EKS-SCP-00091

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SCP-00091

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	305.0	1.8E-91	2447	2746	300

Status

Reviewed

Ensembl Protein

SPCC23B6.03c.1:pep

UniProt Accession

O74630;

Protein Name

Serine/threonine-protein kinase tel1

Protein Synonyms/Alias

ATM homolog; DNA-damage checkpoint kinase tel1; Telomere length regulation protein 1;

Gene Name

tel1

Gene Synonyms/Alias

tel1; SPCC23B6.03c;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
SPCC23B6.03c	SPCC23B6.03c.1:pep	SPCC23B6.03c.1

Organism

Schizosaccharomyces pombe

Functional Description

Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Undirectly involved in the phosphorylation of rad32 which is necessary for its telomere function. Required for the control of telomere length and genome stability.

Protein Length

2812

Protein Sequence
(FASTA)

MTSLNDIVNK LSSSKIKTRS DALQNLRSYI IYSRNGNSLN QEDALIIEKA IKRAFELEWQ 60

ISANHGKRQI SKASQEQKLQ DISYLLRTCV ESYILLFREP HILALLDIIL RHTFTANGSI 120

CEVVCLNFSK ALRLLLSHSP HLHHLRFSDW QSLVSYCCQA IEKLSIAEET YVSDSEEEPI 180

SQKNYQEISI WKSHDVIRVK QEVVELIYVM RSLVQWYAAP INFVSEQLLK FFEFFFYAYT 240

EETDAHLPAL QCLFQLCAYA IPNCNDYSAS VVLLVFKILI NSDKWKRLDL RLQLIQCLAI 300

SYPLWSNSET WDPHRSIRSF NLDLLNSSFF SLKNFLNFFG KRSSLSLANF RFHTVEPKNN 360

IAKLYDPRLH LFFSLRHNSF FESYFIYFFL AKLILLKKTV LSLASTEQAN KKQKTCSQIE 420

ELLLQAELAN ISASSFSLQL MVIITAISDN LTNDDLLSIQ KMSLNFTEKK NELQSWSFFI 480

LFNICYNKAY SSMLTTSCKK EILAAASRGL LNSVTSPVCY QILTYFNMYR PLCFASIFPF 540

IKQQFILFND YSPMLSYEAI DYWKSLYILL NENLFVGQSS FKSVFLKWLK WHLYHLFSKE 600

GELPFFSFTD SSIIIFDLLM MIFYRPLSLS YITTEIRSPF ERNLFHLKEA WSPVTLRFPY 660

TTDEICKQST EGCYPFNSNH TIDCDSLQNV IKMLESSIDE ISSASYDKDE LDKETPSFEA 720

VMIFSQISFL CGFLNCFIQK KGIHNVTPNN LVIFKNLFPE VLSFVKSNHS YDPIINCIST 780

NLQFTISDEP KHLRYEIGSD LIRSTHFRDS NPLKTLVLYI MDMASKNVFI KPQEFDHDEY 840

FSQEEEDIYR PENLIRNHQI LGLMEGSLEQ IRNTDLFILQ KYIDYFSSHP HDSLINILHL 900

YPIETFCFGM SAIGAYFLDV ARTSEPIFYK CLEILAQKIL MNYDYERDEV YLMIFIKIFQ 960

KCVHSKLQFT DATLKLIVKI TKFIEKVFIE TKFSSLSGRQ TFLKFIFQLS PTSHVYSKFD 1020

YQKLISLTLK DSDVCVIYNF VDDLVIFLKK CDKTLIEGFV LPILSIKIEK SLYKGFCYLY 1080

LTLKVFLSIS SNRSALLYQL LKLANSYETS TIFEPLLRKL HIQSANIKQL FRIYRLEIFW 1140

SFVSKDLSNT TNDFLEFPYK PIYFSLSDFL KENSDEIILV LILTKNITLA KLITSRMSVD 1200

FSEKYTQLIP VITTYTHLSE VENKKYSLRF NSIDEALDVE LLNRSKAFLF CLEMLKEVKE 1260

LGSTFKSISS TSFKVYSQLT IFANRVSFNN STAIPFFSTK SVLWYCNRLF QELEGFSSIP 1320

SVIDLVLRRL AIQLHFATDE ELQVTISFRL CAFLCFSDPF ITSNYLVMIV LRIARQLLSI 1380

PCTQSLGLGI ARFHLKKFKP TDFDYFFQLA EFCMDFLGFC YNTIGTKMEA IQDFYTWFDG 1440

YVTALLNFEY EGYGFLRCQI NFVRSVMTTK NEWIEVSNKL FERGHFLKRI AMNNYLCLYF 1500

WQVLDACPRN VLHSLSLEIW KCYKAYDITE FPDSLKLFFS DIMGWNFFKS PEIADLNHYI 1560

PKTDPRLCDT KTYEESKLII WKLICQKACS LLFKYDILLD SFIEDCIRMF FENGNHQELR 1620

KFLNFPKDSI IYDSDFKTLV SEEGSFQWVK LQPTNFDSLS NWTKEETLKL LNMMGKSSTT 1680

HSLKLLSTYM VGFSTSIIQY IIHLILLEFD FNGNNKKQKE YVTQLILSGL LNKNTNSIRK 1740

TCMNILLYLR RQLGHHALNP FEANYWVPIN YSVAASTAYD CHLYEQSLLF LTIHNTKTDE 1800

LDITLLSDIL SQLPCPDAYY GIKRETSFKN ILLKAVHEKR SPLAISYLDA ANMYRSNEDE 1860

GTKMMFSNTL NNAGFFSLNE FYIDSLKAND AIDECSNEVY ASAWRMQKWD IPPLSLDNKT 1920

TKDCLVFEVL HAVHNYAIYG NYLHLEEYIN KKLLLINPNE EPDSLLFYAL AYDLKFLIRC 1980

NQSQFNCDIL QLLKENKQMS SQLHECFQLL LEIRNVLLSL LQSHKQLDLS DDLASFRKYY 2040

ILELLKISES FLIVDNLQNA FSVAMLSDAL YRKFDLADEN LKHDIDFLSS KILWQRDEKI 2100

DAIGMLSESL SKTNSSIFPS ISYAYLGNWL YTTKSEKTEL VSKNYFEKSL SHMSHLNAKE 2160

KAKIYCMFAQ FCDNNYSSPD LTEDFKRMEK LYFEKKNDIQ QLERSIVNAS NMKEEKMLKN 2220

HHSREMSSFI IDEREYLRMS TFRSKMLTQS ITHYLKCLSE SDENDVLISR CCTMWLSNSH 2280

LDELNNSLQH YLQNLPCKKF IPVFYQLAAR LMNENSKFQQ SLTSICYNVG RNHPYHSLHV 2340

LFSLVSNVPE IENLDAGSRY RAVKKILDLL KVNQGLSNLV TKLLCSFENY VSLAEWNPRS 2400

KVDSTSFSRF PGYKWFLKDA ANYGLPPITM NVKVNDTGDY SNIPTVSSFD DTIHFASGIN 2460

APKVITCLGS NGHTYKQLVK GGNDDLRQDA VMEQVFEQVN GFLRSYRKTS QRNLSMRTYK 2520

VIPLALKTGV IEWVQDTIPL GEYLDSAHKV YHPKEWSLST CRKLIAEKQM EDLETRLKVY 2580

DLVCRHYRPV FRHFFLESYA DPVQWFTTQT NYARSTAVAS VLGHVLGLGD RHGQNILIDK 2640

TSGEVIHIDL GIAFEQGKKL PVPECVPFRL TRDVVDGMGI TGVEGVFRRC MEFTLETLRR 2700

EEDSLLSVLE VLRYDPLFSW LISPLRRMKK QKMQLENFNQ PESGNITTDA SRDPKIQRNN 2760

VSGESEAERA ILKVRQKLSS TLSVEASVGE LIRIAQDPSY LALMFCGWSA FQ 2812

Nucleotide Sequence
(FASTA)

ATGACTTCTC TAAATGACAT CGTTAATAAG TTGTCTTCAT CAAAAATCAA AACACGATCA 60

GATGCTCTAC AAAATCTTCG CAGCTACATA ATTTACTCCA GAAATGGAAA TTCGCTAAAT 120

CAGGAAGATG CTTTAATAAT CGAAAAGGCC ATAAAGCGAG CATTCGAACT TGAATGGCAA 180

ATTTCTGCTA ATCATGGTAA ACGTCAAATT TCCAAAGCTT CCCAAGAGCA GAAGCTTCAA 240

GATATTAGCT ATTTGTTAAG AACATGTGTT GAATCTTATA TTTTATTATT TAGGGAGCCT 300

CATATTTTAG CGCTTCTAGA TATAATTCTA AGACATACTT TCACAGCTAA TGGTTCTATA 360

TGTGAGGTAG TCTGTTTGAA TTTTTCTAAG GCTCTTCGGC TACTATTATC CCATTCTCCT 420

CATTTGCATC ATCTTCGTTT CTCGGATTGG CAATCACTAG TTTCCTATTG TTGTCAAGCT 480

ATTGAAAAAC TAAGTATAGC TGAAGAAACT TATGTTAGTG ATAGTGAAGA AGAGCCAATA 540

AGCCAAAAAA ACTATCAAGA AATATCTATC TGGAAATCGC ACGATGTTAT AAGAGTAAAG 600

CAAGAAGTCG TTGAGCTCAT TTACGTTATG CGTTCTCTTG TTCAATGGTA TGCGGCTCCA 660

ATTAATTTTG TTAGTGAGCA ACTGCTGAAA TTTTTTGAGT TCTTTTTTTA TGCTTACACG 720

GAAGAAACAG ATGCGCATCT ACCAGCTTTG CAGTGTTTGT TTCAGTTATG TGCATATGCG 780

ATCCCCAATT GTAATGATTA TTCCGCAAGC GTTGTTTTAT TAGTCTTTAA GATTCTTATA 840

AACTCTGATA AATGGAAGCG TCTGGATTTA AGATTGCAGC TTATACAATG CTTAGCCATT 900

TCTTATCCAC TTTGGTCCAA TTCAGAAACA TGGGATCCCC ATCGTTCCAT TAGATCTTTT 960

AATTTAGATC TTCTTAACTC TTCGTTTTTT TCTTTAAAAA ATTTCTTAAA TTTTTTTGGA 1020

AAACGCTCCT CATTATCGCT TGCGAATTTT AGATTCCATA CAGTTGAGCC TAAGAACAAC 1080

ATTGCAAAAC TTTACGATCC ACGGCTACAC CTTTTTTTTT CTCTTAGACA TAATTCTTTC 1140

TTTGAATCTT ACTTTATTTA TTTTTTTCTT GCAAAACTAA TTCTCCTCAA AAAAACCGTG 1200

TTGTCCTTAG CAAGCACGGA GCAAGCCAAC AAAAAGCAGA AAACATGTTC TCAAATAGAG 1260

GAACTGCTTT TGCAAGCTGA GCTAGCCAAT ATCTCGGCTT CCTCTTTTTC ATTGCAACTC 1320

ATGGTAATTA TCACTGCTAT TTCTGACAAT CTAACAAACG ATGATCTATT GTCAATTCAA 1380

AAAATGAGTC TTAACTTTAC TGAGAAAAAA AATGAACTTC AAAGCTGGTC TTTTTTTATA 1440

TTGTTCAACA TTTGTTACAA CAAAGCTTAC TCTTCGATGC TTACGACTTC ATGTAAAAAG 1500

GAAATTTTGG CTGCTGCTTC TCGTGGTCTC CTGAATTCTG TTACGTCTCC TGTATGCTAT 1560

CAAATTTTAA CTTATTTTAA CATGTATCGG CCTTTGTGCT TCGCGAGCAT TTTTCCTTTC 1620

ATAAAGCAAC AGTTTATTTT ATTTAATGAT TACTCGCCAA TGCTTTCATA TGAAGCCATT 1680

GATTACTGGA AATCTCTGTA CATATTACTT AATGAAAACC TATTTGTTGG TCAAAGCTCT 1740

TTTAAATCTG TGTTTCTAAA ATGGTTGAAG TGGCATCTAT ATCATTTGTT CAGCAAAGAG 1800

GGTGAACTAC CATTTTTCTC ATTTACCGAT TCTTCTATTA TCATTTTTGA TTTGTTAATG 1860

ATGATCTTCT ATAGACCGTT GTCATTATCT TATATCACCA CAGAAATACG ATCACCTTTC 1920

GAACGTAATT TGTTTCACCT CAAAGAAGCA TGGTCGCCTG TTACGCTTCG TTTTCCTTAT 1980

ACTACTGACG AAATATGTAA ACAGTCTACA GAAGGATGCT ATCCTTTCAA TAGTAACCAT 2040

ACTATTGACT GTGATAGTTT GCAAAATGTC ATTAAAATGT TGGAGAGCTC GATAGACGAA 2100

ATTAGCTCAG CATCTTATGA CAAAGATGAG CTTGACAAGG AAACCCCAAG CTTCGAAGCA 2160

GTTATGATAT TTTCTCAGAT ATCATTTTTA TGTGGCTTTC TAAATTGTTT TATCCAGAAA 2220

AAAGGTATTC ATAATGTTAC TCCTAACAAT CTTGTCATTT TTAAAAATTT ATTCCCTGAA 2280

GTCCTTTCTT TCGTTAAGTC TAATCACAGT TATGACCCAA TAATAAATTG CATCTCTACT 2340

AATTTGCAGT TTACTATTTC TGATGAGCCA AAACATCTTC GGTATGAAAT TGGAAGCGAC 2400

TTAATTCGTT CAACTCATTT TCGAGACAGT AATCCGCTCA AAACCTTGGT TCTTTATATA 2460

ATGGATATGG CTTCTAAAAA CGTATTCATA AAGCCTCAAG AATTTGATCA CGATGAGTAT 2520

TTCTCCCAGG AGGAAGAAGA TATTTATCGG CCAGAAAATT TAATCAGGAA TCATCAAATA 2580

CTTGGTTTGA TGGAAGGATC GCTTGAGCAA ATACGGAATA CTGATCTTTT TATTTTACAA 2640

AAATATATCG ACTACTTTTC TAGTCATCCT CATGACAGCT TAATTAATAT TCTTCATTTG 2700

TATCCCATTG AAACTTTTTG TTTTGGTATG TCTGCAATTG GTGCATATTT CCTAGATGTT 2760

GCGCGGACAT CCGAACCTAT TTTCTACAAA TGTCTTGAAA TACTGGCTCA AAAAATTTTA 2820

ATGAATTATG ATTATGAAAG AGACGAAGTC TATCTAATGA TTTTTATTAA AATATTTCAA 2880

AAATGTGTTC ATTCTAAACT TCAGTTCACG GACGCAACTT TGAAACTTAT TGTGAAGATT 2940

ACAAAATTCA TTGAAAAGGT TTTTATTGAG ACTAAATTTT CATCATTATC TGGTAGACAA 3000

ACTTTTTTAA AATTTATATT TCAGTTATCC CCTACATCTC ACGTTTATTC AAAATTCGAT 3060

TATCAAAAAT TGATTTCTTT AACTCTTAAA GACTCTGATG TTTGTGTTAT TTATAACTTT 3120

GTTGACGATT TGGTGATTTT TCTTAAAAAA TGTGATAAAA CGTTAATTGA AGGTTTTGTT 3180

CTCCCAATTT TAAGCATTAA AATTGAGAAG TCATTGTATA AAGGCTTCTG CTATTTATAT 3240

TTGACTTTAA AGGTTTTTTT GTCAATAAGT TCCAATCGAT CAGCATTGTT GTATCAGCTG 3300

CTTAAGCTTG CAAACAGCTA TGAAACGTCA ACTATTTTTG AACCTTTGCT TCGTAAGCTT 3360

CACATTCAGA GTGCAAATAT TAAGCAACTG TTTCGAATAT ACAGGTTAGA GATATTTTGG 3420

TCATTCGTCA GCAAAGATCT TTCTAATACA ACCAATGACT TTCTAGAATT CCCCTACAAA 3480

CCAATTTATT TCAGCCTTTC CGATTTTTTA AAAGAAAACA GCGACGAAAT TATACTTGTT 3540

CTTATTCTGA CTAAGAATAT AACCTTGGCT AAACTCATTA CTTCACGCAT GTCTGTTGAT 3600

TTTTCTGAAA AGTATACGCA ATTGATCCCT GTTATAACAA CTTATACTCA TCTAAGTGAA 3660

GTAGAGAATA AAAAGTATTC GTTGAGATTT AATTCTATTG ATGAAGCACT TGATGTGGAA 3720

TTACTCAACC GCTCCAAAGC TTTTTTGTTC TGCTTAGAGA TGCTTAAAGA GGTTAAAGAA 3780

TTAGGCTCTA CTTTTAAATC TATAAGCTCA ACTTCGTTTA AGGTGTACTC ACAATTAACA 3840

ATTTTTGCCA ATCGCGTCTC TTTTAACAAT AGCACAGCGA TACCATTCTT TTCTACAAAA 3900

TCTGTGTTAT GGTATTGCAA TAGACTCTTC CAAGAATTAG AGGGCTTCTC CTCTATCCCT 3960

TCAGTCATTG ATTTAGTTTT AAGGAGACTT GCAATACAAC TACACTTTGC GACGGATGAA 4020

GAACTTCAAG TTACTATTTC TTTTAGATTG TGTGCTTTTC TATGTTTCTC TGATCCTTTT 4080

ATCACTTCAA ACTATTTGGT AATGATAGTA CTTAGGATAG CTAGACAATT ACTCTCAATA 4140

CCTTGTACCC AATCACTAGG ATTAGGAATT GCGCGCTTTC ATTTGAAAAA ATTCAAACCT 4200

ACTGATTTTG ATTATTTCTT TCAACTAGCC GAATTCTGTA TGGACTTTTT GGGTTTTTGC 4260

TACAACACTA TTGGTACGAA GATGGAGGCT ATCCAAGATT TTTATACTTG GTTTGATGGT 4320

TACGTTACTG CTTTACTAAA TTTTGAGTAT GAAGGTTATG GATTTTTACG CTGTCAAATA 4380

AACTTTGTAC GTTCAGTGAT GACAACCAAA AATGAATGGA TAGAGGTTTC AAATAAACTG 4440

TTCGAAAGAG GTCACTTTCT TAAGAGAATC GCAATGAATA ATTATCTTTG TCTCTACTTT 4500

TGGCAAGTCC TCGATGCTTG TCCCAGAAAT GTTTTACACT CCTTAAGCCT TGAAATTTGG 4560

AAATGTTACA AAGCATACGA TATTACTGAA TTTCCTGACT CTTTGAAGCT CTTTTTTTCA 4620

GACATCATGG GCTGGAATTT TTTCAAATCT CCGGAAATTG CTGATCTCAA TCATTATATA 4680

CCCAAAACCG ATCCTCGATT ATGCGATACT AAAACTTATG AAGAATCAAA ACTTATTATT 4740

TGGAAATTGA TATGTCAAAA AGCATGTTCT CTTTTATTTA AATATGACAT TTTATTAGAT 4800

TCATTCATTG AGGATTGCAT TAGGATGTTC TTTGAAAATG GTAATCACCA AGAGCTTAGA 4860

AAATTTTTAA ATTTTCCAAA AGATAGTATC ATCTACGATA GTGATTTCAA GACTCTTGTT 4920

TCTGAGGAAG GTTCTTTTCA ATGGGTAAAA TTACAACCCA CAAATTTTGA TTCTTTGTCA 4980

AATTGGACTA AGGAAGAGAC GCTGAAATTA TTAAATATGA TGGGAAAATC ATCAACAACA 5040

CATTCTCTAA AATTGCTGAG TACTTACATG GTGGGGTTTT CAACTTCAAT TATTCAATAT 5100

ATTATACATT TGATTCTGTT GGAGTTTGAT TTTAATGGTA ACAACAAAAA GCAAAAGGAG 5160

TATGTAACAC AACTGATCTT ATCTGGTTTG TTAAATAAAA ATACAAATAG TATTCGAAAG 5220

ACTTGCATGA ATATTTTATT ATACCTTCGT CGGCAATTAG GGCATCATGC TCTTAATCCA 5280

TTTGAAGCAA ACTACTGGGT TCCCATTAAT TACAGTGTTG CAGCATCAAC TGCTTATGAT 5340

TGCCATTTGT ATGAACAGAG TCTACTTTTC TTGACAATAC ATAATACAAA AACAGATGAA 5400

TTGGACATCA CCCTTTTATC GGACATTCTT TCCCAACTGC CTTGTCCGGA TGCTTATTAC 5460

GGAATAAAAC GCGAAACTAG CTTCAAAAAT ATTTTGCTCA AGGCGGTGCA TGAAAAGCGG 5520

AGCCCATTAG CCATTTCGTA CCTCGATGCT GCAAATATGT ATCGAAGCAA TGAAGATGAG 5580

GGGACTAAGA TGATGTTTTC AAATACTCTT AATAACGCTG GATTCTTTAG CTTGAATGAA 5640

TTTTACATCG ATTCACTCAA AGCCAATGAT GCTATTGATG AATGCAGCAA CGAAGTGTAT 5700

GCTTCTGCTT GGCGGATGCA AAAATGGGAT ATCCCTCCAC TTTCTTTGGA CAATAAGACT 5760

ACTAAGGATT GTTTGGTTTT TGAGGTATTA CATGCAGTGC ATAACTACGC TATTTACGGT 5820

AATTATTTGC ACCTCGAAGA ATACATTAAC AAAAAATTAT TACTAATTAA TCCCAACGAG 5880

GAACCCGATA GTCTACTATT TTATGCTTTG GCTTATGATT TGAAGTTTTT AATACGATGC 5940

AATCAGTCTC AGTTTAATTG TGATATCCTT CAATTGCTTA AGGAGAATAA GCAAATGTCA 6000

TCACAGTTAC ATGAATGTTT TCAGTTATTA CTTGAAATTA GAAACGTCCT ACTTTCCTTG 6060

CTACAGTCAC ACAAACAACT GGACTTGTCT GACGATCTAG CCTCATTTCG CAAGTACTAT 6120

ATCTTGGAAC TCTTAAAGAT TAGCGAGTCT TTTTTAATAG TTGACAACCT TCAAAATGCA 6180

TTTTCCGTGG CTATGTTAAG TGATGCTCTT TATCGAAAGT TTGATTTGGC AGATGAAAAC 6240

CTTAAGCACG ATATAGATTT TCTTTCATCT AAAATCTTAT GGCAACGTGA TGAAAAGATT 6300

GATGCCATTG GCATGCTCTC CGAATCACTT TCAAAAACAA ATTCGTCCAT TTTTCCATCT 6360

ATTAGCTATG CATATCTTGG AAACTGGTTG TATACAACAA AATCCGAAAA GACTGAATTA 6420

GTCTCAAAAA ATTATTTTGA GAAATCCCTT TCCCATATGT CACACTTGAA CGCCAAAGAA 6480

AAAGCTAAAA TTTATTGTAT GTTTGCTCAA TTTTGCGACA ATAATTATTC TAGCCCGGAT 6540

CTGACTGAAG ATTTCAAGCG TATGGAAAAG CTTTATTTTG AGAAAAAGAA TGATATCCAA 6600

CAGTTAGAGC GTTCCATTGT AAATGCTTCT AATATGAAGG AAGAAAAAAT GCTAAAAAAC 6660

CATCATTCTA GGGAAATGTC TTCATTTATC ATTGATGAAC GCGAATATTT AAGAATGTCA 6720

ACTTTTAGGA GTAAAATGCT CACTCAAAGT ATAACTCATT ATTTGAAATG TTTAAGTGAA 6780

AGTGACGAAA ACGATGTTTT GATATCTAGA TGCTGTACTA TGTGGCTTTC AAATTCACAT 6840

TTAGATGAAC TGAACAATTC CTTACAGCAC TATTTACAAA ACTTGCCTTG TAAAAAGTTT 6900

ATACCTGTCT TTTATCAATT GGCAGCTCGT TTGATGAACG AGAACTCGAA ATTTCAACAA 6960

TCGTTGACAT CTATATGCTA CAACGTTGGA CGTAATCATC CTTATCACTC TTTGCATGTT 7020

TTGTTTTCGC TTGTGTCCAA TGTTCCAGAA ATTGAAAATC TCGATGCTGG ATCACGGTAT 7080

AGAGCAGTTA AAAAAATCCT TGATCTGTTA AAAGTTAATC AAGGATTATC CAATTTAGTC 7140

ACCAAACTTT TGTGCTCCTT TGAAAACTAT GTAAGTTTAG CAGAGTGGAA TCCCAGGAGC 7200

AAAGTTGACA GTACATCTTT TAGTCGATTT CCTGGATATA AATGGTTTCT AAAAGATGCA 7260

GCAAACTATG GATTACCTCC TATAACAATG AACGTAAAGG TAAATGATAC AGGTGATTAT 7320

TCAAACATCC CTACCGTTTC TTCATTCGAT GATACCATTC ATTTTGCCTC AGGGATTAAT 7380

GCGCCAAAAG TTATTACATG TTTGGGCTCA AATGGTCACA CATATAAACA GTTGGTTAAA 7440

GGGGGGAATG ATGATCTTCG TCAAGATGCT GTTATGGAAC AGGTGTTTGA GCAAGTAAAC 7500

GGATTTCTCA GGAGCTATCG AAAAACCAGT CAAAGAAATC TGTCAATGCG TACTTATAAG 7560

GTGATTCCAT TAGCATTAAA GACAGGTGTC ATAGAGTGGG TTCAAGATAC CATTCCCTTG 7620

GGTGAGTATC TGGATTCGGC TCACAAGGTT TACCATCCTA AGGAATGGTC TTTGAGTACT 7680

TGTCGAAAAT TAATAGCTGA GAAACAAATG GAGGATTTGG AAACTAGATT GAAAGTTTAC 7740

GATTTAGTTT GTAGACATTA TCGTCCTGTC TTTCGCCATT TTTTCCTCGA GAGTTACGCT 7800

GATCCAGTGC AATGGTTTAC AACGCAAACA AATTACGCAC GAAGCACTGC TGTTGCTTCT 7860

GTCCTGGGAC ATGTTTTGGG ACTTGGAGAT AGACATGGGC AAAATATTTT AATAGACAAA 7920

ACGAGTGGAG AAGTGATTCA CATTGATCTA GGAATTGCTT TCGAACAAGG TAAAAAACTA 7980

CCCGTTCCTG AATGTGTTCC CTTTCGACTT ACAAGAGACG TTGTAGATGG TATGGGAATT 8040

ACCGGGGTTG AAGGGGTATT TCGAAGATGC ATGGAGTTTA CATTAGAAAC ACTTCGACGG 8100

GAAGAGGATT CACTACTGTC TGTCCTGGAA GTTTTAAGAT ATGATCCATT ATTTTCTTGG 8160

CTTATTTCAC CTTTGAGAAG GATGAAAAAA CAAAAGATGC AACTTGAAAA CTTTAATCAA 8220

CCAGAGAGCG GGAATATTAC AACGGATGCT TCTAGAGACC CCAAGATACA AAGGAATAAT 8280

GTATCGGGAG AATCGGAAGC CGAAAGAGCT ATACTTAAAG TAAGACAGAA ATTATCAAGT 8340

ACTCTTTCAG TAGAAGCTTC TGTGGGAGAA TTGATTCGAA TTGCTCAAGA TCCCTCATAT 8400

CTCGCACTTA TGTTTTGTGG ATGGTCTGCC TTTCAATGA 8439

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkg.keDlrqdervlqlfslvNtlLakd  60

          +fd++++  +  ++pk ++ +Gs+g++y +Lvkg ++Dlrqd++++q+f+ vN +L+

Q: 2447  SSFDDTIHFASGINAPKVITCLGSNGHTYKQLVKGgNDDLRQDAVMEQVFEQVNGFLRSY  2506

         5899999999999********************862799*********************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

          +ts+r+L++rtykV+pl  + g+iewv++t++L+e+l      ++v+       ++k++

Q: 2507  RKTSQRNLSMRTYKVIPLALKTGVIEWVQDTIPLGEYLD---SAHKVY-------HPKEW  2556

         **************************************4...444555.......57***

S: 121   stvqarkpklkhlkls....levfkevlenlvpkdllkklllekfpspeewfelrkaytr  176

         s   +rk  ++ +++     l+v+  v+ +  p  ++++++le+  +p +wf+ +++y+r

Q: 2557  SLSTCRKLIAEKQMEDletrLKVYDLVCRHYRP--VFRHFFLESYADPVQWFTTQTNYAR  2614

         ******77777666666666***********9*..9************************

S: 177   slAvislvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrn  236

         s+Av+s+ g++LgLgdrh +n+lid+++gev+hid+g+afe++k  l+vpe vPFRLTr+

Q: 2615  STAVASVLGHVLGLGDRHGQNILIDKTSGEVIHIDLGIAFEQGKK-LPVPECVPFRLTRD  2673

         *********************************************.**************

S: 237   ivnalgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.kkktsketee  295

         +v+++g+tgveGvfr+++e +l+ lr+++++ll++Lev+ ydpl+ w     +  k+++

Q: 2674  VVDGMGITGVEGVFRRCMEFTLETLRREEDSLLSVLEVLRYDPLFSWLIsPLRRMKKQKM  2733

         ***********************************************9854556666777

S: 296   elaekakaealki  308

         +l++ +++e+ +i

Q: 2734  QLENFNQPESGNI  2746

         7777777666655

Domain Sequence
(FASTA)

SSFDDTIHFA SGINAPKVIT CLGSNGHTYK QLVKGGNDDL RQDAVMEQVF EQVNGFLRSY 60

RKTSQRNLSM RTYKVIPLAL KTGVIEWVQD TIPLGEYLDS AHKVYHPKEW SLSTCRKLIA 120

EKQMEDLETR LKVYDLVCRH YRPVFRHFFL ESYADPVQWF TTQTNYARST AVASVLGHVL 180

GLGDRHGQNI LIDKTSGEVI HIDLGIAFEQ GKKLPVPECV PFRLTRDVVD GMGITGVEGV 240

FRRCMEFTLE TLRREEDSLL SVLEVLRYDP LFSWLISPLR RMKKQKMQLE NFNQPESGNI 300

Keyword

ATP-binding; Chromatin regulator; Chromosome; Complete proteome; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Telomere; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

spo:SPCC23B6.03c

;

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013