EKS-CAE-00239

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00239

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	420.2	8.5E-126	332	649	318

Status

Reviewed

Ensembl Protein

T04C10.1

UniProt Accession

Q8WQL7; Q22155;

Protein Name

Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1

Protein Synonyms/Alias

Dual specificity Yak1-related kinase mbk-1; Minibrain Kinase 1;

Gene Name

mbk-1

Gene Synonyms/Alias

mbk-1; T04C10.1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
T04C10.1	T04C10.1	T04C10.1

Organism

Caenorhabditis elegans

Functional Description

Possible role in the function of olfactory neurons.

Protein Length

882

Protein Sequence
(FASTA)

MNTADVPDNL QSWGQQPSSS YSNTQQHSQM TNLPPINHNN LCDTEPMNED FQLQDVQADE 60

LQKQQKQQEQ QHIQQQNAQR FIAQSRQPHS NILRFPQPPI TSIKTNSHAF YPQQEVTQVR 120

PKKHRVSMTN AEAALTPGMP PEKQAAKKRN IGQFSTDTVP AGIGMIGIPF ESTSKPLQIQ 180

QFRNPQDAPV RKLTSDLIKT YKAINESFYL RKQVRRDRHK SQDAGKPKGS KDGSGASLTD 240

TFSIHNAIPI TSSDNHYQQD AHQNAPPLLD TNAPPTSTMV VPMRTETDLQ QQQRQKSSRG 300

GPYNNGYDDQ NYDYILKNGE IFDKRYVILS DTPVGKGSFG QVTKAYDTLN KEEVAIKIIK 360

NKKTFFDQAQ IEIHLLELTN AHDKDNKYNI VTLKGHFVHR AHLCLVFELL SYNLYDLLKN 420

TSFRGVSLNL ARKFAQQLGK TLLFLSSPEL SIIHCDLKPE NVLLVNAKRS QIRVIDFGSS 480

CQTGHRIYQY IQSRFYRSPE VLLGIAYDTK IDMWSLGCIL VEMHTGEPLF AGSSEVDQMM 540

KIVEVLGMPP KEMLDIGPKT HKYFDKTEDG IYYCKKTRDG YRHTYKAPGA RKLHEILGVT 600

SGGPGGRRLG EPGHSVEDYS KFKDLIKRML QFDPKQRISP YYVVRHPFLK QKEERVPSQP 660

PVSHSNLQQQ QQLYIQQPSS QMSQVMESPS VGSVYVEDNG MYRQAPGSSA NPISVTSSFD 720

EGDAMEVDAG RRRFSAHQQN YHNPNYQYSQ PQQQQQQQYQ QTQRTQLEQQ QKQAQLQQQL 780

QQQQMQQQQQ QQQQRQHMPQ AQSSSQQHLQ SRARPRQQDQ NEWRNQFELD DTFQQKQRKV 840

DDSVSNQISR NQFNPQQVSM THGNVNANNR EMEKLDYPNN KL 882

Nucleotide Sequence
(FASTA)

ATGAACACAG CAGACGTGCC TGACAATCTT CAATCATGGG GCCAACAACC ATCATCAAGT 60

TACTCAAATA CCCAGCAACA CTCACAAATG ACTAATCTTC CGCCTATCAA TCACAATAAT 120

CTTTGCGACA CCGAACCGAT GAACGAGGAC TTTCAACTTC AAGACGTGCA AGCTGACGAA 180

CTTCAGAAGC AGCAAAAACA GCAAGAGCAG CAACACATTC AACAGCAAAA TGCACAACGT 240

TTCATTGCAC AAAGCCGTCA ACCACATTCC AACATTCTGA GATTCCCACA GCCACCAATC 300

ACTTCAATTA AGACGAATTC ACACGCTTTC TATCCACAGC AAGAGGTCAC CCAAGTCCGG 360

CCAAAGAAGC ATCGCGTATC CATGACTAAT GCAGAAGCGG CACTAACTCC CGGAATGCCT 420

CCGGAAAAAC AAGCCGCAAA GAAGAGAAAT ATTGGCCAGT TCTCGACAGA TACTGTTCCG 480

GCTGGAATTG GAATGATTGG TATCCCGTTT GAATCTACCT CAAAGCCACT CCAAATTCAA 540

CAATTCCGAA ATCCTCAAGA CGCGCCAGTC AGAAAACTAA CCAGTGATCT CATCAAAACT 600

TACAAGGCTA TCAATGAGTC TTTCTACCTA CGGAAACAGG TTCGACGTGA TCGTCACAAG 660

AGTCAAGATG CCGGAAAGCC AAAGGGATCC AAGGATGGTT CCGGGGCGAG CCTGACTGAC 720

ACATTCTCCA TTCACAATGC GATTCCAATT ACGAGTTCTG ATAATCATTA TCAGCAAGAT 780

GCTCATCAAA ATGCTCCTCC TCTACTTGAC ACTAATGCTC CGCCCACCTC AACAATGGTT 840

GTTCCTATGC GCACAGAGAC TGATCTTCAA CAGCAGCAGC GACAGAAAAG TAGTCGTGGC 900

GGTCCGTACA ATAACGGGTA TGACGATCAG AATTACGACT ATATTCTTAA AAATGGAGAG 960

ATATTTGACA AGAGATACGT GATTCTCAGT GACACGCCGG TTGGCAAAGG ATCTTTCGGG 1020

CAAGTTACAA AAGCTTACGA CACGCTGAAT AAAGAAGAAG TCGCTATTAA AATTATCAAG 1080

AATAAGAAGA CTTTCTTCGA TCAAGCTCAG ATTGAGATTC ATCTTTTAGA ATTGACAAAT 1140

GCACATGACA AGGATAATAA GTATAATATT GTTACGCTCA AAGGGCACTT TGTGCATCGG 1200

GCTCATCTTT GCTTGGTATT CGAGCTTCTC TCCTACAACC TCTATGATCT TTTGAAGAAC 1260

ACCAGTTTCC GTGGCGTTTC GTTGAATTTG GCACGCAAAT TTGCCCAGCA ATTAGGAAAA 1320

ACTCTTCTCT TCCTGTCATC TCCAGAATTA TCGATTATCC ATTGTGATTT GAAGCCGGAA 1380

AATGTGCTAC TAGTTAACGC GAAGCGGTCT CAAATTCGTG TGATAGATTT TGGATCTTCT 1440

TGTCAGACTG GACACCGAAT CTACCAGTAC ATTCAGTCGA GATTCTATCG TTCGCCGGAA 1500

GTGCTGCTCG GCATCGCGTA CGACACGAAA ATTGATATGT GGTCCCTGGG ATGCATTCTC 1560

GTCGAAATGC ACACCGGAGA GCCGCTGTTT GCCGGGTCAT CGGAGGTTGA CCAAATGATG 1620

AAAATTGTGG AAGTTCTTGG TATGCCACCA AAAGAGATGT TAGACATTGG CCCGAAAACA 1680

CACAAGTATT TTGACAAAAC TGAGGATGGG ATCTACTATT GTAAGAAGAC TCGTGACGGA 1740

TACCGCCATA CCTACAAAGC TCCTGGAGCC AGGAAACTTC ACGAAATTCT GGGTGTGACT 1800

TCTGGCGGGC CCGGAGGTCG CCGGCTTGGA GAGCCAGGAC ATTCTGTTGA AGATTACAGC 1860

AAATTCAAAG ACTTAATAAA GAGAATGTTG CAATTTGACC CCAAACAAAG AATTTCGCCC 1920

TATTATGTGG TTCGGCATCC GTTCTTGAAG CAGAAGGAAG AGCGAGTTCC ATCTCAACCG 1980

CCGGTGTCTC ACTCGAACCT TCAGCAACAA CAGCAATTGT ACATACAGCA GCCGTCAAGC 2040

CAAATGAGTC AAGTGATGGA ATCTCCGTCG GTTGGATCAG TCTATGTGGA AGATAACGGG 2100

ATGTATCGCC AGGCGCCTGG ATCTTCTGCC AACCCAATTT CCGTCACATC ATCGTTTGAC 2160

GAAGGAGATG CCATGGAAGT TGATGCTGGG AGAAGACGCT TCTCTGCTCA TCAGCAAAAT 2220

TACCACAATC CAAACTATCA GTACTCTCAA CCACAACAGC AACAGCAGCA GCAGTATCAG 2280

CAGACACAGC GAACGCAACT GGAGCAGCAG CAGAAACAGG CTCAACTCCA ACAGCAGCTC 2340

CAGCAACAGC AAATGCAGCA ACAGCAGCAA CAGCAACAAC AACGCCAGCA CATGCCACAA 2400

GCGCAGAGCA GTTCCCAACA GCACCTCCAA TCACGGGCGC GGCCACGACA ACAGGATCAG 2460

AACGAGTGGA GGAATCAGTT TGAGCTGGAT GACACGTTTC AGCAGAAGCA GCGAAAAGTT 2520

GATGACTCTG TATCGAATCA GATTTCTAGA AATCAATTCA ATCCACAACA GGTATCGATG 2580

ACGCATGGAA ATGTAAATGC TAACAACCGA GAGATGGAGA AACTCGATTA CCCGAACAAC 2640

AAACTCTGA 2649

Domain Profile

S: 5     evigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeekynvv  64

         + +gkGsfgqV+ka+d+ +ke+vaikiiknkk+f +qaq+E+++Le  n +dk++kyn+v

Q: 332   TPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIV  391

         569*********************************************************

S: 65    rllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk..elk  122

          l+ +fv+r hlclvfells+nLy+llk+++f+g+sl+l rk+aqq+ k+L +L+  el+

Q: 392   TLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSspELS  451

         *******************************************************899**

S: 123   iiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglkydea  182

         iiH+DlKPeN+llv++krs+++viDFGss+++ ++ iy+yiqsrfYr+PE++lg+ yd++

Q: 452   IIHCDLKPENVLLVNAKRSQIRVIDFGSSCQTGHR-IYQYIQSRFYRSPEVLLGIAYDTK  510

         ***********************************.************************

S: 183   iDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftkkeap  242

         iDmWSlGc+l+E++tG+pLf+G++evdq+++ivevlg+pp+++l+ + k++k+f+k+e+

Q: 511   IDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTEDG  570

         ************************************************************

S: 243   kyilktk..........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.fkdl  291

          y++k++           + rk +++l+v++ +     p+ ++lge+ +++ed++ fkdl

Q: 571   IYYCKKTrdgyrhtykaPGARKLHEILGVTSGG-----PGGRRLGEPGHSVEDYSkFKDL  625

         *99999999999999888889999999998888.....99********************

S: 292   lkrmleldpakRitpkealkhpfv  315

         +krml++dp++Ri+p+++++hpf+

Q: 626   IKRMLQFDPKQRISPYYVVRHPFL  649

         ***********************6

Domain Sequence
(FASTA)

TPVGKGSFGQ VTKAYDTLNK EEVAIKIIKN KKTFFDQAQI EIHLLELTNA HDKDNKYNIV 60

TLKGHFVHRA HLCLVFELLS YNLYDLLKNT SFRGVSLNLA RKFAQQLGKT LLFLSSPELS 120

IIHCDLKPEN VLLVNAKRSQ IRVIDFGSSC QTGHRIYQYI QSRFYRSPEV LLGIAYDTKI 180

DMWSLGCILV EMHTGEPLFA GSSEVDQMMK IVEVLGMPPK EMLDIGPKTH KYFDKTEDGI 240

YYCKKTRDGY RHTYKAPGAR KLHEILGVTS GGPGGRRLGE PGHSVEDYSK FKDLIKRMLQ 300

FDPKQRISPY YVVRHPFL 318

Keyword

ATP-binding; Complete proteome; Kinase; Magnesium; Nucleotide-binding; Nucleus; Olfaction; Reference proteome; Sensory transduction; Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0040011	; P:locomotion
GO:0040010	; P:positive regulation of growth rate
GO:0050896	; P:response to stimulus
GO:0007608	; P:sensory perception of smell

KEGG

cel:CELE_T04C10.1

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013