EKS-CAE-00123

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00123

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	364.7	4.7E-109	47	306	260

Status

Reviewed

Ensembl Protein

T01H8.1b

UniProt Accession

Q21734; Q58A96; Q7YSN4; Q93972; Q93973;

Protein Name

Putative ribosomal protein S6 kinase alpha-1

Protein Synonyms/Alias

Gene Name

rskn-1

Gene Synonyms/Alias

rskn-1; T01H8.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
T01H8.1	T01H8.1a	T01H8.1a
T01H8.1	T01H8.1c	T01H8.1c
T01H8.1	T01H8.1b	T01H8.1b
T01H8.1	T01H8.1e	T01H8.1e
T01H8.1	T01H8.1d	T01H8.1d

Organism

Caenorhabditis elegans

Functional Description

Serine/threonine kinase that may play a role inmediating the growth-factor and stress induced activation of transcription (By similarity).

Protein Length

727

Protein Sequence
(FASTA)

MLILAEVEEF AENEIEQGEE KTDSSSETEI DIGDVRKCGE KADPRQFELL KVLGQGSFGK 60

VFLVRKVRGR DSGHVYAMKV LKKATLKVRD RQRTKLERNI LAHISHPFIV KLHYAFQTEG 120

KLYLILDFLR GGDLFTRLSK EVMFTEDDVK FYLAELTLAL EHLHSLGIVY RDLKPENILL 180

DADGHIKVTD FGLSKEAIDS EKKTYSFCGT VEYMAPEVIN RRGHSMAADF WSLGVLMFEM 240

LTGHLPFQGR DRNDTMTQIL KAKLSMPHFL TQEAQSLLRA LFKRNSQNRL GAGPDGVEEI 300

KRHAFFAKID FVKLLNKEID PPFKPALSTV DSTSYFDPEF TKRTPKDSPA LPASANGHEI 360

FRGFSFVSNA VMEERKLIAK SVRSVPTAKT NPFTDDYEIL EKIGNGAHSV VHKCQMKATR 420

RKYAVKIVKK AVFDATEEVD ILLRHSHHQF VVKLFDVYED ETAIYMIEEL CEGGELLDKL 480

VNKKSLGSEK EVAAIMANLL NAVQYLHSQQ VAHRDLTAAN ILFALKDGDP SSLRIVDFGF 540

AKQSRAENGM LMTPCYTAQF VAPEVLRKQG YDRSCDVWSL GVLLHTMLTG CTPFAMGPND 600

TPDQILQRVG DGKISMTHPV WDTISDEAKD LVRKMLDVDP NRRVTAKQAL QHKWIGQKEA 660

LPDRPIQSEQ VGELDMQNVK VALEQTYKAI ASAPSVQLRP VGSSALAKRR MKEILYANYT 720

KNVSANA 727

Nucleotide Sequence
(FASTA)

ATGTTAATTT TGGCGGAAGT TGAAGAATTT GCTGAAAATG AAATCGAACA AGGAGAAGAA 60

AAGACCGATT CATCATCAGA AACCGAAATT GACATTGGAG ATGTCCGAAA GTGTGGTGAG 120

AAGGCCGATC CTCGACAGTT TGAACTGCTC AAAGTCCTCG GCCAAGGATC ATTTGGAAAG 180

GTCTTTCTGG TGCGAAAAGT ACGTGGACGA GATTCAGGGC ATGTCTATGC AATGAAAGTT 240

CTGAAAAAGG CTACGCTGAA AGTCCGTGAT CGTCAACGAA CGAAGCTAGA ACGGAACATC 300

CTGGCTCATA TTTCGCATCC GTTCATCGTC AAACTGCATT ACGCTTTCCA AACTGAAGGA 360

AAATTATACC TGATTCTCGA TTTCCTGCGT GGTGGAGATC TCTTCACTCG ACTATCGAAA 420

GAGGTTATGT TCACAGAGGA TGATGTGAAG TTCTATCTGG CAGAACTCAC ATTGGCACTG 480

GAACATCTCC ACAGTTTAGG AATTGTCTAC AGAGATTTGA AACCAGAAAA CATTCTGCTC 540

GATGCTGATG GTCACATCAA AGTCACAGAT TTCGGGCTCA GCAAAGAAGC AATCGATAGT 600

GAGAAGAAAA CTTATAGTTT CTGTGGAACA GTGGAATATA TGGCTCCAGA AGTTATTAAT 660

CGGCGTGGAC ATTCAATGGC TGCAGATTTC TGGTCTTTAG GAGTGTTAAT GTTTGAGATG 720

CTCACAGGAC ACTTGCCATT TCAAGGAAGA GATCGAAATG ACACTATGAC GCAGATTTTG 780

AAAGCCAAAC TCTCGATGCC ACACTTCTTG ACACAAGAGG CTCAATCTTT GCTTCGAGCT 840

CTTTTTAAAC GAAATTCGCA AAACCGCCTC GGAGCGGGCC CCGATGGCGT TGAAGAGATC 900

AAACGGCATG CATTTTTTGC TAAAATTGAT TTTGTGAAGT TGCTCAACAA AGAGATTGAT 960

CCACCATTCA AACCAGCACT CTCCACTGTC GATAGCACTT CGTACTTTGA TCCAGAATTC 1020

ACGAAACGGA CACCAAAAGA TTCTCCAGCT CTTCCTGCAT CTGCCAACGG CCACGAGATA 1080

TTCAGAGGAT TTTCATTTGT CTCAAATGCA GTTATGGAGG AGAGAAAGCT TATCGCAAAG 1140

TCTGTCAGAT CTGTACCAAC AGCAAAAACA AATCCATTCA CTGATGACTA TGAGATTCTC 1200

GAGAAAATTG GAAATGGTGC ACATTCGGTG GTTCACAAGT GCCAAATGAA GGCTACAAGA 1260

AGGAAATATG CTGTGAAGAT TGTCAAGAAA GCAGTGTTTG ACGCAACAGA GGAAGTTGAT 1320

ATTCTTCTGA GACACTCTCA CCATCAATTT GTTGTTAAAT TGTTCGACGT TTATGAAGAT 1380

GAGACAGCGA TCTACATGAT TGAAGAGTTG TGTGAAGGAG GAGAACTTTT GGACAAACTT 1440

GTGAACAAGA AGTCGTTGGG AAGCGAGAAG GAAGTTGCCG CTATTATGGC AAATCTTTTG 1500

AACGCAGTTC AATATCTGCA CTCCCAACAA GTTGCTCATC GTGATCTGAC AGCTGCAAAT 1560

ATTCTTTTCG CTTTAAAGGA CGGAGATCCA AGTTCGTTGA GAATTGTTGA TTTTGGGTTT 1620

GCCAAGCAAT CGAGAGCAGA AAATGGAATG CTCATGACTC CATGTTACAC TGCTCAATTT 1680

GTGGCTCCGG AAGTTCTTCG CAAACAAGGA TACGATCGTT CTTGTGATGT CTGGTCCCTT 1740

GGAGTTCTAC TTCACACAAT GCTCACCGGC TGCACTCCGT TCGCGATGGG TCCAAATGAT 1800

ACACCTGATC AGATATTACA ACGTGTTGGA GATGGAAAGA TTTCAATGAC ACATCCAGTT 1860

TGGGACACAA TTTCCGATGA AGCAAAGGAT CTTGTAAGAA AGATGTTAGA TGTCGATCCA 1920

AATAGAAGAG TCACAGCAAA ACAAGCATTG CAACATAAGT GGATCGGACA AAAGGAAGCA 1980

CTTCCGGATC GGCCAATTCA ATCAGAACAA GTTGGAGAGC TTGATATGCA AAATGTCAAG 2040

GTTGCACTTG AGCAGACATA TAAAGCAATC GCATCGGCTC CAAGTGTTCA ACTTCGTCCA 2100

GTTGGATCGT CTGCACTTGC GAAACGACGA ATGAAGGAGA TTCTTTACGC CAACTACACG 2160

AAGAATGTGT CAGCAAATGC ATGA 2184

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvkkkkertkeereiLeeveh  60

         fellkvlg+G++gkvflvrkv+++d+g++ya+Kvlkka+l++++++rtk er+iL++++h

Q: 47    FELLKVLGQGSFGKVFLVRKVRGRDSGHVYAMKVLKKATLKVRDRQRTKLERNILAHISH  106

         89**********************************************************

S: 61    pfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylHsk  120

         pfivklh+afq+e klyl+l++l+Gg+L++rl+k+ +f+e++++f+lael+lale+lHs

Q: 107   PFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEDDVKFYLAELTLALEHLHSL  166

         ************************************************************

S: 121   gvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkgyd  180

         g+vyrDLkpeNilld +gh+k+tDfgl+ke+i ++e+k+ysfcgT+ey+aPev++r+g++

Q: 167   GIVYRDLKPENILLDADGHIKVTDFGLSKEAI-DSEKKTYSFCGTVEYMAPEVINRRGHS  225

         ******************************99.9999999********************

S: 181   eavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvkkl  240

          a+D+wslGvl++emLtG+ Pf+g++r++t+++ilk+k  l++p++  l++ea++l+++l

Q: 226   MAADFWSLGVLMFEMLTGHLPFQGRDRNDTMTQILKAK--LSMPHF--LTQEAQSLLRAL  281

         **************************************..******..************

S: 241   LkkdpakRlga...taeeikehkfl  262

         +k+++++Rlga   ++eeik+h f+

Q: 282   FKRNSQNRLGAgpdGVEEIKRHAFF  306

         ***********9*99********97

Domain Sequence
(FASTA)

FELLKVLGQG SFGKVFLVRK VRGRDSGHVY AMKVLKKATL KVRDRQRTKL ERNILAHISH 60

PFIVKLHYAF QTEGKLYLIL DFLRGGDLFT RLSKEVMFTE DDVKFYLAEL TLALEHLHSL 120

GIVYRDLKPE NILLDADGHI KVTDFGLSKE AIDSEKKTYS FCGTVEYMAP EVINRRGHSM 180

AADFWSLGVL MFEMLTGHLP FQGRDRNDTM TQILKAKLSM PHFLTQEAQS LLRALFKRNS 240

QNRLGAGPDG VEEIKRHAFF 260

Keyword

Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

cel:CELE_T01H8.1

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013