EKS-CAE-00360

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00360

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	503.9	1.6E-151	125	382	258

Status

Reviewed

Ensembl Protein

W10G6.2a

UniProt Accession

Q2PJ68; Q2PJ69;

Protein Name

Serine/threonine-protein kinase sgk-1

Protein Synonyms/Alias

Serum- and glucocorticoid-inducible kinase homolog; Serum/glucocorticoid-regulated kinase 1;

Gene Name

sgk-1

Gene Synonyms/Alias

sgk-1; W10G6.2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
W10G6.2	W10G6.2b	W10G6.2b
W10G6.2	W10G6.2a	W10G6.2a

Organism

Caenorhabditis elegans

Functional Description

Acts downstream of age-1 and pdk-1 in the daf-2/insulinreceptor-like transduction pathway. Essential role in regulating development, stress response, and longevity. Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function. Acts downstream of rict-1 to regulate fat storage, size, and development. Does not appear to play a role in immune function.

Protein Length

453

Protein Sequence
(FASTA)

MVRKDEVTCN VIIGDDKKTV VYALRIGNGP IMQKTFEEYE RFFTTEKDMI PATIFTAPKK 60

KFLQADSKFY EKRRVWILVI SQHLVDNNLR SEDVRRFFHL ESPDDDENNV DLGPSERKTA 120

TANDFDYLTT IGKGSFGRVY QVRHKETKKI YAMKILSKEH IRKKNEVKHV MAERNVLINN 180

FKHPFLVSLH FSFQNKEKLY FVLDHLNGGE LFSHLQREKH FSESRSRFYA AEIACALGYL 240

HEKNIIYRDL KPENLLLDDK GYLVLTDFGL CKEDMQGSKT TSTFCGTPEY LAPEIILKKP 300

YDKTVDWWCL GSVLYEMIFG LPPFYSKDHN EMYDKIINQP LRLKHNISVP CSELITGLLQ 360

KDRSKRLGHR NDFRDIRDHP FFLPVDWDKL LNRELKAPFI PKVKNAMDTS NISKEFVEIQ 420

IDPSSLAPQQ LAVTHRDHDF ENFTFVDTNR VLV 453

Nucleotide Sequence
(FASTA)

ATGGTGAGGA AAGATGAGGT GACATGCAAT GTTATTATAG GAGATGATAA GAAAACTGTG 60

GTTTACGCGC TCCGTATCGG AAATGGCCCA ATTATGCAAA AAACGTTTGA AGAATATGAA 120

AGATTTTTTA CAACTGAAAA GGATATGATC CCGGCTACAA TTTTCACTGC GCCGAAAAAG 180

AAGTTCCTGC AAGCTGACAG CAAGTTCTAC GAGAAAAGAC GTGTTTGGAT CCTTGTGATT 240

AGTCAGCATC TTGTTGATAA TAATTTAAGA AGTGAGGATG TCCGTCGGTT CTTCCATCTC 300

GAAAGTCCGG ATGATGATGA GAATAATGTT GATCTCGGAC CAAGTGAGAG GAAAACAGCC 360

ACCGCCAATG ATTTCGATTA TCTGACAACT ATCGGAAAAG GAAGCTTTGG AAGAGTTTAC 420

CAAGTCAGGC ACAAGGAGAC CAAAAAAATC TACGCCATGA AAATTCTGTC CAAGGAACAT 480

ATCAGAAAAA AGAACGAGGT GAAACACGTC ATGGCAGAAA GAAATGTGCT CATTAACAAC 540

TTTAAGCACC CTTTCCTTGT TTCACTTCAC TTTTCGTTCC AAAATAAGGA GAAGCTGTAT 600

TTTGTGCTCG ATCACTTGAA CGGAGGAGAG CTTTTCTCTC ACCTCCAACG CGAGAAACAT 660

TTTTCCGAGT CGAGAAGTCG TTTTTACGCG GCCGAGATTG CATGTGCTCT GGGTTATCTT 720

CACGAGAAAA ACATTATCTA CAGAGATTTG AAGCCTGAAA ACCTTCTGTT GGACGATAAA 780

GGTTACTTGG TGCTCACCGA CTTTGGGCTC TGTAAAGAAG ATATGCAAGG AAGCAAGACA 840

ACTTCCACAT TTTGTGGGAC GCCGGAGTAC TTGGCCCCGG AAATTATTCT GAAAAAGCCT 900

TACGACAAGA CTGTTGACTG GTGGTGTTTG GGATCGGTTC TCTATGAAAT GATTTTTGGA 960

TTGCCTCCAT TCTACTCAAA AGATCATAAC GAGATGTACG ACAAGATCAT CAACCAGCCA 1020

CTTCGTCTCA AGCACAACAT CTCTGTGCCA TGCAGTGAGC TCATCACCGG GCTCTTGCAA 1080

AAAGACCGTT CAAAGCGTCT GGGCCATCGC AATGATTTCC GTGACATTCG TGATCATCCA 1140

TTCTTCCTTC CGGTTGATTG GGATAAGCTT CTGAATCGTG AGCTTAAGGC TCCGTTCATT 1200

CCGAAAGTGA AAAACGCAAT GGATACATCC AATATTTCAA AGGAGTTCGT GGAGATTCAA 1260

ATTGATCCAT CTTCGTTGGC ACCGCAACAA CTTGCTGTCA CTCATCGAGA TCACGATTTT 1320

GAGAACTTTA CATTCGTCGA CACCAATCGC GTTTTGGTCT GA 1362

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         fd+l++igkgsfg+v+++++k+++k+ya+k+l+k++i+kk+e kh+maernvl++n+khp

Q: 125   FDYLTTIGKGSFGRVYQVRHKETKKIYAMKILSKEHIRKKNEVKHVMAERNVLINNFKHP  184

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flv+lh+sfq++eklyfvld++nggelf+hlqre++f+e+r+rfyaaeia+algylh++n

Q: 185   FLVSLHFSFQNKEKLYFVLDHLNGGELFSHLQREKHFSESRSRFYAAEIACALGYLHEKN  244

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         i+yrdlkpen+lld+kg++vltdfglcke+++ ++ttstfcgtpeylape++ kkpyd+t

Q: 245   IIYRDLKPENLLLDDKGYLVLTDFGLCKEDMQGSKTTSTFCGTPEYLAPEIILKKPYDKT  304

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclg+vlyem++glppfys+d++emyd+i+n+pl+lk++isv+++el+++ll+kdr+

Q: 305   VDWWCLGSVLYEMIFGLPPFYSKDHNEMYDKIINQPLRLKHNISVPCSELITGLLQKDRS  364

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlg+++df++i++h+ff

Q: 365   KRLGHRNDFRDIRDHPFF  382

         *****************9

Domain Sequence
(FASTA)

FDYLTTIGKG SFGRVYQVRH KETKKIYAMK ILSKEHIRKK NEVKHVMAER NVLINNFKHP 60

FLVSLHFSFQ NKEKLYFVLD HLNGGELFSH LQREKHFSES RSRFYAAEIA CALGYLHEKN 120

IIYRDLKPEN LLLDDKGYLV LTDFGLCKED MQGSKTTSTF CGTPEYLAPE IILKKPYDKT 180

VDWWCLGSVL YEMIFGLPPF YSKDHNEMYD KIINQPLRLK HNISVPCSEL ITGLLQKDRS 240

KRLGHRNDFR DIRDHPFF 258

Keyword

Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Developmental protein; Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication
GO:0043053	; P:dauer entry
GO:0008340	; P:determination of adult lifespan
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0018991	; P:oviposition
GO:0006950	; P:response to stress

KEGG

cel:CELE_W10G6.2

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013