGGCCTGTT 2160
CCGAGAGGCA TGGAAAGAGA AGGTGATTGT GAATACATTG CGCCTGAGGT TCTTGCTAAC 2220
CATTTGTATG ATAAACCTGC TGATATTTTC AGTTTGGGTA TCACAGTCTT CGAAGCTGCT 2280
GCTAACATTG TTCTTCCTGA TAACGGTCAG TCTTGGCAGA AATTACGTTC CGGTGACTTA 2340
TCAGATGCTC CTCGACTTTC TTCAACAGAC AACGGTTCAT CTCTTACTTC TTCTTCTCGT 2400
GAAACACCGG CTAATAGTAT AATAGGCCAA GGGGGACTTG ATCGCGTTGT AGAGTGGATG 2460
CTATCTCCAG AGCCTAGGAA CCGACCTACC ATAGATCAAA TTTTGGCAAC TGATGAGGTT 2520
TGCTGGGTTG AAATGCGTAG AAAAGCCGGA GCCATAATTT ATGAAGGTAT TCATGGATCT 2580
TCTTCTAACC CCCAGGGTGA TCAAATGATG GAAGATTGGC AGGTGAATGT TTAA 2634
Domain Profile
S: 1     FeevekiGkGefgevfkvvkr.edgklyAikkskkplkglskekkalrEvtahavlgqhe  59
         F +v  +G+Gef+evf+v +  e   +yA+kk k +++g +++++ l+Ev  +  l+ h+
Q: 566   FRNVTLLGSGEFSEVFQVEDPvEKTLKYAVKKLKVKFSGPKERNRLLQEVSIQRALKGHD  625
         88999*************986255679*********************************
S: 60    nvvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglryl  119
         ++v+++ +We+ + ly+q ElCe+gsL+ +l+e  +  ++l+e +++kil+++ lgl+++
Q: 626   HIVELMDSWEHGGFLYMQVELCENGSLDRFLEEQGQ-LSRLDEFRVWKILVEVALGLQFI  684
         ******************************998755.559********************
S: 120   HssslvHlDikpenifitkevtlklgDlGlvtelnsedkskveEGDsrylakEilqeeys  179
         H ++ vHlD+kp+n++it+e+tlk+gD+G+++      +  + EGD++y+a+E+l ++++
Q: 685   HHKNYVHLDLKPANVMITFEGTLKIGDFGMASVW-PVPRGMEREGDCEYIAPEVLANHLY  743
         ******************************9877.778999*******************
S: 180   klkaDiFslgltilevaanvelPsnGeaWhklRkgklpd.......eilkelsedlre..  230
         +  aDiFslg+t++e+aan+ lP+nG++W+klR+g+l+d       +          +  
Q: 744   DKPADIFSLGITVFEAAANIVLPDNGQSWQKLRSGDLSDaprlsstD--------NGSsl  795
         **************************************755544441........22233
S: 231   ....................llklmlepdperRptaeellkhev  254
                             ++++ml p+p++Rpt +++l++++
Q: 796   tsssretpansiigqggldrVVEWMLSPEPRNRPTIDQILATDE  839
         44566677788888888888*******************99875
Domain Sequence
(FASTA)
FRNVTLLGSG EFSEVFQVED PVEKTLKYAV KKLKVKFSGP KERNRLLQEV SIQRALKGHD 60
HIVELMDSWE HGGFLYMQVE LCENGSLDRF LEEQGQLSRL DEFRVWKILV EVALGLQFIH 120
HKNYVHLDLK PANVMITFEG TLKIGDFGMA SVWPVPRGME REGDCEYIAP EVLANHLYDK 180
PADIFSLGIT VFEAAANIVL PDNGQSWQKL RSGDLSDAPR LSSTDNGSSL TSSSRETPAN 240
SIIGQGGLDR VVEWMLSPEP RNRPTIDQIL ATDE 274
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Magnesium; Metal-binding; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00398
EKS-ANC-00413
EKS-BOT-00428
EKS-CAE-00361
EKS-CAJ-00430
EKS-CAF-00425
EKS-CAP-00453
EKS-CII-00244
EKS-CIS-00174
EKS-DAR-00819
EKS-DIO-00074
EKS-DRM-00200
EKS-ECT-00015
EKS-EQC-00419
EKS-ERE-00016
EKS-FEC-00408
EKS-GAM-00248
EKS-GAG-00360
EKS-GAA-00520
EKS-GOG-00418
EKS-HOS-00432
EKS-ICT-00411
EKS-LAC-00440
EKS-LOA-00435
EKS-MAM-00425
EKS-MEG-00353
EKS-MIM-00066
EKS-MOD-00416
EKS-MUM-00460
EKS-MUP-00422
EKS-MYL-00422
EKS-NOL-00389
EKS-OCP-00090
EKS-ORN-00543
EKS-ORA-00375
EKS-ORC-00399
EKS-ORL-00499
EKS-OTG-00432
EKS-PAT-00403
EKS-PES-00378
EKS-PEM-00236
EKS-POA-00415
EKS-PTV-00122
EKS-RAN-00439
EKS-SAH-00398
EKS-SOA-00018
EKS-SUS-00381
EKS-TAG-00497
EKS-TAR-00540
EKS-TAS-00055
EKS-TEN-00537
EKS-TUT-00133
EKS-XET-00536
EKS-XIM-00534
EKS-SAC-00032
Gene Ontology
GO:0071341; C:medial cortical node
GO:0005654; C:nucleoplasm
GO:0005816; C:spindle pole body
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0051519; P:activation of bipolar cell growth
GO:0051301; P:cell division
GO:0000077; P:DNA damage checkpoint
GO:0007067; P:mitosis
GO:0031661; P:negative regulation of cyclin-dependent protein kinase activity involved in G2/M
GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0008361; P:regulation of cell size
KEGG
spo:SPCC18B5.03;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013