EKS-CAE-00098

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00098

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LRRK	412.9	7.7E-124	1695	1986	292

Status

Reviewed

Ensembl Protein

T27C10.6

UniProt Accession

Q9TZM3; A3KFB1;

Protein Name

Leucine-rich repeat serine/threonine-protein kinase 1

Protein Synonyms/Alias

Leucine-rich repeats, ras-like domain, kinase protein 1; PARK8-related kinase;

Gene Name

lrk-1

Gene Synonyms/Alias

lrk-1; T27C10.6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
T27C10.6	T27C10.6	T27C10.6

Organism

Caenorhabditis elegans

Functional Description

Determines polarized sorting of synaptic vesicle (SV)proteins to the axons by excluding SV proteins from the dendrite- specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.

Protein Length

2393

Protein Sequence
(FASTA)

MDLSSGGPSS SSDVASELDN SDAMQLVRQA VLFENVELLA DLFKVNPWVW NRVDRHGRTP 60

LMLAAHNGKL DSLRTILMLS PNSLNLVNDR GKTALHMAAE SGETSIVLEL VELGSDPMKS 120

DNEGHCALEL AQMAGHNEVA AKLIDAIQKE SEDLNEAHTM IISACISGSA DVVYEISRRF 180

MEKKQSREIL FNGRNEEDET ALLIACTNGH IEIVRHLLQF EEHLLQSHVS KDTVIHAAVS 240

SQNVEVLQLC LEKFPQLVKS TNNEGSTCLH WAARCGSSEC VSTILNFPFP SEFIIEIDTV 300

GAPAYQLALD VNEVDGECRT AMYLAVAEGH LEVVKAMTDF KCTSIDGRQR CPFQLDVYCT 360

RGRTPFMLAA FNQNLPLMTL LLDAGADVNL PLAVLDTEYS VEEGRCIGSG ALVEAVRSDG 420

LHIVHFLLDR GALDTDNKAL RLAAQGKNEK LIRVFLVRLV FADPEYKINK KNIDVGQIQV 480

GQSLLPSSLC PSKAAQLNWN SANLEQLQSD WFVAAALHVN PRLRTTRLSL AAITRVDLSD 540

NRLNTFPSIL FQMPSLRSLN LADNSIRKIE IPTYYISSTS LEILNLRNNQ LECIAIQFLS 600

SLPQLQQLDV SKNELSQLPE YIWLCPALKE LNASYNRLST LPMVARASRG ERPRLNNSNN 660

NFNTQSPTQE SNPIVVDDPP NVTSNPLRRQ NVWQASINLS KVDDDSLFPD FPVTSSNTLT 720

TINLSFNKFH TFPFCLACTC PRLLILNMSN NSMTSLPPMA CVPAHLRTLD LSYNKIQESF 780

IEASPLHVVC HAVPPTTSNG SMLPKRRNSP ARQHRSRSKS AVRSQRSLSV SRHHALIDPQ 840

KEEESCVHKR HDSLEWLKTL QLAGNRLRSI SVTNAASKVL LPALNVMDIS DNKLLQAPPD 900

VARLTLLSML NLSGNTAIKE LPPDYGMLSR LWSLSLKGCS LKEPLESMVN VENCKTVEIV 960

AYLKTILEES KTYHHLRLMI LGSDGVGKSV IWDALCKEAV QKRQPIHSET GVIRQAEWKF 1020

EAKRSKGDKN LGPVGFSVID FGGQREYHST HQYFLSKRSL NLVLWKITDG DEALAQLDTW 1080

LVNIHARAPN STVILVGTNL DQVASNSSKF GPGYIDIMEQ KVRTRYMVAD ADKSGLPRIV 1140

DVILINSTSR NDVKALLNTI YRTAWEVRMG KERAMEQQIP SSYIALMKVT KELGVEFRKE 1200

GQPAVMTVEA YRERVKKRMI SKFGRPFRDD IEFYAACTFL HDCGELVRFE DATLRDLIFV 1260

DPLWLAEFLT SVVILRSPNL PAGLLSTDAI NPHTRSFKSG ALLMLKTQLL DLLHKFELAL 1320

ATQPRQLLIP SLLPDEYRLR SDFLASAVKI RMKMSQWNVR CPSPAGSPTK SPLRRTSPTD 1380

QNGVGSEDVM LQFTYDDDQL LRRIYALAYI PSGFWSRLVT RIVGDKNVCA AIESIFMTTS 1440

ADRAKIADIA TKHAKAEWVV WQTGIELHVK GHSLFTLKQF LPLAEVRDID YSAIDMRAKD 1500

EQKRWRTWNQ PSHRPIVEMV VNSLSISAAS QHGRKLSMKT DVEGRSRLLA MISDLLDTLL 1560

EDWYPALGTR FVHSSEGDLL VSRYVLCPQC VRDAERNGSR SRTSSSASHR RSQDDGELPI 1620

TSSSHMKGSR TTGDISKCRG GVVHCFVIEE CMLAGREYNW VECPSHGGLH MRELAPDTVF 1680

ADIENALTIH PDQLKRSRML GRGAFGFVFR ATVRQPNGEL CEVAQKMLEP VDPGPGGRPS 1740

ALAAYKAAAD KWKRDSMEFA CRAYCTSRQE LSLLSRMKHP NVIGLVGVCT FPLSLVVELA 1800

PLGALNQLLG SHRKAGTKLS LGVIKESAVQ VARALEYLHS AHIIYRDLKS ENVLGWRFPA 1860

PFSPQTDVLL KLGDYGISRS VLPSGGAKGF GGTEGFMAPE IVRFNGEEEY TQKVDCFSFG 1920

MFLYELLTLK FPFESEEHVK ERMLDGARPV LLPHELLLPT PMLDLLVHCW SAHPESRPSS 1980

SQLVGFCAAP EFTHLLDVCE LGEALPPTQL MAVGITDEID DPDDFEAQLW LSGREMVVMG 2040

CTQYGFVDQK SIELPHRGKY VSKVRDSVWS CDECGQVTVY GISLHETGHL QLPSLNGTLI 2100

CAPELISNDV LILISDKQIV LLKLSESNSV SHLGTIDSPY EIRTATFLGN GSTRQIWAGH 2160

SEGRISIHHI ASNDSFSFSS SLYLPDDKCI VRQLVGSKDA QKVWIALEKS SKVQMVEVEK 2220

RQVTGSLDIR KVMPGSETIH TIDMEMASQN YVTCIGLLER NDGDQLYIGT SKGLLVIAHA 2280

TTLQPLSACR PFEGDITSIC ILEEPSREEE NTRGKATTLS TASSESGLGW VRERVSETVD 2340

RFRSSPATVE TQGAALVVCI GRQFRSLSHR FVAEEKLADV YSIAVWRTEE WAL 2393

Nucleotide Sequence
(FASTA)

ATGGACCTCT CAAGTGGGGG TCCGTCATCT TCAAGCGATG TAGCTTCAGA ATTGGATAAT 60

TCGGATGCAA TGCAACTGGT TAGACAGGCA GTATTATTCG AGAACGTGGA GCTGCTGGCC 120

GACTTGTTCA AAGTGAATCC TTGGGTATGG AATCGGGTTG ATCGACATGG AAGGACACCG 180

TTAATGTTAG CTGCTCATAA TGGGAAGCTG GATAGTTTGA GGACTATTTT AATGCTTAGT 240

CCTAATTCTC TAAATCTTGT GAACGATCGT GGTAAGACCG CACTTCATAT GGCAGCCGAA 300

TCAGGTGAAA CTTCGATTGT TTTGGAGCTT GTCGAACTGG GCTCCGATCC AATGAAATCT 360

GATAATGAAG GACATTGTGC ATTGGAGTTA GCTCAAATGG CTGGACATAA TGAGGTTGCC 420

GCAAAGCTTA TTGATGCTAT TCAAAAAGAA AGTGAAGATC TAAATGAAGC CCACACAATG 480

ATCATCAGTG CATGCATATC TGGAAGTGCT GACGTTGTTT ATGAAATTTC AAGGAGATTT 540

ATGGAAAAAA AACAAAGCCG CGAAATATTA TTCAACGGTC GAAATGAAGA GGATGAGACT 600

GCACTCTTGA TTGCCTGCAC AAACGGTCAT ATCGAAATCG TCCGTCACTT ATTACAATTC 660

GAAGAGCATC TTCTACAAAG CCACGTATCC AAGGATACAG TAATCCATGC GGCAGTGTCG 720

TCACAGAATG TGGAAGTGTT GCAGCTGTGT TTGGAGAAAT TCCCTCAACT CGTCAAATCT 780

ACCAACAACG AGGGCTCTAC GTGTCTACAT TGGGCCGCCC GTTGTGGATC TTCGGAATGT 840

GTTTCCACAA TTCTAAACTT TCCATTCCCA TCTGAATTTA TAATCGAAAT CGACACAGTT 900

GGAGCACCAG CTTATCAGCT TGCTCTAGAC GTGAATGAAG TTGACGGAGA GTGTCGAACG 960

GCAATGTATC TAGCGGTTGC CGAAGGACAT TTGGAAGTTG TCAAGGCGAT GACTGATTTC 1020

AAATGCACAT CAATCGACGG AAGACAACGT TGCCCGTTTC AACTTGACGT CTACTGTACT 1080

CGAGGACGAA CACCATTCAT GTTGGCCGCT TTTAATCAGA ATCTTCCATT GATGACGCTT 1140

CTTCTCGACG CTGGTGCAGA TGTCAACTTG CCGCTGGCAG TCTTGGACAC AGAGTACAGC 1200

GTAGAAGAAG GTCGATGCAT TGGCTCGGGT GCTCTCGTTG AAGCTGTACG ATCTGATGGA 1260

CTACACATTG TGCACTTTCT GTTAGACCGT GGAGCTCTGG ACACTGATAA CAAGGCTCTT 1320

CGACTTGCTG CTCAGGGGAA GAACGAGAAG CTCATTCGGG TTTTTCTGGT TCGCCTGGTT 1380

TTTGCGGACC CTGAATATAA GATCAATAAG AAAAACATTG ATGTAGGTCA GATTCAAGTT 1440

GGTCAGAGTC TGCTACCAAG TTCACTGTGC CCATCAAAAG CCGCCCAACT GAATTGGAAT 1500

TCAGCCAATT TGGAGCAACT TCAATCGGAT TGGTTTGTGG CGGCAGCTCT ACACGTGAAC 1560

CCGAGACTCC GAACAACGAG GTTATCACTG GCAGCAATCA CTCGGGTCGA TTTATCGGAC 1620

AATCGTCTCA ACACATTCCC AAGTATTCTA TTCCAAATGC CATCGCTCAG ATCTCTAAAT 1680

CTAGCTGATA ATAGTATACG TAAAATTGAA ATTCCAACTT ATTACATTAG TTCAACATCG 1740

CTAGAGATTC TCAATTTACG GAATAATCAA CTCGAGTGTA TAGCCATTCA ATTTCTATCA 1800

TCTCTTCCAC AATTGCAACA ATTGGATGTA TCGAAGAACG AGTTGAGCCA ACTTCCCGAG 1860

TATATATGGT TGTGTCCAGC GTTGAAAGAG CTCAATGCAT CCTATAATAG ACTGAGCACA 1920

CTTCCGATGG TTGCAAGAGC ATCAAGAGGA GAGAGACCAC GACTCAATAA TTCTAACAAC 1980

AATTTCAACA CCCAATCTCC AACACAAGAA TCGAATCCAA TCGTCGTTGA TGATCCTCCG 2040

AATGTCACTT CAAACCCTCT GCGTCGCCAA AATGTGTGGC AAGCGAGTAT CAATTTGTCA 2100

AAAGTCGACG ACGATTCCCT GTTCCCCGAC TTCCCGGTCA CTTCCAGTAA CACATTGACG 2160

ACGATAAATC TATCTTTCAA TAAATTCCAC ACATTCCCAT TCTGCCTGGC ATGCACATGT 2220

CCCCGGCTTC TGATTCTAAA CATGTCAAAC AACTCAATGA CGTCACTTCC ACCTATGGCT 2280

TGTGTACCTG CGCATCTGAG GACGTTGGAT CTGTCTTACA ATAAGATACA AGAAAGTTTC 2340

ATCGAAGCTT CACCTCTCCA CGTGGTCTGT CACGCGGTCC CACCGACAAC GTCTAATGGC 2400

TCAATGCTCC CAAAGCGAAG AAATTCTCCA GCTCGGCAAC ATAGAAGTCG TTCGAAGTCT 2460

GCAGTTAGAT CACAGAGAAG TCTCAGTGTT TCTCGCCATC ATGCGCTAAT TGATCCACAA 2520

AAAGAAGAAG AAAGTTGTGT TCATAAGCGT CACGATTCAT TAGAATGGCT CAAGACACTA 2580

CAATTGGCTG GAAATCGACT CCGATCAATT TCAGTGACAA ATGCAGCTTC AAAAGTTCTC 2640

CTTCCAGCTC TGAACGTGAT GGATATCAGT GACAACAAAT TGCTACAAGC ACCACCGGAT 2700

GTTGCACGGC TCACACTTCT TTCAATGCTC AACTTATCAG GAAATACTGC AATTAAAGAA 2760

CTACCACCAG ATTATGGAAT GCTCTCTCGT CTTTGGAGTC TATCTTTGAA AGGATGCTCA 2820

CTGAAAGAAC CACTTGAATC AATGGTTAAT GTGGAGAACT GCAAGACAGT GGAAATTGTG 2880

GCGTATTTGA AGACAATTCT AGAAGAATCC AAGACATACC ATCATTTGAG ATTAATGATT 2940

TTGGGAAGTG ATGGCGTTGG AAAATCTGTT ATTTGGGATG CACTGTGCAA GGAAGCAGTA 3000

CAGAAACGGC AGCCTATTCA CTCGGAAACT GGTGTTATTC GGCAAGCTGA ATGGAAGTTC 3060

GAAGCGAAAC GATCTAAAGG CGATAAGAAT CTTGGGCCTG TCGGATTTTC TGTAATCGAC 3120

TTTGGAGGTC AACGAGAATA TCATTCCACT CATCAATATT TCCTGAGCAA ACGATCCTTG 3180

AACTTGGTTC TTTGGAAGAT CACAGACGGG GATGAAGCAC TGGCGCAGCT TGATACTTGG 3240

CTAGTTAATA TCCATGCAAG AGCGCCAAAC TCGACAGTAA TACTAGTGGG AACCAATTTG 3300

GATCAAGTGG CATCGAATAG TTCGAAATTT GGACCTGGAT ACATAGACAT CATGGAGCAA 3360

AAAGTGCGGA CCCGTTATAT GGTTGCAGAT GCGGATAAGT CAGGATTGCC ACGTATTGTT 3420

GATGTAATTT TGATCAATTC AACGTCAAGA AATGATGTAA AAGCACTGCT AAACACAATA 3480

TATAGAACTG CGTGGGAAGT ACGAATGGGA AAAGAAAGAG CTATGGAACA ACAGATTCCA 3540

TCTTCTTACA TTGCTTTGAT GAAAGTAACA AAAGAATTAG GCGTCGAGTT TCGGAAAGAG 3600

GGGCAGCCGG CTGTAATGAC TGTAGAGGCA TATAGAGAAA GAGTCAAGAA AAGGATGATT 3660

AGCAAGTTTG GCAGACCGTT TAGGGACGAC ATTGAATTCT ACGCCGCATG CACATTCCTT 3720

CACGATTGTG GTGAATTAGT TCGATTTGAG GATGCCACTC TTCGGGATCT GATTTTTGTA 3780

GATCCGCTGT GGCTCGCCGA GTTTCTCACT TCTGTCGTCA TTCTAAGAAG CCCAAATCTT 3840

CCAGCTGGAC TTCTTTCAAC AGACGCTATA AATCCGCATA CTCGTTCATT CAAATCAGGA 3900

GCACTTTTAA TGCTCAAAAC ACAGCTTTTG GATCTTCTTC ACAAATTCGA ATTGGCACTT 3960

GCTACCCAGC CTCGACAGCT TCTGATTCCA AGCCTGCTAC CAGATGAGTA CAGGCTACGA 4020

TCTGATTTCT TAGCATCTGC AGTTAAAATC CGAATGAAAA TGTCACAGTG GAATGTCAGA 4080

TGTCCAAGTC CCGCTGGATC ACCGACCAAA TCCCCACTCC GTCGAACATC ACCTACGGAT 4140

CAGAACGGTG TTGGATCAGA GGATGTTATG CTTCAATTCA CTTATGACGA TGATCAATTG 4200

TTAAGAAGGA TTTATGCGTT GGCTTATATA CCTTCAGGAT TTTGGAGTCG CCTAGTGACT 4260

CGTATAGTTG GAGATAAAAA CGTGTGTGCA GCAATTGAAA GTATTTTCAT GACAACAAGT 4320

GCGGATCGAG CAAAGATTGC AGATATAGCC ACTAAGCATG CAAAAGCTGA ATGGGTTGTG 4380

TGGCAAACTG GAATAGAGCT TCATGTTAAA GGACATTCAC TTTTCACTCT GAAACAGTTT 4440

CTACCGTTGG CAGAGGTTAG AGACATTGAC TACAGCGCCA TAGACATGCG CGCAAAGGAT 4500

GAACAAAAAC GATGGAGGAC ATGGAATCAA CCTTCACACC GCCCAATTGT CGAAATGGTT 4560

GTTAACTCAT TGAGCATTTC AGCAGCTTCA CAACACGGAA GAAAACTTTC AATGAAAACA 4620

GATGTGGAAG GAAGAAGCCG ATTATTGGCA ATGATATCAG ATTTATTGGA CACGTTACTC 4680

GAAGACTGGT ATCCGGCTCT TGGAACTCGA TTTGTTCACA GTTCGGAAGG CGACTTGCTT 4740

GTTTCACGAT ATGTGCTTTG TCCGCAGTGT GTCAGGGATG CTGAGAGAAA TGGCTCACGG 4800

AGCCGAACTT CTTCTTCAGC GTCACACCGA AGATCACAGG ATGACGGAGA GCTTCCAATA 4860

ACCAGCAGCT CTCACATGAA AGGTTCTCGA ACAACAGGAG ACATTTCAAA ATGTCGCGGA 4920

GGAGTTGTTC ACTGTTTCGT TATTGAGGAA TGTATGCTGG CTGGAAGAGA GTACAACTGG 4980

GTAGAATGCC CATCTCATGG TGGTCTTCAT ATGAGAGAAC TTGCACCGGA TACTGTATTT 5040

GCTGATATCG AAAATGCTTT GACAATTCAC CCGGATCAGT TAAAACGAAG CAGAATGCTC 5100

GGAAGAGGAG CGTTTGGTTT CGTTTTTCGG GCTACAGTAA GACAACCAAA TGGAGAACTT 5160

TGTGAAGTTG CTCAGAAAAT GTTGGAGCCT GTAGACCCAG GGCCTGGAGG CAGGCCTTCG 5220

GCTCTCGCAG CTTATAAGGC AGCAGCAGAC AAATGGAAGA GGGATAGTAT GGAATTTGCG 5280

TGTAGAGCAT ACTGTACTTC AAGACAAGAG CTCAGTTTAT TGAGTAGGAT GAAACATCCA 5340

AATGTTATTG GACTAGTTGG AGTTTGCACT TTTCCATTGT CTCTTGTTGT AGAGCTTGCA 5400

CCTCTCGGAG CACTTAACCA GCTGCTGGGA TCTCATCGAA AAGCTGGAAC TAAGCTCTCA 5460

CTTGGAGTTA TCAAAGAGTC TGCAGTTCAA GTTGCTCGAG CACTGGAATA TCTTCATTCT 5520

GCACATATTA TCTACAGAGA TCTCAAGTCG GAAAATGTAC TTGGATGGAG ATTTCCTGCT 5580

CCATTCAGTC CACAGACTGA TGTTCTATTG AAACTTGGAG ATTACGGGAT ATCAAGAAGT 5640

GTACTTCCAT CAGGTGGAGC AAAGGGATTC GGAGGAACGG AAGGATTTAT GGCTCCAGAA 5700

ATTGTAAGGT TCAATGGAGA AGAGGAATAT ACACAAAAAG TGGATTGCTT TTCGTTTGGA 5760

ATGTTCCTCT ATGAACTTCT CACTCTGAAA TTCCCATTCG AAAGTGAAGA GCATGTGAAA 5820

GAAAGAATGC TCGACGGAGC CCGTCCCGTA CTTTTACCGC ACGAGCTTCT CCTTCCAACT 5880

CCAATGCTGG ATCTTCTCGT TCACTGCTGG TCGGCTCATC CAGAATCCCG ACCTTCGTCG 5940

TCTCAACTAG TCGGATTCTG TGCAGCTCCA GAATTCACAC ATCTTCTTGA TGTTTGTGAA 6000

CTTGGAGAAG CTCTACCACC AACTCAGCTG ATGGCAGTAG GAATAACGGA CGAAATTGAT 6060

GATCCGGATG ACTTTGAAGC TCAACTTTGG CTCAGTGGAC GGGAAATGGT AGTCATGGGA 6120

TGCACACAAT ACGGATTTGT TGACCAAAAA TCGATTGAGT TACCTCATCG AGGCAAGTAT 6180

GTGAGCAAGG TTCGAGATTC TGTGTGGTCT TGCGACGAAT GTGGACAGGT TACTGTATAT 6240

GGAATATCTC TACATGAAAC CGGGCACTTG CAGTTGCCAT CACTTAATGG AACTTTGATT 6300

TGTGCACCTG AACTGATAAG CAACGACGTG CTTATACTAA TTTCTGATAA ACAAATTGTG 6360

CTTTTGAAGC TTTCCGAATC AAATTCCGTA TCCCATCTTG GAACAATCGA TTCACCGTAT 6420

GAAATTCGGA CAGCCACATT CCTGGGCAAT GGTTCAACCC GTCAAATATG GGCGGGACAT 6480

TCAGAAGGAC GAATTTCAAT TCATCATATA GCTTCGAACG ATTCTTTCAG CTTCTCGTCA 6540

AGTCTTTATC TTCCAGATGA TAAGTGTATT GTCAGACAGT TAGTTGGCTC GAAAGATGCA 6600

CAAAAAGTGT GGATCGCATT AGAGAAAAGC TCGAAAGTTC AAATGGTTGA AGTGGAAAAA 6660

CGACAAGTGA CTGGATCACT GGATATTCGA AAAGTGATGC CTGGAAGTGA AACAATTCAT 6720

ACAATTGATA TGGAAATGGC CAGTCAGAAT TATGTTACAT GTATTGGTTT ATTGGAAAGA 6780

AATGACGGAG ATCAACTGTA CATTGGAACT TCCAAAGGGC TGCTAGTCAT AGCTCACGCT 6840

ACTACACTTC AACCATTGTC AGCATGCCGT CCATTTGAAG GAGACATCAC ATCAATTTGT 6900

ATATTGGAAG AACCATCCCG TGAAGAAGAA AATACACGTG GAAAGGCTAC CACATTGAGC 6960

ACAGCTTCAT CAGAAAGTGG TCTTGGATGG GTACGGGAAA GAGTCAGCGA AACTGTTGAT 7020

AGATTCCGCT CGAGCCCAGC TACAGTAGAA ACTCAGGGAG CCGCTCTTGT TGTGTGCATT 7080

GGACGACAAT TCAGAAGCCT TTCACATCGT TTCGTGGCTG AGGAGAAGCT TGCCGACGTC 7140

TATTCCATTG CTGTCTGGAG GACCGAGGAA TGGGCTCTGT GA 7182

Domain Profile

S: 2     kkgsllGrGafGsvyraavk......................Geevavkafkiaadklkr  39

         k++++lGrGafG+v+ra+v+                      G+++a++a+k+aadk+kr

Q: 1695  KRSRMLGRGAFGFVFRATVRqpngelcevaqkmlepvdpgpgGRPSALAAYKAAADKWKR  1754

         789*********************************************************

S: 40    dslelalkayselrqelsvLlalkhPsivsLvgisikPlalvleLaplgsLdrlLsedkk  99

         ds+e+a++ay+++rqels+L+++khP++++Lvg++++Pl+lv+eLaplg+L++lL +++k

Q: 1755  DSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRK  1814

         ************************************************************

S: 100   sssklgrtltkkialqvargleyLhkkkiiyrdLksenvLvwsl....spkeailiklad  155

         +++kl+  ++k++a+qvar+leyLh+++iiyrdLksenvL w++    sp++++l+kl+d

Q: 1815  AGTKLSLGVIKESAVQVARALEYLHSAHIIYRDLKSENVLGWRFpapfSPQTDVLLKLGD  1874

         ********************************************9999************

S: 156   yGisrqslrs.GakgveGteGfraPeivr..gevvydekvdvfsfGlllyellsgkrpve  212

         yGisr++l+s Gakg++GteGf+aPeivr  ge++y++kvd+fsfG++lyell++k+p+e

Q: 1875  YGISRSVLPSgGAKGFGGTEGFMAPEIVRfnGEEEYTQKVDCFSFGMFLYELLTLKFPFE  1934

         **********99************************************************

S: 213   geeqlkivekllkGkrPvlvkeeevlptplldLlveCwkekPekrPtasqvvsi  266

         +ee++k  e++l+G+rPvl+++e +lptp+ldLlv+Cw+++Pe+rP++sq+v++

Q: 1935  SEEHVK--ERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLVGF  1986

         ******..*******************************************986

Domain Sequence
(FASTA)

KRSRMLGRGA FGFVFRATVR QPNGELCEVA QKMLEPVDPG PGGRPSALAA YKAAADKWKR 60

DSMEFACRAY CTSRQELSLL SRMKHPNVIG LVGVCTFPLS LVVELAPLGA LNQLLGSHRK 120

AGTKLSLGVI KESAVQVARA LEYLHSAHII YRDLKSENVL GWRFPAPFSP QTDVLLKLGD 180

YGISRSVLPS GGAKGFGGTE GFMAPEIVRF NGEEEYTQKV DCFSFGMFLY ELLTLKFPFE 240

SEEHVKERML DGARPVLLPH ELLLPTPMLD LLVHCWSAHP ESRPSSSQLV GF 292

Keyword

ANK repeat; ATP-binding; Complete proteome; Golgi apparatus; GTP-binding; Kinase; Leucine-rich repeat; Magnesium; Manganese; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Stress response; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0043025	; C:neuronal cell body
GO:0005524	; F:ATP binding
GO:0005525	; F:GTP binding
GO:0046872	; F:metal ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0048846	; P:axon extension involved in axon guidance
GO:0034613	; P:cellular protein localization
GO:0034976	; P:response to endoplasmic reticulum stress
GO:0006979	; P:response to oxidative stress
GO:0007264	; P:small GTPase mediated signal transduction
GO:0048489	; P:synaptic vesicle transport

KEGG

cel:CELE_T27C10.6

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR011009	; Kinase-like_dom.
IPR001611	; Leu-rich_rpt.
IPR003591	; Leu-rich_rpt_typical-subtyp.
IPR013684	; MIRO-like.
IPR000719	; Prot_kinase_cat_dom.
IPR020859	; ROC_GTPase.
IPR017986	; WD40_repeat_dom.

Pfam

PF00023	; Ank; 1.
PF12796	; Ank_2; 2.
PF08477	; Miro; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00248	; ANK; 8.
SM00369	; LRR_TYP; 1.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS51450	; LRR; 10.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; FALSE_NEG.
PS51424	; ROC; 1.

Prints

PR01415

; ANKYRIN.

Created Date

20-Feb-2013