EKS-SAC-00090

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00090

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	257.1	8.6E-77	2432	2746	315

Status

Reviewed

Ensembl Protein

YBL088C

UniProt Accession

P38110; D6VPR6;

Protein Name

Serine/threonine-protein kinase TEL1

Protein Synonyms/Alias

ATM homolog; DNA-damage checkpoint kinase TEL1; Telomere length regulation protein 1;

Gene Name

TEL1

Gene Synonyms/Alias

TEL1; YBL088C; YBL0706;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YBL088C	YBL088C	YBL088C

Organism

Saccharomyces cerevisiae

Functional Description

Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited by the MRX-complex to sites of DNA lesions immediately after damage to initiate non- homologous end-joining (NHEJ). Subsequently displaced by the RPA complex in a reaction probably involving the SAE2 protein. Phosphorylates MRE11 and XRS2, 2 subunits of the MRX-complex. The phosphorylation of MRE11 is a feedback response from the checkpoint signaling pathway. Phosphorylates RAD9, CHK1 and RAD53, leading to the activation of the CHK1 and RAD23 kinases involved in the DNA damage response cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are involved in genome stability. Required for the control of telomere length and genome stability.

Protein Length

2787

Protein Sequence
(FASTA)

MEDHGIVETL NFLSSTKIKE RNNALDELTT ILKEDPERIP TKALSTTAEA LVELLASEHT 60

KYCDLLRNLT VSTTNKLSLS ENRLSTISYV LRLFVEKSCE RFKVKTLKLL LAVVPELMVK 120

DGSKSLLDAV SVHLSFALDA LIKSDPFKLK FMIHQWISLV DKICEYFQSQ MKLSMVDKTL 180

TNFISILLNL LALDTVGIFQ VTRTITWTVI DFLRLSKKEN GNTRLIMSLI NQLILKCHCF 240

SVIDTLMLIK EAWSYNLTIG CTSNELVQDQ LSLFDVMSSE LMNHKLPYMI GQENYVEELR 300

SESLVSLYRE YILLRLSNYK PQLFTVNHVE FSYIRGSRDK NSWFALPDFR LRDRGGRSVW 360

LKILGITKSL LTYFALNRKN ENYSLLFKRR KCDSDIPSIL RISDDMDTFL IHLLEENSSH 420

EFEVLGLQLC SFYGTLQDFT KSFAEQLKEL LFSKFEKIQC FNWVCFSFIP LLSQKECELS 480

NGDMARLFKV CLPLVKSNES CQLSCLLLAN SIKFSKQLLS DEKTINQIYD LYELSDILGP 540

ILVTNESFML WGYLQYVGKD FQSMNGISSA DRIFEWLKSK WNQLRGTDAK QDQFCNFISW 600

LGNKYDPENP FNDKKGEGAN PVSLCWDESH KIWQHFQEQR EFLLGVKPEE KSECFNTPFF 660

NLPKVSLDLT RYNEILYRLL ENIESDAFSS PLQKFTWVAK LIQIVDNLCG DSTFSEFIAA 720

YKRTTLITIP QLSFDSQNSY QSFFEEVLSI RTINVDHLVL DKINMKEIVN DFIRMQKNKS 780

QTGTSAINYF EASSEDTTQN NSPYTIGGRF QKPLHSTIDK AVRAYLWSSR NKSISERLVA 840

ILEFSDCVST DVFISYLGTV CQWLKQAIGE KSSYNKILEE FTEVLGEKLL CNHYSSSNQA 900

MLLLTSYIEA IRPQWLSYPE QPLNSDCNDI LDWIISRFED NSFTGVAPTV NLSMLLLSLL 960

QNHDLSHGSI RGGKQRVFAT FIKCLQKLDS SNIINIMNSI SSYMAQVSYK NQSIIFYEIK 1020

SLFGPPQQSI EKSAFYSLAM SMLSLVSYPS LVFSLEDMMT YSGFNHTRAF IQQALNKITV 1080

AFRYQNLTEL FEYCKFDLIM YWFNRTKVPT SKLEKEWDIS LFGFADIHEF LGRYFVEISA 1140

IYFSQGFNQK WILDMLHAIT GNGDAYLVDN SYYLCIPLAF ISGGVNELIF DILPQISGKT 1200

TVKYHKKYRL LMLKWIIRFT DLGSLTELRS TVEKLFPTSY LSPYLFENSS VSMRYQYPLH 1260

IPLALGATLV QTQFAHEKNN THEFKLLFLS VITDLEKTST YIGKLRCARE LKYLFVLYEN 1320

VLVKSSTLNF IIIRLSKFLI DTQIHDEVIT IFSSLLNLAD KNTFEIEPSL PNLFCKIFIY 1380

LRENKQLSPS FQQAIKLLEH RDLIKIKTWK YCLDAIFGNI VQDDIYENTE LLDASDCGVD 1440

DVVLVSLLFS YARRPVASKI GCSLSKAAAI NILKHHVPKE YLSKNFKLWF AALSRRILQQ 1500

EVQRERSTNF NNEVHLKNFE MVFRHPEQPH MIYQRISTFN KEAELYDSTE VFFISECILT 1560

YLVGYSIGNS ESEFCFRDNI MNENKDKVAP LDKDVLNAIY PLANNFGMES FICDTYLSVN 1620

EPYNCWLSKF ARSLIHQISF NIPPIVCLYP LCKGSTAFCE LVLTDLFFLS TTYDPKSCLN 1680

WSNRIFTQIA MLLHVKDSEI KLKMLFNVIK MIRMGSRCKE RNCLRIYSSL DLQEICQISL 1740

KIKEFKFGYL LFEEMNMPNI REMNINTLQK IYECINDGDF LAGLPVPHSI EGVLNSINRI 1800

DSDTWKRFLF NNADFDANYT TSLEEEKESL IKATEDSGFY GLTSLLESRL SGSSDVYKWN 1860

LELGDWKLLT PKVVDSKAKG LYYAIKNLPQ DVGFAEKSLE KSLLTIFDSR QHFISQTEWM 1920

DTLNAIIEFI KIAAIPQDVT SFPQTLMSIM KADKERLNTI DFYDHKTTLK SRHTLMNVLS 1980

RNSLDENVKC SKYLRLGSII QLANYVQLAI ANGAPQDALR NATLMSKTVK NIAKLYDDPS 2040

VVSQIEKLAS FTSANALWES REYKAPVMIM RDLLAQNEKN ISESILYDDF KLLINVPMDQ 2100

IKARLVKWSS ESRLEPAAAI YEKIIVNWDI NVEDHESCSD VFYTLGSFLD EQAQKLRSNG 2160

EIEDREHRSY TGKSTLKALE LIYKNTKLPE NERKDAKRHY NRVLLQYNRD SEVLKALLLQ 2220

KEKFLWHALH FYLNTLVFSN RYDNDIIDKF CGLWFENDDN SKINQLLYKE IGTIPSWKFL 2280

PWVNQIASKI SMEENEFQKP LQLTMKRLLY KLPYDSLYSV MSILLYEKQS NKDTNISQKI 2340

QAVKKILLEL QGYDRGAFAK KYLLPVQEFC EMSVELANLK FVQNTKTLRL ANLKIGQYWL 2400

KQLNMEKLPL PTSNFTVKSS ADGRKARPYI VSVNETVGIT TTGLSLPKIV TFNISDGTTQ 2460

KALMKGSNDD LRQDAIMEQV FQQVNKVLQN DKVLRNLDLG IRTYKVVPLG PKAGIIEFVA 2520

NSTSLHQILS KLHTNDKITF DQARKGMKAV QTKSNEERLK AYLKITNEIK PQLRNFFFDS 2580

FPDPLDWFEA KKTYTKGVAA SSIVGYILGL GDRHLNNILL DCSTGEPIHI DLGIAFDQGK 2640

LLPIPELVPF RLTRDIVDGF GVTGVDGLFR RSCERVYAVL RKDYVKVMCV LNILKWDPLY 2700

SWVMSPVKKY EHLFEEEHEI TNFDNVSKFI SNNDRNENQE SYRALKGVEE KLMGNGLSVE 2760

SSVQDLIQQA TDPSNLSVIY MGWSPFY 2787

Nucleotide Sequence
(FASTA)

ATGGAGGATC ATGGGATTGT AGAAACTTTA AACTTTCTAT CATCAACAAA AATCAAAGAG 60

AGAAACAATG CTTTAGATGA GCTAACAACA ATTTTAAAAG AAGATCCGGA AAGGATACCA 120

ACCAAGGCCC TATCTACAAC GGCAGAAGCT TTGGTAGAGT TACTTGCATC TGAACACACA 180

AAATACTGTG ACCTTCTTCG AAACTTGACA GTGTCAACCA CAAACAAGCT ATCACTTAGT 240

GAGAACAGAC TCTCCACGAT ATCGTACGTT TTAAGATTAT TTGTAGAAAA ATCATGTGAG 300

AGATTTAAAG TGAAAACGTT GAAGTTACTT TTAGCAGTAG TACCTGAATT AATGGTCAAA 360

GATGGTTCCA AAAGTTTATT GGATGCCGTT TCAGTACATT TATCGTTTGC TTTGGATGCC 420

CTAATTAAAA GTGACCCTTT CAAACTGAAA TTCATGATAC ACCAATGGAT ATCCTTAGTC 480

GATAAAATTT GCGAGTACTT TCAAAGCCAA ATGAAATTAT CTATGGTAGA CAAAACATTG 540

ACCAATTTCA TATCGATCCT CCTGAATTTA TTGGCGTTAG ACACAGTTGG TATATTTCAA 600

GTGACAAGGA CAATTACTTG GACCGTAATA GATTTTTTGA GGCTCAGCAA AAAAGAAAAT 660

GGAAATACGA GATTAATAAT GTCATTAATA AATCAATTAA TTTTGAAGTG CCATTGTTTT 720

AGTGTTATTG ATACGCTAAT GCTTATAAAA GAAGCATGGA GTTACAACCT GACAATTGGC 780

TGTACTTCCA ATGAGCTAGT ACAAGACCAA TTATCACTGT TTGATGTTAT GTCAAGTGAA 840

CTAATGAACC ATAAACTTCC TTATATGATT GGTCAAGAGA ATTATGTTGA AGAGCTTCGG 900

TCCGAATCTC TTGTATCTCT ATACCGTGAG TACATTCTAC TGCGCTTAAG TAATTATAAG 960

CCTCAATTAT TTACCGTAAA CCATGTGGAA TTCTCATATA TTCGAGGTTC AAGGGATAAA 1020

AATTCATGGT TTGCATTACC TGATTTTAGA CTTAGAGATA GGGGAGGCAG ATCGGTGTGG 1080

TTAAAAATAC TCGGAATTAC CAAATCATTG TTAACATATT TTGCATTGAA CAGAAAAAAT 1140

GAAAATTACT CATTATTATT TAAAAGAAGA AAATGTGATT CGGATATACC TTCTATCCTA 1200

CGGATTTCTG ACGATATGGA CACATTTCTT ATTCATCTTT TAGAGGAGAA CAGCTCACAT 1260

GAGTTTGAAG TGCTAGGATT ACAATTGTGC TCATTTTATG GAACTTTACA AGACTTCACT 1320

AAAAGTTTTG CAGAACAGCT GAAAGAACTT CTGTTTTCAA AATTCGAAAA AATCCAATGC 1380

TTTAATTGGG TTTGTTTTTC TTTTATTCCT TTATTATCCC AAAAAGAATG CGAATTAAGC 1440

AATGGCGACA TGGCACGCCT ATTTAAAGTT TGCTTACCAT TAGTAAAATC AAATGAATCT 1500

TGCCAGTTAA GTTGTCTTTT ATTAGCCAAC TCCATAAAGT TTTCAAAGCA GCTTTTATCC 1560

GATGAGAAAA CTATCAATCA GATATATGAT CTTTACGAAT TATCCGATAT TTTGGGTCCC 1620

ATATTAGTTA CTAATGAATC GTTCATGCTA TGGGGATACC TTCAGTACGT TGGTAAAGAC 1680

TTCCAATCTA TGAACGGTAT ATCGTCCGCT GATAGAATTT TTGAGTGGCT AAAATCAAAG 1740

TGGAACCAGT TGCGCGGAAC TGATGCTAAA CAGGATCAGT TCTGCAATTT TATATCCTGG 1800

TTAGGTAACA AATATGACCC AGAGAACCCT TTCAACGATA AAAAAGGCGA AGGAGCTAAT 1860

CCTGTCTCAC TATGTTGGGA TGAAAGCCAC AAGATTTGGC AACATTTTCA AGAGCAGAGG 1920

GAATTTCTTT TAGGCGTAAA ACCAGAAGAA AAGTCAGAAT GTTTTAACAC TCCCTTTTTT 1980

AATTTACCAA AAGTTTCCTT AGACCTCACA CGTTATAATG AAATTCTTTA CAGATTACTG 2040

GAAAATATTG AAAGTGATGC ATTTTCATCT CCACTACAAA AATTTACTTG GGTAGCAAAA 2100

TTAATACAAA TAGTTGATAA TCTTTGTGGA GATTCCACTT TTTCTGAGTT TATTGCAGCA 2160

TATAAGAGAA CAACCTTAAT AACTATTCCA CAACTTAGTT TTGATAGCCA AAACTCCTAC 2220

CAATCATTTT TTGAGGAGGT TTTATCGATA CGGACCATAA ATGTAGACCA TTTAGTGCTT 2280

GACAAAATTA ATATGAAGGA AATCGTTAAT GATTTTATCA GGATGCAAAA AAACAAATCT 2340

CAAACAGGAA CTTCTGCCAT CAATTACTTC GAAGCCTCTT CAGAAGACAC TACCCAGAAT 2400

AATAGTCCGT ACACAATTGG AGGTAGATTT CAGAAGCCTC TGCACTCCAC TATAGATAAA 2460

GCAGTGCGAG CTTACCTATG GTCTTCAAGA AATAAATCCA TTTCAGAGCG TTTGGTAGCC 2520

ATATTGGAAT TTTCTGATTG CGTTAGCACA GATGTATTTA TATCTTATCT TGGCACTGTT 2580

TGCCAGTGGT TAAAACAAGC AATCGGGGAG AAATCTTCTT ACAACAAAAT CCTGGAAGAA 2640

TTCACTGAAG TCTTGGGTGA AAAATTGCTT TGCAACCACT ATAGTTCTTC CAATCAAGCT 2700

ATGCTTTTAC TTACATCTTA TATCGAAGCA ATAAGACCTC AATGGTTATC TTACCCCGAG 2760

CAGCCTTTGA ATTCGGACTG CAATGATATC CTGGACTGGA TCATATCTAG ATTTGAGGAC 2820

AATTCTTTCA CTGGTGTGGC CCCTACGGTC AACCTTTCTA TGCTGCTGCT TAGCCTACTT 2880

CAAAATCATG ATCTTTCCCA CGGATCAATC AGAGGTGGGA AGCAGAGAGT CTTTGCAACT 2940

TTTATTAAAT GCCTGCAAAA GCTAGACTCC TCCAATATTA TTAACATAAT GAACAGTATT 3000

TCGAGTTATA TGGCCCAAGT GAGCTATAAG AATCAAAGTA TCATATTTTA TGAGATTAAG 3060

AGCTTATTTG GTCCGCCTCA GCAAAGTATT GAAAAGTCCG CTTTCTACTC TCTTGCAATG 3120

TCCATGTTGT CTTTGGTGTC TTACCCAAGC TTAGTTTTTT CTTTGGAGGA TATGATGACA 3180

TACTCTGGCT TCAATCATAC TCGTGCGTTT ATCCAACAAG CTCTGAACAA AATTACGGTC 3240

GCTTTTCGCT ACCAAAACCT TACAGAGCTC TTCGAATATT GTAAGTTTGA TTTGATTATG 3300

TACTGGTTTA ACAGAACAAA AGTCCCTACT TCTAAATTGG AGAAAGAATG GGATATATCT 3360

CTTTTTGGAT TTGCCGATAT TCATGAATTT TTAGGAAGAT ACTTTGTAGA AATTTCTGCA 3420

ATCTACTTTT CTCAAGGTTT CAACCAAAAA TGGATCTTAG ACATGTTACA CGCGATTACT 3480

GGAAACGGTG ATGCTTATCT GGTGGATAAC AGCTATTACT TGTGTATTCC ACTTGCCTTT 3540

ATCAGTGGCG GTGTGAATGA ACTAATATTT GATATATTGC CCCAAATATC AGGTAAAACA 3600

ACAGTAAAAT ACCATAAAAA ATACCGTCTA CTGATGTTAA AGTGGATCAT AAGATTTACT 3660

GATTTGGGCT CACTTACTGA ACTTAGATCT ACTGTTGAAA AATTATTCCC AACTTCATAC 3720

CTTTCGCCAT ATTTATTTGA AAATTCCAGT GTTTCAATGA GGTATCAATA CCCACTTCAT 3780

ATACCCTTGG CATTAGGAGC AACCTTAGTT CAGACGCAGT TTGCTCATGA AAAGAACAAC 3840

ACACACGAAT TCAAGCTTTT GTTTTTATCG GTTATTACAG ACCTTGAAAA GACATCGACT 3900

TACATAGGAA AACTGCGATG TGCAAGGGAG TTAAAATATC TTTTTGTGTT GTATGAGAAT 3960

GTACTTGTAA AATCATCAAC TTTAAACTTC ATCATAATTC GGCTTTCAAA ATTCTTAATA 4020

GATACACAAA TTCACGATGA AGTAATAACA ATTTTCAGCT CATTGTTAAA TCTGGCTGAC 4080

AAAAATACGT TTGAAATAGA GCCATCTCTG CCCAATTTAT TTTGCAAAAT ATTCATTTAT 4140

TTGAGGGAAA ACAAACAGCT CAGTCCATCC TTCCAGCAGG CTATAAAGCT TTTAGAGCAT 4200

CGGGATCTCA TCAAAATAAA AACTTGGAAA TACTGCCTTG ATGCAATATT CGGAAATATA 4260

GTCCAAGATG ATATTTATGA AAATACGGAA CTTTTGGATG CTAGTGATTG TGGCGTAGAC 4320

GATGTTGTAT TGGTTTCTTT ACTCTTTTCT TATGCCAGGA GACCGGTAGC TTCAAAAATC 4380

GGTTGTTCGC TTTCTAAAGC TGCTGCAATT AACATTTTGA AACACCATGT TCCAAAGGAA 4440

TATTTGAGTA AAAACTTCAA ACTATGGTTC GCTGCTCTTT CAAGAAGAAT TTTACAGCAA 4500

GAAGTTCAAA GAGAGAGATC TACAAACTTT AATAATGAAG TTCATTTGAA AAACTTTGAA 4560

ATGGTATTTC GCCATCCCGA ACAACCACAT ATGATATACC AACGTATTTC GACCTTCAAT 4620

AAAGAAGCTG AGTTATATGA TTCTACTGAA GTGTTTTTTA TTTCTGAGTG CATTCTAACG 4680

TACCTAGTGG GCTACTCAAT AGGAAATAGC GAAAGTGAAT TTTGTTTTAG GGATAACATA 4740

ATGAACGAGA ACAAAGATAA AGTTGCTCCA TTGGACAAGG ATGTACTGAA TGCTATATAC 4800

CCGTTGGCAA ACAATTTTGG GATGGAATCA TTCATATGCG ATACTTATTT GTCAGTGAAC 4860

GAACCCTACA ACTGCTGGCT AAGCAAATTC GCCCGTAGTT TGATTCACCA AATATCATTT 4920

AATATACCTC CTATTGTTTG CTTGTATCCT TTATGCAAAG GATCAACAGC TTTTTGTGAA 4980

TTAGTACTTA CTGACCTCTT TTTTCTTTCA ACGACTTACG ATCCGAAAAG CTGTTTGAAT 5040

TGGAGCAATC GAATATTCAC TCAAATAGCA ATGTTGCTGC ATGTTAAAGA TTCTGAGATA 5100

AAGCTAAAGA TGCTTTTCAA TGTAATTAAA ATGATTAGGA TGGGTTCTAG ATGCAAGGAA 5160

CGAAACTGTC TGCGCATATA TTCTAGCTTA GATTTACAAG AAATATGTCA AATTTCTCTT 5220

AAAATAAAAG AGTTCAAGTT TGGCTATTTG TTATTTGAGG AAATGAACAT GCCAAACATA 5280

AGAGAAATGA ATATAAATAC ACTTCAGAAG ATTTACGAAT GCATAAATGA CGGCGATTTT 5340

CTAGCAGGCT TACCTGTTCC ACACTCAATA GAGGGTGTTT TGAACTCTAT CAATAGAATT 5400

GACTCAGATA CGTGGAAACG TTTTCTTTTC AACAACGCCG ATTTTGATGC CAATTACACT 5460

ACTTCACTAG AAGAGGAAAA GGAATCATTA ATCAAGGCCA CAGAAGATAG CGGTTTCTAC 5520

GGGTTGACAA GCTTATTGGA AAGTAGACTT TCTGGATCCA GTGATGTCTA CAAATGGAAT 5580

TTAGAATTGG GAGACTGGAA GCTATTGACT CCAAAAGTTG TTGATTCCAA AGCCAAAGGT 5640

TTATACTATG CCATAAAAAA TTTACCACAG GACGTTGGTT TTGCTGAAAA AAGTTTAGAA 5700

AAATCCTTAT TAACTATTTT TGATTCTCGA CAACATTTTA TTAGCCAAAC TGAATGGATG 5760

GATACTCTGA ACGCGATTAT TGAATTTATA AAAATAGCAG CAATCCCTCA GGACGTTACT 5820

TCCTTCCCCC AAACATTGAT GTCTATTATG AAGGCCGATA AGGAGAGACT TAATACAATA 5880

GACTTCTATG ATCACAAAAC AACGTTAAAG AGTAGACATA CTTTAATGAA TGTGCTCTCG 5940

AGGAATTCAT TAGATGAAAA CGTAAAATGC TCGAAATATT TACGCCTTGG ATCCATTATT 6000

CAGCTTGCTA ATTACGTTCA GCTGGCAATT GCCAATGGTG CGCCTCAAGA TGCGTTACGA 6060

AATGCCACTC TAATGAGCAA AACAGTGAAG AATATTGCAA AATTATACGA TGATCCCTCT 6120

GTAGTATCTC AAATTGAGAA ATTGGCAAGT TTCACATCTG CTAATGCCCT CTGGGAGTCT 6180

CGAGAGTACA AGGCACCTGT AATGATAATG AGAGATCTTT TAGCTCAAAA TGAGAAGAAT 6240

ATTAGCGAAA GTATCCTTTA TGACGATTTT AAGCTACTCA TTAATGTGCC TATGGACCAA 6300

ATTAAAGCTC GACTAGTTAA ATGGAGCTCA GAATCAAGGC TTGAACCAGC TGCTGCAATA 6360

TATGAAAAAA TCATTGTCAA TTGGGATATA AATGTCGAAG ATCATGAATC ATGTTCTGAT 6420

GTTTTCTACA CACTCGGAAG TTTTCTGGAT GAACAGGCAC AAAAGTTACG ATCAAATGGA 6480

GAAATCGAAG ATAGAGAACA TAGGTCATAT ACTGGAAAAT CTACCTTGAA AGCTTTGGAG 6540

CTGATATATA AAAACACAAA ATTACCAGAA AATGAAAGAA AAGATGCGAA AAGGCATTAT 6600

AATCGTGTCT TGCTACAATA TAATAGAGAT TCTGAAGTAC TAAAGGCACT GCTTCTTCAA 6660

AAAGAAAAAT TTTTATGGCA TGCACTCCAT TTCTATCTCA ATACCTTAGT TTTCAGCAAC 6720

AGATATGATA ATGACATTAT TGATAAGTTT TGTGGTTTAT GGTTCGAGAA TGATGACAAT 6780

AGCAAGATCA ATCAATTACT ATATAAAGAA ATTGGAACAA TACCGAGCTG GAAGTTTTTG 6840

CCCTGGGTCA ATCAGATTGC GTCAAAAATA TCTATGGAGG AGAATGAATT TCAAAAGCCA 6900

TTGCAACTAA CCATGAAACG ACTTCTTTAC AAACTACCGT ATGACTCCCT TTATTCAGTG 6960

ATGAGCATAC TACTATATGA AAAGCAATCC AATAAGGACA CCAACATATC CCAAAAAATT 7020

CAAGCTGTCA AAAAGATTCT TTTAGAATTG CAAGGATATG ACAGGGGTGC CTTTGCGAAA 7080

AAGTATTTAC TTCCTGTGCA AGAGTTTTGC GAGATGTCTG TAGAGTTAGC TAATCTTAAG 7140

TTTGTGCAAA ATACGAAGAC GTTACGCTTA GCTAATTTGA AGATTGGCCA ATATTGGCTG 7200

AAACAGCTAA ACATGGAGAA GCTTCCCCTA CCGACCAGTA ATTTTACAGT CAAAAGTTCT 7260

GCTGATGGAA GAAAAGCCCG CCCTTATATT GTATCCGTCA ATGAAACAGT AGGCATTACT 7320

ACCACAGGAT TGTCCCTGCC GAAAATAGTC ACCTTCAACA TCTCAGATGG TACAACGCAG 7380

AAAGCTTTGA TGAAAGGAAG TAATGACGAT TTGAGACAAG ATGCAATTAT GGAACAAGTG 7440

TTTCAACAAG TTAATAAAGT TCTACAAAAT GATAAAGTAT TAAGAAATCT AGATCTGGGT 7500

ATTAGAACAT ACAAAGTGGT TCCATTAGGA CCAAAGGCAG GAATCATTGA ATTTGTCGCA 7560

AATTCTACAT CATTACATCA AATTTTGAGT AAGCTACATA CCAACGATAA GATAACCTTC 7620

GATCAGGCAA GAAAAGGCAT GAAAGCAGTT CAAACAAAAT CAAATGAAGA GAGGCTGAAA 7680

GCTTATTTAA AAATCACTAA TGAAATAAAA CCGCAGTTAA GAAACTTTTT TTTTGATTCC 7740

TTTCCCGATC CGTTGGATTG GTTTGAAGCT AAGAAAACGT ACACAAAAGG TGTCGCAGCT 7800

AGCTCTATCG TTGGATACAT ATTAGGCCTC GGTGATAGGC ACTTAAACAA TATCCTGCTT 7860

GACTGCTCAA CAGGGGAGCC TATTCATATA GACCTGGGAA TTGCGTTTGA TCAGGGAAAA 7920

TTACTCCCCA TTCCAGAGTT GGTCCCTTTC AGATTAACTA GAGATATCGT TGATGGATTT 7980

GGAGTCACAG GCGTGGATGG CCTATTCAGG CGGAGTTGTG AAAGAGTTTA CGCAGTATTA 8040

AGAAAAGATT ATGTCAAGGT GATGTGTGTT TTGAATATCT TAAAATGGGA TCCCCTTTAT 8100

TCCTGGGTAA TGTCACCAGT TAAAAAATAC GAACACTTAT TTGAAGAAGA ACATGAAATT 8160

ACAAATTTCG ATAACGTCAG CAAGTTCATA AGTAACAACG ACAGGAACGA AAACCAAGAG 8220

TCTTATAGGG CCCTTAAAGG TGTAGAAGAG AAGCTTATGG GTAATGGACT AAGTGTAGAG 8280

TCTAGCGTAC AAGATTTGAT TCAGCAAGCC ACGGATCCAT CAAATTTGAG TGTTATATAT 8340

ATGGGATGGT CACCTTTTTA TTAA 8364

Domain Profile

S: 3     gfderveilask.qkpkklllrGsdgkeypyLvkg.keDlrqdervlqlfslvNtlLakd  60

         +++e+v i ++    pk +++  sdg +   L+kg ++Dlrqd+ ++q+f+ vN++L++d

Q: 2432  SVNETVGITTTGlSLPKIVTFNISDGTTQKALMKGsNDDLRQDAIMEQVFQQVNKVLQND  2491

         677888888776589******************994589*********************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         k  ++  L irtykVvpl+++ g+ie v n++sL+++l kl  + ++  d       +

Q: 2492  KVLRNLDLGIRTYKVVPLGPKAGIIEFVANSTSLHQILSKLHTNDKITFD-------QAR  2544

         *************************************************8.......444

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + ++a ++k+    ++l+ + ++ ++++p   l+++++ +fp+p +wfe +k yt+ +A

Q: 2545  KGMKAVQTKS--NEERLKAYLKITNEIKP--QLRNFFFDSFPDPLDWFEAKKTYTKGVAA  2600

         5555554444..455566999********..5****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrhl+n+l+d  tge +hid+g+af+++k  l++pe vPFRLTr+iv++

Q: 2601  SSIVGYILGLGDRHLNNILLDCSTGEPIHIDLGIAFDQGKL-LPIPELVPFRLTRDIVDG  2659

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk..............k  286

          gvtgv+G+fr+sce v  vlr++  k++ +L+++  dpl  w +              +

Q: 2660  FGVTGVDGLFRRSCERVYAVLRKDYVKVMCVLNILKWDPLYSWVMspvkkyehlfeeehE  2719

         ********************************************9887744444433322

S: 287   kktsketeeelaekakaealkikklls  313

          ++  + ++ ++++++ e++++ ++l+

Q: 2720  ITNFDNVSKFISNNDRNENQESYRALK  2746

         222222233333344444444444444

Domain Sequence
(FASTA)

SVNETVGITT TGLSLPKIVT FNISDGTTQK ALMKGSNDDL RQDAIMEQVF QQVNKVLQND 60

KVLRNLDLGI RTYKVVPLGP KAGIIEFVAN STSLHQILSK LHTNDKITFD QARKGMKAVQ 120

TKSNEERLKA YLKITNEIKP QLRNFFFDSF PDPLDWFEAK KTYTKGVAAS SIVGYILGLG 180

DRHLNNILLD CSTGEPIHID LGIAFDQGKL LPIPELVPFR LTRDIVDGFG VTGVDGLFRR 240

SCERVYAVLR KDYVKVMCVL NILKWDPLYS WVMSPVKKYE HLFEEEHEIT NFDNVSKFIS 300

NNDRNENQES YRALK 315

Keyword

ATP-binding; Chromatin regulator; Chromosome; Complete proteome; DNA damage; DNA repair; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Telomere; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000781	; C:chromosome, telomeric region
GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0042162	; F:telomeric DNA binding
GO:0000077	; P:DNA damage checkpoint
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006302	; P:double-strand break repair
GO:0016572	; P:histone phosphorylation
GO:0090399	; P:replicative senescence
GO:0010212	; P:response to ionizing radiation
GO:0000723	; P:telomere maintenance

KEGG

sce:YBL088C

;

InterPros

IPR015519	; ATM/Tel1.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR014009	; PIK_FAT.
IPR021668	; TAN.

Pfam

PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF11640	; TAN; 1.

SMARTs

SM00146

; PI3Kc; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013