EKS-SAC-00091

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-SAC-00091

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	254.9	3.9E-76	2047	2316	270

Status

Reviewed

Ensembl Protein

YBR136W

UniProt Accession

P38111; D6VQD2; Q02580;

Protein Name

Serine/threonine-protein kinase MEC1

Protein Synonyms/Alias

ATR homolog; DNA-damage checkpoint kinase MEC1; Mitosis entry checkpoint protein 1;

Gene Name

MEC1

Gene Synonyms/Alias

MEC1; ESR1, SAD3; YBR136W; YBR1012;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
YBR136W	YBR136W	YBR136W

Organism

Saccharomyces cerevisiae

Functional Description

Serine/threonine protein kinase which activatescheckpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited in complex with protein LCD1 by the single-strand-binding protein complex RPA to DNA lesions in order to initiate the DNA repair by homologous recombination, after the MRX-complex and TEL1 are displaced. Phosphorylates LCD1 and RPA2, a subunit of RPA, involved in DNA replication, repair and recombination. Phosphorylates RAD9, CHK1 and RAD53, which leads to the activation of the CHK1 and RAD53 kinases involved in DNA damage repair cascade. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Phosphorylates also SLX4 and RTT107 which are proteins involved in genome stability. Required for cell growth and meiotic recombination.

Protein Length

2368

Protein Sequence
(FASTA)

MESHVKYLDE LILAIKDLNS GVDSKVQIKK VPTDPSSSQE YAKSLKILNT LIRNLKDQRR 60

NNIMKNDTIF SKTVSALALL LEYNPFLLVM KDSNGNFEIQ RLIDDFLNIS VLNYDNYHRI 120

WFMRRKLGSW CKACVEFYGK PAKFQLTAHF ENTMNLYEQA LTEVLLGKTE LLKFYDTLKG 180

LYILLYWFTS EYSTFGNSIA FLDSSLGFTK FDFNFQRLIR IVLYVFDSCE LAALEYAEIQ 240

LKYISLVVDY VCNRTISTAL DAPALVCCEQ LKFVLTTMHH FLDNKYGLLD NDPTMAKGIL 300

RLYSLCISND FSKCFVDHFP IDQWADFSQS EHFPFTQLTN KALSIVYFDL KRRSLPVEAL 360

KYDNKFNIWV YQSEPDSSLK NVTSPFDDRY KQLEKLRLLV LKKFNKTERG TLLKYRVNQL 420

SPGFFQRAGN DFKLILNEAS VSIQTCFKTN NITRLTSWTV ILGRLACLES EKFSGTLPNS 480

TKDMDNWYVC HLCDIEKTGN PFVRINPNRP EAAGKSEIFR ILHSNFLSHP NIDEFSESLL 540

SGILFSLHRI FSHFQPPKLT DGNGQINKSF KLVQKCFMNS NRYLRLLSTR IIPLFNISDS 600

HNSEDEHTAT LIKFLQSQKL PVVKENLVIA WTQLTLTTSN DVFDTLLLKL IDIFNSDDYS 660

LRIMMTLQIK NMAKILKKTP YQLLSPILPV LLRQLGKNLV ERKVGFQNLI ELLGYSSKTI 720

LDIFQRYIIP YAIIQYKSDV LSEIAKIMCD GDTSLINQMK VNLLKKNSRQ IFAVALVKHG 780

LFSLDILETL FLNRAPTFDK GYITAYLPDY KTLAEITKLY KNSVTKDASD SENANMILCS 840

LRFLITNFEK DKRHGSKYKN INNWTDDQEQ AFQKKLQDNI LGIFQVFSSD IHDVEGRTTY 900

YEKLRVINGI SFLIIYAPKK SIISALAQIS ICLQTGLGLK EVRYEAFRCW HLLVRHLNDE 960

ELSTVIDSLI AFILQKWSEF NGKLRNIVYS ILDTLIKEKS DLILKLKPYT TLALVGKPEL 1020

GILARDGQFA RMVNKIRSTT DLIPIFANNL KSSNKYVINQ NLDDIEVYLR RKQTERSIDF 1080

TPKKVGQTSD ITLVLGALLD TSHKFRNLDK DLCEKCAKCI SMIGVLDVTK HEFKRTTYSE 1140

NEVYDLNDSV QTIKFLIWVI NDILVPAFWQ SENPSKQLFV ALVIQESLKY CGLSSESWDM 1200

NHKELYPNEA KLWEKFNSVS KTTIYPLLSS LYLAQSWKEY VPLKYPSNNF KEGYKIWVKR 1260

FTLDLLKTGT TENHPLHVFS SLIREDDGSL SNFLLPYISL DIIIKAEKGT PYADILNGII 1320

IEFDSIFTCN LEGMNNLQVD SLRMCYESIF RVFEYCKKWA TEFKQNYSKL HGTFIIKDTK 1380

TTNMLLRIDE FLRTTPSDLL AQRSLETDSF ERSALYLEQC YRQNPHDKNQ NGQLLKNLQI 1440

TYEEIGDIDS LDGVLRTFAT GNLVSKIEEL QYSENWKLAQ DCFNVLGKFS DDPKTTTRML 1500

KSMYDHQLYS QIISNSSFHS SDGKISLSPD VKEWYSIGLE AANLEGNVQT LKNWVEQIES 1560

LRNIDDREVL LQYNIAKALI AISNEDPLRT QKYIHNSFRL IGTNFITSSK ETTLLKKQNL 1620

LMKLHSLYDL SFLSSAKDKF EYKSNTTILD YRMERIGADF VPNHYILSMR KSFDQLKMNE 1680

QADADLGKTF FTLAQLARNN ARLDIASESL MHCLERRLPQ AELEFAEILW KQGENDRALK 1740

IVQEIHEKYQ ENSSVNARDR AAVLLKFTEW LDLSNNSASE QIIKQYQDIF QIDSKWDKPY 1800

YSIGLYYSRL LERKKAEGYI TNGRFEYRAI SYFLLAFEKN TAKVRENLPK VITFWLDIAA 1860

ASISEAPGNR KEMLSKATED ICSHVEEALQ HCPTYIWYFV LTQLLSRLLH SHQSSAQIIM 1920

HILLSLAVEY PSHILWYITA LVNSNSSKRV LRGKHILEKY RQHSQNPHDL VSSALDLTKA 1980

LTRVCLQDVK SITSRSGKSL EKDFKFDMNV APSAMVVPVR KNLDIISPLE SNSMRGYQPF 2040

RPVVSIIRFG SSYKVFSSLK KPKQLNIIGS DGNIYGIMCK KEDVRQDNQY MQFATTMDFL 2100

LSKDIASRKR SLGINIYSVL SLREDCGILE MVPNVVTLRS ILSTKYESLK IKYSLKSLHD 2160

RWQHTAVDGK LEFYMEQVDK FPPILYQWFL ENFPDPINWF NARNTYARSY AVMAMVGHIL 2220

GLGDRHCENI LLDIQTGKVL HVDFDCLFEK GKRLPVPEIV PFRLTPNLLD ALGIIGTEGT 2280

FKKSSEVTLA LMRKNEVALM NVIETIMYDR NMDHSIQKAL KVLRNKIRGI DPQDGLVLSV 2340

AGQTETLIQE ATSEDNLSKM YIGWLPFW 2368

Nucleotide Sequence
(FASTA)

ATGGAATCAC ACGTCAAATA TCTTGACGAA TTGATATTGG CAATAAAAGA CCTGAACTCG 60

GGGGTGGATT CAAAGGTGCA GATTAAAAAA GTGCCCACGG ATCCATCTTC TTCTCAGGAG 120

TACGCCAAGA GTTTAAAGAT CCTGAACACC CTCATAAGAA ACCTAAAAGA TCAAAGAAGG 180

AACAATATCA TGAAAAATGA TACTATATTT TCGAAAACAG TTTCCGCCCT TGCCTTATTG 240

TTGGAGTACA ACCCCTTCTT GCTTGTTATG AAGGATTCCA ACGGGAACTT TGAGATACAA 300

AGGCTGATAG ATGATTTCCT CAACATATCC GTTCTGAACT ATGATAATTA CCACAGAATA 360

TGGTTTATGA GGCGAAAATT AGGCAGCTGG TGCAAAGCAT GTGTCGAATT TTACGGAAAA 420

CCTGCTAAGT TTCAGCTTAC TGCACATTTT GAGAACACCA TGAATCTTTA CGAACAGGCC 480

TTGACTGAAG TCTTGTTGGG CAAGACTGAG CTTCTCAAAT TTTATGACAC CTTGAAGGGT 540

CTATACATTC TTTTATACTG GTTCACTTCG GAGTATAGTA CTTTTGGGAA CTCTATAGCA 600

TTCTTAGATT CTTCTTTGGG GTTCACGAAA TTTGACTTTA ACTTCCAACG ATTAATCAGG 660

ATTGTTCTTT ACGTCTTTGA TTCCTGCGAA CTAGCAGCAC TAGAATATGC CGAAATCCAA 720

CTCAAATATA TTTCTCTAGT TGTGGACTAT GTTTGCAATA GAACAATTTC CACAGCCCTG 780

GATGCCCCAG CGTTAGTTTG TTGTGAACAA TTAAAGTTTG TATTGACTAC TATGCATCAT 840

TTTTTGGATA ACAAGTATGG GCTCTTGGAT AATGACCCCA CTATGGCCAA AGGAATTCTT 900

CGACTATATT CTCTTTGCAT TTCTAACGAT TTCTCAAAAT GCTTTGTAGA CCACTTCCCA 960

ATTGACCAGT GGGCAGATTT TTCACAAAGT GAACATTTTC CGTTCACGCA GTTGACTAAT 1020

AAAGCTCTCT CGATTGTATA TTTTGATTTG AAAAGAAGGT CCCTACCTGT TGAAGCTTTA 1080

AAGTACGATA ATAAGTTCAA CATCTGGGTA TACCAATCGG AGCCGGACTC GAGCTTGAAA 1140

AATGTCACTT CTCCCTTTGA TGATCGATAT AAGCAGCTGG AAAAGCTAAG GTTGCTAGTA 1200

CTAAAGAAGT TTAACAAGAC AGAAAGAGGA ACTTTGCTCA AATACCGCGT GAACCAGCTA 1260

AGTCCTGGAT TTTTTCAAAG AGCTGGAAAC GATTTCAAGC TAATTTTAAA TGAAGCATCT 1320

GTATCCATTC AAACTTGTTT CAAGACAAAC AATATAACAA GGCTAACATC ATGGACTGTA 1380

ATTCTCGGAC GTCTAGCCTG TCTAGAATCA GAGAAGTTTT CCGGCACTCT GCCAAATTCC 1440

ACAAAGGATA TGGATAATTG GTATGTTTGT CATTTATGCG ATATTGAGAA AACTGGCAAC 1500

CCTTTCGTGC GAATAAATCC AAATAGACCA GAGGCTGCGG GTAAATCAGA AATCTTCAGG 1560

ATACTTCATT CAAACTTTCT ATCTCACCCA AATATAGATG AATTTAGCGA ATCTTTGTTA 1620

AGTGGCATCT TATTTTCTCT ACATAGGATA TTTTCACACT TTCAACCTCC AAAACTTACA 1680

GATGGAAACG GTCAAATCAA TAAGAGCTTT AAACTGGTAC AAAAGTGCTT TATGAATTCT 1740

AACAGATACC TACGTTTATT AAGTACTAGA ATTATACCTT TATTCAATAT ATCAGACTCT 1800

CATAATTCCG AAGATGAACA CACTGCCACG CTGATAAAGT TTCTACAATC TCAAAAATTG 1860

CCAGTGGTGA AAGAAAATTT AGTCATTGCT TGGACACAAT TAACATTGAC GACTTCTAAT 1920

GATGTATTTG ATACACTACT TTTGAAACTG ATTGATATTT TCAATTCTGA TGATTATAGT 1980

TTACGAATAA TGATGACTTT GCAAATTAAA AATATGGCCA AAATTTTAAA GAAAACACCA 2040

TATCAATTAC TATCGCCTAT TTTACCTGTA TTACTAAGAC AGTTGGGAAA AAACCTCGTG 2100

GAAAGAAAAG TTGGCTTTCA AAATTTAATA GAATTATTGG GATATTCTTC AAAAACAATT 2160

CTCGATATTT TCCAGAGATA TATCATCCCT TATGCAATTA TTCAATATAA GAGCGATGTG 2220

CTAAGTGAAA TTGCTAAGAT TATGTGTGAT GGCGATACAA GTTTAATTAA CCAAATGAAG 2280

GTTAATTTAC TGAAAAAAAA CAGTAGGCAA ATATTTGCCG TAGCTTTGGT AAAACACGGA 2340

TTATTTTCTT TGGATATCTT GGAAACCCTT TTTTTAAATA GGGCTCCAAC TTTTGACAAA 2400

GGATATATAA CTGCATACCT TCCCGATTAT AAAACTTTAG CTGAAATAAC GAAGCTCTAC 2460

AAAAACAGCG TTACTAAAGA TGCAAGTGAC AGCGAGAATG CTAATATGAT TTTATGCTCT 2520

TTGCGATTTT TAATCACCAA TTTTGAAAAA GACAAAAGGC ATGGTTCGAA GTACAAAAAT 2580

ATCAATAACT GGACGGATGA TCAGGAACAA GCGTTCCAAA AGAAACTACA GGATAATATC 2640

TTAGGTATTT TCCAAGTTTT TTCGAGTGAC ATACATGATG TTGAAGGCCG CACCACTTAC 2700

TACGAAAAGT TAAGGGTTAT CAATGGCATT TCTTTTCTTA TCATATATGC CCCCAAAAAA 2760

TCAATAATTT CCGCATTAGC CCAGATTAGT ATTTGTTTGC AAACAGGACT TGGGCTTAAG 2820

GAAGTTCGAT ACGAGGCCTT TAGATGTTGG CATCTGTTAG TTCGCCATCT AAATGATGAA 2880

GAACTCTCTA CTGTTATAGA TAGCTTAATT GCATTCATAC TTCAAAAGTG GTCTGAGTTC 2940

AACGGAAAAC TTCGAAATAT AGTGTACAGT ATACTGGATA CCTTAATCAA AGAGAAATCG 3000

GACCTGATTT TGAAATTAAA ACCTTACACT ACTTTGGCTT TAGTAGGCAA GCCTGAATTA 3060

GGTATTTTAG CTCGTGATGG CCAATTTGCA AGAATGGTGA ATAAAATAAG AAGTACCACG 3120

GACCTTATAC CCATATTTGC TAATAACTTG AAAAGTAGTA ACAAGTATGT CATAAACCAA 3180

AATTTAGACG ATATAGAGGT ATATCTTCGG AGAAAGCAGA CAGAAAGATC GATTGATTTT 3240

ACACCAAAGA AGGTTGGGCA AACTTCTGAT ATAACATTAG TTTTGGGTGC TTTATTAGAC 3300

ACTTCTCATA AGTTTAGAAA TTTAGACAAG GACCTATGCG AGAAGTGCGC CAAATGTATC 3360

AGTATGATTG GTGTTTTAGA CGTTACAAAG CATGAGTTTA AAAGAACAAC ATATTCAGAA 3420

AACGAAGTTT ATGATTTGAA TGATAGTGTT CAAACTATTA AGTTCTTGAT ATGGGTCATA 3480

AATGATATCC TCGTTCCTGC GTTTTGGCAA AGTGAGAATC CCAGCAAGCA ATTGTTTGTT 3540

GCCCTTGTCA TACAGGAATC ATTAAAATAT TGCGGGCTAA GTTCAGAGTC ATGGGATATG 3600

AACCATAAAG AATTATATCC AAATGAAGCC AAACTATGGG AAAAGTTTAA CTCTGTCTCC 3660

AAGACAACCA TCTATCCGCT TTTATCTTCC TTGTATCTTG CGCAATCATG GAAAGAATAT 3720

GTCCCGCTAA AATATCCTTC TAATAACTTC AAGGAAGGAT ACAAAATTTG GGTGAAAAGG 3780

TTTACATTGG ATTTATTGAA AACAGGTACA ACAGAAAATC ATCCATTACA CGTGTTTTCC 3840

TCTTTGATTA GGGAAGATGA TGGCTCACTA TCAAATTTTT TGCTACCTTA TATTTCTCTG 3900

GACATTATTA TCAAGGCAGA AAAAGGAACT CCATACGCTG ATATTTTAAA CGGGATTATT 3960

ATTGAATTTG ACAGCATTTT CACGTGCAAT CTGGAAGGAA TGAATAACTT GCAAGTGGAT 4020

TCGTTAAGAA TGTGCTATGA ATCCATCTTC AGAGTTTTCG AATATTGCAA AAAATGGGCA 4080

ACTGAGTTTA AACAAAATTA CAGTAAACTA CACGGCACTT TTATCATTAA AGATACGAAA 4140

ACAACTAACA TGCTTTTGAG AATAGATGAG TTTTTGCGAA CAACCCCTTC AGATTTGCTA 4200

GCTCAACGCT CCTTAGAGAC GGATTCTTTT GAAAGGTCTG CTCTATACCT TGAACAGTGC 4260

TATCGACAGA ATCCTCACGA TAAGAACCAA AATGGACAAC TACTGAAAAA TTTACAAATC 4320

ACATACGAAG AAATAGGAGA CATTGACTCA CTCGATGGTG TACTGAGAAC CTTTGCTACA 4380

GGAAACTTGG TTTCTAAAAT TGAAGAATTG CAATATTCTG AAAACTGGAA ACTCGCACAA 4440

GACTGCTTTA ATGTCCTCGG CAAATTTTCA GATGACCCCA AAACTACAAC CAGGATGCTA 4500

AAGTCTATGT ATGACCACCA ATTGTATTCT CAAATAATAT CGAACTCTTC GTTCCATTCT 4560

TCAGACGGAA AAATTTCTTT GTCTCCAGAT GTGAAGGAAT GGTACAGCAT AGGTCTTGAA 4620

GCTGCAAATC TAGAAGGCAA TGTTCAAACT TTGAAAAATT GGGTAGAACA AATAGAGAGT 4680

TTAAGAAATA TTGACGATAG AGAAGTACTT TTGCAGTACA ATATTGCGAA AGCTTTAATT 4740

GCCATCTCAA ACGAGGATCC ATTAAGGACT CAAAAATACA TCCACAATTC CTTTAGGCTT 4800

ATCGGAACAA ATTTTATAAC GTCATCTAAA GAGACGACGC TGCTAAAGAA ACAGAATTTA 4860

TTGATGAAAT TACACAGTTT ATATGACCTC AGTTTTTTAT CTTCTGCGAA AGATAAGTTT 4920

GAATACAAAA GTAACACTAC CATACTCGAT TATCGAATGG AACGTATTGG GGCTGACTTC 4980

GTGCCAAATC ATTACATATT GTCAATGAGA AAGTCATTTG ACCAATTGAA AATGAATGAA 5040

CAAGCAGACG CTGACTTAGG AAAAACATTC TTCACTTTAG CCCAATTGGC GAGAAACAAC 5100

GCTAGGCTAG ATATAGCCTC CGAATCATTA ATGCATTGTT TGGAAAGGCG GTTGCCTCAG 5160

GCAGAGTTGG AGTTTGCTGA AATACTATGG AAGCAAGGTG AGAATGATAG AGCCTTAAAG 5220

ATAGTGCAAG AAATACATGA AAAGTATCAA GAAAATTCCT CGGTTAATGC TCGCGATCGT 5280

GCCGCCGTGC TATTAAAGTT TACTGAATGG TTAGACCTTT CGAACAATTC AGCGTCCGAA 5340

CAAATTATTA AACAATATCA GGATATTTTT CAGATTGATT CTAAATGGGA TAAACCATAT 5400

TACTCTATTG GCTTATACTA TAGTAGACTA CTTGAGCGCA AAAAAGCAGA GGGTTATATT 5460

ACTAATGGTC GTTTTGAGTA CAGGGCAATA TCTTACTTTT TATTGGCATT TGAAAAGAAC 5520

ACTGCTAAAG TAAGAGAAAA TTTGCCCAAA GTTATCACGT TTTGGCTAGA TATTGCGGCC 5580

GCATCAATTT CTGAAGCTCC TGGAAACAGA AAGGAAATGC TGAGTAAGGC TACGGAAGAT 5640

ATATGTAGTC ATGTTGAAGA AGCGCTGCAG CATTGTCCCA CTTATATTTG GTACTTTGTT 5700

TTGACTCAGT TGTTATCTAG GTTATTACAT TCTCATCAAT CATCGGCCCA GATAATAATG 5760

CACATACTGC TAAGTTTGGC TGTTGAATAC CCCTCTCATA TTTTATGGTA TATCACAGCC 5820

CTTGTAAATT CCAATTCTTC AAAAAGAGTT CTTCGTGGTA AGCATATTTT AGAAAAGTAT 5880

AGACAACATT CGCAAAATCC TCATGATCTA GTTTCTAGTG CATTGGATTT AACGAAAGCA 5940

TTAACTCGTG TCTGTTTGCA AGATGTCAAA AGCATTACAA GTAGATCAGG CAAATCTTTA 6000

GAAAAAGACT TCAAATTTGA CATGAACGTG GCCCCATCTG CAATGGTTGT TCCAGTAAGA 6060

AAAAATTTAG ACATCATTTC ACCACTAGAG TCTAACTCAA TGAGGGGCTA TCAACCATTT 6120

AGGCCGGTTG TTTCTATAAT TAGATTCGGA TCATCTTATA AAGTGTTTTC TTCATTAAAG 6180

AAGCCAAAAC AATTGAACAT AATAGGTTCA GATGGCAACA TTTATGGGAT CATGTGTAAG 6240

AAGGAAGATG TCCGACAAGA TAACCAATAT ATGCAGTTCG CCACAACAAT GGATTTTCTT 6300

CTGAGTAAGG ACATAGCTTC AAGAAAAAGA AGCCTGGGCA TAAATATTTA CTCCGTACTA 6360

TCTCTTCGAG AAGACTGTGG GATATTGGAA ATGGTACCGA ATGTTGTAAC TTTAAGATCT 6420

ATTCTTTCTA CAAAGTACGA AAGTCTGAAA ATTAAGTATA GCCTGAAAAG TCTACATGAT 6480

AGGTGGCAGC ACACCGCAGT AGATGGAAAA CTCGAGTTTT ACATGGAACA GGTAGATAAA 6540

TTTCCTCCAA TCTTGTACCA ATGGTTTTTA GAAAACTTTC CTGATCCAAT CAATTGGTTC 6600

AACGCCAGGA ATACGTATGC CAGATCTTAC GCCGTCATGG CAATGGTTGG CCATATATTA 6660

GGTCTAGGTG ATAGGCACTG TGAAAACATA TTACTAGATA TACAGACGGG TAAAGTTCTT 6720

CATGTAGACT TCGACTGTTT ATTTGAGAAA GGCAAAAGGT TACCTGTCCC AGAAATTGTT 6780

CCCTTCAGAC TAACACCAAA TTTATTGGAT GCGTTGGGCA TAATTGGGAC AGAAGGAACA 6840

TTTAAGAAGT CTAGTGAAGT CACGTTGGCT TTAATGAGAA AAAATGAAGT AGCGTTGATG 6900

AATGTGATCG AAACAATTAT GTACGATAGA AACATGGACC ACTCAATTCA AAAAGCGCTA 6960

AAGGTCTTAA GAAACAAAAT CCGCGGTATA GATCCGCAGG ATGGCCTGGT ATTGAGTGTT 7020

GCTGGCCAAA CAGAAACATT GATCCAAGAA GCAACATCAG AAGACAATCT AAGCAAGATG 7080

TATATTGGTT GGCTTCCATT TTGGTAA 7107

Domain Profile

S: 2     agfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakdk  61

          +f  + ++ +s++kpk+l + Gsdg +y  ++k keD rqd+  +q+   +  lL kd

Q: 2047  IRFGSSYKVFSSLKKPKQLNIIGSDGNIYGIMCK-KEDVRQDNQYMQFATTMDFLLSKDI  2105

         57788889*************************9.89***********************

S: 62    etsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdls  121

         ++++r L i  y+V  l + +g++e v+n v+L+ +l   +e+ +++++         l+

Q: 2106  ASRKRSLGINIYSVLSLREDCGILEMVPNVVTLRSILSTKYESLKIKYS---------LK  2156

         *************************************999999999997.........33

S: 122   tvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAvi  181

                + +++  +le ++e + ++ p  +l +++le+fp+p +wf+ r+ y+rs Av+

Q: 2157  SLHD-RWQHTAVDGKLEFYMEQVDKFPP--ILYQWFLENFPDPINWFNARNTYARSYAVM  2213

         3333.33444555567999999***777..******************************

S: 182   slvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivnal  241

          +vg+iLgLgdrh en+l+d +tg+v+h+df + fek+k  l+vpe+vPFRLT+n+ +al

Q: 2214  AMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKR-LPVPEIVPFRLTPNLLDAL  2272

         ****************************************.*******************

S: 242   gvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk  285

         g++g+eG f++s e +l ++r+++  l++++e+++yd  +d +

Q: 2273  GIIGTEGTFKKSSEVTLALMRKNEVALMNVIETIMYDRNMDHSI  2316

         *************************************9998876

Domain Sequence
(FASTA)

IRFGSSYKVF SSLKKPKQLN IIGSDGNIYG IMCKKEDVRQ DNQYMQFATT MDFLLSKDIA 60

SRKRSLGINI YSVLSLREDC GILEMVPNVV TLRSILSTKY ESLKIKYSLK SLHDRWQHTA 120

VDGKLEFYME QVDKFPPILY QWFLENFPDP INWFNARNTY ARSYAVMAMV GHILGLGDRH 180

CENILLDIQT GKVLHVDFDC LFEKGKRLPV PEIVPFRLTP NLLDALGIIG TEGTFKKSSE 240

VTLALMRKNE VALMNVIETI MYDRNMDHSI 270

Keyword

ATP-binding; Chromatin regulator; Complete proteome; DNA damage; DNA repair; Kinase; Meiosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000077	; P:DNA damage checkpoint
GO:0006975	; P:DNA damage induced protein phosphorylation
GO:0006281	; P:DNA repair
GO:0006260	; P:DNA replication
GO:0016572	; P:histone phosphorylation
GO:0007131	; P:reciprocal meiotic recombination
GO:0000722	; P:telomere maintenance via recombination

KEGG

sce:YBR136W

;

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR011009	; Kinase-like_dom.
IPR027011	; Mec1.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS00915	; PI3_4_KINASE_1; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013