EKS-CAE-00048

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-CAE-00048

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	353.4	1.2E-105	5	289	285

Status

Unreviewed

Ensembl Protein

Y39G10AL.3.1

UniProt Accession

G5EFV5;

Protein Name

Protein Synonyms/Alias

Cyclin-dependent kinase 7 homolog; Protein CDK-7;

Gene Name

cdk-7

Gene Synonyms/Alias

cdk-7; CELE_Y39G10AL.3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
Y39G10AL.3	Y39G10AL.3.2	Y39G10AL.3.2
Y39G10AL.3	Y39G10AL.3.1	Y39G10AL.3.1

Organism

Caenorhabditis elegans

Functional Description

Protein Length

330

Protein Sequence
(FASTA)

MSRRYDTIKH LGEGQFANVY LAQDLESGEC VAIKKIKLGS REEAKDGINR TAIREIKLLK 60

EIHHDNIIGL RDVIGHRTSI QLVFDFMDTD LEHVIKDKEI ILMPAHIKNI TMQMLLGLEF 120

LHVHWILHRD LKPNNLLMNK MGRVKLTDFG LARFFGSPNR NYTHQVVTRW YRAPELLFGA 180

RSYGVGIDIW SVGCIIAELL LRNPIFPGES DIDQLVKIFN ILGCPTPETW PNMTEMNSYV 240

IIKPQTEYMA LNYYFSAAPQ DLLDLMAGMW TFDPIKRLTC TQSLQMEYFR TQPFCCLDEE 300

LPLPKKQQPQ KRSRRLDDDG TRPVRRLNFD 330

Nucleotide Sequence
(FASTA)

ATGAGTAGAC GTTACGATAC AATAAAGCAT CTTGGAGAAG GACAATTCGC CAACGTTTAT 60

CTCGCACAAG ACCTCGAATC GGGCGAATGT GTGGCTATTA AAAAAATCAA ACTAGGATCG 120

AGAGAAGAAG CAAAAGATGG AATCAATCGA ACGGCGATTC GAGAGATTAA ACTTTTGAAG 180

GAAATTCATC ATGACAATAT TATCGGGTTA CGAGATGTGA TTGGACATCG AACAAGTATT 240

CAACTGGTTT TCGACTTTAT GGATACAGAT CTCGAACATG TGATTAAGGA TAAAGAAATT 300

ATTCTAATGC CAGCACATAT CAAAAATATT ACGATGCAAA TGCTTCTGGG ACTCGAATTT 360

CTACACGTTC ACTGGATTCT TCACAGAGAT CTGAAGCCAA ATAACCTGCT GATGAACAAA 420

ATGGGACGCG TGAAGCTCAC CGATTTCGGT TTGGCTCGAT TCTTCGGATC TCCAAACAGA 480

AATTACACTC ATCAGGTTGT GACAAGATGG TATCGAGCCC CTGAGTTGCT CTTTGGAGCA 540

CGTTCCTATG GAGTTGGAAT TGATATTTGG TCGGTTGGAT GTATCATTGC CGAATTGTTG 600

TTGAGAAATC CAATATTCCC TGGTGAAAGT GACATTGATC AACTCGTGAA AATCTTCAAT 660

ATTCTCGGAT GTCCAACACC AGAAACATGG CCAAATATGA CTGAAATGAA CAGTTATGTC 720

ATTATTAAAC CACAGACGGA GTATATGGCT CTAAATTACT ATTTCTCGGC TGCTCCGCAA 780

GATTTGCTCG ATTTGATGGC GGGAATGTGG ACATTTGACC CAATAAAACG TCTGACTTGT 840

ACTCAATCTC TTCAAATGGA ATATTTCCGA ACTCAACCAT TCTGCTGCCT TGACGAAGAG 900

CTTCCACTTC CGAAAAAACA ACAGCCACAG AAGAGATCTC GACGGCTTGA CGACGATGGA 960

ACTCGCCCCG TTCGACGATT GAATTTTGAT TAA 993

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         y++++++geG++++vy a+d e+ge+vA+Kki+l +++e   g++ ta+rEi+llke++h

Q: 5     YDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEakdGINRTAIREIKLLKEIHH  64

         8999******************************77664444******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ L +v+  +++++ Lvf+f+++dL++++k+k++  l ++++k++++q+l gl++lH

Q: 65    DNIIGLRDVIG-HRTSIQLVFDFMDTDLEHVIKDKEI-ILMPAHIKNITMQMLLGLEFLH  122

         ***********.99***********************.999*******************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

          ++ilHRDlKp+NlL++k g++kl+DfGlar f+sp+++yt++vvT+wYraPelL+ga++

Q: 123   VHWILHRDLKPNNLLMNKMGRVKLTDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARS  182

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  +DiWsvgci+aell r+p+f+g+s+idql +if++lg p+ ++wp+++++++y

Q: 183   YGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVII  242

         **********************************************************88

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

          p++++  l+ +++++ ++ ldl+  + ++dp kR+++++ lq +yf

Q: 243   KPQTEYMALNYYFSAAPQDLLDLMAGMWTFDPIKRLTCTQSLQMEYF  289

         8888888******999999***************************8

Domain Sequence
(FASTA)

YDTIKHLGEG QFANVYLAQD LESGECVAIK KIKLGSREEA KDGINRTAIR EIKLLKEIHH 60

DNIIGLRDVI GHRTSIQLVF DFMDTDLEHV IKDKEIILMP AHIKNITMQM LLGLEFLHVH 120

WILHRDLKPN NLLMNKMGRV KLTDFGLARF FGSPNRNYTH QVVTRWYRAP ELLFGARSYG 180

VGIDIWSVGC IIAELLLRNP IFPGESDIDQ LVKIFNILGC PTPETWPNMT EMNSYVIIKP 240

QTEYMALNYY FSAAPQDLLD LMAGMWTFDP IKRLTCTQSL QMEYF 285

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

cel:CELE_Y39G10AL.3

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013