EPS-CAE-00018

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-CAE-00018

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	495.5	7.7E-149	184	494	311

Status

Unreviewed

Ensembl Protein

Y39B6A.2a.1

UniProt Accession

Q9NES8;

Protein Name

Protein Synonyms/Alias

Protein PPH-5, isoform a;

Gene Name

pph-5

Gene Synonyms/Alias

pph-5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
Y39B6A.2	Y39B6A.2b	Y39B6A.2b
Y39B6A.2	Y39B6A.2a.1	Y39B6A.2a.1
Y39B6A.2	Y39B6A.2a.2	Y39B6A.2a.2

Organism

Caenorhabditis elegans

Functional Description

Protein Length

496

Protein Sequence
(FASTA)

MAATITDDIV ATVLESIEEK SYEDEKEKAG MIKDEANQFF KDQVYDVAAD LYSVAIEIHP 60

TAVLYGNRAQ AYLKKELYGS ALEDADNAIA IDPSYVKGFY RRATANMALG RFKKALTDYQ 120

AVVKVCPNDK DARAKFDECS KIVRRQKFEA AISTDHDKKT VAETLDINAM AIEDSYDGPR 180

LEDKITKEFV LQLIKTFKNQ QKLHKKYAFK MLLEFYNYVK SLPTMVEITV PTGKKFTICG 240

DVHGQFYDLC NIFEINGYPS ETNPYLFNGD FVDRGSFSVE TIFTMIGFKL LYPNHFFMSR 300

GNHESDVMNK MYGFEGEVKA KYTQQMCDMF TETFCWLPLC HLINEKIFVC HGGLFKEDGV 360

TLEDIRKTDR NRQPPDEGIM CDLLWSDPQP INGRSPSKRG VGCQFGPDVT SKWCETNGIE 420

YVVRSHEVKP EGYEMHHNGQ CFTVFSAPNY CDQMNNKGAF ITITGDNLTP RFTPFDAVPH 480

PKLPPMAYAN SLFGFN 496

Nucleotide Sequence
(FASTA)

ATGGCTGCCA CTATAACAGA TGACATTGTG GCGACAGTTT TGGAGTCAAT TGAGGAAAAG 60

TCGTACGAAG ATGAGAAGGA GAAGGCTGGA ATGATTAAAG ATGAAGCTAA TCAGTTTTTT 120

AAGGATCAAG TGTACGACGT GGCCGCCGAC CTCTACTCTG TCGCAATTGA GATTCATCCG 180

ACGGCGGTTC TTTACGGAAA CCGTGCACAG GCCTATCTGA AGAAAGAGCT CTACGGAAGT 240

GCTCTTGAGG ATGCGGACAA CGCGATTGCA ATTGATCCGT CATATGTGAA GGGATTCTAT 300

AGAAGAGCTA CCGCCAATAT GGCTCTGGGG CGGTTTAAAA AGGCGTTGAC CGATTATCAG 360

GCGGTTGTTA AGGTTTGCCC CAACGACAAA GACGCTCGCG CAAAATTCGA CGAATGCTCG 420

AAAATCGTCC GCCGACAGAA GTTTGAAGCC GCAATTTCGA CGGATCACGA CAAGAAAACC 480

GTCGCCGAGA CTCTTGATAT TAATGCAATG GCTATTGAGG ATTCGTATGA TGGTCCACGG 540

CTGGAAGATA AAATAACCAA GGAATTCGTG TTGCAACTCA TCAAAACGTT CAAAAATCAG 600

CAAAAATTGC ACAAAAAGTA CGCGTTCAAG ATGCTCCTCG AGTTTTATAA TTATGTCAAA 660

TCACTGCCAA CAATGGTTGA AATTACGGTG CCAACTGGCA AGAAATTCAC GATTTGCGGT 720

GATGTTCACG GACAATTCTA CGATTTGTGC AATATTTTCG AGATTAATGG ATATCCATCG 780

GAGACTAATC CATATCTTTT CAACGGTGAT TTCGTGGATC GTGGCTCATT TTCCGTTGAA 840

ACAATTTTCA CAATGATTGG CTTCAAACTT CTATACCCAA ATCATTTCTT TATGTCACGT 900

GGAAATCACG AATCTGACGT CATGAATAAA ATGTACGGAT TTGAGGGTGA AGTTAAGGCG 960

AAATATACTC AACAAATGTG TGATATGTTT ACGGAGACGT TCTGCTGGTT ACCATTGTGC 1020

CATTTGATTA ATGAGAAGAT TTTTGTGTGC CATGGTGGAT TATTCAAAGA AGACGGTGTA 1080

ACACTGGAAG ATATTCGAAA AACTGACAGA AATCGTCAGC CACCAGATGA GGGTATCATG 1140

TGTGATCTAC TTTGGTCAGA TCCTCAACCA ATCAACGGCC GGAGCCCGTC AAAACGTGGT 1200

GTCGGCTGTC AATTTGGACC AGATGTGACG TCAAAATGGT GTGAAACGAA TGGAATTGAA 1260

TATGTAGTGA GATCACATGA AGTGAAGCCA GAAGGATATG AAATGCACCA TAATGGACAA 1320

TGTTTTACCG TTTTCTCGGC ACCAAATTAT TGTGATCAAA TGAATAATAA GGGAGCTTTT 1380

ATCACGATTA CTGGCGATAA TTTGACGCCC CGATTCACGC CATTCGACGC GGTTCCACAT 1440

CCGAAATTGC CTCCAATGGC CTACGCGAAC AGTCTTTTCG GATTTAATTA G 1491

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         k+++ef+ +l++ +k+++kl++k a+++l++  + +  l +++e ++   +k+t+cGd+h

Q: 184   KITKEFVLQLIKTFKNQQKLHKKYAFKMLLEFYNYVKSLPTMVEITVPTGKKFTICGDVH  243

         789*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gqfydl nife+nG pse+npylfnGdfvdrGsfsve i+t+ g+kllyP+hff+ rGnh

Q: 244   GQFYDLCNIFEINGYPSETNPYLFNGDFVDRGSFSVETIFTMIGFKLLYPNHFFMSRGNH  303

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         esd mnk+yGfegevkakyt+++ ++f+e+f+wlPl++lin+k++v hGGlf edgvtl+

Q: 304   ESDVMNKMYGFEGEVKAKYTQQMCDMFTETFCWLPLCHLINEKIFVCHGGLFKEDGVTLE  363

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirk +rn+qPP+eG +c+llWsdPq+ nGr++skrGvg+qfGpdvt +++e n ++y++

Q: 364   DIRKTDRNRQPPDEGIMCDLLWSDPQPINGRSPSKRGVGCQFGPDVTSKWCETNGIEYVV  423

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevk eg+e++++g+++tvfsapnycd++ n++++i + +d+l + +  f+av+hp++

Q: 424   RSHEVKPEGYEMHHNGQCFTVFSAPNYCDQMNNKGAFITITGDNLTPRFTPFDAVPHPKL  483

         ************************************************************

S: 302   kpmaysngllg  312

          pmay+n+l+g

Q: 484   PPMAYANSLFG  494

         ********997

Domain Sequence
(FASTA)

KITKEFVLQL IKTFKNQQKL HKKYAFKMLL EFYNYVKSLP TMVEITVPTG KKFTICGDVH 60

GQFYDLCNIF EINGYPSETN PYLFNGDFVD RGSFSVETIF TMIGFKLLYP NHFFMSRGNH 120

ESDVMNKMYG FEGEVKAKYT QQMCDMFTET FCWLPLCHLI NEKIFVCHGG LFKEDGVTLE 180

DIRKTDRNRQ PPDEGIMCDL LWSDPQPING RSPSKRGVGC QFGPDVTSKW CETNGIEYVV 240

RSHEVKPEGY EMHHNGQCFT VFSAPNYCDQ MNNKGAFITI TGDNLTPRFT PFDAVPHPKL 300

PPMAYANSLF G 311

Keyword

Complete proteome; Iron; Metal-binding; Reference proteome; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0072686	; C:mitotic spindle
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0045920	; P:negative regulation of exocytosis
GO:0006470	; P:protein dephosphorylation
GO:0033365	; P:protein localization to organelle

KEGG

cel:CELE_Y39B6A.2

;

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156

; PP2Ac; 1.

Prosites

PS50005	; TPR; 2.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013