EKS-SAC-00081

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00081

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	400.5	1.2E-120	824	1083	260

Status

Reviewed

Ensembl Protein

YBL105C

UniProt Accession

P24583; D6VPP8;

Protein Name

Protein kinase C-like 1

Protein Synonyms/Alias

PKC 1;

Gene Name

PKC1

Gene Synonyms/Alias

PKC1; HPO2, STT1; YBL105C; YBL0807;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YBL105C	YBL105C	YBL105C

Organism

Saccharomyces cerevisiae

Functional Description

Required for cell growth and for the G2->M transition ofthe cell division cycle. Mediates a protein kinase cascade; it activates BCK1 which itself activates MKK1/MKK2.

Protein Length

1151

Protein Sequence
(FASTA)

MSFSQLEQNI KKKIAVEENI IRGASALKKK TSNVMVIQKC NTNIREARQN LEYLEDSLKK 60

LRLKTAQQSQ GENGSEDNER CNSKEYGFLS TKSPNEHIFS RLDLVKYDCP SLAQRIQYML 120

QQLEFKLQVE KQYQEANTKL TKLYQIDGDQ RSSSAAEGGA MESKYRIQML NKALKKYQAI 180

NVDFDQFKHQ PNDIMDNQQP KFRRKQLTGV LTIGITAARD VDHIQSPMFA RKPESYVTIK 240

IDDTIKARTK PSRNDRWSED FQIPVEKGNE IEITVYDKVN DSLIPVAIMW LLLSDIAEEI 300

RKKKAGQTNE QQGWVNASNI NGGSSLASEE GSTLTSTYSN SAIQSTSAKN VQGENTSTSQ 360

ISTNSWFVLE PSGQILLTLG FHKSSQIERK QLMGGLHRHG AIINRKEEIF EQHGHHFVQK 420

SFYNIMCCAY CGDFLRYTGF QCQDCKFLCH KKCYTNVVTK CIAKTSTDTD PDEAKLNHRI 480

PHRFLPTSNR GTKWCCHCGY ILPWGRHKVR KCSECGIMCH AQCAHLVPDF CGMSMEMANK 540

ILKTIQDTKR NQEKKKRTVP SAQLGSSIGT ANGSDLSPSK LAERANAPLP PQPRKHDKTP 600

SPQKVGRDSP TKQHDPIIDK RISLQTHGRE KLNKFIDENE AYLNFTEGAQ QTAEFSSPEK 660

TLDPTSNRRS LGLTDLSIEH SQTWESKDDL MRDELELWKA QREEMELEIK QDSGEIQEDL 720

EVDHIDLETK QKLDWENKND FREADLTIDS THTNPFRDMN SETFQIEQDH ASKEVLQETV 780

SLAPTSTHAS RTTDQQSPQK SQTSTSAKHK KRAAKRRKVS LDNFVLLKVL GKGNFGKVIL 840

SKSKNTDRLC AIKVLKKDNI IQNHDIESAR AEKKVFLLAT KTKHPFLTNL YCSFQTENRI 900

YFAMEFIGGG DLMWHVQNQR LSVRRAKFYA AEVLLALKYF HDNGVIYRDL KLENILLTPE 960

GHIKIADYGL CKDEMWYGNR TSTFCGTPEF MAPEILKEQE YTKAVDWWAF GVLLYQMLLC 1020

QSPFSGDDED EVFNAILTDE PLYPIDMAGE IVQIFQGLLT KDPEKRLGAG PRDADEVMEE 1080

PFFRNINFDD ILNLRVKPPY IPEIKSPEDT SYFEQEFTSA PPTLTPLPSV LTTSQQEEFR 1140

GFSFMPDDLD L 1151

Nucleotide Sequence
(FASTA)

ATGAGTTTTT CACAATTGGA GCAGAACATT AAAAAAAAGA TAGCCGTCGA AGAAAATATT 60

ATTCGGGGAG CTTCTGCCCT CAAGAAAAAG ACTAGCAATG TTATGGTCAT TCAGAAATGT 120

AATACGAATA TTAGAGAGGC ACGTCAAAAT CTTGAGTACT TGGAGGATAG CTTAAAAAAA 180

TTACGGTTGA AGACCGCTCA ACAAAGTCAG GGTGAAAATG GCAGCGAAGA TAATGAGCGA 240

TGCAATTCGA AGGAATACGG GTTTCTTTCT ACCAAATCGC CAAATGAACA CATATTTTCT 300

CGTTTGGATT TAGTAAAATA TGATTGCCCT TCTTTGGCGC AAAGAATCCA ATACATGTTG 360

CAACAATTAG AATTCAAATT ACAGGTGGAA AAGCAATACC AAGAAGCCAA TACTAAATTG 420

ACTAAATTGT ATCAAATTGA CGGTGATCAA CGTAGTAGTT CTGCGGCAGA AGGGGGTGCT 480

ATGGAATCCA AATACAGGAT TCAAATGCTT AACAAAGCTT TGAAGAAATA CCAAGCTATT 540

AACGTTGACT TTGATCAATT TAAACACCAA CCCAATGACA TAATGGATAA TCAACAACCG 600

AAATTCCGAA GAAAACAACT GACTGGCGTT CTAACAATTG GAATAACTGC TGCTAGAGAT 660

GTTGACCATA TACAATCACC GATGTTTGCC AGGAAGCCAG AGAGCTACGT TACTATAAAA 720

ATCGATGATA CGATCAAAGC CAGAACGAAG CCTTCTAGAA ATGACAGGTG GAGTGAAGAT 780

TTTCAAATTC CAGTTGAAAA AGGGAATGAA ATCGAGATTA CTGTATATGA TAAGGTGAAC 840

GACTCGCTCA TTCCAGTGGC TATAATGTGG TTACTGCTTT CCGATATCGC TGAAGAAATT 900

CGTAAGAAGA AAGCCGGACA AACAAATGAA CAACAAGGAT GGGTCAACGC TTCAAACATT 960

AATGGTGGTT CTTCTCTCGC TAGCGAAGAG GGAAGCACAT TGACTTCTAC ATACTCAAAC 1020

TCAGCCATTC AGTCTACTTC AGCAAAGAAT GTGCAAGGCG AAAATACATC AACTAGTCAA 1080

ATCAGTACGA ATTCATGGTT TGTCTTAGAA CCATCCGGGC AGATTTTGTT AACACTAGGA 1140

TTCCACAAGT CTTCTCAAAT AGAAAGGAAG CAGTTGATGG GTGGACTACA TCGTCATGGT 1200

GCTATTATCA ATAGGAAAGA AGAGATATTC GAACAGCATG GCCACCACTT TGTACAAAAA 1260

TCATTTTACA ACATTATGTG CTGTGCATAT TGTGGTGATT TCCTTCGGTA TACTGGGTTC 1320

CAATGTCAAG ATTGTAAATT TTTATGTCAC AAAAAATGTT ACACCAATGT TGTTACTAAG 1380

TGTATTGCTA AAACTTCTAC TGATACGGAT CCGGACGAGG CAAAGTTGAA CCACCGTATT 1440

CCTCATAGAT TCCTGCCTAC TTCAAACCGT GGTACTAAAT GGTGCTGTCA CTGTGGTTAT 1500

ATTTTACCAT GGGGTAGACA TAAAGTACGC AAATGTTCTG AATGTGGTAT AATGTGTCAT 1560

GCTCAATGTG CTCATTTGGT TCCCGATTTC TGTGGCATGT CGATGGAAAT GGCTAATAAA 1620

ATTCTGAAAA CGATTCAAGA CACAAAACGT AATCAAGAGA AAAAGAAGAG GACAGTTCCG 1680

TCGGCACAGT TGGGGTCATC TATTGGTACT GCCAATGGTA GTGATCTTTC CCCATCCAAA 1740

TTAGCTGAAA GGGCAAACGC TCCTTTGCCT CCTCAGCCAA GAAAACATGA TAAAACTCCT 1800

TCGCCTCAGA AGGTAGGAAG AGATTCTCCA ACTAAGCAGC ATGATCCTAT TATTGATAAA 1860

AGAATTTCAC TACAAACGCA CGGGCGTGAG AAACTAAATA AATTTATCGA TGAAAATGAG 1920

GCCTATTTAA ATTTTACAGA AGGTGCACAA CAAACCGCCG AATTTTCATC ACCAGAGAAA 1980

ACACTGGATC CAACGTCGAA TAGACGTTCC TTGGGACTCA CTGATTTATC TATTGAGCAT 2040

AGTCAAACTT GGGAATCTAA AGATGATTTA ATGAGAGATG AACTTGAACT GTGGAAAGCA 2100

CAACGTGAGG AAATGGAACT TGAAATAAAA CAAGATAGTG GGGAAATCCA AGAGGATCTA 2160

GAAGTTGATC ACATTGATTT AGAGACCAAA CAGAAACTAG ACTGGGAGAA CAAAAATGAT 2220

TTCCGTGAAG CTGATTTGAC AATAGATTCC ACACACACAA ATCCATTCCG CGATATGAAT 2280

AGTGAAACCT TTCAAATTGA ACAAGACCAT GCTTCAAAGG AAGTACTACA AGAAACAGTG 2340

TCCTTGGCTC CTACAAGTAC TCATGCCTCC AGAACCACTG ATCAACAATC TCCGCAGAAA 2400

TCACAAACCA GCACAAGCGC AAAGCATAAA AAGAGAGCGG CTAAACGTCG TAAGGTTTCA 2460

TTAGATAATT TCGTATTACT CAAAGTTCTT GGTAAAGGTA ATTTTGGTAA AGTTATTTTA 2520

TCTAAATCAA AGAATACTGA CAGGCTTTGT GCCATAAAAG TTCTGAAGAA AGATAATATT 2580

ATTCAAAATC ATGACATCGA GAGTGCAAGA GCAGAAAAGA AAGTATTTTT GTTAGCCACA 2640

AAAACTAAAC ACCCATTCTT AACCAATCTA TACTGCTCTT TTCAAACTGA AAACCGTATA 2700

TATTTTGCTA TGGAGTTTAT TGGGGGCGGT GACTTAATGT GGCATGTTCA AAACCAAAGA 2760

CTATCTGTAA GAAGGGCCAA ATTTTATGCC GCCGAGGTCT TACTGGCTCT GAAATATTTT 2820

CATGATAATG GTGTAATATA CCGTGATTTG AAGTTGGAAA ACATTCTATT AACTCCAGAA 2880

GGTCATATAA AAATTGCCGA TTATGGTTTG TGTAAAGATG AAATGTGGTA TGGTAATAGA 2940

ACTTCTACAT TTTGTGGCAC ACCAGAATTT ATGGCTCCAG AAATTTTAAA AGAGCAAGAA 3000

TATACCAAAG CTGTCGATTG GTGGGCATTT GGGGTGCTGC TATATCAAAT GCTACTGTGC 3060

CAATCTCCAT TCTCAGGAGA TGACGAAGAT GAAGTTTTTA ACGCTATCCT TACCGATGAA 3120

CCCTTATACC CAATAGATAT GGCAGGTGAG ATTGTACAAA TATTCCAAGG CCTATTAACA 3180

AAAGATCCTG AAAAGAGGTT GGGTGCTGGT CCCAGGGACG CAGACGAAGT TATGGAAGAA 3240

CCTTTCTTCC GTAACATCAA CTTTGACGAT ATCTTAAACC TTCGCGTGAA ACCACCCTAC 3300

ATCCCAGAAA TTAAATCTCC GGAAGATACA TCATATTTCG AGCAAGAATT CACCTCTGCG 3360

CCACCCACAC TTACACCTCT GCCCTCTGTT TTGACAACGA GCCAGCAAGA AGAGTTTAGA 3420

GGATTTTCCT TTATGCCAGA TGATTTGGAT TTATGA 3456

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlal..ask  58

         f llkvlGkG+fgkv+l+++k+td+l+aikvlkkd ++q++d+e++++ek+v+ l  ++k

Q: 824   FVLLKVLGKGNFGKVILSKSKNTDRLCAIKVLKKDNIIQNHDIESARAEKKVFLLatKTK  883

         789*************************************************98733678

S: 59    kpflvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhe  118

         +pfl++l+++fqte+r++f++e++ GGdlm+h+q++ +l+ +ra+fyaae++lalk++h+

Q: 884   HPFLTNLYCSFQTENRIYFAMEFIGGGDLMWHVQNQ-RLSVRRAKFYAAEVLLALKYFHD  942

         9*********************************98.9**********************

S: 119   kgiiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeyg  178

         +g+iyrdlkl+n+ll+ eGhik+ad+Glck+e++ g++tstfcGtP+++aPeilke+ey+

Q: 943   NGVIYRDLKLENILLTPEGHIKIADYGLCKDEMWYGNRTSTFCGTPEFMAPEILKEQEYT  1002

         ************************************************************

S: 179   ksvdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkd  238

         k+vdwwa+Gvlly+ml++qsPf+g+dede+f++il++e+lyP  ++ e+v+i++glltkd

Q: 1003  KAVDWWAFGVLLYQMLLCQSPFSGDDEDEVFNAILTDEPLYPIDMAGEIVQIFQGLLTKD  1062

         ************************************************************

S: 239   pekrlGvkeegeedikehaff  259

         pekrlG+ +++ ++++e++ff

Q: 1063  PEKRLGAGPRDADEVMEEPFF  1083

         ********9999********9

Domain Sequence
(FASTA)

FVLLKVLGKG NFGKVILSKS KNTDRLCAIK VLKKDNIIQN HDIESARAEK KVFLLATKTK 60

HPFLTNLYCS FQTENRIYFA MEFIGGGDLM WHVQNQRLSV RRAKFYAAEV LLALKYFHDN 120

GVIYRDLKLE NILLTPEGHI KIADYGLCKD EMWYGNRTST FCGTPEFMAP EILKEQEYTK 180

AVDWWAFGVL LYQMLLCQSP FSGDDEDEVF NAILTDEPLY PIDMAGEIVQ IFQGLLTKDP 240

EKRLGAGPRD ADEVMEEPFF 260

Keyword

ATP-binding; Calcium; Cell cycle; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005856	; C:cytoskeleton
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0030427	; C:site of polarized growth
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0007015	; P:actin filament organization
GO:0007049	; P:cell cycle
GO:0033962	; P:cytoplasmic mRNA processing body assembly
GO:0031505	; P:fungal-type cell wall organization
GO:0007243	; P:intracellular protein kinase cascade
GO:0030242	; P:peroxisome degradation
GO:0060211	; P:regulation of nuclear-transcribed mRNA poly(A) tail shortening

KEGG

sce:YBL105C

;

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR011072	; HR1_rho-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF02185	; HR1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00742	; Hr1; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; FALSE_NEG.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

Created Date

20-Feb-2013