EKS-CAE-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/GSK	441.5	2.0E-132	38	320	283

Status

Reviewed

Ensembl Protein

Y18D10A.5.1

UniProt Accession

Q9U2Q9; Q9Y0C2;

Protein Name

Glycogen synthase kinase-3

Protein Synonyms/Alias

Gene Name

gsk-3

Gene Synonyms/Alias

gsk-3; sgg-1; Y18D10A.5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
Y18D10A.5	Y18D10A.5.2	Y18D10A.5.2
Y18D10A.5	Y18D10A.5.1	Y18D10A.5.1

Organism

Caenorhabditis elegans

Functional Description

Phosphorylates oma-1, a regulator of the oocyte-to-embryo transition, enabling its degradation. Phosphorylates skn-1, preventing it from accumulating in nuclei and thus inhibiting phase II gene expression in the oxidative stress defense. Involved in mesendoderm specification and mitotic spindle orientation in EMS blastomeres. Thought to be a branch point in these processes as proteins downstream are not required. Negatively regulates Wnt signaling in vulval precursor cells and acts as a Wnt-independent repressor of med-1 and med-2 in the C lineage inhibiting mesoderm development. Required for normal lifespan and LiCl-induced lifespan extension.

Protein Length

362

Protein Sequence
(FASTA)

MNKQLLSCSL KSGKQVTMVV ASVATDGVDQ QVEISYYDQK VIGNGSFGVV FLAKLSTTNE 60

MVAIKKVLQD KRFKNRELQI MRKLNHPNIV KLKYFFYSSG EKKDELYLNL ILEYVPETVY 120

RVARHYSKQR QQIPMIYVKL YMYQLLRSLA YIHSIGICHR DIKPQNLLID PESGVLKLCD 180

FGSAKYLVRN EPNVSYICSR YYRAPELIFG ATNYTNSIDV WSAGTVMAEL LLGQPIFPGD 240

SGVDQLVEII KVLGTPTREQ IQSMNPNYKE FKFPQIKAHP WNKVFRVHTP AEAIDLISKI 300

IEYTPTSRPT PQAACQHAFF DELRNPDARL PSGRPLPTLE MDGPMGTGEV STTSGDVAGP 360

SA 362

Nucleotide Sequence
(FASTA)

ATGAATAAGC AGTTACTATC GTGCTCGCTG AAAAGCGGAA AACAAGTGAC GATGGTCGTC 60

GCGTCAGTCG CCACGGATGG TGTTGATCAG CAGGTTGAAA TCTCGTACTA CGATCAGAAA 120

GTGATTGGAA ATGGATCATT CGGAGTGGTA TTCCTTGCCA AACTCTCTAC AACAAATGAA 180

ATGGTTGCAA TCAAGAAAGT TCTTCAGGAC AAACGATTCA AGAATCGTGA ACTACAGATT 240

ATGCGAAAAT TGAATCATCC AAATATCGTG AAGCTCAAAT ACTTTTTCTA TTCGAGCGGC 300

GAGAAGAAGG ATGAACTCTA CTTGAATTTG ATTCTCGAAT ATGTTCCTGA AACTGTCTAC 360

AGAGTTGCCC GGCACTATTC GAAGCAGCGA CAACAAATTC CAATGATTTA TGTCAAATTG 420

TACATGTATC AGCTTCTCCG TTCATTGGCC TACATTCATA GCATTGGAAT CTGTCACCGT 480

GACATTAAGC CTCAGAATTT GCTCATTGAC CCGGAAAGCG GAGTGCTTAA GCTCTGTGAT 540

TTTGGATCTG CCAAATATTT GGTTCGCAAT GAGCCAAACG TCTCGTACAT TTGCTCGCGA 600

TATTATCGTG CTCCGGAGCT CATTTTCGGC GCTACAAACT ACACGAACTC GATTGACGTT 660

TGGTCGGCTG GAACTGTAAT GGCAGAGCTT CTTCTCGGCC AACCAATTTT CCCTGGTGAC 720

TCTGGAGTTG ATCAACTCGT TGAAATTATT AAAGTTCTTG GAACACCGAC TCGTGAACAA 780

ATTCAAAGTA TGAATCCGAA CTACAAGGAA TTCAAATTTC CACAGATAAA GGCACATCCA 840

TGGAATAAGG TATTCCGTGT ACACACGCCT GCTGAAGCGA TTGATCTCAT TTCGAAGATT 900

ATCGAGTATA CGCCGACGTC TCGGCCAACA CCTCAAGCGG CCTGCCAGCA CGCATTCTTT 960

GATGAGCTCC GAAACCCGGA TGCACGTCTT CCATCTGGTC GACCTCTTCC AACACTTGAG 1020

ATGGACGGTC CAATGGGAAC TGGTGAAGTT TCAACGACAA GCGGTGATGT GGCTGGCCCA 1080

TCGGCTTAA 1089

Domain Profile

S: 3     elkligsGsFgnVyqavlseesekevaiKkvlqdkklknlEleilrklkHknivrLlyff  62

         ++k+ig+GsFg+V+ a+ls+++e+ vaiKkvlqdk++kn+El+i+rkl+H+niv+L+yff

Q: 38    DQKVIGNGSFGVVFLAKLSTTNEM-VAIKKVLQDKRFKNRELQIMRKLNHPNIVKLKYFF  96

         789*********************.***********************************

S: 63    sksaekkdkvylnlvleylPetlakvlrelkdkkkkldvlevklytyQlfrglaylhsle  122

         ++s ekkd++ylnl+ley+Pet+++v+r+++++++++++++vkly+yQl+r+lay+hs +

Q: 97    YSSGEKKDELYLNLILEYVPETVYRVARHYSKQRQQIPMIYVKLYMYQLLRSLAYIHSIG  156

         ************************************************************

S: 123   ivHrDiKPqNllvdeetgvlKlcDfGsakrleknepnvsYivsRyYRaPELllgakeytt  182

         i+HrDiKPqNll+d+e+gvlKlcDfGsak l++nepnvsYi+sRyYRaPEL++ga++yt+

Q: 157   ICHRDIKPQNLLIDPESGVLKLCDFGSAKYLVRNEPNVSYICSRYYRAPELIFGATNYTN  216

         ************************************************************

S: 183   kiDvWsagcvlaEllkgkvlfkgksakdqlelivkvlGtptkedikemnvkykekkfkki  242

         +iDvWsag+v+aEll+g+++f+g+s++dql++i+kvlGtpt+e+i++mn++yke+kf++i

Q: 217   SIDVWSAGTVMAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIQSMNPNYKEFKFPQI  276

         ************************************************************

S: 243   kkvslakvlkkkedkeavdllkkilkyepkkRlsalellahpff  286

         k+++++kv++ ++++ea+dl++ki++y+p++R +++ +++h ff

Q: 277   KAHPWNKVFRVHTPAEAIDLISKIIEYTPTSRPTPQAACQHAFF  320

         *******************************************9

Domain Sequence
(FASTA)

DQKVIGNGSF GVVFLAKLST TNEMVAIKKV LQDKRFKNRE LQIMRKLNHP NIVKLKYFFY 60

SSGEKKDELY LNLILEYVPE TVYRVARHYS KQRQQIPMIY VKLYMYQLLR SLAYIHSIGI 120

CHRDIKPQNL LIDPESGVLK LCDFGSAKYL VRNEPNVSYI CSRYYRAPEL IFGATNYTNS 180

IDVWSAGTVM AELLLGQPIF PGDSGVDQLV EIIKVLGTPT REQIQSMNPN YKEFKFPQIK 240

AHPWNKVFRV HTPAEAIDLI SKIIEYTPTS RPTPQAACQH AFF 283

Keyword

ATP-binding; Complete proteome; Developmental protein; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Stress response; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0050321	; F:tau-protein kinase activity
GO:0009792	; P:embryo development ending in birth or egg hatching
GO:0043652	; P:engulfment of apoptotic cell
GO:0010467	; P:gene expression
GO:0007281	; P:germ cell development
GO:0035188	; P:hatching
GO:0040011	; P:locomotion
GO:0007052	; P:mitotic spindle organization
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0002119	; P:nematode larval development
GO:0040010	; P:positive regulation of growth rate
GO:0006898	; P:receptor-mediated endocytosis
GO:0006950	; P:response to stress
GO:0060069	; P:Wnt receptor signaling pathway, regulating spindle positioning

KEGG

cel:CELE_Y18D10A.5

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013