EKS-CAE-00085
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-CAE-00085
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Atypical/PIKK183.21.2E-53318588271
StatusReviewed
Ensembl ProteinY48G1BL.2
UniProt AccessionQ9N3Q4;
Protein NameSerine/threonine-protein kinase ATM
Protein Synonyms/Alias
Gene Nameatm-1
Gene Synonyms/Alias atm-1; Y48G1BL.2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
Y48G1BL.2Y48G1BL.2Y48G1BL.2
OrganismCaenorhabditis elegans
Functional DescriptionSerine/threonine protein kinase which activatescheckpoint signaling in the presence of DNA double strand breaks (DSBs) and other forms of DNA damage induced by ionizing radiation and other genotoxic stresses such as UV.
Protein Length649
Protein Sequence
(FASTA)
MKHYKKIIHQ VLLKLHSVCI GQLSKLEEYR ETRTYRMKQQ AVTAFEQQIQ NSCRTSLARG 60
NSGDEWTKKT VQRVRKEHQF EKNDLEKVDN SLNSAARKAV SSGFDALLCI SQLEDDDEAI 120
RASSLIIFPL IDVIYKYETD VGVIALLKEH TKSKLPSKLW ISATSHIASK CFSIEKSQIT 180
RHLSQILCHL IYDYPYHVLH TILMYDDEKN ASKVKGFLKT IFDARADQRD SSKLKEIVIT 240
IREAHQAYRE IAMLDVRGNV RIQRVEINGK TMYRWPHDLK IFKCKLRQLP IPTISQKIGC 300
PGDYSTTDLI TWKRWKDVFT IADGISTPKI WEIEGSDGKW YKTVWKKDDV RQDVLVEQMF 360
DVTNNMLEKA MLRTYNVVPL DTECGVIEFC GGTVSLKEVM CGVTREGGLH REFNSEEVSA 420
SKVSSMMRQV QTESTETRRQ VFVEICQQYS PVFRHFFYTN FSTAQIWRQK IINYRQSLAT 480
WSIVCYIVGL GDRHASNILF DQKLCTFVHI DLGMILEYSK RTLPVPEQVP FRITRDVLDP 540
ILIEGIENGQ LAEECTQIME KLKENGKVIL GVASALLRET MTNFREAEQA AGRPSYISEM 600
AIGRLREKLR GTDDGVTAQS SNLQIRRLLR EATSADNLSR MFCGWMPFL 649
Nucleotide Sequence
(FASTA)
ATGAAACATT ACAAAAAAAT TATTCATCAG GTTCTCCTAA AACTCCATTC CGTCTGTATT 60
GGCCAACTGT CGAAACTCGA AGAATATCGC GAAACGCGTA CCTACCGTAT GAAGCAGCAG 120
GCGGTCACCG CATTCGAACA ACAAATTCAA AATTCGTGTC GAACCAGTCT GGCACGTGGC 180
AATTCGGGTG ACGAATGGAC GAAAAAAACG GTGCAACGGG TGAGAAAAGA GCATCAGTTT 240
GAGAAGAATG ATTTGGAAAA AGTGGATAAT TCGTTGAATT CGGCGGCCCG GAAAGCTGTA 300
TCGTCGGGTT TTGATGCACT TTTATGCATC AGCCAACTGG AAGACGACGA CGAAGCGATC 360
CGCGCTTCAT CTCTCATAAT ATTTCCATTA ATCGATGTGA TCTACAAATA CGAAACGGAC 420
GTCGGAGTGA TCGCCTTGCT CAAAGAGCAC ACCAAATCGA AGCTCCCGTC GAAGCTGTGG 480
ATAAGTGCCA CCTCACACAT TGCCTCTAAG TGCTTCTCCA TCGAAAAATC GCAAATCACG 540
AGACACTTAT CACAGATTCT GTGTCATCTC ATCTATGACT ACCCGTATCA CGTTTTGCAC 600
ACAATTTTGA TGTATGATGA CGAGAAGAAC GCTTCCAAGG TGAAAGGCTT CTTGAAAACG 660
ATATTTGACG CGCGAGCTGA CCAACGGGAT TCGTCGAAGC TTAAGGAGAT TGTGATTACT 720
ATTCGTGAGG CTCACCAGGC TTATAGAGAA ATTGCAATGC TTGACGTGAG AGGAAACGTT 780
CGGATACAAC GTGTTGAAAT AAACGGAAAA ACGATGTACC GATGGCCACA TGATTTGAAG 840
ATTTTCAAGT GCAAATTGCG TCAATTGCCG ATTCCCACCA TTTCGCAAAA GATTGGTTGC 900
CCGGGTGACT ACTCGACGAC TGACCTAATC ACGTGGAAAC GATGGAAAGA TGTATTCACA 960
ATTGCCGACG GAATTTCCAC TCCAAAAATC TGGGAAATTG AGGGTAGCGA TGGAAAATGG 1020
TATAAAACTG TGTGGAAGAA GGACGACGTA CGACAGGATG TGCTTGTTGA GCAAATGTTT 1080
GATGTTACGA ATAATATGTT GGAGAAGGCG ATGCTTCGGA CGTATAATGT TGTCCCGTTA 1140
GACACTGAAT GTGGAGTTAT AGAGTTTTGT GGTGGAACTG TTAGCTTAAA AGAAGTTATG 1200
TGTGGTGTGA CACGAGAAGG CGGTCTCCAC CGGGAGTTCA ATTCAGAAGA AGTTTCGGCG 1260
AGTAAAGTGT CGTCAATGAT GAGACAAGTA CAGACAGAGT CCACAGAGAC ACGACGACAA 1320
GTTTTTGTGG AGATTTGTCA GCAGTATTCT CCAGTTTTTA GACACTTCTT CTACACCAAC 1380
TTTTCGACGG CGCAGATTTG GCGGCAAAAA ATCATAAATT ACAGGCAGAG CTTGGCCACG 1440
TGGAGTATTG TGTGCTACAT CGTTGGCCTC GGCGATCGAC ACGCGTCGAA TATTCTATTC 1500
GATCAGAAAT TGTGCACATT TGTGCATATC GATTTGGGAA TGATTTTGGA GTATAGTAAA 1560
CGAACGTTGC CAGTTCCCGA ACAAGTTCCA TTCCGTATAA CTCGAGATGT GCTCGACCCG 1620
ATTCTGATTG AAGGAATCGA GAATGGACAG TTGGCTGAGG AATGTACGCA GATTATGGAG 1680
AAATTGAAGG AAAATGGAAA GGTAATCCTC GGTGTCGCCT CTGCTCTACT CCGCGAAACG 1740
ATGACAAATT TCCGAGAAGC CGAACAGGCT GCCGGCCGCC CGTCCTACAT TTCTGAAATG 1800
GCCATCGGAC GGCTTCGAGA AAAGCTACGG GGCACCGATG ACGGTGTGAC GGCCCAATCG 1860
TCGAATCTTC AAATTCGGCG ACTTTTACGA GAAGCTACGA GTGCTGACAA TTTATCGCGA 1920
ATGTTCTGCG GATGGATGCC GTTTTTGTAG 1950
Domain Profile
S: 7     rveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdketsrr  66
           +i      pk   + Gsdgk y    k k+D rqd  v+q+f + N++L+k       
Q: 318   VFTIADGISTPKIWEIEGSDGKWYKTVWK-KDDVRQDVLVEQMFDVTNNMLEKA------  370
         556666678899999**********9887.9********************987......
S: 67    kLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpi..syrykdlstvq  124
            +rty+Vvpl t++g+ie + +tvsLke++   v ++++l+ +    +    + s ++
Q: 371   --MLRTYNVVPLDTECGVIEFCGGTVSLKEVMC-GVTREGGLHREFNseEVSASKVSSMM  427
         ..59****************************6.57778888875542233333444444
S: 125   arkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvislv  184
         ++  +++ +  + +vf e++++  p  ++++++  +f +++ w ++  +y +slA+ s+v
Q: 428   RQV-QTESTETRRQVFVEICQQYSP--VFRHFFYTNFSTAQIWRQKIINYRQSLATWSIV  484
         444.444444446*********999..9********************************
S: 185   gyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnalgvt  244
          yi+gLgdrh++n+l+dq+    vhid+g+ +e  k +l+vpe+vPFR+Tr++ + + + 
Q: 485   CYIVGLGDRHASNILFDQKLCTFVHIDLGMILEYSKRTLPVPEQVPFRITRDVLDPILIE  544
         ************************************************************
S: 245   gve.GvfrasceavlrvlreskeklltiLevflydplvdwkkkk  287
         g+e G ++  c ++++ l+e+ + +l++  ++l++ + ++++ +
Q: 545   GIEnGQLAEECTQIMEKLKENGKVILGVASALLRETMTNFREAE  588
         *866*********************************9999722
Domain Sequence
(FASTA)
VFTIADGIST PKIWEIEGSD GKWYKTVWKK DDVRQDVLVE QMFDVTNNML EKAMLRTYNV 60
VPLDTECGVI EFCGGTVSLK EVMCGVTREG GLHREFNSEE VSASKVSSMM RQVQTESTET 120
RRQVFVEICQ QYSPVFRHFF YTNFSTAQIW RQKIINYRQS LATWSIVCYI VGLGDRHASN 180
ILFDQKLCTF VHIDLGMILE YSKRTLPVPE QVPFRITRDV LDPILIEGIE NGQLAEECTQ 240
IMEKLKENGK VILGVASALL RETMTNFREA E 271
KeywordATP-binding; Cell cycle; Complete proteome; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00087
EKS-ANC-00086
EKS-BOT-00095
EKS-CAJ-00096
EKS-CAF-00097
EKS-CAP-00091
EKS-CIS-00097
EKS-DAR-00348
EKS-DRM-00043
EKS-EQC-00091
EKS-FEC-00090
EKS-GAG-00077
EKS-GAA-00116
EKS-GOG-00093
EKS-HOS-00097
EKS-ICT-00088
EKS-LOA-00090
EKS-MAM-00095
EKS-MEG-00072
EKS-MOD-00092
EKS-MUM-00095
EKS-MUP-00096
EKS-MYL-00105
EKS-NOL-00089
EKS-ORN-00123
EKS-ORA-00077
EKS-ORC-00089
EKS-ORL-00114
EKS-OTG-00098
EKS-PAT-00086
EKS-PES-00081
EKS-PEM-00047
EKS-POA-00090
EKS-RAN-00092
EKS-SAH-00088
EKS-SUS-00084
EKS-TAG-00126
EKS-TAR-00129
EKS-TEN-00120
EKS-XET-00085
EKS-XIM-00120
EKS-SAC-00090
EKS-SCP-00091
Gene Ontology
GO:0000785; C:chromatin
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007049; P:cell cycle
GO:0006281; P:DNA repair
KEGG
cel:CELE_Y48G1BL.2;
InterPros
IPR003152; FATC.
IPR011009; Kinase-like_dom.
IPR000403; PI3/4_kinase_cat_dom.
IPR018936; PI3/4_kinase_CS.
Pfam
PF02260; FATC; 1.
PF00454; PI3_PI4_kinase; 1.
SMARTs
SM00146; PI3Kc; 1.
Prosites
PS51189; FAT; 1.
PS51190; FATC; 1.
PS00915; PI3_4_KINASE_1; FALSE_NEG.
PS00916; PI3_4_KINASE_2; 1.
PS50290; PI3_4_KINASE_3; 1.
Prints
Created Date20-Feb-2013