EKS-SAC-00024

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00024

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	236.4	9.9E-71	1098	1354	257

Status

Reviewed

Ensembl Protein

YAL017W

UniProt Accession

P31374; D6VPK1;

Protein Name

Serine/threonine-protein kinase PSK1

Protein Synonyms/Alias

PAS kinase 1;

Gene Name

PSK1

Gene Synonyms/Alias

PSK1; YAL017W; FUN31, YAL002;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YAL017W	YAL017W	YAL017W

Organism

Saccharomyces cerevisiae

Functional Description

Serine/threonine-protein kinase involved in the controlof sugar metabolism and translation. Phosphorylates UGP1, which is required for normal glycogen and beta-(1,6)-glucan synthesis. This phosphorylation shifts glucose partitioning toward cell wall glucan synthesis at the expense of glycogen synthesis.

Protein Length

1356

Protein Sequence
(FASTA)

MPYIGASNLS EHSFVNLKEK HAITHKGTSS SVASLQTPPS PDQENHIDNE LENYDTSLSD 60

VSTPNKKEGD EFEQSLRDTF ASFRKTKPPP PLDFEQPRLP STASSSVDST VSSPLTDEDI 120

KELEFLPNES THSYSYNPLS PNSLAVRLRI LKRSLEIIIQ NPSMLLEPTP DDLPPLKEFA 180

GRRSSLPRTS ASANHLMNRN KSQIWNTTSA TLNAFVNNTS SSSAASSALS NKKPGTPVFP 240

NLDPTHSQTF HRANSLAYLP SILPEQDPLL KHNNSLFRGD YGNNISPERP SFRQPFKDQT 300

SNLRNSSLLN ERAYQEDETF LPHHGPSMDL LNEQRANLKS LLNLLNETLE KNTSERASDL 360

HMISLFNLNK LMLGDPKKNN SERDKRTEKL KKILLDSLAE PFFEHYNFIG DNPIADTDEL 420

KEEIDEFTGS GDTTAITDIR PQQDYGRILR TFTSTKNSAP QAIFTCSQED PWQFRAANDL 480

ACLVFGISQN AIRALTLMDL IHTDSRNFVL HKLLSTEGQE MVFTGEIIGI VQPETLSSSK 540

VVWASFWAKR KNGLLVCVFE KVPCDYVDVL LNLDDFGAEN IVDKCELLSD GPTLSSSSTL 600

SLPKMASSPT GSKLEYSLER KILEKSYTKP TSTENRNGDE NQLDGDSHSE PSLSSSPVRS 660

KKSVKFANDI KDVKSISQSL AKLMDDVRNG VVFDPDDDLL PMPIKVCNHI NETRYFTLNH 720

LSYNIPCAVS STVLEDELKL KIHSLPYQAG LFIVDSHTLD IVSSNKSILK NMFGYHFAEL 780

VGKSITEIIP SFPKFLQFIN DKYPALDITL HKNKGLVLTE HFFRKIQAEI MGDRKSFYTS 840

VGIDGLHRDG CEIKIDFQLR VMNSKVILLW VTHSRDVVFE EYNTNPSQLK MLKESELSLM 900

SSASSSASSS KKSSSRISTG TLKDMSNLST YEDLAHRTNK LKYEIGDDSR AHSQSTLSEQ 960

EQVPLENDKD SGEMMLADPE MKHKLELARI YSRDKSQFVK EGNFKVDENL IISKISLSPS 1020

TESLADSKSS GKGLSPLEEE KLIDENATEN GLAGSPKDED GIIMTNKRGN QPVSTFLRTP 1080

EKNIGAQKHV KKFSDFVSLQ KMGEGAYGKV NLCIHKKNRY IVVIKMIFKE RILVDTWVRD 1140

RKLGTIPSEI QIMATLNKKP HENILRLLDF FEDDDYYYIE TPVHGETGCI DLFDLIEFKT 1200

NMTEFEAKLI FKQVVAGIKH LHDQGIVHRD IKDENVIVDS KGFVKIIDFG SAAYVKSGPF 1260

DVFVGTIDYA APEVLGGNPY EGQPQDIWAI GILLYTVVFK ENPFYNIDEI LEGDLKFNNA 1320

EEVSEDCIEL IKSILNRCVP KRPTIDDINN DKWLVI 1356

Nucleotide Sequence
(FASTA)

ATGCCCTACA TCGGTGCTTC CAACCTCTCA GAACATTCAT TTGTTAATTT GAAGGAAAAA 60

CATGCGATTA CACATAAAGG TACGAGCAGT TCTGTAGCAT CTTTGCAGAC ACCACCGAGC 120

CCCGATCAAG AGAACCATAT TGACAATGAA TTAGAAAATT ACGATACGTC TTTAAGTGAC 180

GTTTCAACCC CGAATAAAAA GGAAGGTGAT GAGTTCGAGC AAAGTTTAAG AGATACATTT 240

GCGAGCTTTC GGAAGACTAA ACCCCCACCT CCTTTAGATT TTGAACAACC AAGACTTCCT 300

TCGACAGCTT CTTCATCCGT TGATTCAACC GTATCATCGC CCTTAACGGA TGAAGACATA 360

AAGGAGTTAG AGTTTCTTCC GAATGAATCA ACTCATTCTT ATTCGTACAA TCCACTTTCG 420

CCAAATTCCC TGGCAGTCAG ATTGAGGATT TTGAAGAGAT CATTGGAAAT CATAATACAA 480

AACCCAAGTA TGCTACTGGA GCCTACTCCA GATGATTTGC CTCCTTTGAA AGAGTTTGCG 540

GGCCGTAGGA GCAGTTTACC AAGGACATCG GCTTCTGCAA ACCATTTAAT GAACAGAAAT 600

AAGAGCCAGA TTTGGAACAC TACTTCCGCT ACTTTAAATG CATTTGTAAA TAATACCTCT 660

TCCTCCTCAG CAGCATCTTC TGCTTTATCT AACAAAAAAC CGGGCACCCC AGTTTTCCCT 720

AATTTGGATC CAACACATTC TCAAACATTC CATAGAGCCA ACTCGTTGGC TTATTTACCT 780

TCCATCTTAC CTGAGCAAGA TCCGCTGCTC AAACATAATA ATTCTTTATT TCGTGGCGAC 840

TATGGAAACA ACATAAGTCC TGAAAGGCCA AGTTTTAGAC AACCCTTCAA GGATCAAACT 900

AGCAATCTCC GCAATAGCAG TTTACTCAAT GAGAGGGCAT ATCAGGAAGA TGAAACTTTT 960

TTACCGCACC ATGGACCCTC TATGGATCTA TTGAATGAAC AAAGAGCGAA CTTGAAAAGT 1020

CTTCTGAATT TATTAAACGA AACACTGGAG AAAAATACTT CCGAGAGAGC TTCGGATCTT 1080

CATATGATAT CGTTGTTCAA TTTGAATAAA CTAATGCTTG GAGATCCCAA GAAAAATAAT 1140

TCAGAACGCG ATAAAAGAAC TGAAAAGCTT AAAAAGATTT TGCTGGATAG TCTTGCAGAA 1200

CCATTCTTTG AGCACTATAA TTTTATTGGA GATAATCCGA TCGCAGATAC AGATGAACTA 1260

AAGGAGGAAA TTGATGAATT TACAGGTTCT GGAGATACGA CAGCGATAAC AGATATACGG 1320

CCCCAACAGG ACTATGGCCG CATATTGAGG ACATTCACTT CTACCAAAAA TTCCGCCCCA 1380

CAGGCAATTT TTACATGTAG TCAGGAAGAC CCTTGGCAAT TCAGAGCTGC GAATGATCTA 1440

GCGTGCTTAG TATTCGGTAT CTCACAGAAT GCCATTCGCG CTTTAACCTT GATGGATTTA 1500

ATTCACACCG ATAGCAGAAA TTTTGTTTTA CACAAATTAC TTTCTACGGA GGGTCAAGAA 1560

ATGGTTTTCA CAGGCGAAAT CATTGGTATA GTTCAACCAG AAACACTCAG CTCATCCAAA 1620

GTAGTATGGG CATCGTTTTG GGCAAAAAGG AAAAACGGCT TATTAGTTTG TGTTTTCGAA 1680

AAGGTTCCTT GCGATTATGT TGATGTACTT TTGAACCTGG ATGATTTTGG GGCCGAGAAT 1740

ATTGTAGACA AATGTGAGTT ATTATCAGAT GGACCCACAT TGTCTTCCTC TTCTACATTA 1800

TCGCTACCTA AGATGGCTTC TTCACCAACT GGTAGTAAAT TAGAGTATTC GTTGGAGAGG 1860

AAAATCCTGG AAAAGAGTTA TACTAAGCCT ACTTCAACAG AGAATCGCAA CGGCGATGAA 1920

AACCAACTTG ATGGAGATAG TCATTCTGAA CCATCGCTGT CATCATCGCC AGTAAGGTCG 1980

AAGAAAAGTG TAAAGTTCGC AAATGATATT AAAGACGTCA AGAGTATAAG CCAATCGTTA 2040

GCCAAATTAA TGGATGATGT GAGGAATGGG GTTGTATTTG ATCCCGATGA CGACCTTTTG 2100

CCTATGCCCA TCAAAGTTTG CAACCACATT AATGAAACAA GATATTTTAC TCTAAATCAT 2160

CTATCTTATA ATATCCCATG CGCGGTTTCC TCCACTGTGT TGGAGGATGA GCTGAAATTA 2220

AAGATTCACA GTTTACCTTA CCAGGCGGGT TTGTTTATTG TGGATTCGCA TACTTTAGAT 2280

ATTGTAAGTT CCAATAAATC TATTTTAAAA AACATGTTTG GTTATCATTT TGCTGAGCTG 2340

GTGGGAAAAT CCATTACTGA AATAATTCCT TCTTTCCCAA AATTCCTCCA ATTTATAAAT 2400

GACAAATATC CTGCGTTGGA TATCACACTC CATAAAAATA AAGGTTTGGT ATTAACAGAA 2460

CATTTTTTTA GGAAAATTCA GGCAGAGATT ATGGGTGATC GTAAAAGCTT TTATACGTCG 2520

GTGGGTATTG ATGGCCTTCA TAGGGATGGC TGTGAAATCA AAATTGATTT CCAGCTGCGT 2580

GTCATGAATT CTAAAGTGAT TTTGCTTTGG GTTACACATT CGAGAGACGT GGTATTTGAA 2640

GAATATAATA CAAATCCATC TCAATTGAAG ATGCTGAAGG AGAGTGAATT AAGTTTAATG 2700

AGCAGTGCAA GTAGTTCTGC CAGCTCTTCC AAAAAATCTT CGTCTAGGAT ATCCACCGGG 2760

ACATTAAAGG ACATGAGTAA TCTGTCAACA TATGAGGATT TGGCCCACCG AACGAATAAG 2820

CTTAAGTATG AAATCGGAGA TGATTCTAGA GCACATTCTC AATCTACTTT GTCCGAGCAG 2880

GAACAAGTTC CCCTGGAAAA CGATAAGGAC AGTGGCGAGA TGATGCTTGC AGACCCCGAA 2940

ATGAAGCACA AGTTAGAATT GGCCAGAATT TACTCAAGAG ATAAATCTCA ATTTGTGAAA 3000

GAAGGAAATT TTAAAGTTGA CGAAAATTTG ATTATTAGCA AAATTTCACT TTCCCCAAGC 3060

ACTGAATCCT TAGCAGATTC TAAAAGTTCT GGGAAAGGGC TTTCTCCACT TGAAGAGGAA 3120

AAGCTAATTG ACGAAAACGC TACAGAAAAC GGATTAGCGG GATCACCTAA AGACGAAGAC 3180

GGAATCATAA TGACTAACAA GCGAGGAAAC CAACCTGTTA GTACTTTCCT ACGCACCCCC 3240

GAAAAGAACA TCGGTGCTCA AAAGCATGTT AAGAAGTTTT CGGACTTCGT AAGTCTGCAA 3300

AAAATGGGTG AAGGTGCATA TGGTAAGGTC AACCTATGTA TTCATAAGAA GAATAGGTAT 3360

ATTGTGGTGA TTAAGATGAT TTTTAAAGAA AGAATCCTTG TAGATACATG GGTTAGAGAT 3420

AGGAAATTAG GCACTATACC TTCTGAGATC CAAATTATGG CCACGTTGAA CAAAAAACCA 3480

CATGAGAATA TTTTACGGTT ACTGGATTTT TTTGAAGACG ACGATTACTA TTATATCGAA 3540

ACTCCCGTAC ATGGTGAAAC AGGATGTATA GATCTTTTCG ATCTAATTGA ATTTAAAACC 3600

AACATGACCG AATTTGAAGC AAAATTGATA TTCAAGCAGG TTGTAGCGGG AATAAAACAT 3660

CTACACGACC AGGGTATTGT TCACAGAGAT ATCAAGGATG AGAATGTTAT CGTAGATTCT 3720

AAAGGCTTTG TTAAGATTAT TGATTTTGGA TCTGCTGCGT ATGTCAAAAG CGGACCATTT 3780

GATGTTTTTG TTGGGACAAT AGATTATGCT GCCCCTGAAG TCTTAGGAGG AAACCCTTAT 3840

GAGGGCCAAC CACAGGATAT TTGGGCTATT GGTATTCTAT TGTATACGGT GGTCTTCAAA 3900

GAAAACCCCT TCTACAATAT AGATGAAATA TTAGAAGGCG ACCTGAAATT CAATAATGCA 3960

GAGGAAGTTA GTGAAGATTG CATTGAGTTA ATCAAGAGTA TTTTGAACCG TTGCGTACCG 4020

AAGAGACCCA CCATTGACGA CATAAATAAC GACAAATGGT TGGTTATTTG A 4071

Domain Profile

S: 3     llktlGegsfgkVklakhketkekvavKiikkkkl......seeslekikrEieilkklk  56

          l+++Geg++gkV+l++hk+++  v++K+i k+++      ++++l +i +Ei+i+ +l+

Q: 1098  SLQKMGEGAYGKVNLCIHKKNRYIVVIKMIFKERIlvdtwvRDRKLGTIPSEIQIMATLN  1157

         5799******************************99**9999999**************7

S: 57    ...hpniikllevietkkklylvle.yasgg..eLfdyieekgrlkekearklfkqlvsa  110

            h+ni++ll+++e+++++y+ +  + ++g  +Lfd ie k++++e ea+ +fkq+v++

Q: 1158  kkpHENILRLLDFFEDDDYYYIETPvHGETGciDLFDLIEFKTNMTEFEAKLIFKQVVAG  1217

         777*******************99955555588***************************

S: 111   vkYlhskgivHrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellk  170

         +k+lh++givHrD+K eN+++d+k+ +ki+DFG a+++k+g  ++ f+G+++YaaPe+l

Q: 1218  IKHLHDQGIVHRDIKDENVIVDSKGFVKIIDFGSAAYVKSG-PFDVFVGTIDYAAPEVLG  1276

         ************************************99998.99****************

S: 171   gkkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkk..lskelesL  228

         g++Yeg++ D+W++G++Ly++v+++ Pf +       ++il+g+l++++   +s+++++L

Q: 1277  GNPYEGQPQDIWAIGILLYTVVFKENPFYNI------DEILEGDLKFNNAeeVSEDCIEL  1330

         ****************************998......678888887777666********

S: 229   lrklLvvdpekRatieeilkhewl  252

         ++++L++ + kR+ti++i++++wl

Q: 1331  IKSILNRCVPKRPTIDDINNDKWL  1354

         ***********************7

Domain Sequence
(FASTA)

SLQKMGEGAY GKVNLCIHKK NRYIVVIKMI FKERILVDTW VRDRKLGTIP SEIQIMATLN 60

KKPHENILRL LDFFEDDDYY YIETPVHGET GCIDLFDLIE FKTNMTEFEA KLIFKQVVAG 120

IKHLHDQGIV HRDIKDENVI VDSKGFVKII DFGSAAYVKS GPFDVFVGTI DYAAPEVLGG 180

NPYEGQPQDI WAIGILLYTV VFKENPFYNI DEILEGDLKF NNAEEVSEDC IELIKSILNR 240

CVPKRPTIDD INNDKWL 257

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Translation regulation.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004871	; F:signal transducer activity
GO:0045719	; P:negative regulation of glycogen biosynthetic process
GO:0060917	; P:regulation of (1->6)-beta-D-glucan biosynthetic process
GO:0006417	; P:regulation of translation

KEGG

sce:YAL017W

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000014	; PAS.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00091

; PAS; 2.

Prosites

PS50112	; PAS; FALSE_NEG.
PS00107	; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013